Review
Biochemistry & Molecular Biology
Rosalia Crupi, Salvatore Cuzzocrea
Summary: Chronic inflammatory processes play a role in disease progression, particularly in atherosclerosis. Targeted anti-inflammatory treatment shows promise in reducing cardiovascular risk. Long-chain omega-3 polyunsaturated fatty acids (PUFAs) such as EPA have cardioprotective effects and beneficial effects on atherosclerotic plaques.
Article
Veterinary Sciences
Matteo Mezzetti, Fiorenzo Piccioli-Cappelli, Andrea Minuti, Erminio Trevisi
Summary: Experimental results on Italian Holstein cows suggest that infusion of a 10% solution rich in long-chained omega-3 fatty acids after calving can increase plasma fatty acids content, decrease inflammatory state, promote feed intake and milk production.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Kevin C. Maki, Harold E. Bays, Christie M. Ballantyne, James A. Underberg, John J. P. Kastelein, Judith B. Johnson, James J. Ferguson
Summary: This study compared the efficacy and plasma fatty acid levels of EPA+DPA-FFA and EPA-EE in hypertriglyceridemic patients. The results showed that EPA+DPA-FFA significantly improved plasma levels of EPA, DPA, and total omega-3, while reducing triglycerides and high-sensitivity C-reactive protein without increasing low-density lipoprotein cholesterol.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Shuai-Shuai Fu, Min Wen, Ying-Cai Zhao, Hao-Hao Shi, Yu-Ming Wang, Chang-Hu Xue, Zi-Hao Wei, Tian-Tian Zhang
Summary: A study found that dietary supplementation with EPA-pPE can significantly change the fatty acid composition in the brain and liver, especially in increasing the content of DHA. EPA-pPE has a more significant effect on increasing DHA compared to EPA-PC, making it a good nutritional supplement to increase DHA levels in n-3 PUFA-deficient offspring's brains.
Article
Nutrition & Dietetics
Maciej Salaga, Adrian Bartoszek, Agata Binienda, Julia B. Krajewska, Adam Fabisiak, Paula Mosinska, Katarzyna Dziedziczak, Karolina Niewinna, Marcin Talar, Aleksandra Tarasiuk, Radzislaw Kordek, Jakub Fichna
Summary: This study characterized the anti-inflammatory activity and effect on intestinal barrier function of synthetic FFAR agonists in mouse models of colitis. The FFAR4 agonist GSK137647 attenuated colitis and restored tight junction gene expression in the colon, indicating a potential therapeutic target for intestinal inflammation.
Article
Fisheries
Michail I. Gladyshev, Alexander A. Makhrov, Nadezhda N. Sushchik, Olesia N. Makhutova, Anastasia E. Rudchenko, Dmitrii A. Balashov, Evgenii V. Vinogradov, Valentina S. Artamonova
Summary: This study examined the composition and contents of fatty acids (FA) in fillets of seven strains of rainbow trout. The results showed that the diet composition and genetics played a role in the FA composition of the fish. The Steelhead strain of rainbow trout demonstrated a higher ability to regulate its FA composition, particularly regarding the important acids EPA and DHA. Furthermore, FA markers were identified that can be used to differentiate between wild and farmed rainbow trout.
Article
Pharmacology & Pharmacy
Charlotte Smith Bonde, Louis Bornancin, Yi Lu, Henrik Toft Simonsen, Maria Martinez-Valladares, Miguel Pena-Espinoza, Helena Mejer, Andrew R. Williams, Stig Milan Thamsborg
Summary: The study shows that seaweed can provide bioactive compounds with anti-parasitic activity, with Saccharina latissima and Laminaria digitata showing particularly high anti-parasitic activity. Fatty acids may play an important role in controlling intestinal helminth infections.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
William S. Harris, David Leonard, Nina B. Radford, Carolyn E. Barlow, Morgan R. Steele, Stephen W. Farrell, Andjelka Pavlovic, Benjamin L. Willis, Laura F. DeFina
Summary: The study found that an increase in erythrocyte DHA levels was associated with a decrease in LDL-C levels, and initiating the use of fish oil supplements did not raise LDL-C levels.
JOURNAL OF CLINICAL LIPIDOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Zhongyang Lu, Yanchun Li, Hong Yu, Maria F. Lopes-Virella, Yan Huang
Summary: This study found that high-fat diet-induced metabolic syndrome increases alveolar bone loss in mice with ligature-induced periodontitis, and palmitic acid and lipopolysaccharide cooperatively stimulate osteoclast formation and proinflammatory gene expression in macrophages.
Article
Cardiac & Cardiovascular Systems
Richard L. Weinberg, Robert D. Brook, Melvyn Rubenfire, Kim A. Eagle
Summary: Omega-3 polyunsaturated fatty acids play a key role in heart-healthy diet, and can be obtained through fatty fish consumption or fish oil supplementation. They not only treat hypertriglyceridemia, but also prevent cardiovascular events, with additional benefits such as reducing inflammation and improving plaque stability.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Nutrition & Dietetics
Zhongxiang Wang, Jiaqi Wu, Lijun Li, Kanbin Wang, Xiaoyong Wu, Hongyu Chen, Jiujun Shi, Chengwei Zhou, Weijun Zhang, Kai Hang, Deting Xue, Zhijun Pan
Summary: This study found that EPA can promote osteoblast differentiation and regulate the balance between osteoblasts and osteoclasts in an inflammatory environment, thereby preventing osteoporosis. The results show that EPA can inhibit the activation of the NF-kB pathway induced by TNF-a, reduce the expression of RANKL, and inhibit osteoclastogenesis. In addition, the effectiveness of EPA in preventing osteoporosis was also confirmed in an animal model.
CLINICAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Maja Tomczyk, Jeffery L. Heileson, Miroslaw Babiarz, Philip C. Calder
Summary: Fatty fish and certain species of algae are the only natural sources of EPA and DHA, which have various beneficial effects for athletes. Due to limited intake and fluctuating content, athletes may consider using supplements to ensure sufficient EPA and DHA levels.
Review
Environmental Sciences
Priyanshi Sikka, Tapan Behl, Sanchay Sharma, Aayush Sehgal, Saurabh Bhatia, Ahmed Al-Harrasi, Sukhbir Singh, Neelam Sharma, Lotfi Aleya
Summary: Ω-3 fatty acids are recognized for their benefits on physical and mental health, primarily obtained from fish and fish products. Adequate intake of Ω-3 fatty acids can improve brain function and neuronal function, reduce depressive symptoms, and have fewer side effects compared to antidepressants.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Nutrition & Dietetics
Bojung Seo, Keming Yang, Ka Kahe, Abrar A. Qureshi, Andrew T. Chan, Immaculata De Vivo, Eunyoung Cho, Edward L. Giovannucci, Hongmei Nan
Summary: This study suggests that higher intakes of DHA and consumption of canned tuna are associated with longer leukocyte telomere length (LTL) in US males.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Maria Dolores Mesa, Fernando Gil, Pablo Olmedo, Angel Gil
Summary: This study aims to estimate the amount of n-3 LC-PUFA provided by commonly consumed fishes, shrimps, and mollusks, to conduct a risk-benefit analysis of fish consumption. Consuming 2-3 servings of a variety of fishery products per week can help meet recommended n-3 LC-PUFA levels while maintaining a balance to avoid potential risks from contaminants.
Article
Gastroenterology & Hepatology
Michele Russo, Alberto Barchi, Alessandro Mannucci, Marta Puzzono, Raffaella Alessia Zuppardo, Paolo Biamonte, Sarah Bencardino, Gioacchino Leandro, Renato Cannizzaro, Fabio Monica, Rocco Maurizio Zagari, Luigi Pasquale, Elisabetta Goni, Milena Di Leo, Luigi Ricciardiello, Giulia Martina Cavestro
Summary: This study evaluated the approach of Italian gastroenterologists to the management of hereditary colorectal cancer syndromes and assessed the impact of the SARS-CoV-2 pandemic. The results showed a decrease in the number of clinicians with a high volume of patients and reported delays in surveillance due to the pandemic.
DIGESTIVE DISEASES
(2023)
Article
Gastroenterology & Hepatology
Giulia Martina Cavestro, Alessandro Mannucci, Francesc Balaguer, Heather Hampel, Sonia S. Kupfer, Alessandro Repici, Andrea Sartore-Bianchi, Toni T. Seppala, Vincenzo Valentini, Clement Richard Boland, Randall E. Brand, Tineke E. Buffart, Carol A. Burke, Riccardo Caccialanza, Renato Cannizzaro, Stefano Cascinu, Andrea Cercek, Emma J. Crosbie, Silvio Danese, Evelien Dekker, Maria Daca-Alvarez, Francesco Deni, Mev Dominguez-Valentin, Cathy Eng, Ajay Goel, Jose G. Guillem, Britt B. S. L. Houwen, Charles Kahi, Matthew F. Kalady, Fay Kastrinos, Florian Kuehn, Luigi Laghi, Andrew Latchford, David Liska, Patrick Lynch, Alberto Malesci, Gianluca Mauri, Elisa Meldolesi, Pal Moller, Kevin J. Monahan, Gabriela Moeslein, Caitlin C. Murphy, Karlijn Nass, Kimmie Ng, Cristina Oliani, Enrico Papaleo, Swati G. Patel, Marta Puzzono, Andrea Remo, Luigi Ricciardiello, Carla Ida Ripamonti, Salvatore Siena, Satish K. Singh, Zsofia K. Stadler, Peter P. Stanich, Sapna Syngal, Stefano Turi, Emanuele Damiano Urso, Laura Valle, Valeria Stella Vanni, Eduardo Vilar, Marco Vitellaro, Yi-Qian Nancy You, Matthew B. Yurgelun, Raffaella Alessia Zuppardo, Elena M. Stoffel
Summary: This study aimed to develop guidelines for early-onset colorectal cancer (eoCRC). The study found that all individuals younger than 50 should undergo CRC risk stratification and newly diagnosed eoCRC patients should receive germline genetic testing. Furthermore, the treatment of early-onset CRC, including endoscopic, surgical, and oncologic treatment, should not differ from later-onset CRC, except for individuals with pathogenic or likely pathogenic germline variants. The study also highlighted areas for future research.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Chemistry, Applied
Maria Alessia Schouten, Christos Fryganas, Silvia Tappi, Santina Romani, Vincenzo Fogliano
Summary: This study investigated the effects of replacing wheat flour with lupin or chickpea flour on acrylamide formation in biscuits. The results showed that lupin flour increased acrylamide formation, while chickpea flour reduced it.
Article
Food Science & Technology
Devashree Patil, Siyu Chen, Vincenzo Fogliano, Ashkan Madadlou
Summary: This study investigated the impact of proteinase K hydrolysis on bovine lactoferrin, and found that hydrolysis enhanced its cathepsin inhibitory activity and inhibited the infectivity of SARS-CoV-2 pseudovirus.
INTERNATIONAL DAIRY JOURNAL
(2023)
Article
Food Science & Technology
Hao Zhang, Antonio Dario Troise, Shangde Sun, Vincenzo Fogliano
Summary: Plant food by-products such as black currant pomace and red cabbage waste have been studied for their impact on the formation of Maillard reaction and lipid oxidation products in potato-based fried crisps. The water-insoluble fractions of these by-products were found to significantly reduce the formation of acrylamide and 5-hydroxymethylfurfural. On the other hand, the addition of black currant pomace and red cabbage waste promoted the formation of these compounds. Furthermore, all four ingredients inhibited the accumulation of certain processing contaminants.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Applied
Jilu Feng, Claire C. Berton-Carabin, Sylvain Guyot, Agnes Gacel, Vincenzo Fogliano, Karin Schroen
Summary: This paper investigates the emulsification properties of coffee melanoidins. The results show that low concentrations of melanoidins lead to creaming, flocculation, and coalescence, while high concentrations transform the emulsion into a gel-like structure. Intermediate concentrations of melanoidins provide stability to the emulsion. Melanoidins act as emulsifiers by reducing interfacial tension and inducing electrostatic and steric repulsion, and they also function as texture modifiers by increasing the viscosity of the emulsion.
FOOD HYDROCOLLOIDS
(2023)
Article
Agriculture, Multidisciplinary
Ruth Fabiola Pena-Correa, Burce Atac Mogol, Christos Fryganas, Vincenzo Fogliano
Summary: This study compared the chemical characteristics of cocoa nibs roasted by a convective oven (slow roasting) vs cocoa nibs roasted in a fluidized bed roaster (fast roasting) at two temperatures (120 and 140°C). The results showed that fast roasting favored the reactivity of certain amino acids and led to the generation of more intense brown melanoidins, higher catechin content, increased formation of acrylamide, and reduced formation of 5-hydroxymethylfurfural in cocoa compared to slow roasting.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Zhan Huang, Jos Boekhorst, Vincenzo Fogliano, Edoardo Capuano, Jerry M. Wells
Summary: This study examined the impact of high-fiber-low-protein and high-protein-low-fiber diets on microbial catabolism of tryptophan in different compartments of the colon. The results showed that Bacteroidetes were more abundant in the distal colon, while Firmicutes were more abundant in the proximal colon. The high-fiber diet promoted the microbial production of tryptophan catabolites in both compartments.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Jilu Feng, Karin Schroen, Sylvain Guyot, Agnes Gacel, Vincenzo Fogliano, Claire C. Berton-Carabin
Summary: This study demonstrates that coffee extracts can effectively reduce lipid oxidation in emulsions fortified with polyunsaturated fatty acids. Different fractions of coffee extracts play different roles in improving the stability of emulsions. Coffee extracts can be used as multifunctional stabilizers in dispersed systems to enhance the chemical and physical stability of emulsion products.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Applied
Ruth Fabiola Pena-Correa, Burce Atac Mogol, Vincenzo Fogliano
Summary: This study evaluated the impact of two roasting techniques, forced convective oven and fluidized bed, on the microstructure of cocoa nibs and the quality of cocoa butter. Fluidized bed roasting was found to be 12 times faster than oven roasting and resulted in cocoa nibs with higher porosity and better quality cocoa butter. Therefore, the fluidized bed roasting technique should be preferred for cocoa nibs roasting.
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
(2023)
Article
Food Science & Technology
Ying Hui Lee, Pazhanichamy Kalailingam, Jan A. Delcour, Vincenzo Fogliano, Thirumaran Thanabalu
Summary: This study examines the effect of an olive-derived antioxidant dietary fiber (OADF) on relieving symptoms of atopic dermatitis (AD) and its modulation of gut microbiota. The results show that OADF supplementation significantly improves AD-like symptoms and restores the altered gut microbiota composition in AD mice. OADF also influences cytokine profile and butyrate production, which are associated with AD-associated immune response.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Horticulture
Camila Vanessa Buturi, Rosario Paolo Mauro, Vincenzo Fogliano, Cherubino Leonardi, Francesco Giuffrida
Summary: Hidden hunger is a global problem caused by nutrient deficiencies, with iron and zinc deficiency being the most common. This study focused on biofortification of off-season carrots using different forms of foliar applications of iron and zinc. The results demonstrated that chelated forms of the minerals were more effective in enhancing the nutrient content of carrots compared to sulfate forms.
SCIENTIA HORTICULTURAE
(2023)
Article
Microbiology
Hebat Allah Ibrahim Youssef, Paola Vitaglione, Rosalia Ferracane, Jumana Abuqwider, Gianluigi Mauriello
Summary: Two strains of GABA-producing bacteria were microencapsulated in sodium alginate with different concentrations of MSG. The GABA yield in the microcapsules varied with storage time and bacterial culture form. The GABA synthesis in chocolate milk was higher with microcapsules containing fresh cells compared to freeze-dried cells.
Review
Nutrition & Dietetics
Carmen Monge-Montero, Liandre F. van der Merwe, Silvia Tagliamonte, Carlo Agostoni, Paola Vitaglione
Summary: This study aims to gain a deeper understanding of the reasons why mothers choose mixed milk feeding (MMF). The study identified and categorized 13 different drivers/reasons for MMF, including perceived choice, necessity, and pressure. Factors such as perceived breast milk insufficiency, breastfeeding difficulties, and returning to work were commonly reported reasons for MMF.
Article
Biochemistry & Molecular Biology
Aytul Hamzalioglu, Silvia Tagliamonte, Vural Gokmen, Paola Vitaglione
Summary: This study explored the interactions between casein and different phenol compounds during digestion, and monitored their effects on the bioaccessibility of phenol compounds and bioactive peptides. The results showed that co-digestion of casein with phenol compounds increased the bioaccessible total antioxidant capacity and promoted the release of antioxidant peptides. Furthermore, the type and concentration of phenols affected the release of bioactive peptides.
