The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer’s disease amyloid-β peptides

A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease

(2014) Eric Karran et al.   ANNALS OF NEUROLOGY

Lessons from a Failed γ-Secretase Alzheimer Trial

(2014) Bart De Strooper   CELL

Ushering in the study and treatment of preclinical Alzheimer disease

(2013) Jessica B. Langbaum et al.   Nature Reviews Neurology

Gamma-Secretase Inhibitor Activity of aPterocarpus erinaceusExtract

(2013) Salim Hage et al.   Neurodegenerative Diseases

Presenilins and  -Secretase: Structure, Function, and Role in Alzheimer Disease

(2013) B. De Strooper et al.   Cold Spring Harbor Perspectives in Medicine

Discovery of a Novel Pharmacological and Structural Class of Gamma Secretase Modulators Derived from the Extract of Actaea racemosa

(2012) Mark A. Findeis et al.   ACS Chemical Neuroscience

Alzheimer’s Disease, Cholesterol, and Statins: The Junctions of Important Metabolic Pathways

(2012) Tiago Silva et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Drug repositioning for Alzheimer's disease

(2012) Anne Corbett et al.   NATURE REVIEWS DRUG DISCOVERY

New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs

(2011) Salvatore Salomone et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The NCGC Pharmaceutical Collection: A Comprehensive Resource of Clinically Approved Drugs Enabling Repurposing and Chemical Genomics

(2011) R. Huang et al.   Science Translational Medicine

NerveCenter: New evidence of preserved cognition in unresponsive TBI patient raises questions, concerns

(2010) Kurt Samson   ANNALS OF NEUROLOGY

Novel γ-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1

(2010) Fang Wu et al.   FASEB JOURNAL

Tarenflurbil for Alzheimer's disease: a “shot on goal” that missed

(2010) Bruno Vellas   LANCET NEUROLOGY

An APP inhibitory domain containing the Flemish mutation residue modulates γ-secretase activity for Aβ production

(2010) Yuan Tian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alzheimer's Disease: From Pathology to Therapeutic Approaches

(2009) Roland Jakob-Roetne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Herbals in the control of ageing

(2009) Vijay K. Kapoor et al.   DRUG DISCOVERY TODAY

Recent Advances in the Identification of γ-Secretase Inhibitors To Clinically Test the Aβ Oligomer Hypothesis of Alzheimer’s Disease

(2009) Anthony F. Kreft et al.   JOURNAL OF MEDICINAL CHEMISTRY

Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements

(2008) Matthew L Hemming et al.   PLOS BIOLOGY