Article
Immunology
Katarzyna Okreglicka, Irina Iten, Lea Pohlmeier, Lucas Onder, Qian Feng, Michael Kurrer, Burkhard Ludewig, Peter Nielsen, Christoph Schneider, Manfred Kopf
Summary: PPAR gamma and Spi-C are crucial for maintaining the identity, cell cycling, migration, and localization of splenic iron-recycling red pulp macrophages and bone marrow erythroblastic island macrophages, but do not affect function in mature red pulp macrophages. Lack of Spi-C leads to loss of identity in red pulp macrophages, while deficiencies in Pparg and Spic results in shared transcriptional changes in the cells.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Cell Biology
Kathrin Werth, Elin Hub, Julia Christine Gutjahr, Berislav Bosjnak, Xiang Zheng, Anja Bubke, Stefan Russo, Antal Rot, Reinhold Foerster
Summary: A study identifies a vascular compartment within the spleen, delineated by endothelial cells expressing ACKR4, which supports the homing of T cells into the spleen.
Review
Oncology
David Oscier, Kostas Stamatopoulos, Amatta Mirandari, Jonathan Strefford
Summary: This review summarizes the clinical and laboratory features of hairy cell leukemia, as well as the chromosome abnormalities, genomic mutations, DNA methylation patterns, and immunoglobulin gene usage observed in this disease. The discovery of a specific mutation in the BRAF gene, present in almost all cases of hairy cell leukemia, has provided new insights into its biology, a new diagnostic test, and a potential therapeutic target. Understanding the biological features of hairy cell leukemia has important clinical implications for diagnosis, prognosis assessment, and treatment response.
Review
Pharmacology & Pharmacy
Alexandre M. M. Dias, Alan Courteau, Pierre-Simon Bellaye, Evelyne Kohli, Alexandra Oudot, Pierre-Emmanuel Doulain, Camille Petitot, Paul-Michael Walker, Richard Decreau, Bertrand Collin
Summary: This review discusses the various applications of superparamagnetic iron oxide nanoparticles (SPIONs) in cancer immunotherapy, focusing on their theranostic properties for targeting tumor-associated macrophages (TAMs) and generating magnetic hyperthermia. SPIONs have shown potential in combining different approaches to enhance the efficacy of immunotherapies.
Article
Oncology
Elias D. Buhrer, Michael A. Amrein, Stefan Forster, Stephan Isringhausen, Christian M. Schuerch, Salil S. Bhate, Tess Brodie, Joel Zindel, Deborah Stroka, Mohamad Al Sayed, Cesar Nombela-Arrieta, Ramin Radpour, Carsten Riether, Adrian F. Ochsenbein
Summary: The study demonstrated that in CML, LSCs preferentially accumulate in the spleen, where red pulp macrophages form a niche for maintaining LSCs, leading to disease progression and resistance to therapy.
Article
Immunology
Ina N. Eckert, Eliana Ribechini, Katja J. Jarick, Sandra Strozniak, Sarah J. Potter, Andreas Beilhack, Manfred B. Lutz
Summary: The study discovered that the adhesion of VLA-1 integrin to collagen IV plays a critical role in extending the contact time between MDSCs and T cells, which is necessary for suppression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Applied
Hassan Mohammadi, Mehrorang Ghaedi, Mehdi Fazeli, Mohammad Mehdi Sabzehmeidani
Summary: In this study, a magnetic composite of CoFe2O4/PANI was successfully used for the removal of Cr(VI) ions and AR18 dye from aqueous solutions, with maximum monolayer adsorption capacities reaching 103.11 mg/g and 172.41 mg/g, respectively. The adsorption processes were found to be spontaneous and endothermic, and the magnetically recyclable composite showed suitable reusability during cyclic adsorption.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Review
Oncology
Elif Yilmaz, Arashpreet Chhina, Victor E. Nava, Anita Aggarwal
Summary: Splenic diffuse red pulp small B-cell lymphoma (SDRPL) is a rare disease, difficult to diagnose without splenic tissue examination. It has distinct immunophenotypic features that differentiate it from other types of lymphomas, with no standard treatment regimen established yet, suggesting a need for further research into effective therapeutic approaches.
Article
Oncology
Charlotte Nazon, Marina Pierrevelcin, Thibault Willaume, Benoit Lhermitte, Noelle Weingertner, Antonio Di Marco, Laurent Bund, Florence Vincent, Guillaume Bierry, Anne Gomez-Brouchet, Francoise Redini, Nathalie Gaspar, Monique Dontenwill, Natacha Entz-Werle
Summary: This study correlates radiological and immunohistochemical data with the outcome in pediatric osteosarcomas (OTS) and identifies imaging and immunohistochemical markers associated with a worse overall survival. These findings suggest a potential dual signature association that can be used in future protocols to predict the outcome of OTS.
Article
Cell Biology
Birte S. Steiniger, Henriette Pfeffer, Michael Guthe, Oleg Lobachev
Summary: This study provides a detailed anatomical analysis of the microvasculature in the human spleen, revealing unique structures of sheathed capillaries and their biological significance. The 3D model constructed and evaluated in virtual reality enhances our understanding of the complex blood circulation system in the spleen.
HISTOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Engineering, Chemical
Do Thi Hai, Nguyen Thu Phuong, Pham Xuan Cong, Nguyen Hong Nam, Le Phuong Thu, Nguyen Thi Thu Trang, Nguyen Thi Thom, Pham Thi Nam, Magdalena Osial, Dinh Thi Mai Thanh
Summary: This work demonstrates a nanostructural composite, based on superparamagnetic iron oxide nanoparticles (SPIONs) coated with hydroxyapatite (HAp), as an effective adsorbent for removing Congo red (CR) from aqueous solutions. The composite exhibits good adsorption performance and magnetic separation ability, with the adsorption of CR following the pseudo-second-order kinetic model and the Langmuir model. The material has a satisfactory adsorption capacity and can be easily separated using magnets, making it a promising candidate for wastewater treatment.
DESALINATION AND WATER TREATMENT
(2023)
Article
Hematology
Suying Zheng, Ling Lin, Jing Jin, Fang Liu, Jianguo Wei, Yi Feng, Yaping Zhang, Hongqiang Luo, Jiayue Qin, Weiying Feng
Summary: This study presents the case of a 62-year-old patient with splenic diffuse red pulp small B-cell lymphoma (SDRPL). Immunohistochemistry indicated positive CD20 and CD79a, and the Ki-67 labeling index was approximately 5%, consistent with the pathological characteristics of splenic B-cell lymphoma. Next-generation sequencing of spleen tissue and peripheral blood samples detected possible mutations in CXCR4 and TRAF3 genes, which may be related to the pathogenesis of SDRPL. This finding could offer insights into the molecular pathogenesis of SDRPL and aid in molecular diagnosis and targeted therapy for SDRPL.
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2023)
Article
Oncology
Paolo Lopedote, Ahmad Al Nawaiseh, Anita Malek, Garrey Faller, Mariana Hattar, Edward Dow, Olga Kozyreva
Summary: Splenic diffuse red pulp small B-cell lymphoma (SDRPL) is a rare disease with potential for progression after splenectomy. We report a case of a patient diagnosed with SDRPL who transformed to diffuse large B-cell lymphoma six months after splenectomy, with gene mutations involving CREBBP, NOTCH1, ARID2, and TNFRSF14.
LEUKEMIA RESEARCH REPORTS
(2023)
Article
Hematology
Lisa-Maj Christensen, Marianne Tang Severinsen, Pragya Katoch, Andreas Kiesbye Ovlisen, Thor Hoyer, Paw Jensen, Karen Dybkaer, Daniel Tuyet Kristensen
Summary: Splenic diffuse red pulp small B-cell lymphoma (SDRPL) is an extremely rare B-cell lymphoma. This study highlights a case of SDRPL with an unusually aggressive course, transforming into diffuse large B-cell lymphoma and experiencing multiple relapses following immunochemotherapy cessation. Whole-exome sequencing revealed a novel somatic mutation in RB1 that may be the driver of this aggressive form, a finding not previously reported in SDRPL.
JOURNAL OF HEMATOLOGY
(2023)
Article
Materials Science, Ceramics
J. Dey, M. Wojcik, E. Jedryka, R. Kalvig, U. Wiedwald, R. Salikhov, M. Farle, J. Rosen
Summary: Zero-field NMR investigations were conducted on an epitaxial Mn2GaC(0001) MAX phase film grown on a MgO(111) substrate. The observed gallium resonances exhibited a well-defined crystal field, confirming high crystal quality. The non-magnetic gallium atoms experienced a transferred hyperfine magnetic field, indicating the presence of an uncompensated ferromagnetic moment within the manganese sublattice. A more advanced study is needed to understand the detailed magnetic structure of this material.
CERAMICS INTERNATIONAL
(2023)
Article
Cell Biology
Celina Eckfeld, Benjamin Schoeps, Daniel Haeussler, Julian Fraedrich, Felix Bayerl, Jan Philipp Boettcher, Percy Knolle, Simone Heisz, Olga Prokopchuk, Hans Hauner, Enkhtsetseg Munkhbaatar, Ihsan Ekin Demir, Chris D. Hermann, Achim Krueger
Summary: The study reveals that TIMP-1 interacts with APP family members and triggers monocyte activation, leading to proinflammatory cytokine expression. This mechanism is confirmed in clinical cancer samples and suggests that TIMP-1 can be a potential therapeutic target for inflammatory diseases.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Quanzheng Tao, Joseph Halim, Justinas Palisaitis, Adam Carlsson, Martin Dahlqvist, Ulf Wiedwald, Michael Farle, Per O. A. Persson, Johanna Rosen
Summary: The recent discovery of chemical ordering in quaternary borides opens up new possibilities for exploring the properties and functionalities of these laminated phases. In this study, we synthesized and investigated the chemical ordering of the Mo4MnSiB2 (T2) phase, introducing a magnetic element into the o-MAB family of materials. Through various analyses, we found evidence of out-of-plane chemical ordering of Mo and Mn, with Mn and B forming quasi-two-dimensional layers. Magnetic properties were studied, with no long-range magnetic order observed. Density functional theory calculations showed that while an antiferromagnetic configuration is the most stable, ferromagnetic ordering is very close in energy.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Physics, Applied
Benedikt Beckmann, Tarek A. El-Melegy, David Koch, Ulf Wiedwald, Michael Farle, Fernando Maccari, Joshua Snyder, Konstantin P. Skokov, Michel W. Barsoum, Oliver Gutfleisch
Summary: Reactive single-step hot-pressing at high temperature and pressure can produce dense, near single-phase Fe-based MAB samples with favorable magnetocaloric properties. Ge and Ga doping can tailor the magnetic and magnetocaloric properties, increasing the Curie temperature and spontaneous magnetization. The hot-pressed samples show a second-order magnetic phase transition and have potential applications in low-cost and low-criticality magnetocaloric devices around room temperature.
JOURNAL OF APPLIED PHYSICS
(2023)
Review
Gastroenterology & Hepatology
Neda Yahoo, Michael Dudek, Percy Knolle, Mathias Heikenwaelder
Summary: The liver plays a central role in metabolism and immune functions. When overwhelmed by obesity and a sedentary lifestyle, it can lead to the development of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Genetic and environmental factors, including the gut microbiome, also contribute to the development and progression of NAFLD and liver cancer. CD8+CXCR6+PD1+ T cells are implicated in the transition from NASH to hepatocellular carcinoma (HCC), and their characteristics may affect responses to immune checkpoint inhibitors. This review focuses on the role of T cells in NASH and discusses preventive measures and therapeutic strategies for managing NASH-HCC.
JOURNAL OF HEPATOLOGY
(2023)
Article
Physics, Multidisciplinary
Thomas Feggeler, Johanna Lill, Damian Guenzing, Ralf Meckenstock, Detlef Spoddig, Maria Efremova, Sebastian Wintz, Markus Weigand, Benjamin W. Zingsem, Michael Farle, Heiko Wende, Katharina J. Ollefs, Hendrik Ohldag
Summary: Different phasic magnetic resonance modes were observed using time-resolved scanning transmission x-ray microscopy within a chain of dipolarly coupled Fe3O4 nanoparticles in a magnetotactic bacterium. These modes are well resembled by micromagnetic simulations.
NEW JOURNAL OF PHYSICS
(2023)
Article
Nanoscience & Nanotechnology
Benjamin Zingsem, Thomas Feggeler, Ralf Meckenstock, Detlef Spoddig, Taddaeus Schaffers, Santa Pile, Hendrik Ohldag, Michael Farle, Heiko Wende, Andreas Ney, Katharina Ollefs
Summary: We propose a statistically motivated method to extract magnonic contrast from time-resolved scanning transmission x-ray microscopy (TRSTXM) measurements. TR-STXM is an element-specific method that offers nanometer spatial resolution and picosecond temporal resolution for resolving spin-dynamics in space and time. The presented method allows for obtaining phase and amplitude profiles of spin waves and transforming them to reciprocal magnon k-space, revealing k-dependent magnon properties. We demonstrate the effectiveness of the method using X-band ferromagnetic resonance on a micrometer-sized permalloy assembly.
Article
Chemistry, Multidisciplinary
Eirini Myrovali, Kyrillos Papadopoulos, Georgia Charalampous, Paraskevi Kesapidou, George Vourlias, Thomas Kehagias, Makis Angelakeris, Ulf Wiedwald
Summary: Magnetic particle hyperthermia (MPH) is a promising cancer treatment method that uses magnetic nanoparticles (MNPs) to generate localized heating. The MNPs are subjected to an alternating magnetic field to heat the cancer cells while minimizing side effects on healthy tissues. The size of the MNPs is crucial for maximizing heating efficiency and minimizing toxicity, and various synthetic controls have been developed to achieve the optimal size for MPH treatment.
Article
Materials Science, Multidisciplinary
Kaustubh Sudhakar, Takayuki Kono, Tarek El-Melegy, Hussein Badr, Prajwal M. Laxmeesha, Kiana Montazeri, Anna Semisalova, Michael Farle, Ulf Wiedwald, Michel W. Barsoum
Summary: We describe a new, simple and scalable method for synthesizing ferrite nanoparticles. Insoluble iron boride powders are immersed in high pH aqueous solutions and subjected to temperatures between 50°C and 80°C for several hours. The resulting iron oxide nanoparticles exhibit ferrimagnetic behavior with a high saturation magnetization. The average size of the nanoparticles depends on the reaction time.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2023)
Article
Chemistry, Inorganic & Nuclear
Pavel Varlamov, Anna Semisalova, Anh Dung Nguyen, Michael Farle, Yannis Laplace, Michele Raynaud, Olivier Noel, Paolo Vavassori, Vasily Temnov
Summary: In this study, we investigated the magnetic and morphological properties of irradiated FeRh thin films using high-intensity laser pulses. Through scanning magneto-optical Kerr effect microscopy, we observed a transition from antiferromagnetic to ferromagnetic behavior at the bottom of laser-ablated craters. The ablation threshold coincided with the antiferromagnet-to-ferromagnet phase transition, and temperature-dependent measurements confirmed the existence of this phase transition.
Article
Chemistry, Multidisciplinary
Benedikt Eggert, Asli Cakir, Damian Guenzing, Nicolas Josten, Franziska Scheibel, Richard A. Brand, Michael Farle, Mehmet Acet, Heiko Wende, Katharina Ollefs
Summary: The precipitation process of L2(1)-ordered Ni2MnSn and L1(0)-ordered NiMn in off-stoichiometric Ni50Mn45Sn5 during temper annealing is investigated using X-ray diffraction and Sn-119 Mossbauer spectroscopy. The induced magnetic Sn moment is shown to be a powerful tool for detecting microscopic structural changes and investigating the formation of nano-precipitates. Similar research can be conducted in the future on different pinning type magnets like Sm-Co or Nd-Fe-B.
Article
Chemistry, Physical
Niels Kubitza, Ruiwen Xie, Ivan Tarasov, Chen Shen, Hongbin Zhang, Ulf Wiedwald, Christina S. Birkel
Summary: By microwave heating, we have successfully synthesized a previously unknown MAX phase solid-solution (V1-x Cr x )(2)GaC, which exhibits a crucial coupling between chemical composition and electronic structure, providing important guidelines for the synthesis of long-range ordered magnetic MAX phases.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Physical
Kyrillos Papadopoulos, Eirini Myrovali, Dimitrios Karfaridis, Michael Farle, Ulf Wiedwald, Mavroeidis Angelakeris
Summary: Highly crystalline BiFeO3 (BFO), Bi0.97Sm0.03FeO3, and BiFe0.97Co0.03O3 nanoparticles were successfully synthesized via the chemical co-precipitation method and investigated for their structural, magnetic, and heating properties. The results showed that cation substitution and size confinement can significantly enhance the magnetic features of the doped nanoparticles and inhibit the spiral spin structure of BFO at room temperature. These doped nanoparticles also demonstrated potential application as heating agents in magnetic hyperthermia for cancer treatment.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)