Article
Oncology
Chi-Chang Yu, Yun-Chung Cheung, Chuen Hsueh, Shin-Cheh Chen
Summary: IC tumor size and the presence of LVI are independent risk predictors of SLN metastasis. With the absence of any predictors, the incidence of positive SLNs is very low, suggesting that SLNB may be omitted in patients who initially underwent BCS without risk predictors identified on final pathological assessment. Further prospective studies are needed before clinical application.
Article
Endocrinology & Metabolism
Feng Zhao, Changjing Cai, Menghan Liu, Jidong Xiao
Summary: This study constructed a clinical prediction model using the features of automated breast volume scanning (ABVS) and the results of sentinel lymph node biopsy (SLNB) to predict the probability of axillary lymph node tumor burden in breast cancer. It can be a useful tool for individual decision-making in the diagnosis and treatments of breast cancer.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Toralf Reimer
Summary: The local treatment of axilla in early breast cancer patients without clinically evident lymph node metastases is a subject of debate. Various prospective randomized surgical trials are currently being conducted to evaluate the safety of omitting sentinel lymph node biopsy in upfront breast-conserving surgery and neoadjuvant setting. These trials aim to determine whether it is possible to make therapeutic decisions without pathologic evaluation of nodal status. Additionally, ongoing trials are investigating the possibility of de-escalating surgery based on the response to neoadjuvant systemic therapy.
Article
Oncology
Sophie H. H. Chung, Susanna W. L. de Geus, Grant Shewmaker, Kelsey S. S. Romatoski, Frederick T. T. Drake, Naomi Y. Y. Ko, Andrea L. L. Merrill, Ariel E. E. Hirsch, Jennifer F. F. Tseng, Teviah E. E. Sachs, Michael R. R. Cassidy
Summary: This study compared the survival outcomes of men with positive sentinel lymph nodes after either sentinel lymph node biopsy (SLNB) alone or complete axillary dissection (ALND) in breast cancer. The results showed that ALND was associated with superior survival compared to SLNB alone in early-stage male breast cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Min Young Jang, Parth N. Patel, Alexandre C. Pereira, Jon A. L. Willcox, Alireza Haghighi, Angela C. Tai, Kaoru Ito, Sarah U. Morton, Joshua M. Gorham, David M. McKean, Steven R. DePalma, Daniel Bernstein, Martina Brueckner, Wendy K. Chung, Alessandro Giardini, Elizabeth Goldmuntz, Jonathan R. Kaltman, Richard Kim, Jane W. Newburger, Yufeng Shen, Deepak Srivastava, Martin Tristani-Firouzi, Bruce D. Gelb, Jr George A. Porter, Christine E. Seidman, Jonathan G. Seidman
Summary: This study aims to improve the diagnostic classification of genetic variants in patients with congenital heart disease (CHD) by assessing the impact of noncanonical splice region variants on RNA splicing. The results show that through the assessment of RNA splicing, a new loss-of-function variant within a CHD gene was identified in 78 probands, of whom 69 did not have a previously established genetic explanation for CHD.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2023)
Article
Oncology
Kun Xu, Runtian Wang, Hui Xie, Longfei Hu, Cong Wang, Jiali Xu, Chengjun Zhu, Yiqiu Liu, Fangyan Gao, Xintong Li, Cenzhu Wang, Jinyi Huang, Wenbin Zhou, Guohua Zhou, Yongqian Shu, Xiaoxiang Guan
Summary: This study utilized single-cell sequencing to analyze the transcriptome profile of breast cancer lymph node metastasis, identifying key breast cancer stem cells and their evolution, as well as revealing the interactions between breast cancer cells and tumor microenvironment cells.
Article
Acoustics
Rui Zhao, Huan Jiang, Jingyan Cao, Bo Li, Lili Xu, Shaochun Dai
Summary: The aims of this study were to investigate the value of sound touch elastography (STE) in predicting axillary lymph node metastasis (ALNM) in patients with invasive breast cancer (IBC) and to explore whether lysyl oxidase (LOX) is correlated with increasing stiffness and promotion of metastasis in IBC. The study found that STE could serve as a non-invasive method for assessing lymph node status before surgery, and the maximum stiffness value and maximum shell stiffness value could be used to predict axillary lymph node metastasis of IBC. Furthermore, the overexpression of LOX and increased collagen fiber contributed to the increased stiffness in the lesions and metastases of IBC.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Mathematical & Computational Biology
Xingyi Liu, Bin Yang, Xinpeng Huang, Wenying Yan, Yujuan Zhang, Guang Hu
Summary: Complex diseases are caused by disorders of biological networks and mutations in multiple genes. This study proposes a differential modular analysis approach that integrates protein-protein interactions with gene expression profiles. The approach identifies the core network module that quantifies significant phenotypic variation and predicts key factors such as functional protein-protein interactions, pathways, and driver mutations.
INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES
(2023)
Article
Surgery
Jamie R. Oliver, Kepal N. Patel, Clifford M. Chang, Chelsey K. Baldwin, Preneet C. Brar, Luc G. T. Morris, Babak Givi
Summary: Pediatric medullary thyroid carcinoma has lower rates of lymph node metastases compared to adults. The youngest children have lower risk of lymph node disease, while older children (6-19 years) are at considerable risk for occult metastases. Multifocal tumors increase the risk of metastases in adults, but not in children.
Article
Microbiology
Qianqian Shao, Xudong Jia, Yuanzhu Gao, Zhe Liu, Huan Zhang, Qiqi Tan, Xin Zhang, Huiqiong Zhou, Yinyin Li, De Wu, Qinfen Zhang
Summary: Mosquito viruses, including the Omono River virus (OmRV), exhibit extracellular transmission abilities, a feature not commonly found in members of the Totiviridae family. The high-resolution cryo-electron microscopy structure of a new strain, OmRV-LZ, revealed an unexpected protrusion at the five-fold vertex, potentially associated with the virus's transmission. Structural and molecular experiments were conducted to investigate the function of this protrusion and enhance our understanding of OmRV and other double-stranded RNA viruses.
Article
Medical Laboratory Technology
Rebecca Czaja, Ruizhe Wu, Julie M. Jorns
Summary: In recent years, there has been a trend towards less aggressive surgical management of axillary lymph nodes in breast cancer. This study evaluated the effectiveness of evaluating axillary sentinel lymph nodes and found that serial sectioning at 2-mm intervals reduced false negatives due to macrometastatic disease. Discordant cases were mostly false negatives detected on the first permanent section level due to sampling errors.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Oncology
Xiaodong Zhang, Menghan Liu, Wanqing Ren, Jingxiang Sun, Kesong Wang, Xiaoming Xi, Guang Zhang
Summary: A multiparametric MRI model was developed to predict axillary lymph node metastasis in invasive breast cancer. This model combined T2WI, DWI, and DCE-MRI models, and deep learning technology was used to improve diagnostic performance.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Xuefei Wang, Guochao Zhang, Zhichao Zuo, Qingli Zhu, Shafei Wu, Yidong Zhou, Feng Mao, Yan Lin, Songjie Shen, Xiaohui Zhang, Xue Qin, Cunli Yan, Xiaoying Ma, Yue Shi, Qiang Sun
Summary: This retrospective study found an association between SLN positive rate and non-SLN metastasis in breast cancer, with SLN-PR > 0.333 being a potential risk factor for non-SLN metastasis. The results provide valuable reference for guiding adjuvant treatment in breast cancer patients.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Oncology
Victoria Ngai, Justina Cheh Juan Tai, Saima Taj, Heba Khanfar, Elefterios Sfakianakis, Athanasios Bakalis, Rose Baker, Muneer Ahmed
Summary: This study found that the number of abnormal lymph nodes on axillary ultrasound is the strongest predictor of axillary burden in breast cancer patients. It can help to quantify axillary nodal burden and identify patients with high axillary burden.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Medicine, General & Internal
Bo Chen, Guochun Zhang, Jianguo Lai, Weikai Xiao, Xuerui Li, Cheukfai Li, Hsiaopei Mok, Kai Li, Yulei Wang, Li Cao, Minghan Jia, Chongyang Ren, Lingzhu Wen, Guangnan Wei, Jiali Lin, Yingzi Li, Yuchen Zhang, Xiaoqing Chen, Xueying Wu, Henghui Zhang, Min Li, Jing Liu, Charles M. Balch, Ning Liao
Summary: This study revealed significant differences in molecular and immune profiles between single lymph node metastases and multiple lymph node metastases in breast cancer patients. Single lymph node metastases were associated with more aggressive tumor characteristics and more favorable immune characteristics compared to multiple lymph node metastases.
Article
Environmental Sciences
Yanxin Li, Ben C. Shirley, Ruth C. Wilkins, Farrah Norton, Joan H. M. Knoll, Peter K. Rogan
RADIATION PROTECTION DOSIMETRY
(2019)
Article
Chemistry, Multidisciplinary
Ankur Jai Sood, Coby Viner, Michael M. Hoffman
JOURNAL OF CHEMINFORMATICS
(2019)
Review
Endocrinology & Metabolism
Peter K. Rogan
MOLECULAR GENETICS AND METABOLISM
(2019)
Article
Genetics & Heredity
Eliseos J. Mucaki, Ben C. Shirley, Peter K. Rogan
FRONTIERS IN GENETICS
(2020)
Article
Multidisciplinary Sciences
Peter K. Rogan, Eliseos J. Mucaki, Ruipeng Lu, Ben C. Shirley, Edward Waller, Joan H. M. Knoll
Article
Biology
Ben C. Shirley, Joan H. M. Knoll, Jayne Moquet, Elizabeth Ainsbury, Ngoc-Duy Pham, Farrah Norton, Ruth C. Wilkins, Peter K. Rogan
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2020)
Review
Biology
Patrick Ostheim, Sally A. Amundson, Christophe Badie, Dimitry Bazyka, Angela C. Evans, Shanaz A. Ghandhi, Maria Gomolka, Milagrosa Lopez Riego, Peter K. Rogan, Robert Terbrueggen, Gayle E. Woloschak, Frederic Zenhausern, Hanns L. Kaatsch, Simone Schule, Reinhard Ullmann, Matthias Port, Michael Abend
Summary: Radiation-induced gene expression changes can serve as early diagnostic and prognostic tools in nuclear or radiological events, helping differentiate exposure levels and predicting health effects, with the advantage of high-throughput and point-of-care diagnosis.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Biology
Eliseos J. Mucaki, Ben C. Shirley, Peter K. Rogan
Summary: Combining expressed genes using machine learning can distinguish radiation-exposed blood samples from normal controls but with some misclassification rates; the accuracy of these signatures is compromised by certain blood disorders and infections, necessitating the development of novel gene expression signatures for better discrimination.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Genetics & Heredity
Seana L. Hill, Peter K. Rogan, Yi Xuan Wang, Joan H. M. Knoll
Summary: Differentiation of chromatin structure during mitosis is critical for the fidelity of cell division, and allelic differences in chromosomal accessibility are organized into distinct domains that extend beyond individual DNA probes. These regions of differential accessibility seem to be conserved across different cell types and stages of cell differentiation, suggesting a role in maintaining cellular chromosome memory across generations.
MOLECULAR CYTOGENETICS
(2021)
Article
Medicine, Research & Experimental
Ashis J. Bagchee-Clark, Eliseos J. Mucaki, Tyson Whitehead, Peter K. Rogan
Meeting Abstract
Oncology
Beth A. Pitel, Shruti Rao, Catherine Del Vecchio Fitz, Subha Madhavan, Rodrigo Dientsmann, Peter Horak, Ian King, Susan M. Mockus, Gordana Raca, Damian T. Rieke, Peter Rogan, Dmitriy Sonkin, David Tamborero, Ioannis S. Vlachos, Brian Walsh, Jeremy L. Warner, Malachi Griffith, Obi L. Griffith, Debyani Chakravarty, Alex H. Wagner
Article
Oncology
Shruti Rao, Beth Pitel, Alex H. Wagner, Simina M. Boca, Matthew Mccoy, Ian King, Samir Gupta, Ben Ho Park, Jeremy L. Warner, James Chen, Peter K. Rogan, Debyani Chakravarty, Malachi Griffith, Obi L. Griffith, Subha Madhavan
JCO CLINICAL CANCER INFORMATICS
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
P. K. Rogan, E. J. Mucaki, J. Z. L. Zhao, J. H. M. Knoll
EUROPEAN JOURNAL OF HUMAN GENETICS
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
P. K. Rogan, E. J. Mucaki, J. Z. L. Zhao, J. H. M. Knoll
EUROPEAN JOURNAL OF HUMAN GENETICS
(2019)
Article
Biochemistry & Molecular Biology
Eliseos J. Mucaki, Jonathan Z. L. Zhao, Daniel J. Lizotte, Peter K. Rogan
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2019)