Article
Chemistry, Analytical
Natalie J. Norman, Joyce Ghali, Tatiana L. Radzyukevich, Judith A. Heiny, Julio Landero-Figueroa
Summary: We developed a sensitive method using ICP-MS to simultaneously measure 13C-labeled glucose and rubidium in biological samples. The method extracts the analytes from mammalian tissues using probe-assisted ultra-sonication with water. The method achieves a stable 13C/12C signal without spectral interferences and can detect 60μM of 13C-labeled glucose in biological tissues.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Paula Menero-Valdes, Ana Lores-Padin, Beatriz Fernandez, C. Derrick Quarles Jr, Montserrat Garcia, Hector Gonzalez-Iglesias, Rosario Pereiro
Summary: Single cell-inductively coupled plasma-mass spectrometry (sc-ICP-MS) and laser ablation (LA)-ICP-MS were used to comprehensively study the expression of APOE and claudin-1 in ARPE-19 cells treated with glucose. The introduction of microFAST Single Cell set-up improved cellular transport efficiency, and specific immunoprobes labelled with IrNCs were used for protein determination. The results obtained by sc-ICP-MS were validated with commercial ELISA kits, and the distribution of target proteins in individual cells was revealed by LA-ICP-MS with high resolution images.
Article
Chemistry, Analytical
Marzia Cosmi, Nathaly Gonzalez-Quinonez, Pablo Tejerina Diaz, Angel Manteca, Elisa Blanco-Gonzalez, Jorg Bettmer, Maria Montes-Bayon, Mario Corte-Rodriguez
Summary: By utilizing SP-ICP-MS and TEM techniques, the study detected the release of metallic nanoparticles from dental implants in the oral environment. The addition of mucosal bacteria significantly decreased the production of nanoparticles, indicating a potential impact on biotribocorrosion.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2021)
Article
Chemistry, Analytical
Yan Xu, Beibei Chen, Man He, Zewei Cui, Bin Hu
Summary: This study developed an all-in-one microfluidic chip system for efficient separation and quantitative analysis of rare CTCs and their ASGPR surface biomarkers.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yan Xu, Beibei Chen, Man He, Zewei Cui, Bin Hu
Summary: This study developed an all-in-one microfluidic chip system combined with single cell-inductively coupled plasma mass spectrometry (SC-ICP-MS) for efficient separation and quantitative analysis of circulating tumor cells (CTCs). The method showed high separation efficiency and purity, allowing for accurate analysis of surface receptors on CTCs, which can be useful for studying targeted drug delivery in cancer therapy.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Zichao Zhou, Ahmed Al Hejami, Mirah J. Burgener, John Burgener, Diane Beauchemin
Summary: This study optimized a total consumption infrared-heated sample introduction system for single particle inductively coupled plasma mass spectrometry, achieving efficient sample transport, improved detection sensitivity, and method size detection limit.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2022)
Article
Chemistry, Analytical
Raquel Gonzalez de Vega, Samantha Goyen, Thomas E. Lockwood, Philip A. Doble, Emma F. Camp, David Clases
Summary: This study investigates various strategies to enhance the detection and characterization of microplastics in complex matrices like seawater. It is found that ICP-MS/MS methods can improve size detection limits, reduce background signal, and increase selectivity.
ANALYTICA CHIMICA ACTA
(2021)
Article
Environmental Sciences
Ersin Nazlican, Enes Arica, Ismail Ethem Goren, Betul Kilincli, Burak Mete, Nebile Daglioglu
Summary: The study aimed to assess the levels of heavy metals in breast milk samples of mothers in the Cukurova region, Turkey, showing high exposure levels for Cr and As. These metals can cross the placenta and accumulate in breast milk postnatally.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Geochemistry & Geophysics
Alexander Simpson, Sarah Gilbert, Renee Tamblyn, Martin Hand, Carl Spandler, Jack Gillespie, Angus Nixon, Stijn Glorie
Summary: Lu-Hf geochronology is a powerful method for constraining the temporal evolution of geological systems, with traditional methods requiring time-consuming chemical separations and potentially losing the textural context of analysed minerals. In contrast, the in-situ approach offers rapid analysis with high spatial resolution, but is hindered by isobaric interferences of Yb-176 and Lu-176 on Hf-176.
Article
Chemistry, Analytical
Xiangwei Tian, Haowen Jiang, Meng Wang, Wenbin Cui, Yingying Guo, Lingna Zheng, Ligang Hu, Guangbo Qu, Yongguang Yin, Yong Cai, Guibin Jiang
Summary: To meet the demand for multi-element/isotope analysis at the single nanoparticle (NP) or cell level, different types of inductively coupled plasma mass spectroscopy (ICP-MS) have been used to simultaneously monitor multiple mass-to-charge ratios in single-particle/cell ICP-MS (SP/SC-ICP-MS) analysis. Systematic evaluation and comparison of the performance of these techniques are urgently required.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Aaron J. Goodman, Alexander Gundlach-Graham, Shaun G. Bevers, James F. Ranville
Summary: This study analyzed sub-micron and nano-scale mineral dust aerosols (MDAs) in wet deposition from storms using single particle inductively coupled plasma mass spectrometry (spICP-MS). High particle number concentrations (PNCs) of MDAs were found, and the number concentrations varied with storm strength and meteorological conditions. The particle size distributions (PSDs) of MDAs followed the Pareto distribution, and the composition largely followed elemental crustal abundance ratios. Single particle ICP-time-of-flight MS analysis and clustering algorithm were used to characterize the MDA particle types.
ENVIRONMENTAL SCIENCE-NANO
(2022)
Article
Spectroscopy
Jenee L. Jacobs, R. S. Houk
Summary: The paper discusses the application of Collision Reaction Interface (CPI) in ICP-MS and experiments estimating collision cross sections of singly charged cations using a hexapole collision cell. General characteristics of the collision region in the CRI are determined and discussed based on the determined cross sections.
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
(2021)
Article
Biochemical Research Methods
Sam Wouters, Sebastiaan Eeltink, Rob Haselberg, Govert W. Somsen, Andrea F. G. Gargano
Summary: A membrane-based microfluidic chip was developed for selective post-column removal of TFA anions from HILIC, improving ionization and reducing TFA adduct formation. The device's multichannel design allows the use of 0.1% TFA mobile phases while maintaining separation selectivity and efficiency.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Guosheng Yang, Jian Zheng, Eunjoo Kim, Shuai Zhang, Hatsuho Seno, Munehiko Kowatari, Tatsuo Aono, Osamu Kurihara
Summary: A method for urinary bioassay of ultra-trace Np-237 and Pu isotopes using SF-ICP-MS and ICP-MS/MS was developed in this study. The method showed high decontamination efficiency and sensitivity, making it suitable for screening activities in unexpected actinide exposure. Validation experiments and practical applications confirmed the effectiveness of the method.
ANALYTICA CHIMICA ACTA
(2021)
Article
Environmental Sciences
Fazel Abdolahpur Monikh, Latifeh Chupani, Martina G. Vijver, Willie J. G. M. Peijnenburg
Summary: This study used different sizes of Fe-PS-NPD and Eu-PS-NPD to evaluate the trophic transfer of NPD in food chains, finding that smaller NPD are more likely to transfer along food chains. Exposure to Fe-PS-NPD resulted in affected reproduction in daphnids, while offspring exposed to Eu-PS-NPD may be impacted by NPD transfer.
ENVIRONMENTAL POLLUTION
(2021)
Article
Chemistry, Analytical
Alicia Surrao, Skyler W. Smith, Emma Foerster, Henry B. Spitz, Donald G. Graczyk, Julio A. Landero-Figueroa, Derek R. McLain, William B. Connick, Jennifer L. Steeb
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Lucas Schmidt, Diogo La Rosa Novo, Gabriel Toneto Druzian, Julio Alberto Landero, Joseph Caruso, Marcia Foster Mesko, Erico Marlon Moraes Flores
Summary: This study assessed the influence of culinary treatments on the total concentration and bioavailability of Cd, Cr, Cu, and Pb in seafood, finding that only Cd (in scallop) was influenced by culinary treatments, while bioavailability percentage was not affected. The analytical method used was deemed adequate for assessing food safety in relation to metal concentration and bioavailability in seafood.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Nicholas Raffa, Tae Hyung Won, Andrew Sukowaty, Kathleen Candor, Chengsen Cui, Saayak Halder, Mingji Dai, Julio A. Landero-Figueroa, Frank C. Schroeder, Nancy P. Keller
Summary: Fungi maintain the balance of metal micronutrient pools through various homeostasis mechanisms. Metabolites derived from the xan biosynthetic gene cluster in Aspergillus fumigatus bind copper, affect cellular copper content, and exhibit significant metal-dependent antimicrobial properties. These metabolites also demonstrate copper-dependent antimicrobial properties against a variety of human pathogenic fungi and bacteria.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Genetics & Heredity
Maria F. Czyzyk-Krzeska, Julio A. Landero Figueroa, Shuchi Gulati, John T. Cunningham, Jarek Meller, Behrouz ShamsaeI, Bhargav Vemuri, David R. Plas
Summary: Personalized medicine utilizes multiple omics platforms and environmental factors to guide treatments for clear cell renal carcinoma. Different genetic subtypes have varying prognoses, with altered metabolism being a key feature of the disease. Single-cell combined multi-omics approaches will provide deeper insights into ccRCC progression and lead to the design of specific signatures for better clinical outcomes.
Article
Public, Environmental & Occupational Health
Nagendra Monangi, Huan Xu, Rasheda Khanam, Waqasuddin Khan, Saikat Deb, Jesmin Pervin, Joan T. Price, Stephen H. Kennedy, Abdullah Al Mahmud, Yuemei Fan, Thanh Q. Le, Angharad Care, Julio A. Landero, Gerald F. Combs, Elizabeth Belling, Joanne Chappell, Fansheng Kong, Criag Lacher, Salahuddin Ahmed, Nabidul Haque Chowdhury, Sayedur Rahman, Furqan Kabir, Imran Nisar, Aneeta Hotwani, Usma Mehmood, Ambreen Nizar, Javairia Khalid, Usha Dhingra, Arup Dutta, Said Ali, Fahad Aftab, Mohammed Hamad Juma, Monjur Rahman, Bellington Vwalika, Patrick Musonda, Tahmeed Ahmed, Md Munirul Islam, Ulla Ashorn, Kenneth Maleta, Mikko Hallman, Laura Goodfellow, Juhi K. Gupta, Ana Alfirevic, Susan Murphy, Larry Rand, Kelli K. Ryckman, Jeffrey C. Murray, Rajiv Bahl, James A. Litch, Courtney Baruch-Gravett, Zarko Alfirevic, Per Ashorn, Abdullah Baqui, Jane Hirst, Cathrine Hoyo, Fyezah Jehan, Laura L. Jelliffe-Pawlowski, Anisur Rahman, Daniel E. Roth, Sunil Sazawal, Jeffrey Stringer, Ge Zhang, Louis Muglia
Summary: The study found associations between maternal selenium concentration and preterm birth and gestational duration, with varying effects across different sites and cohorts. Further investigation is needed to understand the heterogeneity of the findings.
Article
Obstetrics & Gynecology
Angharad G. Care, Juhi K. Gupta, Laura Goodfellow, Ge Zhang, Nagendra Monangi, Elizabeth Belling, Julio Landero, Joanne Chappell, Andrew Sharp, Ana Alfirevic, Bertram Mueller-Myhsok, Louis J. Muglia, Zarko Alfirevic
Summary: The study found that low plasma Se is associated with sPTB risk, but is not sufficiently predictive at the individual patient level. While a non-coding region variant in the FOXN3 gene showed a genetic association with sPTB, there was no genetic link found between Se-related genes and maternal Se levels.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Chemistry, Applied
Aline Pereira de Oliveira, Juliana Naozuka, Julio Alberto Landero-Figueroa
Summary: This study aimed to evaluate the protective effect of Se(IV) and Se(VI) on elemental uptake and accumulation as well as protein distribution in Pleurotus mushrooms. The results showed that supplementation with Se(IV) or Se(VI) decreased Cd accumulation in mushrooms, while Se(VI) increased Pb accumulation. It was suggested that Se(VI) can be used to reduce Cd accumulation and produce Se-enriched mushrooms.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2022)
Meeting Abstract
Oncology
Shuchi Gulati, Bhargav Vemuri, Dina Secic, Behrouz Shamsaei, David R. Plas, John T. Cunningham, Jarek Meller, Julio Alberto Landero, Maria F. Czyzyk-Krzeska
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Immunology
Debabrata Chowdhury, Jason C. Gardner, Abhijit Satpati, Suba Nookala, Santhosh Mukundan, Aleksey Porollo, Julio A. Landero Figueroa, Kavitha Subramanian Vignesh
Summary: This study reveals a negative regulation role of MT3 in controlling non-canonical inflammasome activation, by increasing intracellular zinc levels to inhibit caspase-11. MT3 suppresses activation of caspase-11 inflammasome and synergizes with caspase-11 in impairing antibacterial immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Marjorie J. Haskell, Kenneth Maleta, Charles D. Arnold, Josh M. Jorgensen, Yue-Mei Fan, Ulla Ashorn, Andrew Matchado, Nagendra K. Monangi, Ge Zhang, Huan Xu, Elizabeth Belling, Julio Landero, Joanne Chappell, Louis J. Muglia, Mikko Hallman, Per Ashorn, Kathryn G. Dewey
Summary: Provision of small-quantity lipid-based nutrient supplements containing 130 mu g/d selenium to pregnant Malawian women for similar to 16 wk increased plasma selenium concentrations in late pregnancy.
CURRENT DEVELOPMENTS IN NUTRITION
(2022)
Article
Chemistry, Applied
Aline Pereira de Oliveira, Juliana Naozuka, Julio Alberto Landero-Figueroa
Summary: This study investigates the potential of Pleurotus ostreatus and Pleurotus djamor mushrooms to absorb and accumulate selenium in organic substrate. The results show that Pleurotus djamor grown on Se(IV)-supplemented substrate has the greatest potential for selenium uptake and accumulation. Various selenium species, including selenomethionine, selenocystine, and Se-methylselenocysteine, were identified in the mushrooms. In vitro digestion assays showed high bioaccessibility of selenium. The bioaccessible selenium species were found to be mainly associated with low molecular weight proteins in the mushrooms.
Article
Biochemistry & Molecular Biology
Rita Verma, Parul Aggarwal, Megan E. Bischoff, James Reigle, Dina Secic, Collin Wetzel, Katherine VandenHeuvel, Jacek Biesiada, Birgit Ehmer, Julio A. Landero Figueroa, David R. Plas, Mario Medvedovic, Jarek Meller, Maria F. Czyzyk-Krzeska
Summary: Microtubule-associated protein 1 light chain 3 gamma (MAP1LC3C or LC3C) is a crucial protein involved in autophagosome formation and lysosomal degradation. Its expression is dependent on kidney cancer tumor suppressors and it has shown tumor-suppressing activity. Loss of LC3C leads to peripheral positioning of lysosomes and lysosomal exocytosis, independent of LC3C's autophagic activity. This reprogramming of lysosomal localization and zinc metabolism, accompanied by altered gene expression and amino acid levels, contributes to the tumor-suppressing activity of LC3C.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Skyler W. Smith, Roy W. Martin, Nicole Hanks, Patricia A. Creed, Kasey Kovalcik, Robert A. Wilson, Kevin Kubachka, Judith A. Brisbin, Julio A. Landero Figueroa, John T. Creed
Summary: This study evaluated three mass oriented rare earth element M2+ correction approaches for use in an ICP-MS environmental method update and assessed their performance using a multi-variant analysis. The results showed that the dual M2+ internal standard and in-sample M2+ correction methods had lower correction errors compared to the fixed factor and M1+ internal standard methods.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2022)
Article
Medicine, Research & Experimental
Diego C. P. Rossi, Julio A. Landero Figueroa, William R. Buesing, Kathleen Candor, Logan T. Blancett, Heather M. Evans, Rena Lenchitz, Bradford L. Crowther, Waleed Elsegeiny, Peter R. Williamson, Jan Rupp, George S. Deepe
Summary: Research has shown that using the glucose analog 2-DG can empower macrophages to eliminate intracellular fungal pathogens. This method of killing is not dependent on altering access to carbon-containing molecules, ATP, ER stress, or autophagy, but rather on reducing the macrophages' intake of exogenous zinc, leading to zinc starvation and subsequent death of the pathogen.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Chemistry, Analytical
Skyler W. Smith, Nicole Hanks, Patricia A. Creed, Kasey Kovalcik, Robert A. Wilson, Kevin Kubachka, Judith A. Brisbin, Julio Landero Figueroa, John T. Creed
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2019)
