期刊
SCIENTIFIC REPORTS
卷 4, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep05344
关键词
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资金
- JSPS KAKENHI Grant [25304045, 25660229, 23658243]
- Japan Society for the Promotion of Science
- Health and Labour Sciences Research Grant on Emerging and Re-emerging Infectious Diseases from the Japanese Ministry of Health, Labour and Welfare
- Research on International Cooperation in Medical Science (Japan-US Cooperative Program), Health and Labour Sciences Research Grants
- Cooperative Research Grant(s) of NEKKEN
- Japan Initiative for Global Research Network on Infectious Diseases
- Grants-in-Aid for Scientific Research [25304045, 25660229, 23658243] Funding Source: KAKEN
Tick-borne encephalitis virus (TBEV) causes acute central nervous system disease. Here, we investigated the roles of the TNF-alpha, IL-10 and other cytokines in appropriate KO mice following infection with Oshima and Sofjin strains of TBEV. Following infection with the Oshima strain, mortality rates were significantly increased in TNF-alpha KO and IL-10 KO mice compared with wild type (WT) mice. These results suggested that TNF-alpha and IL-10 play protective roles against fatal infection due to Oshima strain infection. However, viral loads and proinflammatory cytokine levels in the brain of TNF-alpha KO and IL-10 KO mice were not significantly different compared with those of WT mice. On the other hand, all WT, TNF-alpha KO and IL-10 KO mice died following infection with Sofjin strain. Interestingly, Sofjin-infected mice did not exhibit an up-regulated mRNA level of IL-2 in the spleen in all groups of mice, whereas Oshima-infected mice showed significantly increased level of IL-2 compared with mock-infected mice. From these results, we suggest that TNF-alpha, IL-10 and IL-2 are key factors for disease remission from fatal encephalitis due to infection with Oshima strain of TBEV.
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