Article
Medicine, General & Internal
Goran Savic, Ivana Stevanovic, Dusan Mihajlovic, Milena Jurisevic, Nevena Gajovic, Ivan Jovanovic, Milica Ninkovic
Summary: COVID-19 development is influenced by immune and inflammatory responses, with matrix metalloproteinases contributing to tissue destruction. VEGF A and BDNF play active roles, and the MMP-9/BDNF ratio could be a suitable marker for assessing the stage of the disease.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Monika Matusiak, Dominika Ozieblo, Monika Oldak, Emilia Rejmak, Leszek Kaczmarek, Henryk Skarzynski
Summary: Congenitally deaf children who undergo cochlear implantation before 1 year of age show faster auditory skills development compared to those implanted later. In this study, plasma levels of certain proteins were measured in a group of implanted children divided into two subgroups based on their age at implantation. Results showed higher BDNF levels and lower LEAQ scores in the younger subgroup. Significant differences were observed in BDNF levels and LEAQ scores between the subgroups over time, as well as in MMP-9 levels. Comparison with a control group showed significant differences in protein levels between the older study subgroup and age-matched controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Lihong Pan, Zhonghai Cao, Lianghu Chen, Min Qian, Yuzhong Yan
Summary: This study found that SNPs of BDNF and MMP-9 are related to the clinical features of schizophrenia and could serve as useful biomarkers for changes, remission, or deterioration of the clinical status of schizophrenia.
FRONTIERS IN PSYCHIATRY
(2022)
Retraction
Chemistry, Multidisciplinary
Laura Fisher
Summary: The study investigates the role of miR-26b in regulating morphine tolerance, showing that miR-26b alleviates morphine tolerance by inhibiting BDNF through the Wnt/beta-catenin pathway.
Article
Multidisciplinary Sciences
Samantha T. Reyes, Robert M. J. Deacon, Scarlett G. Guo, Francisco J. Altimiras, Jessa B. Castillo, Berend van der Wildt, Aimara P. Morales, Jun Hyung Park, Daniel Klamer, Jarrett Rosenberg, Lindsay M. Oberman, Nell Rebowe, Jeffrey Sprouse, Christopher U. Missling, Christopher R. McCurdy, Patricia Cogram, Walter E. Kaufmann, Frederick T. Chin
Summary: Fragile X syndrome (FXS) is a prevalent genetic form of intellectual disability and autism spectrum disorder, with ANAVEX2-73 potentially offering a new treatment option. Experimental use of blarcamesine in FXS mice has shown promising results in improving cognitive and behavioral impairments associated with the disorder.
SCIENTIFIC REPORTS
(2021)
Article
Toxicology
Anna K. Wojtowicz, Agnieszka M. Sitarz-Gtownia, Agnieszka Wnuk, Ma lgorzata Kajta, Konrad A. Szychowski
Summary: This study investigated the mechanism of action of DEHP and found that it has a pro-apoptotic effect on neurons while increasing the proliferation of astrocytes and altering the expression of related proteins.
TOXICOLOGY IN VITRO
(2023)
Article
Surgery
Feng Wu, Brooke Dorman, Ahmad Zeineddin, Rosemary Ann Kozar
Summary: Obesity is associated with higher mortality following trauma, and both obesity and trauma can affect endothelial cell function. Fibrinogen-based resuscitation can attenuate the adverse effects of obesity on endothelium.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Psychology, Developmental
Javid Rezaei Lord, Farhad Mashayekhi, Zivar Salehi
Summary: The study found a significant association between MMP-9 genetic variation and serum concentration with autism spectrum disorder, suggesting that the TT genotype may be a risk factor for ASD.
DEVELOPMENT AND PSYCHOPATHOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kanishk Luhach, Giriraj T. Kulkarni, Vijay P. Singh, Bhupesh Sharma
Summary: The study found that papaverine can improve behavioral deficits related to autism spectrum disorder in rats with hyperserotonemia, and has significant effects on neuronal function, brain inflammation, and brain oxidative stress.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qi Li, Yaxin Shi, Xiang Li, Yuan Yang, Xirui Zhang, Lisha Xu, Zhe Ma, Jia Wang, Lili Fan, Lijie Wu
Summary: Abnormal lipid metabolism is suggested to contribute to the pathogenesis of autism spectrum disorder (ASD). Using proteomic and bioinformatics analysis, this study identified differentially expressed proteins enriched in lipid metabolic pathways in hippocampal tissues of ASD mice. Apolipoprotein A-I (ApoA-I) was found to be significantly upregulated in ASD mice. Further experiments showed that inhibiting the SphK pathway improved ASD core phenotype and related protein levels. Proteins related to neuron synapse development and function were also restored to normal levels in ASD mice. Elucidating the mechanism of ApoA-I in ASD-associated phenotypes may provide new insights into the etiology of ASD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Aisha Farhana, Abdullah Alsrhani, Nazia Nazam, Muhammad Ikram Ullah, Yusuf Saleem Khan, Zafar Rasheed
Summary: Breast cancer has a high prevalence in females worldwide, and its treatment poses persistent challenges. This study explores the therapeutic potential of gold nanoparticles (AuNPs) in the regulation of microRNA and the protein MMP-9. The results show that AuNPs inhibit MMP-9 expression through the upregulation of microRNA-204-5p in breast cancer cells. Additionally, AuNPs also inhibit NF-?B activation. These findings demonstrate the novel therapeutic role of AuNPs in breast cancer.
Article
Medicine, Research & Experimental
Juli Choi, Hyejin Kwon, Pyung-Lim Han
Summary: The study demonstrates that hyperoxygenation treatment increases the expression of MMP-2, MMP-9, and tPA in the hippocampus of Tg-APP/PS1 mice, with MMP-9 being upregulated via MeCP2 in neuronal cells, and MMP-2 and tPA being upregulated through MeCP2 and other nuclear factors.
EXPERIMENTAL NEUROBIOLOGY
(2021)
Article
Physiology
Ming-Ming Zhu, Yi Ma, Meng Tang, Li Pan, Wen-Ling Liu
Summary: This study investigated the role of MMP-9 in hypoxia-induced BM degradation in rat bone marrow and found that upregulation of MMP-9 led to downregulation of COL4A1, resulting in increased BM degradation.
PHYSIOLOGICAL RESEARCH
(2022)
Review
Neurosciences
Ruchi Kumari, Aanchal Verma, Nandini Dubey, Anant Agrawal
Summary: Parkinson's disease is a multifactorial movement disorder characterized by neurodegeneration. Oxidative stress and the activation of matrix metalloproteinase (MMP-9) have been implicated in its pathogenesis. MMP-9 has important roles in various diseases, including inflammatory disorders, cardiovascular diseases, and neurodegenerative disorders. Understanding the biological activities of MMP-9 is crucial for identifying therapeutic targets for disease treatment. This review provides an overview of MMPs and discusses the involvement of MMP-9 in Parkinson's disease.
NEUROCHEMICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Saadet Busra Aksoyer Sezgin, Burcu Bayoglu, Feyzullah Ersoz, Murat Sarici, Mutlu Niyazoglu, Ahmet Dirican, Mujgan Cengiz
Summary: IL-10, MMP-2, and MMP-9 play important roles in obesity development and its related clinical phenotypes. The gene expression of MMP-2 and MMP-9 was significantly downregulated in obesity patients, while IL-10 levels were elevated. MMP-2 was positively correlated with fasting blood glucose levels and negatively correlated with BMI and weight in the obesity group.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2022)
Article
Neurosciences
Sang Eun Park, Ji Hoon Song, Chansik Hong, Dong Eun Kim, Jee-Won Sul, Tae-Youn Kim, Bo-Ra Seo, Insuk So, Sang-Yeob Kim, Dong-Jun Bae, Mi-Ha Park, Hye Min Lim, In-Jeoung Baek, Antonio Riccio, Joo-Yong Lee, Woo Hyun Shim, Bumwoo Park, Jae-Young Koh, Jung Jin Hwang
MOLECULAR NEUROBIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Jae-Won Eom, Tae-Youn Kim, Bo-Ra Seo, Hwangseo Park, Jae-Young Koh, Yang-Hee Kim
ACS CHEMICAL NEUROSCIENCE
(2019)
Article
Cell Biology
Ji Hyun Shin, So Jung Park, Doo Sin Jo, Na Yeon Park, Joon Bum Kim, Ji-Eun Bae, Yoon Kyung Jo, Jung Jin Hwang, Jin-A Lee, Dong-Gyu Jo, Jin Cheon Kim, Yong Keun Jung, Jae-Young Koh, Dong-Hyung Cho
Review
Neurosciences
Jae-Young Koh, Ha Na Kim, Jung Jin Hwang, Yang-Hee Kim, Sang Eun Park
Article
Multidisciplinary Sciences
YoungSoo Kim, Yong Kyoung Yoo, Hye Yun Kim, Jee Hoon Roh, Jinsik Kim, Seungyeop Baek, Jinny Claire Lee, Hye Jin Kim, Myung-Sic Chae, Dahye Jeong, Dongsung Park, Sejin Lee, HoChung Jang, Kyeonghwan Kim, Jeong Hoon Lee, Byung Hyun Byun, Su Yeon Park, Jeong Ho Ha, Kyo Chul Lee, Won Woo Cho, Jae-Seung Kim, Jae-Young Koh, Sang Moo Lim, Kyo Seon Hwang
Article
Cell Biology
Doo Sin Jo, So Jung Park, Ae-Kyeong Kim, Na Yeon Park, Joon Bum Kim, Ji-Eun Bae, Hyun Jun Park, Ji Hyun Shin, Jong Wook Chang, Peter K. Kim, Yong-Keun Jung, Jae-Young Koh, Seong-Kyu Choe, Kyu-Sun Lee, Dong-Hyung Cho
Article
Multidisciplinary Sciences
Young Hyun Cho, Seung-Hwan Lee, Sook-Jeong Lee, Ha Na Kim, Jae-Young Koh
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Bo Young Choi, Jeong Hyun Jeong, Jae-Won Eom, Jae-Young Koh, Yang-Hee Kim, Sang Won Suh
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Neurosciences
Hyun-Seo Park, Min Heui Yoo, Jae-Young Koh
NEUROBIOLOGY OF DISEASE
(2020)
Article
Cell & Tissue Engineering
Bo Young Choi, Dae Ki Hong, Jeong Hyun Jeong, Bo Eun Lee, Jae-Young Koh, Sang Won Suh
Review
Neurosciences
Jae-Young Koh, Sook-Jeong Lee
Review
Neurosciences
Yang-Hee Kim, Jae-Won Eom, Jae-Young Koh
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Endocrinology & Metabolism
Eoi Jong Seo, Jeong A. Choi, Jae-Young Koh, Young Hee Yoon
BMJ OPEN DIABETES RESEARCH & CARE
(2020)
Article
Neurosciences
Huikyong Lee, Jae-Young Koh
Summary: The study revealed that cAMP can reverse lysosomal acidification defects through the activation of protein kinase A, and increase autophagy flux. Moreover, in the presence of v-ATPase inhibition, H+/K+-ATPase may act as an alternative route for lysosomal acidification.
Article
Pharmacology & Pharmacy
Jun-Sub Jung, A. Ra Kho, Song Hee Lee, Bo Young Choi, Shin-Hae Kang, Jae-Young Koh, Sang Won Suh, Dong-Keun Song
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2020)