Article
Biology
Hung-yin Lai, Alexander Chen, Po-chiung Fang, Hun-ju Yu, Ming-tse Kuo
Summary: This study compared tear film viscosity in Sjogren and non-Sjogren dry eye diseases. They found that Sjogren patients had lower tear film viscosity indices and higher symptom severity. The researchers concluded that tear film viscosity indices can be useful in early detection of Sjogren dry eye disease.
Article
Ophthalmology
Gun Tae Jung, Minha Kim, Jong Suk Song, Tae Im Kim, Tae Young Chung, Chul Young Choi, Hyun Seong Kim, Woo Ju An, Su Jin Jeong, Hye Sun Lee, Soyoung Jeon, Kwang Pyo Kim, Hyung Keun Lee
Summary: The study aimed to identify specific tear biomarkers for dry eye disease (DED) through tear proteomic analysis and clinical parameters. The results showed improvements in tear break-up time, corneal erosion, conjunctival erosion, and symptom assessment scores after treatment. However, no significant differences were found among the different drug groups, except for corneal erosion score. Useful tear protein biomarkers, clinically acceptable biomarker combinations, and adequate levels of specificity and sensitivity were not identified.
Article
Biochemistry & Molecular Biology
Kristina Krajcikova, Agnieszka Balicka, Maria Lapsanska, Alexandra Trbolova, Zuzana Gulasova, Daria Kondrakhova, Vladimir Komanicky, Adriana Rasiova, Vladimira Tomeckova
Summary: Dry eye disease is a chronic ophthalmological disease for which current therapy focuses on symptom suppression. Polyphenols have shown potential in improving dry eye disease therapy. This study aimed to target pathophysiological mechanisms by adding fisetin to the cyclosporine treatment protocol, but it was found that fisetin did not restore tear production but influenced molecular pathological events through MMP-9.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Martina Menchini, Francesco Sartini, Michele Figus, Giovanna Gabbriellini
Summary: In patients with moderate to severe primary Sjogren syndrome-related dry eye disease, short-term treatment with pulsed low-dose hydrocortisone sodium phosphate eye drops improves symptoms and signs of dry eye disease without affecting intraocular pressure.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Soojung Shin, Seul-Gi Yoon, Miso Kim, Eun Jeong Cheon, Youngseo Jeon, Hyun Jung Lee, So-Hyang Chung
Summary: This study aimed to investigate the effects of mesenchymal stem cells (hMSCs) on dry eyes (DE) in a Sjogren's syndrome (SS) mouse model. The results showed that treatment with hMSCs via subconjunctival or lacrimal gland injections alleviated DE symptoms by reducing clinical markers such as tear secretion and corneal staining, goblet cell counts, and inflammatory foci infiltration. In addition, the expression of proinflammatory cytokines and autophagy markers in the lacrimal glands and cornea decreased in the hMSCs-treated mice. These findings suggest the therapeutic potentials of hMSCs in SS-related DE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yu-Ting Hsiao, Yu-Ting Huang, Hun-Ju Yu, Po-Chiung Fang, Ming-Tse Kuo
Summary: This study investigates the tear protein alterations in dry eye disease (DED) with primary Sjogren syndrome (pSS) and secondary Sjogren syndrome (sSS). The researchers identify ADAM10 and EGF as novel biomarkers for differentiating between primary and secondary SS patients with DED.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Maria L. Merino, Javier Belmonte, Jose Rosas, M. Carmen Acosta, Juana Gallar, Carlos Belmonte
Summary: This study aims to measure the tear flow changes evoked by controlled sensory stimulation of the eye surface using i-Onion (TM), a new stimulation device, in healthy subjects and dry eye disease (DED) patients. The results showed that CO2 stimulation significantly increased tear volume in 78% of control subjects, while DED patients had lower basal tear volume (BTV) and stimulated tear volume (STV) compared to healthy controls.
Article
Chemistry, Multidisciplinary
Deborah Lee, Seoyoon Song, Geonho Cho, Lucia C. Dalle Ore, Noah Malmstadt, Ahmed Fuwad, Sun Min Kim, Tae-Joon Jeon
Summary: This study reveals the important role of lysozyme in tear film lipid layer functionality, improving ocular health through increased tear evaporation and resistance to bacterial invasion.
Article
Ophthalmology
Vatinee Y. Bunya, Maureen G. Maguire, Esen K. Akpek, Mina Massaro-Giordano, Sean Hennessy, Frederick B. Vivino, John A. Gonzales, Alan N. Baer, Gui-Shuang Ying
Summary: A screening questionnaire was developed to identify patients with dry eye who are likely to have underlying Sjogren syndrome. Statistical analysis identified four key questions related to SS, which showed significant predictive value in assessing disease risk. The questionnaire demonstrated a high AUC value, indicating its potential as an effective screening tool.
Article
Biochemistry & Molecular Biology
Saki Sakakura, Emi Inagaki, Yuichiro Ochiai, Masatoshi Yamamoto, Naofumi Takai, Taeko Nagata, Kazunari Higa, Yasunori Sato, Hiroshi Toshida, Dogru Murat, Masatoshi Hirayama, Yoko Ogawa, Kazuno Negishi, Shigeto Shimmura
Summary: The tear film stability of a rabbit dry eye model induced by dacryoadenectomy was assessed in this study. The results showed that this model partially captured the phenotypes of human short TBUT-type dry eye, making it a potentially useful animal model for investigating potential drug candidates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Atsushi Kawahara
Summary: Dry eye disease is a multifactorial disorder characterized by tear fluid imbalance. In Asia, the focus of treatment is on tear film stabilization. Traditional therapies like artificial tears and steroids have limitations, while new generation therapies have shown to be more effective in Asia.
Article
Chemistry, Medicinal
Mohammad, Vaidehi Garg, Jayabalan Nirmal, Musarrat H. Warsi, Deepti Pandita, Prashant Kesharwani, Gaurav Kumar Jain
Summary: Topical tacrolimus loaded propylene glycol modified nano-vesicles were found to be more effective than tacrolimus solution in treating experimental dry eye syndrome in rabbits, improving tear production, tear break-up time, ocular surface temperature, and ocular and epithelial damage.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Medicine, General & Internal
Yaying Wu, Chunyang Wang, Xin Wang, Yujie Mou, Kelan Yuan, Xiaodan Huang, Xiuming Jin
Summary: Dry eye-related ocular surface examination is crucial for the diagnosis and treatment of dry eye disease. However, there is still confusion about the choice of examination method, ensuring repeatability, and accurately interpreting the results. This review systematically evaluates previous examinations, analyzes the latest views and research hotspots, and provides a reference for the diagnosis and management of dry eye.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Qiankun Chen, Zhengjiang Wei, Leying Wang, Xizhan Xu, Zhenyu Wei, Panpan Zheng, Kai Cao, Zijun Zhang, Kexin Chen, Qingfeng Liang
Summary: Patients with schizophrenia are more likely to experience asymptomatic dry eye disease, with mild symptoms and obvious signs. The inflammatory cytokines in the tears of schizophrenic patients differed greatly from that of non-schizophrenic patients.
FRONTIERS IN MEDICINE
(2022)
Review
Biology
Robinson T. Barrientos, Fernando Godin, Carlos Rocha-De-Lossada, Matias Soifer, Jose-Maria Sanchez-Gonzalez, Esteban Moreno-Toral, Ana-Luisa Gonzalez, Mike Zein, Pablo Larco, Carolina Mercado, Maria-Adelaida Piedrahita
Summary: This article provides a systematic and critical review of scientific publications on dry eye disease and SS, summarizing their conceptualization, prevalence, risk factors, etiopathogenesis, clinical manifestations, diagnosis, and treatment.