Article
Medicine, Research & Experimental
Lin Han, Yamei Yan, Meiyang Fan, Shanfeng Gao, Lingyu Zhang, Xiaofan Xiong, Rufeng Li, Xuan Xiao, Xiaofei Wang, Lei Ni, Dongdong Tong, Chen Huang, Youlong Cao, Juan Yang
Summary: Pt3R5G exhibits anticancer activity by reducing cell activity through blocking cell cycle, inducing cell apoptosis, and triggering ferroptosis in colon cancer cells. Furthermore, Pt3R5G inhibits tumor growth through down-regulating SLC7A11.
Article
Pharmacology & Pharmacy
Jiayan Liu, Tao Mi, Zhaoxia Zhang, Liming Jin, Maoxian Li, Chenghao Zhanghuang, Mujie Li, Jinkui Wang, Xin Wu, Zhaoying Wang, Xiaojun Tan, Zhang Wang, Dawei He
Summary: Malignant rhabdoid tumor of the kidney (MRTK) has a poor prognosis and is unresponsive to radiotherapy and chemotherapy. In this study, BKM120 was identified as a potential therapeutic agent for MRTK by inhibiting the PI3K/Akt signaling pathway to induce cell apoptosis and cycle arrest. Both in vitro and in vivo experiments confirmed the inhibitory effects of BKM120 on MRTK.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Kensei Taguchi, Bertha C. Elias, Sho Sugahara, Snehal Sant, Benjamin S. Freedman, Sushrut S. Waikar, Ambra Pozzi, Roy Zent, Raymond C. Harris, Samir M. Parikh, Craig R. Brooks
Summary: Acute kidney injury (AKI) can lead to chronic kidney disease (CKD) through maladaptive repair of proximal tubule cells (PTCs), involving dedifferentiation and profibrotic cytokine secretion. Cyclin G1 (CG1) and cyclin-dependent kinase 5 (CDK5) are key factors in maladaptive dedifferentiation and could be therapeutic targets for CKD.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Nanoscience & Nanotechnology
Haoyu Tian, Yingying Guo, Jinyu Zhang, Zhuoli Zhang, Shuomin Chen, Ying Liu, Abdulrab Ahmed M. Alkhanjaf, Tao Liu, Dianbao Zhang
Summary: Aspergillumarin A inhibits the proliferation of HCC cells by inducing cell cycle arrest at the G(0)/G(1) phase. It shows promise as a novel candidate for HCC therapy.
SCIENCE OF ADVANCED MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Ying Hou, Rong Liu, Mengwei Xia, Chong Sun, Bingling Zhong, Jie Yu, Nana Ai, Jin-Jian Lu, Wei Ge, Bo Liu, Xiuping Chen
Summary: NAN triggers G1 phase cell cycle arrest and caspase-independent apoptosis in CRC cells through downregulation of cyclin D1 and inhibition of eEF1A-targeted translation.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Oncology
Yuchen Jiang, Xia Peng, Yinchun Ji, Yang Dai, Yanfen Fang, Bing Xiong, Wenming Ren, Youhong Hu, Yi Chen, Jing Ai
Summary: The study identified a novel selective RET inhibitor, SYHA1815, which demonstrated potent antitumor efficacy and selectivity for RET over other kinases. By targeting RET and downregulating c-Myc, SYHA1815 showed promising potential for treating RET-aberrant cancers.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Jiayu Chen, Rui Wang, Ying Li, Chunhe Li, Tao Liu, Yi Xin, Yiling Li, Dianbao Zhang
Summary: Ginkgolic acid (GA) inhibits the proliferation and migration of hepatocellular carcinoma (HCC) cells by inducing G0/G1 cell cycle arrest through activation of p38 MAPK, making it a potential candidate for HCC treatment.
Article
Pharmacology & Pharmacy
Lijie Gong, Chen Chen, Xiaoqin Liu, Xiutao Wu, Ling Zhu, Jianguang Luo, Lingyi Kong
Summary: Hainanolide (HN), a compound extracted from Cephalotaxus fortunei, has been proven to possess potent anti-tumor activities. This study demonstrated that HN inhibits colon cancer cell progression by blocking the cell cycle, inducing apoptosis, and activating the MAPK pathway.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marine Beck, Mathilde Baranger, Ahlam Moufok-Sadoun, Emilie Bersuder, Isabelle Hinkel, Georg Mellitzer, Elisabeth Martin, Laetitia Marisa, Isabelle Duluc, Aurelien de Reynies, Christian Gaiddon, Jean-Noel Freund, Isabelle Gross
Summary: This study focused on the atypical cadherin MUCDHL, which is down-regulated in colorectal tumors, especially in tumors with worse prognosis. Loss of MUCDHL enhanced tumor incidence and burden in intestinal tumor-prone mice, and targeted key oncogenic signaling pathways through its extracellular domain. The study illustrates how the loss of a gene critical for the morphological and functional features of mature cells contributes to tumorigenesis by dysregulating oncogenic pathways.
Article
Cell Biology
Dan Luo, Chune Yu, Jing Yu, Chao Su, Shun Li, Peng Liang
Summary: Killin has been found to play a role in p53-mediated G1 arrest by upregulating p21 protein expression independently of p53. Knockout of Killin significantly decreases p53-mediated G1 arrest, and double knockout of Killin and p21 completely abolishes this arrest. These findings suggest that Killin is involved in multiple cell cycle checkpoint controls, including p53-mediated G1 arrest.
Article
Biology
Gang Xu, Shanshan Bu, Xiushen Wang, Hong Ge
Summary: The study showed that silencing cyclin G1 expression inhibits the proliferation of HCC cells and enhances their radiosensitivity, potentially through regulating apoptosis-related proteins.
RADIATION RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Tomoyuki Kawaguchi, Koichi Okamoto, Shota Fujimoto, Masahiro Bando, Hironori Wada, Hiroshi Miyamoto, Yasushi Sato, Naoki Muguruma, Katsuhisa Horimoto, Tetsuji Takayama
Summary: In this study, lansoprazole was identified as the most effective chemopreventive agent against SSL, inducing G1 cell cycle arrest by downregulating Skp2 and upregulating p27 in SSL cells. The research provided a comprehensive analysis of effective compounds for the chemoprevention of sessile serrated lesions (SSLs) using Connectivity Map (CMAP) analysis.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Environmental Sciences
Haiwei Ni, Guojing Ruan, Cheng Sun, Xuan Yang, Zhenyan Miao, Jifei Li, Ying Chen, Hai Qin, Yichen Liu, Lufeng Zheng, Yingying Xing, Tao Xi, Xiaoman Li
Summary: Tanshinone IIA can reduce the stemness of gastric cancer cells by inducing ferroptosis. Ferroptosis inducers also have the ability to decrease the stemness of gastric cancer cells.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Koji Wada, Masuo Goto, Hisano Tanaka, Megumi Mizukami, Yuji Suzuki, Kuo-Hsiung Lee, Hiroshi Yamashita
Summary: Although many diterpenoid alkaloids have been evaluated for their antiproliferative activity, little is known about the effects of hetisine-type C20-diterpenoid alkaloids and their derivatives. In this study, a total of 43 novel derivatives were prepared and their antiproliferative effects against human cancer cell lines were evaluated. The results showed that some newly synthesized derivatives exhibited significant suppressive effects, suggesting that these compounds could be potential candidates for overcoming triple-negative breast cancer.
Article
Biochemistry & Molecular Biology
Wagdy M. Eldehna, Rofaida Salem, Zainab M. Elsayed, Tarfah Al-Warhi, Hamada R. Knany, Rezk R. Ayyad, Thamer Bin Traiki, Maha-Hamadien Abdulla, Rehan Ahmad, Hatem A. Abdel-Aziz, Radwan El-Haggar
Summary: A new set of carbohydrazide linked benzofuran-isatin conjugates has been designed and synthesised, showing broad anticancer activity and selective cytotoxicity towards colorectal cancer cell lines. The compounds exhibited excellent inhibitory effects on cancer subpanels and provoked apoptosis in a dose dependent manner in SW-620 cells. Additionally, they significantly inhibited the anti-apoptotic Bcl2 protein expression, leading to apoptosis in SW-620 cells.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Ziyu Li, Xiaolong Wu, Xiangyu Gao, Fei Shan, Xiangji Ying, Yan Zhang, Jiafu Ji
Summary: The newly established MMLN staging system based on the number of PMLN and EMLN shows independent and superior prognostic performance in predicting overall survival in patients undergoing curative gastrectomy with D2 or D2 plus lymphadenectomy.
BRITISH JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Yang Du, Meng Cai, Xiaofang Xing, Jiafu Ji, Ence Yang, Jianmin Wu
Summary: The PINA platform has been updated to version 3.0, integrating a unified human interactome with cancer type-specific RNA-seq transcriptomes and mass spectrometry-based proteomes. New analytical tools have been developed to help users identify cancer-specific protein expression, potential biomarkers, and therapeutic targets.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Oncology
Zining Liu, Yinkui Wang, Fei Shan, Xiangji Ying, Yan Zhang, Shuangxi Li, Yongning Jia, Ziyu Li, Jiafu Ji
Summary: In locally advanced gastric cancer, receiving over six cycles of chemotherapy and a TAC duration of less than 42 days are significantly associated with better survival outcomes. Additionally, both POC and PEC groups benefit from a higher number of cycles of chemotherapy, with maximum survival benefits reached after six cycles.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Shuangxi Li, Jacopo Desiderio, Ziyu Li, Federico Tozzi, Jiafu Ji, Amilcare Parisi
Summary: The study found that a nomogram including age, tumor stage, lymph node metastasis, and total number of lymph nodes retrieved showed higher accuracy in predicting overall survival for gastric cancer patients with inadequate lymph node sampling (<30) compared to the conventional TNM staging system.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Jinyao Shi, Zhouqiao Wu, Xiaolong Wu, Fei Shan, Yan Zhang, Xiangji Ying, Ziyu Li, Jiafu Ji
Summary: This study aimed to develop clinically tools for early detection of anastomotic leakage (AL) by analyzing inflammatory factors (IFs) in abdominal drainage. The research proposed an Anastomotic Score system (AScore-POD3) based on IFs with high diagnostic efficacy, which was validated in an independent cohort. A nomogram combining AScore-POD3 with other clinical risk factors showed high C-index, suggesting the potential for early diagnosis of AL after gastric cancer surgery.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Feng Su, Jianmin Li, Xinya Zhao, Beining Wang, Yajie Hu, Yu Sun, Jiafu Ji
Summary: The study demonstrates the use of a deep learning system to achieve intelligent tumor differentiation grading and microsatellite instability status recognition in gastric cancer. The system shows high accuracy and interpretability, making it a promising tool for artificial intelligence healthcare.
LABORATORY INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Jingwan Zhang, Jianning Zhai, Chi Chun Wong, Huarong Chen, Xiaohong Wang, Jiafu Ji, Jun Yu
Summary: PCID2 is amplified in colorectal cancer (CRC) and promotes cell proliferation, cell cycle progression, and migration/invasion while inhibiting apoptosis. It functions as an oncogene in CRC by enhancing canonical Wnt/beta-catenin signaling and suppressing the CTNNB1-ARF-p53 axis. PCID2 may serve as an independent predictive marker for CRC recurrence.
Article
Surgery
Jinyao Shi, Zhouqiao Wu, Xiaolong Wu, Fei Shan, Yan Zhang, Xiangji Ying, Ziyu Li, Jiafu Ji
Summary: This study found that analyzing inflammatory factors in abdominal drainage fluid can be a useful method for early diagnosis of anastomotic leakage after colorectal surgery. By analyzing six inflammatory factors, researchers were able to accurately predict the occurrence of anastomotic leakage as early as the first day after surgery.
Article
Biochemistry & Molecular Biology
Xiaohong Wang, Lianhai Zhang, Francis K. L. Chan, Jiafu Ji, Jun Yu, Jessie Qiaoyi Liang
Summary: GGT7 is frequently downregulated in gastric cancer and its methylation is correlated with patient survival. GGT7 inhibits gastric cancer cell growth and migration by inducing autophagy.
Review
Oncology
Jiafu Ji, Leiyu Shi, Xiangji Ying, Xinpu Lu, Fei Shan
Summary: The study found that gastric cancer patients who underwent surgery in high-volume centers had better overall survival, lower short-term mortality, more adequate lymphadenectomy, and shorter length of stay. However, hospital volume was not significantly associated with surgical complications, negative margin resection, or disease-free survival.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Xiaohong Wang, Lianhai Zhang, Qiaoyi Liang, Chi Chun Wong, Huarong Chen, Hongyan Gou, Yujuan Dong, Weixin Liu, Ziyu Li, Jiafu Ji, Jun Yu
Summary: This study elucidated the functional significance and molecular mechanisms of DUSP5P1 lncRNA in gastric carcinogenesis. High expression of DUSP5P1 was associated with shortened survival in gastric cancer patients and promoted migration, invasion, and metastasis of gastric cancer cells. Mechanistically, DUSP5P1 activated the transcription of ARHGAP5 and dysregulated focal adhesion and MAPK signaling pathways. DUSP5P1 also played a role in platinum drug resistance.
Review
Oncology
Xiaokang Lei, Yinkui Wang, Fei Shan, Shuangxi Li, Yongning Jia, Rulin Miao, Kan Xue, Zhemin Li, Jiafu Ji, Ziyu Li
Summary: This meta-analysis compared the short- and long-term outcomes of laparoscopic gastrectomy (LG) versus open gastrectomy (OG) for gastric cancer. The results showed that the intraoperative complication rate was similar between the two groups, but LG had fewer postoperative complications. The severe postoperative complication rate and perioperative mortality were comparable. LG had a lower number of retrieved lymph nodes and a shorter proximal resection margin distance compared to OG. However, the distal resection margin distance was similar. LG resulted in shorter recovery time, including time to first ambulation and time to first flatus. Additionally, LG had a shorter postoperative length of stay. The 5-year overall survival and disease-free survival were similar between the two groups.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Meng He, Zi-Fan Chen, Li Zhang, Xiangyu Gao, Xiaoyi Chong, Hao-shen Li, Lin Shen, Jiafu Ji, Xiaotian Zhang, Bin Dong, Zi-Yu Li, Tang Lei
Summary: This study aimed to assess the correlation between CT-derived body composition parameters and SII and OS in patients with advanced gastric cancer receiving dual PD-1 and HER2 blockade. The study found that high SII and high SFA were associated with OS, while sarcopenia was not an independent prognostic factor.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Multidisciplinary Sciences
Jinyao Shi, Zhouqiao Wu, Xiaolong Wu, Longtao Huangfu, Ting Guo, Xiaojing Cheng, Jing Han, Ziyu Li, Xiaofang Xing, Jiafu Ji
Summary: This study used multi-omics data of 2471 gastric cancer samples to identify glycometabolic subtypes and immune clustering subgroups of gastric cancer, and established a scoring system to predict the survival and response of chemotherapy and immunotherapy. The assessment of tumor glucose metabolism and immune microenvironment in gastric cancer has application value for predicting curative effects and formulating combined treatment strategies.
Article
Cell Biology
Zhonghua Ma, Xiangyu Gao, You Shuai, Xiaolong Wu, Yan Yan, Xiaofang Xing, Jiafu Ji
Summary: Linc01503 is significantly upregulated in GC and closely associated with patient survival. The transcription factor EGR1 activates linc01503 transcription. Knockdown of linc01503 leads to apoptosis activation and G1/G0 phase arrest in GC. Linc01503 interacts with histone modification enzymes EZH2 and LSD1 to silence DUSP5/CDKN1A expression in GC, mediating cell cycle progression and tumorigenesis.
CELL PROLIFERATION
(2021)
