Secreted Thrombospondin-1 Regulates Macrophage Interleukin-1β Production and Activation through CD47

Thrombospondin-1 (TSP1) Contributes to the Development of Vascular Inflammation by Regulating Monocytic Cell Motility in Mouse Models of Abdominal Aortic AneurysmNovelty and Significance

(2015) Zhenjie Liu et al.   CIRCULATION RESEARCH

Molecular Pathways: Activating T Cells after Cancer Cell Phagocytosis from Blockade of CD47 "Don't Eat Me" Signals

(2015) M. N. McCracken et al.   CLINICAL CANCER RESEARCH

CD47 Receptor Globally Regulates Metabolic Pathways That Control Resistance to Ionizing Radiation

(2015) Thomas W. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like receptor co-receptors as master regulators of the immune response

(2015) Marco Di Gioia et al.   MOLECULAR IMMUNOLOGY

CD47 Promotes Protective Innate and Adaptive Immunity in a Mouse Model of Disseminated Candidiasis

(2015) Dhammika H. M. L. P. Navarathna et al.   PLoS One

Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling

(2015) Julian Alvarez-Zarate et al.   PLoS One

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Pre-Clinical Development of a Humanized Anti-CD47 Antibody with Anti-Cancer Therapeutic Potential

(2015) Jie Liu et al.   PLoS One

CD47 in the Tumor Microenvironment Limits Cooperation between Antitumor T-cell Immunity and Radiotherapy

(2014) D. R. Soto-Pantoja et al.   CANCER RESEARCH

Signal-regulatory proteinαfrom the NOD mouse binds human CD47 with an exceptionally high affinity - implications for engraftment of human cells

(2014) Lai Shan Kwong et al.   IMMUNOLOGY

Cutting Edge: CD47 Controls the In Vivo Proliferation and Homeostasis of Peripheral CD4+CD25+Foxp3+ Regulatory T Cells That Express CD103

(2014) V. Q. Van et al.   JOURNAL OF IMMUNOLOGY

CD47 Deficiency Protects Mice from Lipopolysaccharide-Induced Acute Lung Injury and Escherichia coli Pneumonia

(2014) X. Su et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Endoplasmic Reticulum Stress Licenses Macrophages To Produce Mature IL-1  in Response to TLR4 Stimulation through a Caspase-8- and TRIF-Dependent Pathway

(2014) K. Shenderov et al.   JOURNAL OF IMMUNOLOGY

Elevated postinjury thrombospondin 1-CD47 triggering aids differentiation of patients' defective inflammatory CD1a+ dendritic cells

(2014) Gautam Bandyopadhyay et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Thrombospondin-1 Production Is Enhanced by Porphyromonas gingivalis Lipopolysaccharide in THP-1 Cells

(2014) Misa Gokyu et al.   PLoS One

Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment

(2013) T. Yamauchi et al.   BLOOD

Thrombospondin 1 activates the macrophage Toll-like receptor 4 pathway

(2013) Yanzhang Li et al.   Cellular & Molecular Immunology

Cord Factor and Peptidoglycan Recapitulate the Th17-Promoting Adjuvant Activity of Mycobacteria through Mincle/CARD9 Signaling and the Inflammasome

(2013) K. Shenderov et al.   JOURNAL OF IMMUNOLOGY

Thrombospondin-1 is a CD47-dependent endogenous inhibitor of hydrogen sulfide signaling in T cell activation

(2013) Thomas W. Miller et al.   MATRIX BIOLOGY

CD14 Mediates Binding of High Doses of LPS but Is Dispensable for TNF-αProduction

(2013) Kinga Borzęcka et al.   MEDIATORS OF INFLAMMATION

Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury

(2013) Y Zhao et al.   Mucosal Immunology

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

CD47 deficiency confers cell and tissue radioprotection by activation of autophagy

(2012) David R. Soto-Pantoja et al.   Autophagy

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

The CD47–SIRPα pathway in cancer immune evasion and potential therapeutic implications

(2012) Mark P Chao et al.   CURRENT OPINION IN IMMUNOLOGY

CD47high Expression on CD4 Effectors Identifies Functional Long-Lived Memory T Cell Progenitors

(2012) V. Q. Van et al.   JOURNAL OF IMMUNOLOGY

Thrombospondins in physiology and disease: New tricks for old dogs

(2012) Joanne E. Murphy-Ullrich et al.   MATRIX BIOLOGY

The matricellular protein thrombospondin-1 globally regulates cardiovascular function and responses to stress via CD47

(2012) David D. Roberts et al.   MATRIX BIOLOGY

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

(2012) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Endogenous Thrombospondin-1 Regulates Leukocyte Recruitment and Activation and Accelerates Death from Systemic Candidiasis

(2012) Gema Martin-Manso et al.   PLoS One

Environmental conditioning in the control of macrophage thrombospondin-1 production

(2012) Jezrom B. Fordham et al.   Scientific Reports

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Hydrogen Sulfide Is an Endogenous Potentiator of T Cell Activation

(2011) Thomas W. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombospondin-1: Multiple Paths to Inflammation

(2011) Zenaida Lopez-Dee et al.   MEDIATORS OF INFLAMMATION

Thrombospondin-1 Contributes to Mortality in Murine Sepsis through Effects on Innate Immunity

(2011) Sara McMaken et al.   PLoS One

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Thrombospondin-1 Inhibits VEGF Receptor-2 Signaling by Disrupting Its Association with CD47

(2010) Sukhbir Kaur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Escherichia coli K1 Promotes the Ligation of CD47 with Thrombospondin-1 To Prevent the Maturation of Dendritic Cells in the Pathogenesis of Neonatal Meningitis

(2010) R. Mittal et al.   JOURNAL OF IMMUNOLOGY

Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level

(2009) Xuefeng Zhang et al.   FASEB JOURNAL

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Thrombospondin 1 Promotes Tumor Macrophage Recruitment and Enhances Tumor Cell Cytotoxicity of Differentiated U937 Cells

(2008) G. Martin-Manso et al.   CANCER RESEARCH

CD47 in the Immune Response: Role of Thrombospondin and SIRP-α Reverse Signaling

(2008) Marika Sarfati et al.   CURRENT DRUG TARGETS

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Differential Interactions of Thrombospondin-1, -2, and -4 with CD47 and Effects on cGMP Signaling and Ischemic Injury Responses

(2008) Jeff S. Isenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment of liver ischemia–reperfusion injury by limiting thrombospondin-1/CD47 signaling

(2008) Jeff S. Isenberg et al.   SURGERY