Article
Medicine, Research & Experimental
Yuhao Li, Hongbo Gao, Kolin M. Clark, Liang Shan
Summary: HIV-1 primarily uses CCR5 as its coreceptor but can occasionally switch to a CXCR4-tropic virus during late-stage infection. CCR5+CD4+ T cells, which are abundant in viremic individuals and SIV-infected nonhuman primates, play a major role in virus production. The differentiation and survival of CCR5+CD4+ T cells are regulated by IL-15, suggesting potential implications for HIV-1 infection and the boosting of anti-HIV-1 immunity.
Article
Immunology
Haitao Guo, Qi Wang, Khader Ghneim, Li Wang, Elena Rampanelli, Elizabeth Holley-Guthrie, Liang Cheng, Carolina Garrido, David M. Margolis, Leigh A. Eller, Merlin L. Robb, Rafick-Pierre Sekaly, Xian Chen, Lishan Su, Jenny P. -Y. Ting
Summary: Researchers have found that HIV-1 infection leads to metabolic changes in CD4(+) T cells, with the OXPHOS pathway associated with poor outcomes and NLRX1 promoting viral replication. Inhibiting mitochondrial respiratory complex-I can suppress HIV-1 replication.
Article
Microbiology
M. Znaidia, Y. de Souza-Angelo, S. Letoffe, I. Staropoli, L. Grzelak, J. M. Ghigo, O. Schwartz, N. Casartelli
Summary: Microbial translocation is associated with systemic immune activation in HIV-1 disease. Some bacteria can activate T cells and enhance HIV-1 replication, suggesting a role of bacterial factors in promoting T cell activation and HIV-1 replication.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medicine, Research & Experimental
Chao Zhang, Jin-Wen Song, Hui-Huang Huang, Xing Fan, Lei Huang, Jian-Ning Deng, Bo Tu, Kun Wang, Jing Li, Ming-Ju Zhou, Cui-Xian Yang, Qi-Wen Zhao, Tao Yang, Li-Feng Wang, Ji-Yuan Zhang, Ruo-Nan Xu, Yan-Mei Jiao, Ming Shi, Feng Shao, Rafick-Pierre Sekaly, Fu-Sheng Wang
Summary: Chronic HIV-1 infection leads to CD4(+) T cell loss, with distinct mechanisms affecting pyroptotic and apoptotic CD4(+) T cells. Pyroptosis is closely associated with inflammation and driven by NLRP3 inflammasome activation, while apoptosis is more related to T cell activation status.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Marine & Freshwater Biology
D. Riley Rackliffe, Jason T. Hoverman
Summary: Neonicotinoids have global impacts on natural environments, especially on aquatic insects, and can indirectly increase their mortality through predator pressure.
AQUATIC TOXICOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Stefan Petkov, Francesca Chiodi
Summary: This study compared the transcriptomes of CD4+ T naive (TN) and central memory (TCM) cells between HIV-1 infected patients receiving early antiretroviral therapy (EA) and controls. The results showed that there is a high degree of transcriptional complexity during the transition from CD4+ T-N to T-CM cells in controls, while in EA patients, the modulation of transcription factors is reduced, resulting in impaired T cell differentiation.
Article
Nutrition & Dietetics
Minju Kim, Yeon-hee Kim, Sohyun Min, Seung-Min Lee
Summary: This study investigated the potential side effects of high iron levels in fetuses and throughout their adult life. The results suggest that prolonged exposure to high iron may decrease fat accumulation by altering ferritin expression, adipocyte differentiation, and triglyceride metabolism, leading to an alteration in normal growth.
Article
Immunology
Jamie L. McCall, Melinda E. Varney, Emily Rice, Sebastian A. Dziadowicz, Casey Hall, Kathryn E. Blethen, Gangqing Hu, John B. Barnett, Ivan Martinez
Summary: Prenatal cadmium exposure alters the expression of lncRNAs during T cell activation, with the induction of lncSnhg7 being enhanced in T cells from Cd-exposed offspring leading to upregulation of GALNT7 protein and increased proliferation. Overexpression of miR-34a decreases GALNT7 expression, while knockdown of lncSnhg7 inhibits CD4(+) T cell proliferation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Mikel J. Ruterbusch, Brian D. Hondowicz, Kennidy K. Takehara, Kurt B. Pruner, Thomas S. Griffith, Marion Pepper
Summary: CD4(+) lung-resident memory T cells generated in response to influenza infection can be altered by subsequent exposure to allergens, leading to changes in their function and impact on disease outcomes upon reinfection.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Gabriel Duette, Bonnie Hiener, Hannah Morgan, Fernando G. Mazur, Vennila Mathivanan, Bethany A. Horsburgh, Katie Fisher, Orion Tong, Eunok Lee, Haelee Ahn, Ansari Shaik, Remi Fromentin, Rebecca Hoh, Charline Bacchus-Souffan, Najla Nasr, Anthony L. Cunningham, Peter W. Hunt, Nicolas Chomont, Stuart G. Turville, Steven G. Deeks, Anthony D. Kelleher, Timothy E. Schlub, Sarah Palmer
Summary: Through studying CD4(+) T cells of HIV-1 patients, the importance of effector memory T cells in the persistence of HIV-1 has been identified, and Nef has been suggested as a potential therapeutic target.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cell Biology
Annemarie Laumaea, Lorie Marchitto, Shilei Ding, Guillaume Beaudoin-Bussieres, Jeremie Prevost, Romain Gasser, Debashree Chatterjee, Gabrielle Gendron-Lepage, Halima Medjahed, Hung-Ching Chen, Amos B. Smith III, Haitao Ding, John C. Kappes, Beatrice H. Hahn, Frank Kirchhoff, Jonathan Richard, Ralf Duerr, Andres Finzi
Summary: The conformation of HIV-1 envelope (Env) determines the susceptibility of infected CD4(+) T cells to antibody-dependent cellular cytotoxicity (ADCC). The downregulation of CD4 on infected macrophages by Nef, Vpu, and Env has a lesser impact on Env conformation and ADCC sensitivity compared to CD4(+) T cells. However, treatment of infected macrophages with small CD4 mimetics exposes vulnerable CD4-induced Env epitopes and sensitizes them to ADCC.
Article
Environmental Sciences
Yi-Ming Xiong, Yuan -Yuan Li, Lin Lv, Xuan-Yue Chen, Xing -Hong Li, Zhan- Fen Qin
Summary: There is increasing evidence that certain environmental chemicals can make individuals more vulnerable to stress or injuries, contributing to clinical and subclinical diseases. Tetrabromobisphenol A (TBBPA), a commonly used flame retardant, has been found to impact testis development at the molecular and cellular levels. This study aimed to investigate whether developmental exposure to TBBPA could increase testicular susceptibility to stress in adulthood. The results show that historical exposure to TBBPA increased the susceptibility of mouse testes to spermatogenic stress, leading to severe reproductive problems.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Microbiology
Hala Chaaban, Maulin M. Patel, Kathryn Burge, Jeffrey Eckert, Cristina Lupu, Ravi S. Keshari, Robert Silasi, Girija Regmi, MaJoi Trammell, David Dyer, Steven J. McElroy, Florea Lupu
Summary: Increasing evidence suggests a correlation between prolonged antibiotic therapy in preterm infants and increased mortality and morbidities such as NEC. This study used neonatal mice to test the effects of systemic antibiotic treatment on intestinal development and found that it impaired intestinal development and increased the risk of intestinal injury.
Article
Endocrinology & Metabolism
Grace V. Mercer, Nikita E. Harvey, Katherine L. Steeves, Celine M. Schneider, John G. Sled, Christopher K. Macgowan, Ahmet A. Baschat, John C. Kingdom, Andre J. Simpson, Myrna J. Simpson, Karl J. Jobst, Lindsay S. Cahill
Summary: Exposure to polystyrene nanoplastics during pregnancy caused abnormal fetal brain metabolism in mice, including decreased concentrations of gamma-aminobutyric acid, creatine, and glucose. The change in relative concentration of asparagine was dependent on fetal sex.
Article
Biochemistry & Molecular Biology
Karli S. Swenson, Luis E. Gomez Wulschner, Victoria M. Hoelscher, Lillian Folts, Kamryn M. Korth, Won Chan Oh, Emily Anne Bates
Summary: Thousands of people suffer from pregnancy-related nausea every year. Cannabidiol (CBD), a compound found in cannabis, can help alleviate nausea and is widely available. However, the effects of fetal CBD exposure on embryonic development and postnatal outcomes are still unknown.
MOLECULAR PSYCHIATRY
(2023)
Article
Immunology
Lieve E. H. van der Donk, Julia Eder, John L. van Hamme, Philip J. M. Brouwer, Mitch Brinkkemper, Ad C. van Nuenen, Marit J. van Gils, Rogier W. Sanders, Neeltje A. Kootstra, Marta Bermejo-Jambrina, Teunis B. H. Geijtenbeek
Summary: This study suggests that SARS-CoV-2 does not directly activate TLR4, but instead utilizes intracellular viral sensors for sensing and infecting host cells. This finding may explain the lack of efficient immune response to SARS-CoV-2 early during infection.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Robin Erken, Vladimir Loukachov, Karel Dort, Anne den Hurk, R. Bart Takkenberg, Anniki Niet, Louis Jansen, Sophie Willemse, Henk Reesink, Neeltje Kootstra
Summary: Integrated HBV levels are closely related to clinical outcomes in patients with chronic hepatitis B and can be quantified. Integrated HBV levels are correlated with surrogate markers for virological activity, but not with cccDNA levels, and can predict HBsAg loss.
Article
Immunology
Isabella C. Schoepf, Christian W. Thorball, Bruno Ledergerber, Neeltje A. Kootstra, Peter Reiss, Marieke Raffenberg, Tanja Engel, Dominique L. Braun, Barbara Hasse, Christine Thurnheer, Catia Marzolini, Marco Seneghini, Enos Bernasconi, Matthias Cavassini, Helene Buvelot, Jose R. Arribas, Roger D. Kouyos, Jacques Fellay, Huldrych F. Gunthard, Philip E. Tarr
Summary: The study found that there was a significant decline in telomere length during untreated chronic HIV infection, but no significant change during suppressive antiretroviral therapy.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Myrthe L. Verburgh, Anders Boyd, Ferdinand W. N. M. Wit, Maarten F. Schim van der Loeff, Marc van der Valk, Margreet Bakker, Neeltje A. Kootstra, Lia van der Hoek, Peter Reiss
Summary: In the Amsterdam-based AGE(h)IV Cohort Study, researchers prospectively compared the incidence and risk factors for SARS-CoV-2 infection between HIV-positive and HIV-negative participants. They found that HIV-positive individuals with suppressed viremia and adequate CD4 cell counts had similar risk of SARS-CoV-2 acquisition and similar post-infection nucleocapsid antibody levels compared to a comparable HIV-negative cohort.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Neurosciences
Jasmini Alagaratnam, Davide De Francesco, Henrik Zetterberg, Amanda Heslegrave, Jamie Toombs, Neeltje A. Kootstra, Jonathan Underwood, Magnus Gisslen, Peter Reiss, Sarah Fidler, Caroline A. Sabin, Alan Winston
Summary: In PWH on suppressive antiretroviral treatment, there is a moderate correlation between CSF and plasma NfL, similar to lifestyle-similar HIV-negative individuals. Consideration of renal function and bodyweight may be required when utilizing plasma NfL.
JOURNAL OF NEUROVIROLOGY
(2022)
Article
Medicine, General & Internal
Roos S. G. Sablerolles, Wim J. R. Rietdijk, Abraham Goorhuis, Douwe F. Postma, Leo G. Visser, Daryl Geers, Katharina S. Schmitz, Hannah M. Garcia Garrido, Marion P. G. Koopmans, Virgil A. S. H. Dalm, Neeltje A. Kootstra, Anke L. W. Huckriede, Melvin Lafeber, Debbie van Baarle, Corine H. GeurtsvanKessel, Rory D. de Vries, P. Hugo M. van der Kuy
Summary: This study investigated the immunogenicity and reactogenicity of a homologous or heterologous booster in healthcare workers who had received a single-shot Ad26.COV2.S vaccine. The results showed that booster vaccinations increased the levels of S-specific binding antibodies, neutralizing antibodies, and T-cell responses compared to a single Ad26.COV2.S vaccination. Boosters containing mRNA-based vaccines induced significantly higher levels of binding antibodies than homologous boosters. The mRNA-1273 booster was the most immunogenic but had higher reactogenicity compared to the BNT162b2 and Ad26.COV2.S boosters. Local and systemic reactions were generally mild to moderate in the first 2 days after booster administration.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Hematology
Sabine Haggenburg, Birgit Lissenberg-Witte, Rob S. van Binnendijk, Gerco den Hartog, Michel S. Bhoekhan, Nienke J. E. Haverkate, Dennis M. de Rooij, Johan van Meerloo, Jacqueline Cloos, Neeltje A. Kootstra, Dorine Wouters, Suzanne S. Weijers, Ester M. M. van Leeuwen, Hetty J. Bontkes, Saida Tonouh-Aajoud, Mirjam H. M. Heemskerk, Rogier W. Sanders, Elianne Roelandse-Koop, Quincy Hofsink, Kazimierz Groen, Lucia Cetinel, Louis Schellekens, Yvonne M. den Hartog, Belle Toussaint, Iris M. J. Kant, Thecla Graas, Emma de Pater, Willem A. Dik, Marije D. Engel, Cheyenne R. N. Pierie, Suzanne R. Janssen, Edith van Dijkman, Meliawati Poniman, Judith A. Burger, Joey H. Bouhuijs, Gaby Smits, Nynke Y. Rots, Sonja Zweegman, Arnon P. Kater, Tom van Meerten, Pim G. N. J. Mutsaers, Jaap A. van Doesum, Annoek E. C. Broers, Marit J. van Gils, Abraham Goorhuis, Caroline E. Rutten, Mette D. Hazenberg, Inger S. Nijhof
Summary: Vaccination guidelines for hematological patients are typically conservative. However, this study shows that most patients, even those with compromised immune systems, can develop sufficient antibody concentrations after receiving the Moderna vaccine. However, certain treatments may affect the vaccine's efficacy.
Article
Gastroenterology & Hepatology
Robin Erken, Vladimir V. Loukachov, Annikki de Niet, Louis Jansen, Femke Stelma, Jeltje T. Helder, Martine W. Peters, Hans L. Zaaijer, Neeltje A. Kootstra, Sophie B. Willemse, Hendrik W. Reesink
Summary: In this study, long-term follow-up of patients with chronic hepatitis B was conducted, and it was found that combination treatment did not influence the disappearance of HBsAg, while low baseline HBsAg levels could predict HBsAg loss.
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY
(2022)
Letter
Gastroenterology & Hepatology
Vladimir V. Loukachov, Karel A. van Dort, Robin Erken, Henk W. Reesink, Neeltje A. Kootstra
Article
Immunology
Roos S. G. Sablerolles, Wim J. R. Rietdijk, Abraham Goorhuis, Douwe F. Postma, Leo G. Visser, Katharina S. Schmitz, Daryl Geers, Susanne Bogers, Eva van Haren, Marion P. G. Koopmans, Virgil A. S. H. Dalm, Neeltje A. Kootstra, Anke L. W. Huckriede, Renate Akkerman, Martin Beukema, Melvin Lafeber, Debbie van Baarle, Rory D. de Vries, P. Hugo M. van der Kuy, Corine H. GeurtsvanKessel
Summary: This study found that SARS-CoV-2-specific binding antibodies, neutralizing antibodies, and T cells remained detectable 5 months after boosting with Ad26.COV2.S vaccine, although there was a decline in antibody levels and limited cross-reactivity with Omicron BA.1.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Nienke H. van Teijlingen, Leanne C. Helgers, Ramin Sarrami-Forooshani, Esther M. Zijlstra-Willems, John L. van Hamme, Celia Segui-Perez, Marleen Y. van Smoorenburg, Hanneke Borgdorff, Janneke H. H. M. van de Wijgert, Elisabeth van Leeuwen, Joris Am van der Post, Karin Strijbis, Carla M. S. Ribeiro, Teunis B. H. Geijtenbeek
Summary: Dysbiosis of vaginal microbiota is associated with increased HIV-1 acquisition. Prevotella timonensis induces uptake and transmission of HIV-1 by vaginal Langerhans cells, enhancing infection susceptibility, thus advocating targeted treatment of P. timonensis to limit HIV-1 infection.
Letter
Gastroenterology & Hepatology
Vladimir Loukachov, Karel van Dort, Robin Erken, Henk W. Reesink, Neeltje Kootstra
Meeting Abstract
Hematology
Cilia R. Pothast, Quincy Hofsink, Sabine Haggenburg, Michel Bhoekhan, Nienke J. E. Haverkate, Romy C. Dijkland, Kayleigh van Dijk, Frederik J. H. Falkenburg, Annoek E. C. Broers, Jaap van Doesum, Robert S. van Binnendijk, Gerco den Hartog, Judith A. Burger, Joey H. Bouhuijs, Birgit Lissenberg-Witte, Gaby P. Smits, Dorine Wouters, Ester M. M. van Leeuwen, Hetty J. Bontkes, Neeltje A. Kootstra, Sonja Zweegman, Arnon P. Kater, Kaz Groen, Tom van Meerten, Pim G. N. J. Mutsaers, Tim Beaumont, Marit J. van Gils, Abraham Goorhuis, Mette D. Hazenberg, Inger S. Nijhof, Mirjam H. M. Heemskerk, Caroline E. Rutten
Article
Immunology
Emma F. Avery, Julia N. Kleynhans, Bruno Ledergerber, Isabella C. Schoepf, Christian W. Thorball, Neeltje A. Kootstra, Peter Reiss, Lene Ryom, Dominique L. Braun, Maria C. Thurnheer, Catia Marzolini, Marco Seneghini, Enos Bernasconi, Matthias Cavassini, Helene Buvelot, Roger D. Kouyos, Jacques Fellay, Huldrych F. Guenthard, Philip E. Tarr
Summary: In Switzerland, leukocyte count is independently associated with coronary artery disease (CAD) events in people with HIV (PWH), even after adjusting for traditional and HIV-related risk factors.
CLINICAL INFECTIOUS DISEASES
(2023)
Correction
Immunology
Angela I. Schriek, Marlies M. van Haaren, Meliawati Poniman, Gillian Dekkers, Arthur E. H. Bentlage, Marloes Grobben, Gestur Vidarsson, Rogier W. Sanders, Theo Verrips, Teunis B. H. Geijtenbeek, Raimond Heukers, Neeltje A. Kootstra, Steven W. de Taeye, Marit J. van Gils
FRONTIERS IN IMMUNOLOGY
(2022)