IMP-1 encoded by a novel Tn402-like class 1 integron in clinical Achromobacter xylosoxidans, China

Achromobacter xylosoxidans strain A22732 is isolated from a pneumonia patient in China and produces carbapenemases OXA-114e and IMP-1, which are encoded by chromosome and plasmid, respectively, and confer resistance to multiple beta-lactam antibiotics including carbapenems. The bla(IMP-1) gene together with aacA7 and orfE is captured by a novel Tn402-like class 1 integron in a conjugative IncP-1 beta plasmid. In addition to the intrinsic integron promoter PcW, there is still a bla(IMP-1) gene cassette-specific promoter. This is the first report of carbapenemase-encoding IncP-1 beta plasmid in clinical bacterial isolate.