Article
Oncology
Kohji Yamada, Tsunekazu Oikawa, Ryusuke Kizawa, Saya Motohashi, Saishu Yoshida, Tomotaka Kumamoto, Chisato Saeki, Chika Nakagawa, Yuya Shimoyama, Katsuhiko Aoki, Toshiaki Tachibana, Masayuki Saruta, Masaya Ono, Kiyotsugu Yoshida
Summary: The secreted PKC delta from liver cancer cells acts as a humoral growth factor that enhances cell growth by activating proliferative signaling molecules. Inactivation of cytosolic PKC delta is necessary for its secretion, and it is anchored on the cell surface of liver cancer cells via association with glypican 3.
Article
Biochemistry & Molecular Biology
Kuilong Huang, Zhihao Jia, Haoran Li, Ying Peng, Xiaochang Chen, Nanjian Luo, Tongxing Song, Yingqian Wang, Xin'e Shi, Shihuan Kuang, Gongshe Yang
Summary: FAM83A plays important roles in cancer and has a novel function in adipocyte differentiation. Inhibition of Fam83a results in reduced white adipose tissue mass, smaller adipocytes, and aggravated mitochondrial damage. Loss or knockdown of Fam83a in cultured adipocytes represses lipid droplet formation and downregulates lipogenic genes and proteins, leading to decreased mitochondrial ATP production and enhanced apoptosis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Gastroenterology & Hepatology
Han Wang, Hongji Zhang, Yu Wang, Zachary J. Brown, Yujia Xia, Zheng Huang, Chengli Shen, Zhiwei Hu, Joal Beane, Ephraim A. Ansa-Addo, Hai Huang, Dean Tian, Allan Tsung
Summary: The study shows an increased number of Tregs in NASH-HCC, and depleting Tregs can inhibit the initiation and progression of HCC. There is a positive correlation between increased NETs and hepatic Tregs levels, and NETs promote Treg activity through metabolic reprogramming, linking innate and adaptive immunity. Therapies targeting NETs and Treg interactions may offer a potential strategy for preventing HCC in NASH patients.
JOURNAL OF HEPATOLOGY
(2021)
Article
Automation & Control Systems
Lina Rong, Guo-Ping Jiang, Shengyuan Xu
Summary: This article focuses on the design of distributed nonrecursive averaging filters for the quantized consensus problem of discrete-time first-order multiagent systems over undirected and connected networks. The quantized consensus problem is transformed into a robust consensus problem with sector bound uncertainties associated with communication graphs. Necessary and sufficient conditions for filter parameter preservation of robust consensus with sector bound uncertainties are provided. The optimal filter parameter design is achieved through constrained optimization, ensuring robust consensus with maximal sector bound parameter.
IEEE TRANSACTIONS ON AUTOMATIC CONTROL
(2023)
Article
Automation & Control Systems
Jing Zhao, Xiaoqian Ding, Bin Jiang, Guoping Jiang, Fei Xie
Summary: This article investigates a fault-tolerant control method for quadrotors with variable mass and actuator faults. A mathematical model is established and an adaptive estimation algorithm is designed to estimate the variable mass and actuator fault. Control strategies are then developed based on these estimations to achieve trajectory tracking and attitude control.
INTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL
(2023)
Article
Automation & Control Systems
Lina Rong, Peng Su, Guo-Ping Jiang, Shengyuan Xu
Summary: In this paper, an edge-based augmented system approach is proposed for second-order nodal consensus, utilizing the edge loop transfer matrix of the closed-loop multi-agent system. This approach introduces additional poles and zeros into edges to construct a channel filter with previous data stored in the memories. The effectiveness of the proposed method is verified through illustrative simulations.
Article
Engineering, Electrical & Electronic
Lina Rong, Yuhan Kan, Xiangpeng Xie, Guo-Ping Jiang, Shengyuan Xu
Summary: This study focuses on the problem of edge-preserving consensus in discrete-time multi-agent systems. A method for designing channel filters, consisting of nominal elements and masking elements, is proposed using an edge-based parallel system design approach. Design criteria for edge-preserving protocols are provided based on the edge sensitivity matrix of the multi-agent system being studied. It is demonstrated that the design of masking elements is based on a single parameter of the nominal element and the H-infinity norm of a collapsed system. An algorithm for designing heterogeneous channel filters is also presented, using a cascade realization of several subsystems.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2023)
Article
Engineering, Electrical & Electronic
Huifen Hong, Wenwu Yu, Guo-Ping Jiang, He Wang
Summary: In this paper, a novel type of fixed-time algorithms is investigated to solve time-varying convex optimization problems with time-dependent cost function, constraints or both. First, a general framework algorithm is developed for the unconstrained time-varying optimization problem to track its optimal trajectory within fixed time, which includes the gradient flow-based scheme and Newton-type method as special cases. Then, another algorithm with fixed-time convergence is designed for time-varying optimization problems involving equality constraint, including Newton-type scheme as a special case. The simulation result using first-order Euler discretization is provided to verify the fixed-time convergence achieved by the proposed approach.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2023)
Article
Automation & Control Systems
Yayong Wu, Xinwei Wang, Guo-Ping Jiang, Mengqi Gu
Summary: In this paper, a completely data-driven method based on compressive sensing is proposed to detect the structure of faulty edges in complex dynamical networks. The method can directly obtain the structure of faulty edges from limited measurements and is more efficient in data processing.
JOURNAL OF THE FRANKLIN INSTITUTE-ENGINEERING AND APPLIED MATHEMATICS
(2023)
Article
Physics, Multidisciplinary
Ruqi Li, Yurong Song, Haiyan Wang, Guo-Ping Jiang, Min Xiao
Summary: This study develops a reactive-diffusion epidemic model on human mobility networks to characterize the spatio-temporal propagation of COVID-19 in China. A novel time-dependent function is incorporated to describe the effects of human intervention. The results indicate that human intervention significantly inhibits the correlation between population mobility and infection cases, and spatial diffusion phenomenon of cases from high infection density cities to low infection density cities is revealed.
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2023)
Article
Automation & Control Systems
Binbin Tao, Min Xiao, Wei Xing Zheng, Ying Zhou, Jie Ding, Guoping Jiang, Xiaoqun Wu
Summary: This article proposes a time-delay feedback control strategy with distributed characteristics to address the flaws in existing control strategies. The designed controller ensures the invariance of equilibriums and continuity of stability intervals, effectively improving the bifurcation threshold of the controlled object.
IEEE TRANSACTIONS ON AUTOMATIC CONTROL
(2023)
Article
Automation & Control Systems
Zhikai Yao, Xianglong Liang, Guo-Ping Jiang, Jianyong Yao
Summary: This article introduces a new model-based reinforcement learning controller to improve the control performance of hydraulic systems. By using a recursive robust integral control approach and an actor-critic structure in the reinforcement learning approach, the proposed controller is able to achieve high-accuracy tracking and asymptotic stability guarantees at the system level.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2023)
Article
Mathematics, Interdisciplinary Applications
Y. Wang, H. Yang, X. Y. Yan, G. P. Jiang
Summary: In this paper, a novel coupled code shifted M-ary differential chaos shift keying modulation scheme is proposed for reference removal. The scheme transmits only two information-bearing signals, modulated by selected Walsh code sequences and coupled by the same chaotic message bearer. Theoretical BER expressions are derived and simulations show better performance with lower complexity.
INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS
(2023)
Article
Green & Sustainable Science & Technology
Chaoyue Zheng, Guoping Jiang, Zhiliang Jin
Summary: This paper studies the doping of phosphorus elements in Co3(PO4)2 during the high-temperature phosphorylation reaction. UV-Vis experiments show that the color of the phosphorylation catalyst changes from pink to black-purple, with significantly increased light absorption range and intensity. SEM images reveal the growth of many nanoparticles on the catalyst surface. XPS experiments demonstrate the growth of a stable P (6- )-Co bond on the catalyst surface. The P (6- )-Co bond can inhibit the complexation of photogenerated electron and hole pairs and enhance the transport efficiency of photogenerated electrons, thus improving the hydrogen production performance. Phosphorus-doped Co3(PO4)2 releases three times more hydrogen than CO3(PO4)2. This paper provides a novel design solution for the photocatalyst preparation method.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Engineering, Geological
Yan Wang, Hao-biao Chen, Guo-ping Jiang, Fu-quan Chen
Summary: In this research, a slip-line method and adaptive finite-element software were used to investigate the active earth pressure of narrow and layered backfills against inverted T-type retaining walls rotating around the base mode. Slip-line field calculation models were established for the inverted T-type retaining wall with narrow and layered backfills, considering the effect of the heel bottom plate and the wall characteristics. The proposed method was verified by comparing its results with those from finite-element limit analysis and existing theoretical solutions, and parametric studies were conducted to study the effects of backfill width, heel length, and interface strength.
INTERNATIONAL JOURNAL OF GEOMECHANICS
(2023)
Article
Mathematics
Mengqi Gu, Guo-Ping Jiang
Summary: This paper investigates the observability of discrete-time two-time-scale multi-agent systems with heterogeneous features under leader-follower architecture. It establishes a singular perturbation difference model for the discussed system based on consensus agreement. To eliminate the numerical ill-posed problem, the order of the system model is reduced using the boundary layer theory of the singular perturbation system. Based on matrix theory, algebraic and graphical features that guarantee system observability are obtained. The theoretical results are verified by a numerical example.
Article
Biochemistry & Molecular Biology
Wenjiao Jin, Junming Yu, Yang Su, Hechun Lin, Tengfei Liu, Jing Chen, Chao Ge, Fangyu Zhao, Qin Geng, Lin Mao, Shuqing Jiang, Ying Cui, Taoyang Chen, Guoping Jiang, Jinjun Li, Chunxiao Miao, Xiuying Xiao, Hong Li
Summary: Hepatocellular carcinoma (HCC) is a highly lethal cancer, lacking effective therapies especially for advanced-stage patients. By screening the US FDA drug library, flubendazole, a traditional anthelmintic drug, was identified to significantly suppress HCC cells in vivo and in vitro. Flubendazole reduced PCSK9 expression by directly targeting it, which was found to be increased in HCC tissues and correlated with poor prognosis. The inhibitory effect of flubendazole on HCC relied on PCSK9 expression and was mediated via the Hedgehog signaling pathway. Combining flubendazole with lenvatinib exhibited enhanced efficacy for HCC treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Proceedings Paper
Automation & Control Systems
Manru Cheng, Guo-Ping Jiang, Yurong Song, Chen Yang
Summary: This paper proposes a multi fusion graph network dynamic spatiotemporal traffic flow prediction model based on graph attention, which comprehensively considers various road structure information to construct a traffic graph network and captures the dynamic transformation of traffic flow data through graph attention, thereby improving the accuracy of traffic flow prediction.
2022 41ST CHINESE CONTROL CONFERENCE (CCC)
(2022)