Article
Chemistry, Multidisciplinary
Flavia Sousa, Ana Isabel Costa-Pereira, Andrea Cruz, Fabio Junio Ferreira, Marcos Gouveia, Jose Bessa, Bruno Sarmento, Rui D. M. Travasso, Ines Mendes Pinto
Summary: In this study, a novel approach was developed to target VEGF secretion in GBM cells using a VEGF nanotrapper, improving the effectiveness of bevacizumab-based therapy. The study demonstrated the therapeutic efficacy of this nanocargo in reducing vascularization and tumor cell mass of GBM in vitro and in vivo cancer models.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Developmental Biology
Lois A. Salamonsen, Jennifer C. Hutchison, Caroline E. Gargett
Summary: The human endometrium undergoes unique repair and regeneration processes during a woman's reproductive life, making it an excellent model for study. Endometrial stem/progenitor cells play a crucial role in regeneration, along with the stem cell niche and stem cell-derived extracellular vesicles. Endometrial epithelial organoids are valuable in expanding our understanding of endometrial development and regeneration, as well as potential therapeutic applications.
Article
Multidisciplinary Sciences
Mackenzie J. Dickson, Jeanette Bishop, Thomas R. Hansen, I. Martin Sheldon, John J. Bromfield
Summary: Pregnancy induces changes in the transcriptome of the bovine endometrium, but cows with postpartum bacterial infection of the uterus have lower chances of pregnancy even after the disease is resolved. Uterine bacterial infection alters the endometrial transcriptomic signature of pregnancy after the resolution of disease.
Article
Obstetrics & Gynecology
J. Kanter, S. M. Gordon, S. Mani, A. Sokalska, J. Y. Park, S. Senapati, D. D. Huh, M. Mainigi
Summary: Hormonal stimulation during ART alters maternal immune cell distribution and function, reducing the ability of uterine natural killer cells to promote trophoblast invasion.
HUMAN REPRODUCTION
(2023)
Article
Biotechnology & Applied Microbiology
Xiaojuan Liu, Hui Ma, Lisha Ma, Kun Li, Yanhua Kang
Summary: This study explored the potential function of METTL5 in UCEC and verified the relationship between deficient DNA mismatch repair and METTL5. The results showed that METTL5 expression was increased in UCEC tumor tissue and UCEC patients with high METTL5 expression had worse prognostic outcomes. Knocking down METTL5 weakened UCEC proliferation, increased apoptosis, and influenced the development and prognosis of UCEC through regulating MMR protein levels.
Article
Engineering, Biomedical
Ping Wu, Zan Tong, Lihua Luo, Yanan Zhao, Feixiang Chen, Yinping Li, Celine Huselstein, Qifa Ye, Qingsong Ye, Yun Chen
Summary: The combination of VEGF and Schwann cells in peripheral nerve repair shows promising results in promoting nerve regeneration. The HSPS conduits loaded with VEGF-A overexpressing Schwann cells demonstrate high durability and efficiency in repairing nerve tissue, making them a potential new avenue for nerve tissue engineering.
BIOACTIVE MATERIALS
(2021)
Article
Oncology
Xiaodi Huang, Peng Peng
Summary: This study aimed to investigate the effects of postoperative hormone therapy on recurrence in patients with uterine LG-ESS. The results showed that hormone therapy reduced recurrence in patients with stage II-IV uterine LG-ESS without fertility-sparing, and high-dose progestins treatment within 12 months is recommended. Bilateral oophorectomy can also reduce the risk of recurrence. Patients with fertility-sparing have a high risk of recurrence and poor pregnancy outcomes, and hormone therapy may be a reasonable choice in postoperative management.
FRONTIERS IN ONCOLOGY
(2022)
Article
Microbiology
Marina Santos, Sara B. Pereira, Carlos Flores, Catarina Principe, Narciso Couto, Esther Karunakaran, Sara M. Cravo, Paulo Oliveira, Paula Tamagnini
Summary: The absence of a putative EPS-related protein, KpsM, has a pleiotropic effect on the physiological functions of cyanobacteria, impacting the export of EPS and carbon fluxes. The mutant strain with disrupted EPS secretion exhibits transcriptomic and proteomic adjustments, highlighting the importance of EPS as a major carbon sink in cyanobacteria. Additionally, the accumulation of polyhydroxybutyrate in the mutant cells suggests its potential use as a chassis for the production of compounds of interest.
Article
Obstetrics & Gynecology
Kuniaki Ota, Kenji Sato, Satoru Shiraishi, Toshifumi Takahashi
Summary: The study evaluated temporal changes in endometrial blood flow after LM, finding that recovery was negatively correlated with patient age. The results suggest that endometrial blood flow may play a role in wound healing after myomectomy. Individualized wound healing strategies after myomectomy may be needed based on endometrial blood flow measurements.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tao Wang, Mei Ji, Wenwen Liu, Jing Sun
Summary: This study identified DDR-related lncRNAs (DRLs) in uterine corpus endometrial carcinoma (UCEC) and developed a prognostic signature that can guide clinical treatment. The high-risk group showed upregulated DDR-related pathways, low immune activity, poor response to immune checkpoint blockade, and weak sensitivity to chemotherapeutic agents. AC019069.1 was shown to promote cell proliferation, decrease apoptosis, and maintain genome stability in UCEC cells.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Urology & Nephrology
Yu-Min Chou, Fei-Chi Chuang, Fu-Tsai Kung, Tsai-Hwa Yang, Ling-Ying Wu, Kuan-Hui Huang
Summary: This study demonstrated that sacrospinous ligament fixation (SSLF) is an effective surgical method for pelvic reconstruction using native tissue. Compared to concomitant hysterectomy, SSLF with uterine preservation reduces the anatomical recurrence rate, with shorter operation times and lower recurrence rates.
LUTS-LOWER URINARY TRACT SYMPTOMS
(2021)
Correction
Medicine, Research & Experimental
Woojin Kang, Yuichirou Harada, Kenji Yamatoya, Natsuko Kawano, Seiya Kanai, Yoshitaka Miyamoto, Akihiro Nakamura, Mami Miyado, Yoshiki Hayashi, Yoko Kuroki, Hidekazu Saito, Yasuhiro Iwao, Akihiro Umezawa, Kenji Miyado
LABORATORY INVESTIGATION
(2020)
Article
Medicine, Research & Experimental
Woojin Kang, Yuichirou Harada, Kenji Yamatoya, Natsuko Kawano, Seiya Kanai, Yoshitaka Miyamoto, Akihiro Nakamura, Mami Miyado, Yoshiki Hayashi, Yoko Kuroki, Hidekazu Saito, Yasuhiro Iwao, Akihiro Umezawa, Kenji Miyado
LABORATORY INVESTIGATION
(2020)
Editorial Material
Cell & Tissue Engineering
Mami Miyado, Woojin Kang, Natsuko Kawano, Kenji Miyado
REGENERATIVE THERAPY
(2019)
Article
Biochemistry & Molecular Biology
Daiki Sakaguchi, Kenji Miyado, Teruaki Iwamoto, Hiroshi Okada, Kaoru Yoshida, Woojin Kang, Miki Suzuki, Manabu Yoshida, Natsuko Kawano
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Multidisciplinary Sciences
Kenichi Kinjo, Keisuke Nagasaki, Koji Muroya, Erina Suzuki, Keisuke Ishiwata, Kazuhiko Nakabayashi, Atsushi Hattori, Koji Nagao, Ryu-Suke Nozawa, Chikashi Obuse, Kenji Miyado, Tsutomu Ogata, Maki Fukami, Mami Miyado
SCIENTIFIC REPORTS
(2020)
Review
Biochemistry & Molecular Biology
Mitsutoshi Yamada, Kazuhiro Akashi, Reina Ooka, Kenji Miyado, Hidenori Akutsu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Junki Kamiya, Woojin Kang, Keiichi Yoshida, Ryota Takagi, Seiya Kanai, Maito Hanai, Akihiro Nakamura, Mitsutoshi Yamada, Yoshitaka Miyamoto, Mami Miyado, Yoko Kuroki, Yoshiki Hayashi, Akihiro Umezawa, Natsuko Kawano, Kenji Miyado
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Woojin Kang, Miki Suzuki, Takako Saito, Kenji Miyado
Summary: The TCA cycle serves as the main source of cellular energy and its dysfunction related to human diseases, such as neurometabolic disorders and tumors, has attracted increasing interest. The distinct diseases resulting from loss or dysfunction of TCA cycle-related enzymes suggest each enzyme has a unique function. This review aims to provide a comprehensive overview of the relationship between each TCA cycle-related enzyme and human diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Kazunori Morohoshi, Takeo Yamazaki, Keiji Kito, Ban Sato, Woojin Kang, Taku Hibino, Manabu Yoshida, Kaoru Yoshida, Teruaki Iwamoto, Mitsutoshi Yamada, Kenji Miyado, Natsuko Kawano
Summary: In both men and women, pathogenic bacteria can enter the reproductive tract and cause harmful symptoms. Even in the absence of the majority of seminal proteins, antibacterial activity remains in the seminal plasma. Prostate and testis express a novel antibacterial protein, the sequence of which is broadly conserved across mammals.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Ban Sato, Seiya Kanai, Daiki Sakaguchi, Kodai Yajima, Yu Matsumoto, Kazunori Morohoshi, Shinji Kagaya, Nobuo Izumo, Minoru Ichinose, Woojin Kang, Mami Miyado, Kenji Miyado, Natsuko Kawano
Summary: LF supplementation ameliorates fertility problems in overweight mice but does not effectively reverse female infertility in obese mice.
Article
Nutrition & Dietetics
Woojin Kang, Eri Ishida, Mitsuyoshi Amita, Kuniko Tatsumi, Hitomi Yonezawa, Miku Yohtsu, Daiki Katano, Kae Onozawa, Erika Kaneko, Wakako Iwasaki, Natsuko Naito, Mitsutoshi Yamada, Natsuko Kawano, Mami Miyado, Ban Sato, Hidekazu Saito, Takakazu Saito, Kenji Miyado
Summary: This study reveals the link between autophagic decline and cumulus transformation, and suggests that autophagy maintains the healthy state of supporting cells of human oocytes by suppressing the formation of lysosomes.
Article
Chemistry, Physical
Yoshitaka Miyamoto, Yumie Koshidaka, Katsutoshi Murase, Shoichiro Kanno, Hirofumi Noguchi, Kenji Miyado, Takeshi Ikeya, Satoshi Suzuki, Tohru Yagi, Naozumi Teramoto, Shuji Hayashi
Summary: Establishing a rapid in vitro evaluation system is crucial for drug development. In recent years, microfabrication technology has been used to create in vitro 3D culture models that mimic the functions of living tissues and organs. This study examined the morphology of various nanoparticles and evaluated the liver function of heterospheroids labeled with different nanoparticles.
Article
Chemistry, Multidisciplinary
Thanawat Suwatthanarak, Masayoshi Tanaka, Yoshitaka Miyamoto, Kenji Miyado, Mina Okochi
Summary: The CD9-binding peptide inhibits cancer cell migration by targeting the overexpression of CD9 protein, showing promise as a novel precision antimigratory agent for cancer therapeutics.
CHEMICAL COMMUNICATIONS
(2021)
Article
Ophthalmology
Toshiro Iwagawa, Yuko Aihara, Daisy Umutoni, Yukihiro Baba, Akira Murakami, Kenji Miyado, Sumiko Watanabe
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)
Correction
Biology
Keita Sasaki, Kogiku Shiba, Akihiro Nakamura, Natsuko Kawano, Yuhkoh Satouh, Hiroshi Yamaguchi, Motohiro Morikawa, Daisuke Shibata, Ryuji Yanase, Kei Jokura, Mami Nomura, Mami Miyado, Shuji Takada, Hironori Ueno, Shigenori Nonaka, Tadashi Baba, Masahito Ikawa, Masahide Kikkawa, Kenji Miyado, Kazuo Inaba
COMMUNICATIONS BIOLOGY
(2019)
