Article
Biochemistry & Molecular Biology
Caner Yildirim, Sena Cevik, Hatice Yamaner, Mustafa Orkmez, Omer Eronat, Mehmet Akif Bozdayi, Mehmet Erdem
Summary: This study found that boric acid can attenuate the adverse effects of cisplatin. Boric acid reduces the destructive effect of cisplatin by reducing oxidative stress, and this effect was verified electrophysiologically, behaviorally, and histopathologically.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Chemistry, Analytical
Miao Qi, Rong Liu, Bing Li, Shuai Wang, Runze Fan, Xinyi Zhao, Dehui Xu
Summary: This study investigated the behavioral effects of terahertz radiation on mice, and the results suggest that terahertz waves may enhance anti-anxiety, anti-depression, and social interaction in mice.
Article
Neurosciences
Hakimeh Saadati, Somayeh Noroozzadeh, Hedieh Esmaeili, Keyvan Amirshahrokhi, Javad Shadman, Ali Niapour
Summary: The study demonstrated that mesna has protective effects against cisplatin-induced neurotoxicity, improving behavioral and molecular parameters such as cognitive impairments, anxiety, muscle strength, and inflammatory responses. Mesna showed potential in alleviating both central and peripheral nervous system toxicity induced by cisplatin, as well as partially inhibiting chemotherapy-induced neuropathy.
NEUROTOXICITY RESEARCH
(2021)
Article
Biology
Molly C. Craig, Larissa O. Silva, Steven J. Swoap
Summary: The study found that fasted mice tend to prefer warmer ambient temperatures when given the choice, especially in a selective environment. Additionally, fasted mice are more likely to maintain a higher body temperature in warm environments, which is beneficial for metabolism.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Toxicology
Kevin J. Pollard, Brad Bolon, Michael J. Moore
Summary: The research shows that using microphysiological nerve tissue can replicate the clinical electrophysiological changes and neuropathologic biopsy findings of chemotherapy-induced peripheral neuropathy in both animals and human patients. This approach combines the tight experimental control of in vitro experimentation with the clinically relevant functional and structural outputs typically seen in in vivo models.
TOXICOLOGICAL SCIENCES
(2021)
Article
Chemistry, Medicinal
Ketlyn P. da Motta, Carolina C. Martins, Vanessa M. Macedo, Beatriz F. dos Santos, Nelson Luis De C. Domingues, Cristiane Luchese, Ethel A. Wilhelm
Summary: The study examined the effectiveness of MTDZ in alleviating PTX-induced peripheral neuropathy and its impact on various pathways. The results showed that MTDZ reduced mechanical and thermal sensitivities induced by PTX and modulated multiple pain-related pathways. Additionally, MTDZ reduced NOx levels and modulated Ca2+-ATPase activity.
Article
Environmental Sciences
Eleonora Pozzi, Elisa Ballarini, Virginia Rodriguez-Menendez, Annalisa Canta, Alessia Chiorazzi, Laura Monza, Mario Bossi, Paola Alberti, Alessio Malacrida, Cristina Meregalli, Arianna Scuteri, Guido Cavaletti, Valentina Alda Carozzi
Summary: Chemotherapy-induced peripheral neurotoxicity, a common dose-limiting toxicity of anticancer drugs, was investigated in this study. The study focused on the effects of paclitaxel and cisplatin on satellite glial cells (SGCs) in the dorsal root ganglia (DRG) and their interactions. It was found that paclitaxel strongly activated SGCs, altering their physical contact with sensory neurons. SGCs may play a key role in paclitaxel-induced peripheral neurotoxicity, providing potential druggable targets for its treatment and prevention.
Article
Behavioral Sciences
Vasiliy V. Reshetnikov, Kseniya A. Ayriyants, Yulia A. Ryabushkina, Nikita G. Sozonov, Natalya P. Bondar
Summary: The study found that early-life stress did not alter social behavior in mice, but did affect their levels of locomotor activity and anxiety, with effects varying depending on strain and sex.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Oncology
Roberta Cristina Ribeiro Cruz, Francisco Rinaldi Neto, Ricardo Andrade Furtado, Larissa Mendes Souza, Fernanda Diniz de Sousa, Saulo Duarte Ozelin, Jairo Kenupp Bastos, Georgia Mode Magalhaes, Denise Crispim Tavares, Pollyanna Francielli de Oliveira
Summary: This study evaluated the reduction of toxicity when cisplatin treatment is combined with watermelon pulp juice supplementation in C57BL/6 mice with melanoma. Results showed that watermelon had no antitumor effect but reduced the toxicity of cisplatin, as demonstrated by an increase in the number of bone marrow cells and a decrease in serum creatinine and urea levels. The data suggest that watermelon pulp juice can be an alternative for reducing the side effects of antineoplastic agents.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Yuxin Zhou, Gang Ji, Xiaoyi Yang, Zhenhua Chen, Liangliang Zhou
Summary: The acute model of ulcerative colitis induced by 3% DSS has a certain effect on the behavior of mice, but the mental state of the mice is normal, which may be the abnormal behavior caused by the symptoms of ulcerative colitis. However, the chronic model of ulcerative colitis induced by 1.5% DSS has a significant effect on the behavior of mice, leading to mental disorders in the mice.
BMC GASTROENTEROLOGY
(2023)
Article
Neurosciences
Hiroshi Ueno, Yu Takahashi, Shinji Murakami, Kenta Wani, Tetsuji Miyazaki, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara
Summary: The study aimed to investigate the behavioral abnormalities of Apoeshl mice. The results showed that Apoeshl mice exhibited decreased motor skill learning and increased anxiety-like behavior towards heights. However, they did not show abnormal behavior in the Y-maze test, open-field test, light/dark transition test, and passive avoidance test. The findings suggest the utility of Apoeshl mice in investigating the function of ApoE in the central nervous system.
TRANSLATIONAL NEUROSCIENCE
(2023)
Article
Psychology, Biological
Katelynn M. Corder, Christy S. Carter, Jessica M. Hoffman, Anamarija Sogorovic, Steven N. Austad
Summary: This study compared the differences in physical performance and anxiety-like behavior between CB6F1 mice (created from BALB/c females mated to C57BL/6 males) and C57BL/6 mice (one of the parental strains). Significant correlations were found between physical performance measures not traditionally associated with anxiety-like behavior and anxiety-like behavioral measures, which differed between the two strains. These findings should be considered when designing behavioral studies and choosing model organisms.
BEHAVIOURAL PROCESSES
(2023)
Article
Behavioral Sciences
Melanie P. Leussis, Jessica M. Thanos, Alex Powers, Emalee Peterson, Joshua P. Head, Nathan J. McGovern, Francis J. Malarkey, Anna Drake
Summary: The study showed that prenatal exposure to fluoxetine affects neurodevelopment, mood, social, and repetitive behaviors in mice. High doses of fluoxetine resulted in increased repetitive behaviors and decreased sucrose preference in adult offspring.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Integrative & Complementary Medicine
Kangwook Lee, Jin Mo Ku, Yu-Jeong Choi, Hyun Ha Hwang, Miso Jeong, Yun-Gyeong Kim, Min Jeong Kim, Seong-Gyu Ko
Summary: The study showed that the novel anticancer herbal prescription SH003 alleviates docetaxel-induced neuropathic pain by suppressing nerve damage and inflammation, suggesting its potential as an effective treatment for chemotherapy-induced peripheral neuropathy.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Clinical Neurology
WenWen Zhang, Mahi Jasinarachchi, Linda Seiderer, David J. Szmulewicz, Leslie J. Roberts
Summary: The purpose of this study is to evaluate the presence of neuropathy or neuronopathy in SCA6 patients. The neurophysiological assessment of 24 SCA6 patients revealed that 79.2% of them had no evidence of neuropathy. Therefore, this study does not support the common presence of neuropathy or neuronopathy in SCA6 and highlights the importance of considering comorbidities as the cause of neurophysiological abnormalities.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Matthias Endres, Maria A. Moro, Christian H. Nolte, Claudia Dames, Marion S. Buckwalter, Andreas Meisel
Summary: Inflammation and immune mechanisms play crucial roles in the development, complications, and outcomes of ischemic stroke. Anti-inflammatory drugs show promise in preventing stroke, and the COVID-19 pandemic has highlighted the association between infections and cerebrovascular events. Different immune cells and molecules contribute to cerebral damage and chronic inflammation after stroke. Chronic systemic inflammation and comorbid infections can affect recovery after stroke and increase the risk of recurrence. Immune mechanisms may also play a role in specific complications of stroke.
CIRCULATION RESEARCH
(2022)
Article
Clinical Neurology
Claudio L. A. Bassetti, Mathias Endres, Anja Sander, Michael Crean, Sumathi Subramaniam, Vanessa Carvalho, Giovanni Di Liberto, Oscar H. Franco, Yolande Pijnenburg, Matilde Leonardi, Paul Boon
Summary: Brain health is crucial for overall well-being and the European Academy of Neurology (EAN) has developed a strategy to prevent neurological disorders, preserve brain health, and promote recovery after brain damage. This strategy emphasizes global cooperation and encompasses various aspects including research, education, and public awareness.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Regina von Rennenberg, Thomas Liman, Christian H. Nolte, Alexander H. Nave, Jan F. Scheitz, Sandra Duezel, Vera Regitz-Zagrosek, Denis Gerstorf, Elisabeth Steinhagen-Thiessen, Ilja Demuth, Matthias Endres
Summary: There is evidence of an association between levels of high-sensitivity cardiac troponin T (hs-cTnT) and cognitive decline in older men, as measured by the Digit Symbol Substitution Test (DSST). This association remained significant even after adjusting for age, sex, education, and cardiovascular risk factors. However, there was no significant association between hs-cTnT and different cognitive domains at baseline.
Article
Clinical Neurology
Regina von Rennenberg, Juliane Herm, Thomas Krause, Simon Hellwig, Helena Stengl, Jan F. Scheitz, Thomas Elgeti, Sebastian N. Nagel, Matthias Endres, Karl Georg Haeusler, Christian H. Nolte
Summary: This study found that elevated cardiac biomarkers, such as high-sensitivity cardiac troponin T (hs-cTnT) and brain natriuretic peptide (BNP), in acute stroke patients are strongly associated with pathological findings on cardiac magnetic resonance imaging (CMR). The elevation of these biomarkers may help identify patients who require a more comprehensive cardiology work-up.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Marios K. Georgakis, Rong Fang, Marco Duering, Frank A. Wollenweber, Felix J. Bode, Sebastian Stoesser, Christine Kindlein, Peter Hermann, Thomas G. Liman, Christian H. Nolte, Lucia Kerti, Benno Ikenberg, Kathleen Bernkopf, Holger Poppert, Wenzel Glanz, Valentina Perosa, Daniel Janowitz, Michael Wagner, Katja Neumann, Oliver Speck, Laura Dobisch, Emrah Duezel, Benno Gesierich, Anna Dewenter, Annika Spottke, Karin Waegemann, Michael Goertler, Silke Wunderlich, Matthias Endres, Inga Zerr, Gabor Petzold, Martin Dichgans
Summary: The global burden of small vessel disease (SVD) predicts cognitive and functional outcomes in stroke patients, but the current score used for assessment does not improve prediction capability. Assessing the severity of SVD lesions adds value in predicting outcomes beyond known predictors.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, General & Internal
Petra Huehnchen, Nikola Bangemann, Sandra Lischewski, Stefanie Maerschenz, Friedemann Paul, Tanja Schmitz-Huebsch, Jens-Uwe Blohmer, Cornelia Eberhardt, Geraldine Rauch, Agnes Floeel, Sophie Adam, Philipp Schwenkenbecher, Ivo Meinhold-Heerlein, Oliver Hoffmann, Tjalf Ziemssen, Matthias Endres, Wolfgang Boehmerle
Summary: This study aims to investigate the efficacy of lithium carbonate in the treatment of paclitaxel-induced polyneuropathy and cognitive impairment. The research will be conducted as a randomized, double-blind trial comparing the lithium carbonate group with the placebo group. The primary endpoint is the reduction in neuropathy score two weeks after the last paclitaxel infusion.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Leonie Mueller-Jensen, Sarah Zierold, Judith M. Versluis, Wolfgang Boehmerle, Petra Huehnchen, Matthias Endres, Raphael Mohr, Annette Compter, Christian U. Blank, Tim Hagenacker, Friedegund Meier, Lydia Reinhardt, Anja Gesierich, Martin Salzmann, Jessica C. Hassel, Selma Ugurel, Lisa Zimmer, Patricia Banks, Lavinia Spain, Jennifer A. Soon, Tomohiro Enokida, Makoto Tahara, Katharina C. Kaehler, Ruth Seggewiss-Bernhardt, Catriona Harvey, Georgina V. Long, Florian Schoeberl, Louisa von Baumgarten, Thomas Hundsberger, Max Schlaak, Lars E. French, Samuel Knauss, Lucie M. Heinzerling
Summary: Immune checkpoint inhibitor-induced encephalitis (ICI-iE) is a rare but life-threatening toxicity that shows variable clinical features and can be distinguished from herpes simplex virus (HSV-1) encephalitis and anti-leucine-rich glioma-inactivated 1 (anti-LGI1) encephalitis. Cerebrospinal fluid (CSF) analysis is the most important diagnostic tool for ICI-iE, and early treatment is crucial to prevent complications and death.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Neurosciences
Eckhard Schlemm, Maerit Jensen, Amy Kuceyeski, Keith Jamison, Thies Ingwersen, Carola Mayer, Alina Koenigsberg, Florent Boutitie, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Jens Fiehler, Ivana Galinovic, Robin Lemmens, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Josep Puig, Claus Z. Simonsen, Vincent Thijs, Anke Wouters, Christian Gerloff, Goetz Thomalla, Bastian Cheng
Summary: The study found that symptoms of acute ischemic stroke are related to disruption of the brain network structure. Systemic thrombolysis can preserve structural connectivity and slow down the evolution of network organization. The protective effect of thrombolysis is mainly concentrated on a subnetwork of high centrality.
HUMAN BRAIN MAPPING
(2022)
Article
Biochemistry & Molecular Biology
Sophie Scholz, Karyn Lewis, Frederik Saulich, Matthias Endres, Wolfgang Boehmerle, Petra Huehnchen
Summary: This study investigated the use of induced pluripotent stem cell (iPSC)-derived brain organoids as a human model system to study chemotherapy-induced central nervous system toxicity. The results showed that the brain organoids effectively detected neurotoxicity caused by paclitaxel and provided insights into the underlying molecular mechanisms.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Editorial Material
Clinical Neurology
Leonie Mueller-Jensen, Helene Kriedemann, Kerstin Anvari, Petra Huehnchen, Volker Siffrin
Summary: A 46-year old man with controlled relapsing-remitting multiple sclerosis (MS) and long-term fingolimod treatment developed multiple painful skin lesions. Monkeypox virus infection was revealed by outpatient skin swab. The patient experienced prolonged cutaneous, oral and perianal manifestations, proctitis, gastrointestinal bleeding requiring blood transfusions, lower leg phlegmon, lymphadenopathy, hyperbilirubinemia, acute urinary retention, and hematuria.
Article
Immunology
Leonie Mueller-Jensen, Samuel Knauss, Lorena Ginesta Roque, Christian Schinke, Smilla K. Maierhof, Frederik Bartels, Carsten Finke, Kristin Rentzsch, Claas Ulrich, Raphael Mohr, Werner Stenzel, Matthias Endres, Wolfgang Boehmerle, Petra Huehnchen
Summary: In this study, the characteristics and clinical significance of neuronal autoantibodies in patients treated with immune checkpoint inhibitors (ICI) were investigated. It was found that the prevalence of neuromuscular autoantibodies was higher in patients with irAE-n compared to those without irAE-n. However, the pathogenic significance of brain-reactive autoantibodies in ICI-treated patients remains unclear.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Leonie Mueller-Jensen, Axel R. Schulz, Henrik E. Mei, Raphael Mohr, Claas Ulrich, Philipp Knape, Nikolaj Frost, Stefan Frischbutter, Desiree Kunkel, Christian Schinke, Lorena Ginesta Roque, Smilla K. Maierhof, Florian T. Nickel, Lucie Heinzerling, Matthias Endres, Wolfgang Boehmerle, Petra Huehnchen, Samuel Knauss
Summary: This observational study found profound dysregulation of immune cells, particularly CD8+ T cells and B cells, in patients with irAE-n. Furthermore, the study identified a potential biomarker, CXCL10, for irAE-n.
Article
Cardiac & Cardiovascular Systems
Tim Bastian Braemswig, Madeleine M. D. Kusserow, Jochen Kruppa, Markus Reinthaler, Hebun Erdur, Merve Fritsch, Jonathan Curio, Brunilda Alushi, Kersten Villringer, Ivana Galinovic, Christian Berger, David M. Leistner, Heinrich J. Audebert, Matthias Endres, Ulf Landmesser, Jochen B. Fiebach, Christian H. Nolte, Frederik Beckhoff, Alexander Lauten
Summary: This study aims to identify the procedural step(s) associated with an increased risk of cerebral embolisation during transcatheter edge-to-edge repair of the mitral valve (TEER-MV) and evaluate the risk of stroke and brain ischemia after the procedure. The results showed that there is a higher risk of cerebral embolisation during device interaction with the mitral valve, and larger infarct volume is associated with neurological deterioration.