Article
Immunology
Junhong Hao, Chaochao Shen, Nannan Wei, Minghao Yan, Xuegang Zhang, Guowei Xu, Dajun Zhang, Jing Hou, Weijun Cao, Ye Jin, Keshan Zhang, Haixue Zheng, Xiangtao Liu
Summary: Foot-and-mouth disease virus antagonizes the activation of the IRF3/IFN-β signaling pathway via TPL2 for immune escape and enhanced virus replication. TPL2 deficiency leads to reduced expression of interferon-stimulated genes and interferon regulatory factors, resulting in increased virus replication.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Asela Weerawardhana, Md Bashir Uddin, Joo-Hyung Choi, Prabuddha Pathinayake, Sung Ho Shin, Kiramage Chathuranga, Jong-Hyeon Park, Jong-Soo Lee
Summary: The study reveals that the 2B protein of foot-and-mouth disease virus (FMDV) modulates the host interferon (IFN) signaling pathway by degrading RIG-I and MDA5 proteins, leading to inhibition of IFN production. This finding provides valuable insights into the immune evasion mechanism of FMDV and offers a rational approach for virus attenuation in vaccine development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tingting Ren, Haotai Chen, Xinsheng Liu, Yanxue Wang, Aixia Fan, Linlin Qi, Li Pan, Wenlong Bai, Yongguang Zhang, Yuefeng Sun
Summary: The ID1 protein promotes the degradation of FOXO1, suppresses interferon production, and inhibits HDAC4, ultimately suppressing the replication of FDMV and potentially other viruses.
Article
Virology
Yumei Han, Jingying Xie, Shujuan Xu, Yingjie Bi, Xiangrong Li, Haixia Zhang, Adi Idris, Jialin Bai, Ruofei Feng
Summary: EMCV evades the host’s innate immune response by degrading RLR proteins, with VP2 protein playing a key role in this process. This study reveals a new mechanism for EMCV to counteract the host’s antiviral response, providing insights into virus-host interactions.
JOURNAL OF VIROLOGY
(2021)
Article
Microbiology
Jingying Xie, Xiangrong Li, Shunyu Yang, Zhenfang Yan, Lei Chen, Yanmei Yang, Dianyu Li, Xiangbo Zhang, Ruofei Feng
Summary: DDX56 plays an important role in inhibiting the replication of pseudorabies virus (PRV). It inhibits PRV proliferation by up-regulating cGAS-STING-induced IFN-beta expression. In addition, DDX56 can promote cGAS expression and directly interact with it. These findings contribute to a better understanding of host factors controlling PRV replication.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Virology
Chahui Tan, Xingliang Qin, Yongyao Tan, Xinhuai Dong, Delin Chen, Linyue Liang, Jinling Li, Ruoxi Niu, Kaiyuan Cao, Zhenjian He, Guohong Wei, Mingxing Huang, Xun Zhu
Summary: Enterovirus A71 (EV-A71) is a major global health threat and it has been found that the host restriction factor SHFL can inhibit EV-A71 replication through interacting with its 3Dpol protein. This study validated the upregulation of SHFL in response to EV-A71 infection and identified the molecular mechanism by which SHFL promotes the degradation of EV-A71 3Dpol via the ubiquitin-proteasome pathway. These findings greatly enhance our understanding of the interaction between host and EV-A71.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Yishu Wang, Yiling Chen, Ying Lin, Yingqin Quan, Xiaoping Xiao, Renli Zhang
Summary: RSV infection is a major cause of lower respiratory tract disease, with no effective treatments found yet. Recent studies have shown that TRIM family member TRIM22 plays a crucial role in resisting RSV infection. RSV infection induces TRIM22 expression through the activation of JAK-STAT1/2 signaling.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Virology
Morgan Sarry, Gregory Caignard, Juliette Dupre, Stephan Zientara, Damien Vitour, Labib Bakkali Kassimi, Sandra Blaise-Boisseau
Summary: Foot-and-mouth disease (FMD) is a highly contagious viral disease that affects cloven-hoofed animals. The persistence of its causative agent, foot-and-mouth disease virus (FMDV), may be related to protein-protein interactions (PPI) between viral proteins and cellular proteins involved in the interferon (IFN) response. The 3D(pol) protein has been identified to have a potential role in FMDV innate immune escape by interacting with several IFN pathway proteins.
Article
Immunology
Wanglong Zheng, Nengwen Xia, Jiajia Zhang, Qi Cao, Sen Jiang, Jia Luo, Hui Wang, Nanhua Chen, Quan Zhang, Francois Meurens, Jianzhong Zhu
Summary: The structural protein p17 of African swine fever virus interacts with STING to inhibit the cGAS-STING pathway, thus evading the host immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Heng-Wei Lee, Yi-Fan Jiang, Hui-Wen Chang, Ivan-Chen Cheng
Summary: This study confirms that the foot-and-mouth disease virus (FMDV) 3A protein modifies the endoplasmic reticulum (ER) to form replication organelles (ROs) through interactions with COPII factors and specific regions on the ER membrane. This mechanism, distinct from the traditional COPII pathway, is critical for understanding FMDV replication organelle formation.
Article
Pharmacology & Pharmacy
Kai Qian, Xue-Xia Zheng, Chen Wang, Wen-Guang Huang, Xiao-Bao Liu, Shu-Di Xu, Dan-Kai Liu, Min-Ying Liu, Chang-Song Lin
Summary: The study found that beta-sitosterol (BSS) has potential as a treatment for rheumatoid arthritis (RA) by suppressing the proliferation and migration of endothelial cells, thereby alleviating joint swelling and bone destruction. BSS also prevents synovial angiogenesis by inhibiting VEGFR2 and p-VEGFR2 expression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Fisheries
Siting Wu, Mengshi Sun, Luhao Zhang, Shaozhu Kang, Jiaming Liao, Zheng Zhu, Hong Chen, Zhuqing Xu, Linting Xu, Xin Zhang, Jingguang Wei, Qiwei Qin
Summary: This study cloned and identified a TRAF3 homolog from orange-spotted grouper (EcTRAF3). The results showed that EcTRAF3 plays an important role in the immune response system of fish and negatively regulates the antiviral response.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gaoyang Chen, Shang Wang, Canling Long, Zhenmin Wang, Xin Chen, Wanze Tang, Xiaoqin He, Zhiteng Bao, Baoyu Tan, William W. Lu, Zhizhong Li, Dazhi Yang, Guozhi Xiao, Songlin Peng
Summary: Bone remodeling is a dynamic process involving bone formation and resorption. PiRNA-63049, through the Wnt2b/13-β-catenin signaling pathway, has been shown to inhibit bone formation, making it a potential target for increasing bone formation in disorders such as postmenopausal osteoporosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Virology
Grace Naswa Makokha, Kazuaki Chayama, C. Nelson Hayes, Hiromi Abe-Chayama, Maidina Abuduwaili, Hijikata Makoto
Summary: A study has identified SCAP as a novel host factor that regulates HBV gene expression, suggesting its involvement in the HBV lifecycle. This discovery may contribute to the development of new antiviral strategies against HBV.
Article
Medicine, Research & Experimental
Hye-Min Jeon, Yong Jae Shin, Jaehyun Lee, Nakho Chang, Dong-Hun Woo, Won Jun Lee, Dayna Nguyen, Wonyoung Kang, Hee Jin Cho, Heekyoung Yang, Jin-Ku Lee, Jason K. Sa, Yeri Lee, Dong Geon Kim, Benjamin W. Purow, Yeup Yoon, Do-Hyun Nam, Jeongwu Lee
Summary: The Sema3A/NRP1/TGF-βR1 signaling axis is identified as a critical regulator of GSC propagation and a potential therapeutic target for GBM.
Article
Biochemistry & Molecular Biology
Huanan Liu, Kangli Li, Wenzhe Chen, Fan Yang, Weijun Cao, Keshan Zhang, Pengfei Li, Lijie Tang, Zixiang Zhu, Haixue Zheng
Summary: This study reveals a novel mechanism of SVA 2B protein in antagonizing host innate immune response in both human and porcine cells, providing important insights for understanding the pathogenesis of SVA and oncolytic virotherapy.
MOLECULAR IMMUNOLOGY
(2022)
Article
Virology
Sk Mohiuddin Choudhury, Xusheng Ma, Yuanyuan Li, Xiaofeng Nian, Zhikuan Luo, Yonghua Ma, Zixiang Zhu, Fan Yang, Weijun Cao, Haixue Zheng
Summary: Foot-and-mouth disease virus infection induces inflammatory responses, involving the production of interleukin-1 beta (IL-1 beta) and crucial involvement of NLRP3 in IL-1 beta secretion. Research demonstrates that FMDV L-pro interacts with NLRP3 to promote inflammasome assembly and IL-1 beta release, providing insights into controlling FMDV-induced inflammation.
Article
Environmental Sciences
Ali S. Alshehri, Attalla F. El-Kott, Ayman E. El-Kenawy, Mohamed Samir A. Zaki, Kareem Morsy, Reham A. Ghanem, Eman T. Salem, Eman R. Ebealy, Heba S. Khalifa, Ahmed E. Altyar, Hussah I. M. AlGwaiz, Essam H. Ibrahim, Mohammed S. Mahmoud, Mohammad A. Dallak, Eman M. Abd-Ella
Summary: This study demonstrates that kaempferol has a nephroprotective effect against cadmium-induced nephropathy by reducing kidney damage, improving kidney function, and attenuating oxidative stress and inflammation. It achieves these effects by suppressing NF-kappa B p65 and activating Nrf2.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Essam H. Ibrahim, Mohammad Y. Alshahrani, Hamed A. Ghramh, Hani Alothaid, Mona Kilany, Kareem Morsy, Attalla F. El-kott, Ramadan Taha, Haitham El-Mekkawy, Gamal A. EL-Shaboury, Ahmed A. El-Mansi, Mohammed E. A. Mohammed, Mahmoud A. Sayed, Ibrahim S. Yahia
Summary: The study demonstrates that Origanum majorana leaf acetone extract has anti-colorectal cancer effects by inducing cell division arrest and apoptosis in HT-29 human colon cancer cells.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Multidisciplinary Sciences
Badria M. AL-Shehri, Reham M. Mashat, Rahaf M. H. Alshareef, Wed Mohammed Ali Alaerjani, Khalid Ali Khan, Hamed A. Ghramh, Essam H. Ibrahim, Majed A. Bajaber, Abdulaziz A. Zarbah, Mohammed Elimam Ahamed Mohammed
Summary: This study investigated the presence of artificial sweeteners in honey samples from Asir region-Saudi Arabia and measured their concentration along with glucose oxidase (GOX) activity and other quality parameters. The results showed that Acacia and Zizphus honey samples contained high amounts of sorbitol and trace levels of xylitol. The floral origin and year of harvest significantly influenced the pH, electric conductivity, and acidity of the honey samples.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
F. El-Sayed, Mai S. A. Hussien, T. H. AlAbdulaal, Abdel-Haleem Abdel-Aty, H. Y. Zahran, I. S. Yahia, Mohamed Sh. Abdel-wahab, Essam H. Ibrahim, Medhat A. Ibrahim, Hanan Elhaes
Summary: Cationic dye (methylene blue) and anionic dye (carmine) degradation were demonstrated using SrO and G-SrO NPs. The efficacy of photocatalysis and electro & photo-electrocatalytic oxidation in degrading carmine dye was compared. The study found that graphene-modified SrO nanoparticles showed improved photocatalytic activity and the 0.25G-SrO catalyst achieved high degradation efficiency for methylene blue dye under UV light.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Article
Multidisciplinary Sciences
Mohammad Y. Alshahrani, Essam H. Ibrahim, Mohammed Asiri, Mona Kilany, Ali G. Alkhathami, Mohammed N. Alshahrani, Harish C. Chandramoorthy
Summary: The addition of lycopene to the extract enhances the antioxidant and antibacterial activities, showing potential inhibition against multidrug-resistant bacteria.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Virology
Shuying Chen, Fan Yang, Weijun Cao, Xiangle Zhang, Huisheng Liu, Keshan Zhang, Xiangtao Liu, Jingyu Wang, Haixue Zheng, Zixiang Zhu
Summary: Stress granule (SG) formation induced by Peste des petits ruminants virus (PPRV) N protein plays a positive role in PPRV replication. PPRV N protein interacts with PKR-activating protein (PACT) to enhance PKR activation and subsequent SG formation. The regulatory function of N protein is dependent on the presence of PACT.
JOURNAL OF VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Caihong Fu, Shanshan Zhang, Fan Yang, Ximing Chen, Xiuxia Sun
Summary: This work investigated the factors influencing FilP polymerization under a variety of conditions. The presence of small amounts of divalent cations enhanced the polymerization of FilP, while higher amounts suppressed its polymerization. Moreover, high concentrations of certain salts also suppressed the polymerization of FilP. EDTA had a prohibitive effect on FilP polymerization, and even the addition of Ca2+ could not initiate the assembly of FilP. FilP polymerized under a range of pHs, with the degree of polymerization being sensitive to pH.
PROTEIN AND PEPTIDE LETTERS
(2023)
Article
Virology
Wen Dang, Tao Li, Fan Xu, Yannan Wang, Fan Yang, Haixue Zheng
Summary: Senecavirus A (SVA) is a newly emerged pathogen that causes vesicular diseases in swine with wide genetic diversity and rapid evolution. In this study, an immortalized porcine alveolar macrophage cell line (3D4/21) was found to support productive replication of SVA strains and exhibit innate immune response against SVA infection. The activation of RIG-I-like receptors in 3D4/21 cells leads to sustained expression of interferons and innate immune genes critical for constraining SVA replication.
Article
Microbiology
Huisheng Liu, Zixiang Zhu, Qiao Xue, Fan Yang, Zongqiang Li, Zhaoning Xue, Weijun Cao, Jijun He, Jianhong Guo, Xiangtao Liu, Andrew E. E. Shaw, Donald P. P. King, Haixue Zheng
Summary: This study reveals that picornavirus infection causes mitochondrial dysfunction and leads to the release of mitochondrial DNA through the mitochondrial permeability transition pore. The released mitochondrial DNA activates the cGAS-STING signaling pathway, resulting in the expression of type I interferon and suppression of viral infection. Additionally, picornavirus 2C proteins antagonize the activation of the cGAS-STING signaling pathway through multiple strategies, facilitating virus replication.
Article
Microbiology
Huisheng Liu, Zixiang Zhu, Qiao Xue, Fan Yang, Weijun Cao, Zhaoning Xue, Xiangtao Liu, Haixue Zheng
Summary: This study analyzed the metabolic changes during foot-and-mouth disease virus (FMDV) infection and revealed the virus's ability to utilize amino acids to promote replication. The findings provide new insights for developing preventive strategies against FMDV.
Article
Veterinary Sciences
K. Morsy, S. B. Dajem, A. Alghamdi, A. El-kott, E. Ibrahim, K. Attia, A. Al-Doaiss, H. El-Mekkawy, N. Sheraba, A. Baiomy, M. Fahmy, F. Shalaby
Summary: In 2020, 52 marine fish specimens were caught from boat landing sites along the Alexandria coast in Egypt. Among them, 30 fish were found to be infected with three different parasitic species, which can negatively impact fish health and lead to consumers rejecting the fish.
ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA
(2023)
Article
Virology
Qiao Xue, Huisheng Liu, Zixiang Zhu, Fan Yang, Yingying Song, Zongqiang Li, Zhaoning Xue, Weijun Cao, Xiangtao Liu, Haixue Zheng
Summary: This study analyzed the impact of African swine fever virus (ASFV) infection on the cellular metabolism of the host. It found that ASFV infection increased host TCA cycle and amino acid metabolism, and identified mechanisms by which ASFV inhibits host innate immune responses. These findings are important for guiding the design of prevention strategies against ASFV.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Caina Ma, Shasha Li, Fan Yang, Weijun Cao, Huisheng Liu, Tao Feng, Keshan Zhang, Zixiang Zhu, Xiangtao Liu, Yonghao Hu, Haixue Zheng
Summary: African swine fever (ASF) is a highly pathogenic disease that affects domestic and wild pigs. There is currently no effective vaccine available. This study found that the host factor FoxJ1 plays a role in inhibiting ASFV replication, while ASFV proteins degrade FoxJ1, weakening its antiviral effect. These findings provide insights for the development of antiviral drugs and vaccines against ASFV infection.