Article
Neurosciences
Basil C. Preisig, Lars Riecke, Alexis Hervais-Adelman
Summary: Which processes in the human brain lead to the categorical perception of speech sounds? Investigation of this question is hampered by the fact that categorical speech perception is normally confounded by acoustic differences in the stimulus. By using ambiguous sounds, however, it is possible to dissociate acoustic from perceptual stimulus representations. This study found that various brain regions, including left perisylvian regions, left inferior frontal regions, left supplementary motor cortex, and right motor and somatosensory regions, represent listeners' syllable report irrespective of stimulus acoustics. These regions are outside of what is traditionally regarded as auditory or phonological processing areas.
Review
Audiology & Speech-Language Pathology
Srivatsun Sadagopan, Manaswini Kar, Satyabrata Parida
Summary: To generate insight from experimental data, it is critical to understand the inter-relationships between individual data points and place them in context within a structured framework. Quantitative modeling can provide the scaffolding for such an endeavor, as it offers a compact summary of observed data, makes underlying assumptions explicit, and generates predictions for future experiments.
Article
Multidisciplinary Sciences
Cody L. Call, Dwight E. Bergles
Summary: The myelination patterns in the intact mouse somatosensory cortex are influenced by axon diameter and neuronal identity. In vivo imaging showed that remyelination altered myelin patterns but restored overall myelin content on distinct neuron subtypes.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Michael A. Skinnider, Nichollas E. Scott, Anna Prudova, Craig H. Kerr, Nikolay Stoynov, R. Greg Stacey, Queenie W. T. Chan, David Rattray, Jorg Gsponer, Leonard J. Foster
Summary: This study mapped the interactomes of seven mouse tissues using a novel quantitative proteomic approach, revealing the rewiring of protein interactions and their implications in cellular mechanisms and diseases. The findings open new avenues for understanding regulatory mechanisms shaping interactome responses in mammalian systems.
Article
Neurosciences
Marta Vitorino, Sonia Simao, Joao B. Moreira, Joana Nogueira-Rodrigues, Joana Silva, Ana Sofia Lourenco, Vitor Fernandes, Monica M. Sousa, Gustavo Tiscornia, Ines M. Araujo
Summary: This study presents a coronal brain atlas of the African spiny mouse, providing a new tool for neuroanatomical research and opening new avenues for investigating its regenerative ability in brain disorders.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chunyan Wang, Juan Pablo Palavicini, Xianlin Han
Summary: This study utilized mass spectrometry to analyze the lipid species profiles of sphingolipids in different nervous tissues, revealing distinct profiles and investigating the expression of related metabolism genes. The results showed high selectivity in the synthesis of sphingolipids and provided insights into region-specific lipid levels in the nervous system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kenji Tanaka, Shuma Ohara, Tadaaki Matsuzaka, Aira Matsugaki, Takuya Ishimoto, Ryosuke Ozasa, Yukiko Kuroda, Koichi Matsuo, Takayoshi Nakano
Summary: The auditory brainstem response (ABR) is commonly used to assess auditory function, but determining the ABR threshold has been a challenge. Existing methods lack accuracy, efficiency, and convenience. We proposed an improved algorithm based on mutual covariance to objectively determine the ABR threshold. This method effectively reduced the burden on experimental animals and provided more efficient and accurate results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
B. Riffault, R. Cloarec, H. Rabiei, M. Begnis, D. C. Ferrari, Yehezkel Ben-Ari
Summary: This study provides the first 3D atlases of the cholinergic and catecholaminergic systems in the mouse brain from embryonic day 12 to post-natal day 8 using tissue clearing, immunohistochemistry, lightsheet microscopy, and a multiresolution registration technique. The findings show a logarithmic scale increase of choline acetyltransferase and tyrosine hydroxylase positive neurons from E18 to P8 in several brain structures. Moreover, there are abrupt modifications in the developmental trajectory of many brain structures during the transition from E18 to P0.
Article
Biotechnology & Applied Microbiology
Eun Song Lee, Jung Heo, Woo Young Bang, Kapeel M. Chougule, Nomar Espinosa Waminal, Nguyen Thi Hong, Min Ji Kim, Hong Kwan Beak, Yong Jun Kim, Ryza A. Priatama, Ji In Jang, Kang Il Cha, Seung Han Son, Sujeevan Rajendran, Young-Kug Choo, Jong Hyang Bae, Chul Min Kim, Young Koung Lee, Sangsu Bae, Jonathan D. G. Jones, Kee Hoon Sohn, Jiyoung Lee, Hyun Hee Kim, Jong Chan Hong, Doreen Ware, Keunhwa Kim, Soon Ju Park
Summary: Researchers assembled the genome of the hexaploid black nightshade species, Solanum nigrum, and identified homoeologous gene sets through comparative analysis. By using CRISPR-Cas9-mediated mutagenesis, they generated mutant combinations in these genes, resulting in broad-spectrum effects on the quantitative traits of S. nigrum. Furthermore, they successfully improved the fruit productivity of an orphan cultivar of S. nigrum, suggesting the potential for agricultural improvement of polyploid crops through homoeologous gene engineering.
PLANT BIOTECHNOLOGY JOURNAL
(2023)
Article
Neurosciences
Joon Yul Choi, Siyuan Hu, Ting-Yu Su, Hiroatsu Murakami, Yingying Tang, Ingmar Blumcke, Imad Najm, Ken Sakaie, Stephen Jones, Mark Griswold, Zhong Irene Wang, Dan Ma
Summary: Using 3T MRI, this study investigated the quantitative MR relaxation maps of the human brain cortex and explored the variations in T-1 and T-2 values. The results showed low variability of MRF measurements across subjects, significant differences in T-1 and T-2 among different brain regions, and correlations between age and T-1 and T-2 values. The study established normative MR relaxation atlases of the whole brain, providing a quantitative and region-specific baseline for future brain studies.
Article
Computer Science, Information Systems
Rong Wang, Haowen Yan, Xiaomin Lu
Summary: This paper proposes a new approach to calculate the quantitative relations between topological similarity degree and map scale change of multi-scale contour clusters. It constructs a directed contour tree and develops a quantitative expression based on it, and explores the changing regularity of topological indices with map scale using various contour clusters with different geomorphological types. The results show a close relationship between the quantitative expression of multi-scale topological indices and contour interval change, with power function being the best fit.
ISPRS INTERNATIONAL JOURNAL OF GEO-INFORMATION
(2022)
Article
Computer Science, Information Systems
Rong Wang, Haowen Yan, Xiaomin Lu
Summary: This paper proposes a new approach for calculating the quantitative relations between morphostructural similarity degree and map scale change in multi-scale contour clusters for automatic contour generalization. The method involves extracting terrain lines from unclosed contour lines and using a quantitative expression based on terrain line hierarchical trees. The study investigates the changing patterns of morphostructural similarity indices with map scale using thirteen groups of multi-scale contour clusters with different drainage areas. The results show that the quantitative relations between morphostructural similarity degree and map scale change can be expressed using a power function, facilitating automation of contour generalization.
ISPRS INTERNATIONAL JOURNAL OF GEO-INFORMATION
(2023)
Article
Neurosciences
Jie Zhang, Ye Yao, Jin-song Wu, Edmund T. Rolls, Ce-chen Sun, Ling-hao Bu, Jun-feng Lu, Ching-po Lin, Jian-feng Feng, Ying Mao, Liang-fu Zhou
Summary: This study used multi-modal neuroimaging analyses to localize the cortical regions and white matter tracts responsible for auditory language comprehension. The results showed that cortical areas in the posterior temporal lobe are crucial for language comprehension. The fiber integrity of the arcuate fasciculus and the inferior longitudinal fasciculus was strongly correlated with auditory comprehension and the grey matter volume of the inferior temporal and middle temporal gyri.
HUMAN BRAIN MAPPING
(2023)
Article
Genetics & Heredity
Juying Han, Brian Ritchey, Emmanuel Opoku, Jonathan D. Smith
Summary: Through the study of congenic strains, three atherosclerosis modifier gene regions named Ath28.1, Ath28.2, and Ath28.3 were successfully identified at the distal end of chromosome 2 in mice. The research suggests that even within a relatively small region of the mouse genome, there are multiple genes that influence susceptibility to atherosclerosis.
Article
Multidisciplinary Sciences
Kevin K. Esoh, Tobias O. Apinjoh, Steven G. Nyanjom, Ambroise Wonkam, Emile R. Chimusa, Lucas Amenga-Etego, Alfred Amambua-Ngwa, Eric A. Achidi
Summary: Genetic association studies rely on defining underlying populations, which can be confounded by population structure. A study in Cameroon revealed fine-scale genetic structure and longstanding sympatric differentiation among ethnic groups. Selection signatures in HLA and HBB genes confirmed natural selection and balancing selection in African populations, shaping genomes of Cameroonian populations.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Hiroaki Tsukano, Masao Horie, Kuniyuki Takahashi, Ryuichi Hishida, Hirohide Takebayashi, Katsuei Shibuki
NEUROSCIENCE LETTERS
(2017)
Correction
Neurosciences
Hiroaki Tsukano, Masao Horie, Shinpei Ohga, Kuniyuki Takahashi, Yamato Kubota, Ryuichi Hishida, Hirohide Takebayashi, Katsuei Shibuki
FRONTIERS IN NEURAL CIRCUITS
(2017)
Review
Neurosciences
Hiroaki Tsukano, Masao Horie, Shinpei Ohga, Kuniyuki Takahashi, Yamato Kubota, Ryuichi Hishida, Hirohide Takebayashi, Katsuei Shibuki
FRONTIERS IN NEURAL CIRCUITS
(2017)
Article
Multidisciplinary Sciences
Keiichi Maniwa, Haruyoshi Yamashita, Hiroaki Tsukano, Ryuichi Hishida, Naoto Endo, Minoru Shibata, Katsuei Shibuki
Article
Multidisciplinary Sciences
Tatsuya Yamagishi, Kohei Yoshitake, Daiki Kamatani, Kenji Watanabe, Hiroaki Tsukano, Ryuichi Hishida, Kuniyuki Takahashi, Sugata Takahashi, Arata Horii, Takeshi Yagi, Katsuei Shibuki
SCIENTIFIC REPORTS
(2018)
Article
Neurosciences
Shinpei Ohga, Hiroaki Tsukano, Masao Horie, Hiroki Terashima, Nana Nishio, Yamato Kubota, Kuniyuki Takahashi, Ryuichi Hishida, Hirohide Takebayashi, Katsuei Shibuki
Article
Multidisciplinary Sciences
Nana Nishio, Hiroaki Tsukano, Ryuichi Hishida, Manabu Abe, Junichi Nakai, Meiko Kawamura, Atsushi Aiba, Kenji Sakimura, Katsuei Shibuki
SCIENTIFIC REPORTS
(2018)
Correction
Neurosciences
Shinpei Ohga, Hiroaki Tsukano, Masao Horie, Hiroki Terashima, Nana Nishio, Yamato Kubota, Kuniyuki Takahashi, Ryuichi Hishida, Hirohide Takebayashi, Katsuei Shibuki
Article
Neurosciences
Ryuichi Hishida, Masao Horie, Hiroaki Tsukano, Manavu Tohmi, Kohei Yoshitake, Reiko Meguro, Hirohide Takebayashi, Yuchio Yanagawa, Katsuei Shibuki
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Takeshi Onishi, Tatsunori Watanabe, Mika Sasaki, Yoshinori Kamiya, Masao Horie, Hiroaki Tsukano, Ryuichi Hishida, Tatsuro Kohno, Hirohide Takebayashi, Hiroshi Baba, Katsuei Shibuki
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Multidisciplinary Sciences
Manabu Ogi, Tatsuya Yamagishi, Hiroaki Tsukano, Nana Nishio, Ryuichi Hishida, Kuniyuki Takahashi, Arata Horii, Katsuei Shibuki
Article
Multidisciplinary Sciences
Hiroaki Tsukano, Xubin Hou, Masao Horie, Hiroki Kitaura, Nana Nishio, Ryuichi Hishida, Kuniyuki Takahashi, Akiyoshi Kakita, Hirohide Takebayashi, Sayaka Sugiyama, Katsuei Shibuki
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Destinee A. Aponte, Gregory Handy, Amber M. Kline, Hiroaki Tsukano, Brent Doiron, Hiroyuki K. Kato
Summary: The study found that the direction selectivity of frequency modulation is not due to temporal offsets, but to an asymmetry in total synaptic charge between preferred and non-preferred directions. Inactivation of cortical somatostatin-expressing interneurons was shown to play a role in this process. Theoretical models suggest that charge asymmetry arises from the broad spatial topography of inhibitory neurons.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Amber M. Kline, Destinee A. Aponte, Hiroaki Tsukano, Andrea Giovannucci, Hiroyuki K. Kato
Summary: The integration of multi-frequency sounds in the mouse secondary auditory cortex A2 is crucial for vocal processing. A specific subnetwork of neurons in A2 encodes harmonic sounds and is stable across days, possibly forming during development. Inactivation of A2 impairs performance in a discrimination task for coincident harmonics.
NATURE COMMUNICATIONS
(2021)
Review
Acoustics
Shigeto Furukawa, Hiroki Terashima, Takuya Koumura, Hiroaki Tsukano
ACOUSTICAL SCIENCE AND TECHNOLOGY
(2020)