Article
Immunology
Thauane Silva, Jairo R. Temerozo, Gabriele do Vale, Andre C. Ferreira, Vinicius Cardoso Soares, Suelen Silva Gomes Dias, Gabriela Sardella, Dumith Chequer Bou-Habib, Marilda Siqueira, Thiago Moreno L. Souza, Milene Miranda
Summary: This study found that ligands of the CCR5 receptor can inhibit IAV replication by significantly increasing SAMHD1 levels during the course of IAV infection, providing a new perspective on combating viral replication.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Zhen Zeng, Tianxia Lan, Yuquan Wei, Xiawei Wei
Summary: This review discusses the role of the CCL5/CCR5 axis in the pathological processes of different diseases, including inflammation, chronic diseases, cancers, and COVID-19. It also highlights the regulation of relevant signaling pathways and research and clinical trials for treating CCR5-related diseases.
Article
Biochemistry & Molecular Biology
Reni Ajoy, Yu-Chun Lo, Man-Hau Ho, You-Yin Chen, Yun Wang, Yuan-Hao Chen, Chiu Jing-Yuan, Chun Austin Changou, Yuan-Chin Hsiung, Hui-Min Chen, Tzu-Hao Chang, Cheng-Yang Lee, Yung-Hsiao Chiang, Wen-Chang Chang, Barry Hoffer, Szu-Yi Chou
Summary: In addition to its neuroinflammatory functions, chemokine CCL5 also exhibits strong neurotrophic properties. CCL5 plays a critical role in promoting hippocampal glucoregulatory efficiency, which in turn enhances synaptic plasticity and memory and cognition functions. CCL5's actions on glucose aerobic metabolism are essential for mitochondrial function, contributing to hippocampal spine and synapse formation, ultimately improving learning and memory.
MOLECULAR PSYCHIATRY
(2021)
Article
Immunology
Yue Qiu, Yirui Cao, Guowei Tu, Jiawei Li, Ying Su, Fang Fang, Xuepeng Zhang, Jing Cang, Ruiming Rong, Zhe Luo
Summary: The study demonstrated that MDSCs can significantly alleviate renal fibrosis by promoting the interaction of the CCL5-CCR5 axis and inhibiting the TGF-beta 1/Smad/Snail signaling pathway. This leads to enhanced infiltration of MDSCs and Treg in the kidney, while reducing the levels of T(H)1 cells. The findings suggest an alternative treatment approach for renal fibrosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Clinical Neurology
Weijiang Ma, Aihua Liu, Xinya Wu, Li Gao, Jingjing Chen, Hanxin Wu, Meixiao Liu, Yuxin Fan, Li Peng, Jiaru Yang, Jing Kong, Bingxue Li, Zhenhua Ji, Yan Dong, Suyi Luo, Jieqin Song, Fukai Bao
Summary: Alzheimer's disease is a common neurodegenerative disease with increasing morbidity and mortality. The role of the CCL5/CCR5 axis in the pathogenesis of AD is still not fully understood, with conflicting results from studies.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Yanchun Huang, Lijuan Wu, Yong Sun, Jiwen Li, Nan Mao, Yeqing Yang, Ming Zhao, Sichong Ren
Summary: This study conducted a comprehensive pan-cancer analysis to explore the value of CCL5 in patient prognosis. The results showed that CCL5 was overexpressed in most tumors and significantly associated with clinical prognosis in 10 out of 33 types of tumors. CCL5 was found to be related to tumor mutational burden, DNA methylation, immune infiltration, immune checkpoints, and cytokine signaling, indicating its potential role in tumor pathogenesis and prognosis.
Article
Immunology
Saida Mukanova, Anton Borissenko, Alexey Kim, Aigerim Bolatbek, Ainur Abdrakhmanova, Luca Vangelista, Eva Sonnenberg-Riethmacher, Dieter Riethmacher
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, and its pathogenesis involves complex interactions of various factors. This study investigates the potential crosstalk between the periostin and CCR5 signaling systems and evaluates the therapeutic potential of a CCL5 derivative as a CCR5 antagonist in an IBD model.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Wilfredo Alejandro Gonzalez-Arriagada, Ricardo D. Coletta, Carlo Lozano-Burgos, Cynthia Garcia, Jaime Maripillan, Francisca Alcayaga-Miranda, Bastian Godinez-Pacheco, Sebastian Oyarce-Pezoa, Rene Martinez-Flores, Isaac E. Garcia
Summary: The CCR5/CCL5 axis plays an important role in the behavior of oral cancer, with CCR5 expression associated with clinical stage and metastasis, and CCL5 associated with overall survival. The CCR5 antagonist Maraviroc can inhibit cell proliferation, increase apoptosis, and modify cytoskeletal organization. In vivo studies show that Maraviroc can reduce neck metastasis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anju Krishnan Anitha, Pratibha Narayanan, Neethu Ajayakumar, Krishnankutty Chandrika Sivakumar, Kesavakurup Santhosh Kumar
Summary: This study designed and generated peptide ligands targeting CCR5, which showed significant CCR5 specificity and did not mediate migration of responsive cells.
JOURNAL OF BIOCHEMISTRY
(2022)
Article
Oncology
Yuan Zhuang, Xiaomei Zhao, Baoying Yuan, Zhaochong Zeng, Yixing Chen
Summary: The study showed that the CCR5 antagonist MVC can induce macrophage polarization towards the M1 phenotype by blocking the CCL5-CCR5 signaling pathway, thereby enhancing the sensitivity and apoptosis of human hepatoma cells to radiation.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Article
Multidisciplinary Sciences
Adriana Yndart Arias, Nagesh Kolishetti, Arti Vashist, Lakshmana Madepalli, Lorgeleys Llaguno, Madhavan Nair
Summary: The study found that Cannabidiol (CBD) has more significant anti-inflammatory effects in human microglial cells (HC69.5) infected with HIV compared to & UDelta;(9)-THC. CBD reduces the production of various inflammatory cytokines and chemokines, deactivates caspase 1, and reduces NLRP3 gene expression. Additionally, CBD significantly reduces the expression of HIV. This study demonstrates that CBD has anti-inflammatory properties and shows significant therapeutic potential against HIV-1 infections and neuroinflammation.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Polina Isaikina, Ivana Petrovic, Roman P. Jakob, Parishmita Sarma, Ashutosh Ranjan, Minakshi Baruah, Vineet Panwalkar, Timm Maier, Arun K. Shukla, Stephan Grzesiek
Summary: Non-visual arrestins, arrestin2 and arrestin3, interact with various GPCRs through different phosphorylation patterns, resulting in distinct functional outcomes. In this study, we characterized the interactions between phosphorylated CCR5 and arrestin2. We discovered new phosphorylation sites on CCR5 that are necessary for stable arrestin2 complex formation. The identified motif is responsible for robust arrestin2 recruitment in many other GPCRs. Our findings provide insights into the specificity of arrestin2 and arrestin3 isoforms and shed light on the molecular basis of arrestin signaling.
Article
Biochemistry & Molecular Biology
Adi Moseri, Sabine R. Akabayov, Leah S. Cohen, Fred Naider, Jacob Anglister
Summary: The study reveals that the interaction between gp120 and CCR5 is more complex than previously thought, involving a dynamic equilibrium with multiple binding modes.
Article
Instruments & Instrumentation
Yannick L. Traore, Yufei Chen, Fernanda Padilla, Emmanuel A. Ho
Summary: Vaginal drug delivery is a promising strategy for the prevention of sexually transmitted infections, with advantages such as improved therapeutic efficacy and reduced drug resistance. The developed IVR system can continuously release drugs and nanoparticles in a smart manner, showing positive effects in preventing infections.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Xinyu Ma, Hongjia Zhang, Shirui Wang, Rui Deng, Dan Luo, Meng Luo, Qing Huang, Su Yu, Chunlan Pu, Yuanyuan Liu, Yu Tong, Rui Li
Summary: In recent years, one of the important approaches in the search for anti-HIV drugs is to find lead compounds from natural products followed by structure optimization. Many natural products exert effective anti-HIV activity through mechanisms such as immune regulation, inhibition of related functional enzymes in HIV replication, and anti-oxidation.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Chrysoula Kokotidou, Sai Vamshi R. Jonnalagadda, Asuka A. Orr, George Vrentzos, Androniki Kretsovali, Phanourios Tamamis, Anna Mitraki
Correction
Chemistry, Medicinal
Joseph M. Jakubowski, Asuka A. Orr, Doan A. Le, Phanourios Tamamis
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2020)
Article
Engineering, Environmental
Meichen Wang, Asuka A. Orr, Joseph M. Jakubowski, Kelsea E. Bird, Colleen M. Casey, Sara E. Hearon, Phanourios Tamamis, Timothy D. Phillips
Summary: Montmorillonites amended with carnitine and choline showed high binding capacity for PFAS in stomach-simulating conditions. The interactions of PFAS with amended clays were primarily through hydrophobic and electrostatic interactions, as well as hydrogen bonding. The study confirmed the potential of nutrient-amended clays to reduce the bioavailability of PFAS in contaminated water and diets.
Article
Computer Science, Interdisciplinary Applications
Asuka A. Orr, Shujun He, Meichen Wang, Alicia Goodall, Sara E. Hearon, Timothy D. Phillips, Phanourios Tamamis
COMPUTERS & CHEMICAL ENGINEERING
(2020)
Article
Toxicology
Hyejin Park, Un-Ho Jin, Keshav Karki, Clinton Allred, Laurie A. Davidson, Robert S. Chapkin, Asuka A. Orr, Farrhin Nowshad, Arul Jayaraman, Phanourios Tamamis, Stephen Safe
Summary: Hydroxylated chalcones act as AhR agonists with structure-dependent activity, inducing CYP1A1, CYP1B1, and UGT1A1 genes in Caco2 colon cancer cells. Compounds containing 2,2'-dihydroxy substituents showed the highest AhR activation, while other hydroxychalcones exhibited lower or non-detectable AhR activity in Caco2 cells.
TOXICOLOGICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Oren Ben-Zvi, Itzhak Grinberg, Asuka A. Orr, Dror Noy, Phanourios Tamamis, Iftach Yacoby, Lihi Adler-Abramovich
Summary: The study demonstrates that a specific dipeptide hydrogelator can encapsulate oxygen, restrict its diffusion and penetration in the hydrogel. The mechanism involves pockets formed between aromatic rings in the supramolecular structure to bind oxygen, maintaining the activity of oxygen-sensitive enzymes.
Article
Chemistry, Multidisciplinary
Yu Chen, Yuqin Yang, Asuka A. Orr, Pandeeswar Makam, Boris Redko, Elvira Haimov, Yannan Wang, Linda J. W. Shimon, Sigal Rencus-Lazar, Meiting Ju, Phanourios Tamamis, Hao Dong, Ehud Gazit
Summary: The research describes a minimalistic approach to construct a dipeptide-based nano-superstructure with enzyme-like activity. The self-assembled biocatalyst exhibits remarkable hydrolysis activity and enduring stability, which can be used as basic units to further construct higher-order superstructure.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Moran Aviv, Dana Cohen-Gerassi, Asuka A. Orr, Rajkumar Misra, Zohar A. Arnon, Linda J. W. Shimon, Yosi Shacham-Diamand, Phanourios Tamamis, Lihi Adler-Abramovich
Summary: Supramolecular hydrogels formed by the self-assembly of amino-acid based gelators are gaining attention in the fields of biomedicine and material science. Modifying the position of a single atom, such as fluorine, can have significant effects on the self-assembly process and physical properties of the product, demonstrating fluorination as an effective strategy to influence supramolecular organization on the nanoscale. A deep understanding of the self-assembly process may facilitate the development of optimized amino-acid-based low-molecular-weight hydrogelators for various applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Asuka A. Orr, Meichen Wang, Burcu Beykal, Hari S. Ganesh, Sara E. Hearon, Efstratios N. Pistikopoulos, Timothy D. Phillips, Phanourios Tamamis
Summary: This study investigated the interaction between toxic chemicals and montmorillonite clays through experimental and computational methods, finding that their binding energies can be used to predict adsorption free energies and revealing structural and physicochemical properties associated with chemicals that can be adsorbed to calcium montmorillonite clay. The combined experimental and computational approaches used in this study highlight the importance and potential applicability of analogous methods to study and design novel advanced sorbent systems in the future, broadening their applicability for environmental contaminants.
Article
Environmental Sciences
Sara E. Hearon, Asuka A. Orr, Haley Moyer, Meichen Wang, Phanourios Tamamis, Timothy D. Phillips
Summary: The study found that nutrient-amended clays can effectively reduce the bioavailability of PFAS in soil and decrease the risk of PFAS translocation to plants.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Asuka A. Orr, Sarah K. Kuhlmann, Phanourios Tamamis
Summary: This study computationally investigated the possibility of enhancing the anti-amyloid properties of beta-wrapin AS10 by redesigning its currently non-functional N-terminal domain. The simulations suggest that the redesigned N-terminal domain can bind to A beta fibrils and simultaneously maintain its sequestering properties for A beta monomers.
BIOPHYSICAL CHEMISTRY
(2022)
Article
Engineering, Environmental
Kelly J. Rivenbark, Meichen Wang, Kendall Lilly, Phanourios Tamamis, Timothy D. Phillips
Summary: The study investigates the use of chlorophyll-amended montmorillonite clays to address high levels of benzene contamination after disasters. The results indicate that the addition of chlorophyll improves the binding profile and detoxification ability of the clays, while also protecting sensitive organisms from benzene toxicity.
Article
Chemistry, Physical
Vijay Bhooshan Kumar, Busra Ozguney, Anastasia Vlachou, Yu Chen, Ehud Gazit, Phanourios Tamamis
Summary: The design of novel cancer drug nanocarriers is crucial in cancer therapeutics. Nanomaterials, especially self-assembling peptides, show great potential in drug delivery by promoting drug release and stability while reducing side effects. This review highlights the importance of metal coordination, structure stabilization, cyclization, and minimalism in the design of peptide self-assembled nanocarriers for cancer drug delivery. Future perspectives suggest that incorporating these materials into single or multicomponent systems could lead to novel classes of cancer drug delivery systems.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Chemistry, Physical
Kai Tao, Asuka A. Orr, Wen Hu, Pandeeswar Makam, Jiahao Zhang, Qiang Geng, Boxin Li, Joseph M. Jakubowski, Yancheng Wang, Phanourios Tamamis, Rusen Yang, Deqing Mei, Ehud Gazit
Summary: The coordination of biomolecules and metal ions has been studied, revealing co-crystallization with unusual interactions and significant catalytic behavior. Additionally, the bio-coordinated assemblies showed high piezoelectric properties, demonstrating potential for various applications.
JOURNAL OF MATERIALS CHEMISTRY A
(2021)
Article
Biochemistry & Molecular Biology
Juan C. Gonzalez-Rivera, Asuka A. Orr, Sean M. Engels, Joseph M. Jakubowski, Mark W. Sherman, Katherine N. O'Connor, Tomas Matteson, Brendan C. Woodcock, Lydia M. Contreras, Phanourios Tamamis
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2020)