Article
Allergy
Tim Delemarre, Gabriele Holtappels, Natalie De Ruyck, Nan Zhang, Hans Nauwynck, Claus Bachert, Elien Gevaert
Summary: The study revealed a severe neutrophilic inflammation associated with severe eosinophilic type 2 inflammatory CRSwNP, suggesting a potentially important role of neutrophils in the pathogenesis of CRSwNP.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Health Care Sciences & Services
Eugenio De Corso, Silvia Baroni, Stefano Settimi, Maria Elisabetta Onori, Rodolfo Francesco Mastrapasqua, Eliana Troiani, Giacomo Moretti, Donatella Lucchetti, Marco Corbo, Claudio Montuori, Alessandro Cantiani, Davide Paolo Porru, Simone Lo Verde, Giuseppe Alberto Di Bella, Cristiano Caruso, Jacopo Galli
Summary: This study evaluated the inflammatory load and cytokine profiles in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Two distinct clusters were identified based on cytokine levels and eosinophil count, with IL-5 being the most reliable biomarker for differentiation. This research highlights the potential role of type 2 biomarkers, particularly IL-5, in identifying patients with a more severe phenotype.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Allergy
Julie A. Poposki, Aiko Klingler, Whitney W. Stevens, Lydia A. Suh, Bruce K. Tan, Anju T. Peters, Hiam Abdala-Valencia, Leslie C. Grammer, Kevin C. Welch, Stephanie S. Smith, David B. Conley, Robert C. Kern, Robert P. Schleimer, Atsushi Kato
Summary: This study found that neutrophils accumulate and are highly activated in CRSwNP in Western populations, playing a significant role in the inflammation. This finding has important implications for the pathogenesis and treatment of CRSwNP in Western countries.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Florent Carsuzaa, Emilie Bequignon, Xavier Dufour, Guillaume de Bonnecaze, Jean-Claude Lecron, Laure Favot
Summary: This review summarizes the current state of knowledge regarding the cytokine signature in CRSwNP, as well as the role of cytokines in the pathogenesis of the disease and in intercellular communication between epithelial cells, fibroblasts, and inflammatory cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Bao-Feng Wang, Ping-Ping Cao, James E. Norton, Julie A. Poposki, Aiko I. Klingler, Lydia A. Suh, Roderick Carter, Julia H. Huang, Junqin Bai, Whitney W. Stevens, Bruce K. Tan, Anju T. Peters, Leslie C. Grammer, David B. Conley, Kevin C. Welch, Zheng Liu, Robert C. Kern, Atsushi Kato, Robert P. Schleimer
Summary: This study found that Oncostatin M (OSM) promotes type 2 inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP) by inducing thymic stromal lymphopoietin (TSLP). The researchers observed increased expression of IL-4R and TSLP in nasal polyp tissues and primary epithelial cells from CRSwNP patients. OSM was shown to increase the expression of IL-4R and synergize with IL-4 to induce the synthesis and release of TSLP.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Claus Bachert, Joseph K. Han, Martin Y. Desrosiers, Philippe Gevaert, Enrico Heffler, Claire Hopkins, Jody R. Tversky, Peter Barker, David Cohen, Claire Emson, Ubaldo J. Martin, Vivian H. Shih, Sofia Necander, James L. Kreindler, Maria Jison, Viktoria Werkstrom
Summary: This study assessed the efficacy and safety of benralizumab in treating CRSwNP. The results showed that benralizumab significantly improved NPS and nasal blockage score, and had significant improvement on difficulty with sense of smell score. Subgroup analyses suggested influences of comorbid asthma, number of NP surgeries, sex, body mass index, and baseline blood eosinophil count on treatment effects.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Cell Biology
Jian-Wen Ruan, Jie-Fang Zhao, Xue-Li Li, Bo Liao, Li Pan, Ke-Zhang Zhu, Qi-Miao Feng, Jin-Xin Liu, Zi-E Yu, Jia Song, Hai Wang, Zheng Liu
Summary: In chronic rhinosinusitis with nasal polyps (CRSwNP), tissue neutrophilia is associated with higher levels of inflammatory mediators and lower percentages of apoptotic neutrophils. Neutrophil-high nasal polyps predominantly exhibit type 1 and type 3 endotypes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zeyi Jin, Bing Yan, Luo Zhang, Chengshuo Wang
Summary: In the era of precision medicine, biologics have the potential to provide customized therapies to patients with CRSwNP, particularly those with refractory CRSwNP driven by type 2 inflammation. Large clinical trials and real-world experiences are essential for the application of biologics. In order to make biological therapy more tailored to patients, further research is needed to understand the different mechanisms of biologics, elucidate the relationship between biologics and conventional medical and surgical treatments, and identify predictive biomarkers.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Article
Immunology
Zaichuan Wang, Qiqi Wang, Su Duan, Yuling Zhang, Limin Zhao, Shujian Zhang, Liusiqi Hao, Yan Li, Xiangdong Wang, Chenshuo Wang, Nan Zhang, Claus Bachert, Luo Zhang, Feng Lan
Summary: This study established a diagnostic model using machine learning algorithms, based on biomarkers in nasal secretions and clinical features, which can accurately predict patients with type 2 chronic rhinosinusitis with nasal polyps (CRSwNP). This may be beneficial for patients in daily clinical practice in selecting appropriate treatment methods.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Otorhinolaryngology
Ramon Moreno-Luna, Daniel I. Martin-Jimenez, M. Amparo Callejon-Leblic, Jaime Gonzalez-Garcia, Juan M. Maza-Solano, Cristina Porras-Gonzalez, Alfonso Del Cuvillo-Bernal, Serafin Sanchez-Gomez
Summary: This study introduces bilateral mucoplasty as a complementary technique to extended endoscopic sinus surgery in patients with Chronic Rhinosinusitis with Nasal Polyps. The results show improved endoscopic, radiological, and quality of life outcomes for patients who underwent bilateral mucoplasty in addition to reboot surgery.
Article
Allergy
Ge Luan, Ming Wang, Jing Yuan, Xiangting Bu, Yang Wang, Sun Ying, Chengshuo Wang, Luo Zhang
Summary: This study found that miR-21-5p is upregulated in the nasal mucosa of patients with CRSwNP and is positively correlated with indicators of type 2 inflammation. In a mouse model, miR-21 knockout attenuated type 2 inflammation and downregulated genes associated with type 2 inflammation. miR-21-5p aggravates type 2 inflammation in the nasal mucosa of patients with CRSwNP by targeting the glucagon-like peptide-1 receptor/IL-33 signaling pathway.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Weigang Gan, Hongting Zhang, Fengjuan Yang, Shixi Liu, Feng Liu, Juan Meng
Summary: In Southwest China, the recurrence of nasal polyps is associated with neutrophil-mediated inflammatory response, with no significant correlation with factors like age, sex, asthma, or allergic rhinitis. The recurrent group showed significantly higher total nasal symptom score, eosinophil and neutrophil cell count, and expression levels of IFN-, IL-17A, IL-17E, and IL-18 compared to the non-recurrent group.
SCIENTIFIC REPORTS
(2021)
Article
Allergy
Tanya M. Laidlaw, Joaquim Mullol, Katharine M. Woessner, Nikhil Amin, Leda P. Mannent
Summary: Patients with CRSwNP and asthma often have severe and recurrent disease with tissue eosinophilia and high IgE levels. The shared pathophysiology between upper and lower airways highlights the importance of systemic treatment targeting type 2 inflammatory pathways.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Biotechnology & Applied Microbiology
Zhenghao Deng, Zhi Li, Yongchuan She, Bin Xie
Summary: This study found that elevated levels of SERPINB10 in CRSwNP patients were related to tissue eosinophilic inflammation and disease recurrence. These findings suggest that SERPINB10 may serve as a potential biomarker for predicting relapse after surgery in CRSwNP patients.
Article
Immunology
Xiaoyan Ye, Qing Bao, Hexin Chen, Qingxiang Meng, Qianying Li, Lin Sun, Jian Li, Wenbin Lei, Weiping Wen, Wenjing He, Linyi Jiao, Bixing Fang, Yifang Gao, Chunwei Li
Summary: iNKT cells play a role in the inflammatory subtypes of CRSwNP, with type 2 and type 17 iNKT cells being involved in eosinophilic and neutrophilic inflammation, respectively.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Jin-Young Min, Christopher J. Ocampo, Whitney W. Stevens, Caroline P. E. Price, Christopher F. Thompson, Tetsuya Homma, Julia H. Huang, James E. Norton, Lydia A. Suh, Kathryn L. Pothoven, David B. Conley, Kevin C. Welch, Stephanie Shintani-Smith, Anju T. Peters, Leslie C. Grammer, Kathleen E. Harris, Kathryn E. Hulse, Atsushi Kato, Nikolai N. Modyanov, Robert C. Kern, Robert P. Schleimer, Bruce K. Tan
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2017)
Letter
Allergy
Bruce K. Tan, Aiko I. Klingler, Julie A. Poposki, Whitney W. Stevens, Anju T. Peters, Lydia A. Suh, James Norton, Roderick G. Carter, Kathryn E. Hulse, Kathleen E. Harris, Leslie C. Grammer, Robert P. Schleimer, Kevin C. Welch, Stephanie S. Smith, David B. Conley, Robert C. Kern, Atsushi Kato
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2017)
Letter
Allergy
Noriko Ogasawara, Aiko I. Klingler, Bruce K. Tan, Julie A. Poposki, Kathryn E. Hulse, Whitney W. Stevens, Anju T. Peters, Leslie C. Grammer, Kevin C. Welch, Stephanie S. Smith, David B. Conley, Robert C. Kern, Robert P. Schleimer, Atsushi Kato
Article
Allergy
Y. Imoto, A. Kato, T. Takabayashi, M. Sakashita, J. E. Norton, L. A. Suh, R. G. Carter, A. R. Weibman, K. E. Hulse, W. Stevens, K. E. Harris, A. T. Peters, L. C. Grammer, B. K. Tan, K. Welch, D. B. Conley, R. C. Kern, S. Fujieda, R. P. Schleimer
CLINICAL AND EXPERIMENTAL ALLERGY
(2018)
Article
Allergy
Noriko Ogasawara, Julie A. Poposki, Aiko I. Klingler, Bruce K. Tan, Ava R. Weibman, Kathryn E. Hulse, Whitney W. Stevens, Anju T. Peters, Leslie C. Grammer, Robert P. Schleimer, Kevin C. Welch, Stephanie S. Smith, David B. Conley, Joseph R. Raviv, Pejman Soroosh, Omid Akbari, Tetsuo Himi, Robert C. Kern, Atsushi Kato
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Allergy
Hai Wang, Zhi-Yong Li, Wen-Xiu Jiang, Bo Liao, Guan-Ting Zhai, Nan Wang, Zhen Zhen, Jian-wen Ruan, Xiao-Bo Long, Heng Wang, Wei-Hong Liu, Geng-Tian Liang, Wei-Min Xu, Atsushi Kato, Zheng Liu
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Editorial Material
Allergy
Atsushi Kato, Whitney W. Stevens, Bruce S. Bochner
Review
Allergy
Atsushi Kato, Anju T. Peters, Whitney W. Stevens, Robert P. Schleimer, Bruce K. Tan, Robert C. Kern
Summary: The study of chronic rhinosinusitis (CRS) has shifted from phenotype-based classification to endotype-based classification, identifying three main endotypes that orchestrate the expression of different gene sets. The development of improved methods for endotyping disease is expanding the use of biological therapies, targeting Type 2 inflammation and potentially other inflammatory endotypes in the future.
Review
Allergy
Atsushi Kato, Robert P. Schleimer, Benjamin S. Bleier
Summary: Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by inflammation in the upper airways, which can be divided into two main types based on the presence of nasal polyps. The inflammation is characterized by three different endotypes based on the elevation of specific cytokines. The sinonasal epithelium plays a crucial role in the pathogenesis of CRS by acting as a barrier and participating in both innate and adaptive immunity. Further research is needed to fully understand the mechanisms of CRS pathogenesis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Brian S. Schwartz, Jonathan S. Pollak, Karen Bandeen-Roche, Annemarie G. Hirsch, Ashton E. Lehmann, Robert C. Kern, Bruce K. K. Tan, Atsushi Kato, Robert P. Schleimer, Anju T. Peters
Summary: This study investigates the association between chronic rhinosinusitis (CRS) and new onset asthma. By analyzing electronic health record data from Geisinger, it is found that prevalent CRS is associated with the diagnosis of new onset adult asthma in the following year. These findings have clinical implications for asthma prevention.
Article
Allergy
Marcus M. Soliai, Atsushi Kato, Katherine A. Naughton, James E. Norton, Aiko I. Klinger, Robert C. Kern, Bruce K. K. Tan, Dan L. Nicolae, Robert P. Schleimer, Carole Ober, Jayant M. Pinto
Summary: This study investigated the epigenetic and transcriptional responses in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) to rhinovirus (RV) using a primary sinonasal epithelial cell culture model. They found that RV activates specific epigenetic programs and correlated transcriptional networks in the sinonasal epithelium of individuals with CRSwNP, suggesting potential therapeutic targets for this condition.
Letter
Allergy
Brian S. Schwartz, Annemarie G. Hirsch, Karen Bandeen-Roche, Atsushi Kato, Robert Schleimer
Article
Biochemistry & Molecular Biology
Tetsuya Homma, Atsushi Kato, Masafumi Sakashita, Tetsuji Takabayashi, James E. Norton, Lydia A. Suh, Roderick G. Carter, Kathleen E. Harris, Anju T. Peters, Leslie C. Grammer, Jin-Young Min, Stephanie Shintani-Smith, Bruce K. Tan, Kevin Welch, David B. Conley, Robert C. Kern, Robert P. Schleimer
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2017)
Article
Immunology
Julie A. Poposki, Aiko I. Klingler, Bruce K. Tan, Pejman Soroosh, Homayon Banie, Gavin Lewis, Kathryn E. Hulse, Whitney W. Stevens, Anju T. Peters, Leslie C. Grammer, Robert P. Schleimer, Kevin C. Welch, Stephanie S. Smith, David B. Conley, Joseph R. Raviv, James G. Karras, Omid Akbari, Robert C. Kern, Atsushi Kato
IMMUNITY INFLAMMATION AND DISEASE
(2017)
Article
Allergy
S. Feldman, R. Kasjanski, J. Poposki, D. Hernandez, J. N. Chen, J. E. Norton, L. Suh, R. G. Carter, W. W. Stevens, A. T. Peters, R. C. Kern, D. B. Conley, B. K. Tan, S. Shintani-Smith, K. C. Welch, L. C. Grammer, K. E. Harris, A. Kato, R. P. Schleimer, K. E. Hulse
CLINICAL AND EXPERIMENTAL ALLERGY
(2017)