Article
Environmental Sciences
Sumiko Morimoto, Edgar Solis-Lemus, Jesica Jimenez-Vivanco, Dafne Castellanos-Ruiz, Eulises Diaz-Diaz, C. Adriana Mendoza-Rodriguez
Summary: A study found that low doses of BPS affected glucose metabolism in rats, causing them to exhibit more female-like responses during the perinatal period. However, these effects disappeared in adulthood.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Boya Zhang, Xingpei Fan, Haining Du, Meimei Zhao, Ziyi Zhang, Ruijiao Zhu, Bo He, Yuxia Zhang, Xiaoyan Li, Jiaxin Li, Ning Gu
Summary: Foodborne carbon dots (CDs) are an emerging food nanocontaminant that pose an increasing risk of metabolic toxicity in mammals. Chronic CD exposure disrupts the gut-liver axis in mice, leading to glucose metabolism disorders. CD exposure alters the gut microbiota composition, increasing pro-inflammatory bacteria and inducing intestinal inflammation, systemic inflammation, and hepatic insulin resistance.
Article
Environmental Sciences
Yacong Bo, Yongjian Zhu
Summary: This study found that the OPEs compound DMTP might be associated with impaired glucose homeostasis and may increase the prevalence of T2D in U.S. adults.
Article
Multidisciplinary Sciences
Paulina Podkalicka, Olga Mucha, Katarzyna Kazirod, Krzysztof Szade, Jacek Stepniewski, Liudmyla Ivanishchuk, Hirofumi Hirao, Ewelina Pospiech, Alicja Jozkowicz, Jerzy W. Kupiec-Weglinski, Jozef Dulak, Agnieszka Loboda
Summary: "Duchenne muscular dystrophy (DMD) is characterized by muscle tissue abnormalities and systemic metabolic alterations. This study demonstrates that the loss of miR-378 in mdx mice leads to dysregulation of carbohydrate and lipid metabolism. The absence of miR-378 improves glucose tolerance and insulin sensitivity in mdx mice and restores the expression of genes involved in lipid homeostasis. These findings suggest that inhibiting miR-378 may be a potential strategy to alleviate the multifaceted symptoms of DMD."
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Shouxin Peng, Jinhui Sun, Feifei Liu, Zhaoyuan Li, Chuangxin Wu, Hao Xiang
Summary: This study investigated the short-term association between PM2.5 exposure and glucose homeostasis in healthy populations, revealing a positive relationship between short-term PM2.5 exposure and insulin levels, insulin resistance status, and impaired glucose homeostasis. The results suggest a potential biological pathway underlying the association between PM2.5 exposure and metabolic events.
ATMOSPHERIC ENVIRONMENT
(2022)
Article
Environmental Sciences
Jiaojiao Guo, Jie Huang, Qian Wang, Lu Fang, Shenli Zhang, Bingshui Li, Liangju Lv, Meng Chen, Chonggang Wang
Summary: Exposure to phenanthrene during pregnancy can disturb glucose metabolism in adult offspring, with significant gender differences. Females show glucose intolerance, while males show abnormal blood glucose and insulin levels. Phenanthrene exposure also affects adipocytokine levels, which further influences visceral fat tissue.
Article
Neurosciences
Greg L. McKie, Hesham Shamshoum, Kristin L. Hunt, Hayley H. A. Thorpe, Hana A. Dibe, Jibran Y. Khokhar, Christine A. Doucette, David C. Wright
Summary: The study found that intermittent cold exposure (ICE) improved glucose tolerance but was not an effective treatment for obesity in mice housed under humanized thermoneutral conditions, as ICE exacerbated high-fat diet-induced obesity.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Engineering, Environmental
Hua Guo, Hongxia Zhang, Nan Sheng, Jinghua Wang, Jiamiao Chen, Jiayin Dai
Summary: PFOA exposure induced splenic atrophy in mice, resulting in decreased spleen weight and relative spleen weight, as well as impacting iron levels and gene expression, leading to alterations in cell cycle, autoimmunity, and anemia. The study also indicated that overactivation of macrophages may be a crucial factor in causing splenic atrophy.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Yan Zhang, Linchao Zhang, Jialu Bao, Liantao Liu, Xiaodan Wang
Summary: The study revealed that PFOA can increase liver weight, reduce uterine index, and induce toxic effects on liver and uterine tissues. Additionally, various factors expressed in uterine cells showed dose-dependent changes in response to PFOA exposure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Endocrinology & Metabolism
Maria J. Gonzalez-Rellan, Marcos F. Fondevila, Carlos Dieguez, Ruben Nogueiras
Summary: O-GlcNAcylation, governed by the activity of OGT and OGA enzymes, plays a crucial role in regulating systemic glucose homeostasis. Dysregulation of blood glucose levels can lead to the development of metabolic syndrome and type 2 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Yu-Ting Zhou, Rui Li, Si-Hong Li, Xiang Ma, Lu Liu, Dong Niu, Xing Duan
Summary: Perfluorooctanoic acid (PFOA) exposure during gestation was found to have potential toxic effects on ovarian function and resulted in higher meiotic defects in female offspring. PFOA exposure disrupted early embryonic cleavage and blastocyst formation by impacting spindle assembly and chromosome alignment. Moreover, PFOA exposure caused mitochondrial dysfunction, oxidative stress, DNA damage, autophagy, and apoptosis in 2-cell stage embryos.
ENVIRONMENT INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Francesco Liguori, Elisa Mascolo, Fiammetta Verni
Summary: Diabetes mellitus is a heterogeneous disease characterized by high blood sugar caused by a combination of genetic and environmental factors, with both monogenic and multigenic forms. While many putative causative genes have been identified, a large percentage of cases remain undiagnosed, indicating a need for further research to identify causal variants of diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Md Saidur Rahman, Khandkar Shaharina Hossain, Sharnali Das, Sushmita Kundu, Elikanah Olusayo Adegoke, Md Ataur Rahman, Md Abdul Hannan, Md Jamal Uddin, Myung-Geol Pang
Summary: Insulin, a polypeptide hormone secreted mainly by pancreatic beta cells, coordinates with glucagon to regulate blood glucose levels. It induces glucose storage in the liver, muscles, and adipose tissue, leading to overall weight gain. The modulation of physiological processes by insulin is crucial in the onset and progression of various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
J. J. Schlezinger, T. Hyotylainen, T. Sinioja, C. Boston, H. Puckett, J. Oliver, W. Heiger-Bernays, T. F. Webster
Summary: The study demonstrates that per- and polyfluoroalkyl substances (PFAS) can affect lipid homeostasis in the human body, particularly related to serum triacylglycerides and liver lipids. The impact of perfluorooctanoic acid (PFOA) on lipid homeostasis depends on specific genotypes, especially in relation to peroxisome proliferator activated receptor alpha (hPPAR alpha).
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Adrien Pasquier, Nunzia Pastore, Luca D'Orsi, Rita Colonna, Alessandra Esposito, Veronica Maffia, Rossella De Cegli, Margherita Mutarelli, Susanna Ambrosio, Gennaro Tufano, Antonio Grimaldi, Marcella Cesana, Davide Cacchiarelli, Nathalie Delalleau, Gennaro Napolitano, Andrea Ballabio
Summary: Pancreatic beta cells require precise nutrient-sensing mechanisms to control insulin production. Transcription factors TFEB and TFE3 regulate beta-cell function and insulin gene expression in response to variations in nutrient availability. TFEB and TFE3 are activated by nutrient deprivation, resulting in suppression of insulin gene expression. Genetic manipulation of TFEB and TFE3 affects body weight and glucose tolerance in mice.
Article
Plant Sciences
Qiang Hu, Binyu Jiang, Liru Wang, Yanjing Song, Xiaoli Tang, Yanhong Zhao, Xiaobin Fan, Yafeng Gu, Qiuling Zheng, Jieshan Cheng, Hongxia Zhang
Summary: This study identified and characterized VvGRFs genes in grape, and found that they play a vital role in the growth and stress tolerance of grape vine. The findings provide important information for future research and genetic breeding.
PLANT CELL REPORTS
(2023)
Article
Biochemical Research Methods
Hongzheng Sun, Guangyi Sun, Haotian Zhang, Huiqing An, Yueshuai Guo, Juan Ge, Longsen Han, Shuai Zhu, Shoubin Tang, Congyang Li, Chen Xu, Xuejiang Guo, Qiang Wang
Summary: In this study, the temporal proteomic profiles of mouse oocytes during in vivo maturation were obtained, revealing novel proteomic features and key factors controlling histone acetylation state and meiotic cell cycle in oocytes. A broad resource on the dynamics occurring in oocyte proteome was provided, contributing to a better understanding of the molecular mechanisms during germ cell development.
MOLECULAR & CELLULAR PROTEOMICS
(2023)
Article
Plant Sciences
Jin Yang, Tingting Mao, Zigui Geng, Wenwen Xue, Lan Ma, Yu Jin, Pan Guo, Zitong Qiu, Limin Wang, Chunyan Yu, Yuting Sheng, Juan Zhang, Hongxia Zhang
Summary: In this study, it was demonstrated that ectopic expression of AtSINA2 in soybean improved shoot growth, grain yield, drought tolerance, and seed oil content in transgenic plants. Physiological analyses showed that the increased drought tolerance was accompanied with higher chlorophyll content and lower malondialdehyde accumulation and water loss. Transcriptomic analyses revealed that the expressions of genes related to plant growth, flowering, and stress response were regulated in transgenic soybean under normal and drought stress conditions. These findings suggest that AtSINA2 can improve agricultural production and drought tolerance in soybean.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Forestry
Dongxue Yue, Erkun Chao, Yiheng Deng, Kerui Chen, Zhengning Wang, Nianwei Qiu, Hongxia Zhang
Summary: The needles of Pinus densiflora experience a decrease in photosynthetic rate and freezing injury during the winter, but can gradually recover in the spring. The water content of the needles decreases with leaf age while the cell sap concentration and soluble sugar content decrease with air temperature. However, the carotenoid content increases and soluble sugar and protein contents are important for the recovery of needles in spring.
Article
Cell Biology
Jing Wu, Yuee Liu, Min Xie, Yanzhi Cui, Yaona Wei, Yan Cheng, Jing Yang, Hongxia Zhang, Lei Wang
Summary: The aim of this study was to analyze the distribution characteristics of specific allergens based on IgE tests conducted on patients with allergic diseases in Shanxi, China. The study found that mugwort, dust mite mix, and common ragweed were the most common inhaled allergens, while crab, egg white, and sea fish mix were the most common ingested allergens. The distribution of these allergens varied according to disease profile, season, and age group, and multiple allergens could cosensitize patients.
CELLULAR MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Dalton S. Graham, Gang Liu, Ailar Arasteh, Xiao-Ming Yin, Shengmin Yan
Summary: Increased consumption of fat, especially from a high fat diet, can lead to fatty liver diseases and metabolic syndrome. This study found that high levels of linoleic acid in the diet contribute to liver steatosis and injury, while vitamin E can reverse these effects by inhibiting lipid peroxidation.
Article
Biology
Tianyu Zhu, Yuxin Zhang, Xunlun Sheng, Xiangzheng Zhang, Yu Chen, Hongjing Zhu, Yueshuai Guo, Yaling Qi, Yichen Zhao, Qi Zhou, Xue Chen, Xuejiang Guo, Chen Zhao
Summary: We report CEP78 as a causative gene of a particular syndrome including cone-rod dystrophy (CRD) and male infertility with multiple morphological abnormalities of sperm flagella (MMAF) in human and mouse. Cep78 knockout mice exhibited impaired photoreceptor function and morphology, as well as male infertility and MMAF. CEP78 regulates the interaction, stability, and centriolar localization of its interacting protein, and insufficiency of CEP78 or its interacting protein results in abnormal centriole elongation and cilia shortening. Our study supports the important roles of CEP78 defects in centriole and ciliary dysfunctions and molecular pathogenesis of such multi-system syndrome.
Article
Cell Biology
Bo Yang, Chao Liu, Xiaohui Ju, Bingbing Wu, Zhuangfei Wang, Fucheng Dong, Yanying Yu, Xiaohui Hou, Min Fang, Fei Gao, Xuejiang Guo, Yaoting Gui, Qiang Ding, Wei Li
Summary: This study generated a mouse model expressing human ACE2 and SARS-CoV-2 N gene, allowing for the study of SARS-CoV-2 pathogenesis in specific tissues or organs. The model supports infection by different SARS-CoV-2 variants and can be used to evaluate the effectiveness of antiviral drugs.
Article
Fisheries
Yaqi Geng, Min Wang, Huili Li, Lu Zhang, Kexin Xu, Hongxia Zhang, Li Teng, Zhen Yu, Lihong Chen, Ronglian Xing
Summary: This study determined the relative abundance of methanogens during the decomposition of Chaetomorpha valida in northern China's aquaculture. The results showed that the relative abundance of methanogens increased significantly during decomposition, leading to an increase in CH4 emission flux. It is therefore important to remove decomposed algae in a timely manner and control greenhouse gas emissions from aquaculture ponds to mitigate climate change.
AQUACULTURE REPORTS
(2023)
Article
Environmental Sciences
Lili Ren, Hongxia Zhang, Jiao Zhou, Yajing Wu, Bo Liu, Shuping Wang, Xin Liu, Xin Hao, Lilin Zhao
Summary: The study found that Bactrocera dorsalis has evolved shared metabolic pathways to adapt to heat, hypoxia, and desiccation stresses, while producing cryoprotectants and membrane fatty acids to improve stress resistance efficiency.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Weiqiang Sun, Xuemin Zhang, Ying Qiao, Nathan Griffin, Hongxia Zhang, Li Wang, Hui Liu
Summary: PFOA, a typical perfluoroalkyl group compound, has raised concerns about its potential health risks and the safety of novel perfluoroalkyl analogues. In this study, the physiological and metabolic effects of exposure to PFOA and its analogues were explored in zebrafish, revealing significant impacts on phenotype and metabolism, particularly for HFPO-TA and PFOA. These findings highlight the need for tighter regulation of environmental accumulation of both HFPO-TA and Gen-X.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Forestry
Hongxia Zhang, Nate G. McDowell, Xinrong Li, Jianqiang Huo, Yunfei Li, Zhanjun Wang
Summary: The species-poor woodlands in arid regions are highly susceptible to plant die-off caused by climate change. Identifying suitable species for replanting in these areas is an effective measure to prevent further expansion of desertification. However, there is a lack of comprehensive understanding about the drought resistance of species in the process of ecological restoration.
FOREST ECOLOGY AND MANAGEMENT
(2023)
Article
Plant Sciences
Xiaoli Tang, Yaqiong Hou, Fudong Jiang, Hongshan Lang, Jianzhao Li, Jieshan Cheng, Limin Wang, Xiaohua Liu, Hongxia Zhang
Summary: In this study, 11 AcSINA genes were identified in the kiwifruit genome, showing uneven distribution and high conservation. They play important roles in response to various biotic and abiotic stresses, shedding light on the functional elucidation of vine fruit plants.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Agronomy
Lan Ma, Yanjing Song, Jie Wang, Yan Shan, Tingting Mao, Xiaoyan Liang, Haiyang Zhang, Rao Fu, Junlin Li, Wenjing Nie, Meng Li, Jiajia Li, Kuihua Yi, Lu Wang, Xiangyu Wang, Hongxia Zhang
Summary: The application of porous minerals, especially zeolite, can significantly improve the growth and yield of wheat plants in coastal saline soils by reducing soil sodium content, increasing soil nutrients, and enhancing the diversity of soil microorganisms.
Article
Biology
Xiaoxu Chen, Mingyue Chen, Yuqing Zhu, Haifeng Sun, Yue Wang, Yuan Xie, Lianfu Ji, Cheng Wang, Zhibin Hu, Xuejiang Guo, Zhengfeng Xu, Jun Zhang, Shiwei Yang, Dong Liang, Bin Shen
Summary: A proof-of-concept study demonstrates the potential of using a screened DdCBE pair to correct homoplasmic mitochondrial mutations and restore mitochondrial function in induced pluripotent stem cells.
COMMUNICATIONS BIOLOGY
(2023)
