Potentiation of Glucose-stimulated Insulin Secretion by the GPR40–PLC–TRPC Pathway in Pancreatic β-Cells

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation

(2015) Makoto Shigeto et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of TRPM2 in pancreatic β-cells and the development of diabetes

(2014) Kunitoshi Uchida et al.   CELL CALCIUM

Involvement of cAMP/EPAC/TRPM2 Activation in Glucose- and Incretin-Induced Insulin Secretion

(2014) M. Yosida et al.   DIABETES

Pancreatic β-Cell Response to Increased Metabolic Demand and to Pharmacologic Secretagogues Requires EPAC2A

(2013) Woo-Jin Song et al.   DIABETES

The fatty acid receptor FFA1/GPR40 a decade later: how much do we know?

(2013) Arturo D. Mancini et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Randomized, Double-Blind, Dose-Ranging Study of TAK-875, a Novel GPR40 Agonist, in Japanese Patients With Inadequately Controlled Type 2 Diabetes

(2012) K. Kaku et al.   DIABETES CARE

G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1

(2012) M. Ferdaoussi et al.   DIABETOLOGIA

Exogenous and endogenous ghrelin counteracts GLP-1 action to stimulate cAMP signaling and insulin secretion in islet β-cells

(2012) Boldbaatar Damdindorj et al.   FEBS LETTERS

Optimization of (2,3-Dihydro-1-benzofuran-3-yl)acetic Acids: Discovery of a Non-Free Fatty Acid-Like, Highly Bioavailable G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist as a Glucose-Dependent Insulinotropic Agent

(2012) Nobuyuki Negoro et al.   JOURNAL OF MEDICINAL CHEMISTRY

TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial

(2012) Charles F Burant et al.   LANCET

Ghrelin Attenuates cAMP-PKA Signaling to Evoke Insulinostatic Cascade in Islet  -Cells

(2011) K. Dezaki et al.   DIABETES

GPR40-induced insulin secretion by the novel agonist TAK-875: first clinical findings in patients with type 2 diabetes

(2011) T. Araki et al.   DIABETES OBESITY & METABOLISM

Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells

(2011) Colin A. Leech et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Lack of TRPM2 Impaired Insulin Secretion and Glucose Metabolisms in Mice

(2010) K. Uchida et al.   DIABETES

Regulation of Ca2+ entry by inositol lipids in mammalian cells by multiple mechanisms

(2009) Tamas Balla   CELL CALCIUM

Capacitative calcium entry: from concept to molecules

(2009) James W. Putney   IMMUNOLOGICAL REVIEWS

Sulfonylureas uncouple glucose-dependence for GPR40-mediated enhancement of insulin secretion from INS-1E cells

(2009) Ming Yang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes

(2009) Bo Ahrén   NATURE REVIEWS DRUG DISCOVERY

Protein Kinase C Function in Muscle, Liver, and  -Cells and Its Therapeutic Implications for Type 2 Diabetes

(2008) C. Schmitz-Peiffer et al.   DIABETES

The Role of Transient Receptor Potential Channels in Metabolic Syndrome

(2008) Daoyan Liu et al.   HYPERTENSION RESEARCH