Review
Pharmacology & Pharmacy
Li Zhang, Yue Liu, Haiyan Huang, Hui Xie, Baozhu Zhang, Wujiong Xia, Bing Guo
Summary: Malignant brain tumors are a group of tumors with high invasiveness and destructiveness, and near-infrared optical imaging techniques show potential in the diagnosis and treatment of brain tumors due to their noninvasiveness, high resolution, and large penetration depth.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Oncology
Masaki Kaibori, Hisashi Kosaka, Kosuke Matsui, Morihiko Ishizaki, Hideyuki Matsushima, Takumi Tsuda, Hidehiko Hishikawa, Tadayoshi Okumura, Mitsugu Sekimoto
Summary: The use of NIR fluorescence imaging in liver surgery has advanced significantly, with the development of novel nanoparticles showing promise in imaging cancer tissues and drug delivery. This technology has the potential to greatly impact the treatment of liver tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Si Yang, Chenxi Li, Hongyan Zhan, Rong Liu, Wenliang Chen, Xiaoli Wang, Kexin Xu
Summary: In this study, a label-free fluorescent biosensor for the detection of tetracycline (TET) was developed using specific aptamer-templated silver nanoclusters (AgNCs). The binding of TET to the aptamer led to a conformational change, resulting in the transformation of AgNCs into larger silver nanoparticles (AgNPs) and a decrease in fluorescence. The proposed biosensor exhibited high sensitivity and selectivity for TET detection in milk, with a limit of detection of 11.46 ng/mL and a linear range of 20 ng/mL-10 g/mL. These findings demonstrate the potential of the biosensor for quantitative determination of TET in food samples and expand the application of DNA-AgNCs in related fields.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Wataru Ishii, Yoshinori Okayasu, Yoichi Kobayashi, Rika Tanaka, Shohei Katao, Yoshiko Nishikawa, Takuya Nakashima, Tsuyoshi Kawai
Summary: The optical property of an ionic metal nanocluster (NC) is affected by the ionic interaction with counter ions. The modification of trianionic [Ag29(BDT)12(TPP)4]3- NC with silver(I) complexes led to intense photoluminescence (PL) in the near-infrared (NIR) region. The binding of silver(I) complexes to the peripheral region of Ag29 NC is confirmed by various measurements, and the change in excited-state dynamics by the binding is discussed.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Analytical
Qiang Li, Xiaomeng Zhou, Li-Li Tan, Li Shang
Summary: Ultrasmall gold nanoclusters (AuNCs) with distinct photoluminescence properties were effectively modulated by encapsulating them into zeolite imidazolate frameworks-8 (ZIF-8), resulting in enhanced near-infrared (NIR) fluorescence intensity. The AuNCs@ZIF-8 composites exhibited an emission maximum at 830 nm, longer than AuNCs without ZIF-8 encapsulation. This strategy was utilized for the detection of acetylcholinesterase (AChE) using a ratiometric fluorescent sensing platform, showing high sensitivity and good specificity in biological samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Julia Ackermann, Jan Stegemann, Tim Smola, Eline Reger, Sebastian Jung, Anne Schmitz, Svenja Herbertz, Luise Erpenbeck, Karsten Seidl, Sebastian Kruss
Summary: Optical nanosensors based on single-wall carbon nanotubes are able to capture the dynamics of biochemical processes. A one-step phase separation approach has been developed to isolate monochiral (6,4)-SWCNTs from mixed SWCNT samples, enabling high-resolution imaging in the near-infrared spectrum using standard Si-based cameras. (6,4)-SWCNTs modified with (GT)(10)-ssDNA become highly sensitive to the neurotransmitter dopamine, allowing for fast and high-resolution imaging of dopamine release from cells.
Article
Chemistry, Multidisciplinary
Ming-Yu Wu, Jong-Kai Leung, Chuen Kam, Tsu Yu Chou, Jia-Li Wang, Xueqian Zhao, Shun Feng, Sijie Chen
Summary: This study developed a near-infrared fluorescent probe named TBTCP for real-time imaging of phagocytosis. TBTCP could selectively label the cell plasma membrane and report the cell membrane statuses and macrophage phagocytosis through fluorescence lifetime changes. It provides a functional tool to study phagocytic function-related diseases.
SCIENCE CHINA-CHEMISTRY
(2022)
Article
Chemistry, Physical
Yixiao Li, Shaohua Qu, Yumeng Xue, Lianbing Zhang, Li Shang
Summary: A thorough understanding of antimicrobial mechanism is crucial for developing novel antibacterial agents. In this study, cationic bovine serum albumin-protected AuAgNCs were synthesized and their antimicrobial process was investigated in real-time using fluorescence imaging. The cBSA-AuAgNCs exerted their antimicrobial effects by attaching on the outer membrane of bacteria without obvious internalization. Mechanistically, the cationic NCs caused disruption to the bacterial membrane due to strong electrostatic interactions, leading to the accumulation of reactive oxygen species (ROS) and eventually bactericidal action.
Article
Chemistry, Analytical
Yan-Cai Gao, Chong Wang, Chun-Xia Zhang, Hong-Wei Li, Yuqing Wu
Summary: A controlled method for preparing Au-PtNCs with strong red and NIR emission has been established, which can be used as a novel ratiometric probe for Ag(I). This study provides a new approach for determining Ag(I) with high selectivity and potential application in serum.
Article
Chemistry, Physical
Zhifeng Cai, Liangliang Wu, Jierui Xi, Erxiao Hao, Kaifei Qi
Summary: In this study, silver nanoclusters were utilized as a nanosensor for fluorescence determination of curcumin. The fluorescence quenching mechanism between silver nanoclusters and curcumin was investigated, showing a linear relationship between fluorescence intensity and curcumin concentration. This novel platform could potentially expand the possibilities for a new fluorescence detection method.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Multidisciplinary
Yaowei Peng, Xiaoyu Huang, Fu Wang
Summary: Bi-metallic gold/silver nanoclusters with large Stokes shifts were synthesized using a one-pot method. The silver effect in the gold/silver nanoclusters results in strong NIR fluorescence, making it suitable for use as a two-photon fluorescent contrast agent for in vivo bioimaging.
CHEMICAL COMMUNICATIONS
(2021)
Review
Gastroenterology & Hepatology
Nan-Qing Shi, Xin-Yuan Cui, Cheng Zhou, Ning Tang, Da-Xiang Cui
Summary: Gastrointestinal cancers are a significant cause of cancer-related death. Near-infrared fluorescence imaging (NIRFI) technology has unique advantages in the early diagnosis of gastrointestinal tumors, identification of tumor margins, identification of lymph nodes, and assessment of anastomotic leakage.
GASTROENTEROLOGY REPORT
(2023)
Article
Chemistry, Physical
Junsheng Chen, Ajeet Kumar, Cecilia Cerretani, Tom Vosch, Donatas Zigmantas, Erling Thyrhaug
Summary: Due to desirable optical properties, such as efficient luminescence and large Stokes shift, DNA-templated silver nanoclusters (DNA-AgNCs) have received significant attention over the past decade. In this study, we investigate the early time relaxation dynamics of a 16-atom silver cluster (DNA-Ag16NC) with NIR emission and an unusually large Stokes shift. By using ultrafast optical spectroscopy, we extract a kinetic model to clarify the physical picture of the photoinduced dynamics, which can guide further research on the electronic structure and dynamics of these novel objects and their potential applications.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Engineering, Biomedical
Duo Zhao, Menghong Xu, Shiyuan Yang, Huide Ma, Huiwen Li, Rong Wu, Yu He, Shumin Wang, Xiaolong Liang
Summary: Axillary lymph node metastasis is considered the most important prognostic factor in the treatment of early breast cancer. The current examination methods for accurate diagnosis of early breast cancer with lymph node metastasis are inadequate. Targeted imaging of tumor-associated macrophages (TAM) enables noninvasive and sensitive detection of metastatic lymph nodes, providing valuable guidance for tumor therapy.
Article
Chemistry, Multidisciplinary
Anish Kumar Das, Sourav Biswas, Surya Sekhar Manna, Biswarup Pathak, Sukhendu Mandal
Summary: An atom-precise silver nanocluster was used as a platform to fabricate an artificial light-harvesting system with high energy transfer efficiency. The emission property of the nanocluster was controlled by surface molecular motion and beta-cyclodextrin. The fabricated system achieved a 93% energy transfer efficiency and efficient photocurrent generation.
Article
Nanoscience & Nanotechnology
Yihan Wang, Ke Huang, Zhaojian Qin, Jiayu Zeng, Ying Zhang, Lihong Yin, Xiaohui Liu, Hui Jiang, Xuemei Wang
Summary: With the deepening of cancer clinical research, miRNAs provide new ideas for molecular diagnosis and treatment of tumors. Improving the molecular delivery efficiency of miRNA is the key to the success of miRNA therapy. The study proposes a self-assembly diagnosis and treatment technology based on metal precursor-mediated tumor microenvironmental response, which can achieve accurate targeting and cargo delivery.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemical Research Methods
Weiwei Liu, Farouk Semcheddine, Hui Jiang, Xuemei Wang
Summary: In this study, a multifunctional nanocomposite was successfully synthesized, which could efficiently load an anticancer drug and had excellent cell imaging and photothermal functions. After modification with folic acid, the composite material could target tumor cells and showed a highly effective inhibitory effect against various tumor cells through a chemo-photothermal synergistic effect.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Engineering, Environmental
Tanziela Tanziela, Sana Shaikh, Fawad Ur Rehman, Farouk Semcheddine, Hui Jiang, Zuhong Lu, Xuemei Wang
Summary: Drug resistance is a major obstacle in cancer therapy. The emerging field of nanotechnology and exosomes as drug carriers offer promising strategies for effective and targeted delivery of therapeutic cargo to malignant sites. This study developed a bioresponsive self-assembly drug delivery platform using exosomes isolated from glioblastoma cells, which showed high cancer targeting and biocompatibility. These engineered exosomes can be used for early cancer diagnosis and have potential for targeted chemotherapy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Maonan Wang, Zengchao Guo, Jiayu Zeng, Liu Liu, Yihan Wang, Jinpeng Wang, Hongbing Lu, Haijun Zhang, Hui Jiang, Xuemei Wang
Summary: This study found that KRAS is highly expressed in pancreatic cancer tumors and is closely related to poor patient prognosis. A smart bio-responsive nanomedicine was proposed to target-deliver KRAS shRNA and achieve cancer cell diagnosis and treatment through a special oxidative stress-responsive effect.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Analytical
Xiawei Dong, Jing Ye, Yihan Wang, Hongjie Xiong, Hui Jiang, Hongbing Lu, Xiaohui Liu, Xuemei Wang
Summary: This study engineered ultra-small and metabolizable dual-mode imaging probe Au/Gd@FA NCs using a simple hydrothermal method, which showed superior properties compared to commercial MRI contrast agents. The probes exhibited high quantum yield, near-infrared fluorescence, and a better T-1 nuclear magnetic signal. By modifying the folic acid molecules, the probes achieved specific fluorescence imaging of breast cancer. Moreover, the probes were deemed safe and could promote intracellular ROS production and induce cell apoptosis. This metabolizable probe provides a potential candidate for multimodal imaging and tumor diagnosis in basic research.
Article
Chemistry, Analytical
Jincheng Li, Zengchao Guo, Tengfei Liu, Fangfang Yu, Jiayu Zeng, Ying Zhang, Lihong Yin, Xiaohui Liu, Hui Jiang, Xuemei Wang
Summary: Carbon dots (CDs) are a promising class of carbon-based luminescence materials with good dispersity, stability, low toxicity, and biocompatibility. This study successfully synthesized folic acid-modified cerium-doped CDs (Ce-CDs-FA) using a facile one-step hydrothermal method and demonstrated their potential as a sensitive fluorescent nanoprobe for cancer cell detection. Additionally, the Ce-CDs-FA nanocomposites showed a specific and hypersensitive quenching effect for Fe3+ ions, offering a possibility for the detection of iron ions.
Article
Engineering, Environmental
Zengchao Guo, Jiang Xiao, Weiwei Liu, Yihan Wang, Tengfei Liu, Hui Jiang, Xiaohui Liu, Xuemei Wang
Summary: Researchers have developed a multimode and broad-spectrum antimicrobial system based on cationic polypeptides and in situ self-assembled strategy. This system can effectively kill bacteria under irradiation and demonstrates high biocompatibility.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Hao Liu, Zhiming Liu, Yihan Wang, Jiang Xiao, Xiaohui Liu, Hui Jiang, Xuemei Wang
Summary: The biomineralization of tunable gold nanocrystals with in situ protein coronas by intracellular liquid-liquid phase separation (LLPS) was achieved for in situ molecule surface-enhanced Raman spectrum (SERS) analysis and tumor fluorescence identification. Anisotropic gold nanocrystals were obtained by regulating LLPS, allowing for directional growth and differentiation of clinical tumor tissue samples. This study reveals the mechanism of intracellular tunable nanocrystal biomineralization and provides the basis for its biomedical application.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Analytical
Jinpeng Wang, Qingxiu Xia, Ke Huang, Lihong Yin, Hui Jiang, Xiaohui Liu, Xuemei Wang
Summary: In this study, an ultrafast, specific, and accurate cancer cell imaging strategy based on dynamically self-assembling fluorescent nanoclusters was developed. It can rapidly and accurately distinguish lung cancer cells from normal cells within 1 minute, and has been validated in alveolar lavage fluid samples from lung cancer patients. This strategy provides a safe and promising cancer diagnostic platform for cancer therapy.
Article
Engineering, Environmental
Yi Han Wang, Ke Huang, Zhao Jian Qin, Hong Jie Xiong, Teng Fei Liu, Ting Ya Wang, Xiang Dong Lai, Xiao Hui Liu, Hui Jiang, Xue Mei Wang
Summary: In this study, a unique cancer microenvironment responsive bioreactor was constructed to form fluorescent and magnetic nanocomposites of the Au&Fe3O4-DNA complexes in situ. The Au&Fe3O4-DNA complexes efficiently inhibited tumor growth by consuming intracellular glutathione, inducing oxidative stress injury and activating apoptosis. Moreover, this system allowed enhanced photothermal therapy under near-infrared light irradiation, providing a promising approach for cancer early diagnosis and efficient treatment.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Analytical
Xinyi Xu, Xuemei Wang, Hui Jiang
Summary: This review focuses on the promoting effect of biosensing technology on the diagnosis and treatment of diabetes mellitus. The types of diabetes and their corresponding pathogeneses are introduced, followed by the diabetes prevalence and research progress at home and abroad. Breakthrough technology based on biosensing technology in the field of diabetes diagnosis and treatment is summarized. Diversified ways of blood glucose detection and multiple combinations of diabetes biomarkers are discussed for diagnosis, while various insulin administration routes and non-drug treatment means are presented for treatment. The prospect of the future development of diabetes diagnosis and treatment is put forward at the end of the review.
Review
Chemistry, Multidisciplinary
Hongjie Xiong, Liu Liu, Xiaohui Liu, Hui Jiang, Xuemei Wang
Summary: Aptamers have excellent molecule-targeting ability and are promising candidates for cancer immunotherapy due to their advantages over monoclonal antibodies. By combining tumor- and immune cell-targeting aptamers, multivalent bispecific aptamers were designed to enhance immune efficacy. Aptamers can also be combined with nanomaterials and immune cells, showing potential in targeted cargo delivery, regulation of cell-cell interactions, and tumor immunogenicity activation.
CHEMISTRY-SWITZERLAND
(2023)
Article
Materials Science, Multidisciplinary
Haiming Gao, Zhaojian Qin, Yihan Wang, Hongjie Xiong, Xuemei Wang, Hui Jiang
Summary: This study demonstrates the role of hydroxypropyl-fl-cyclodextrin (HP -fl-CD) in directing the self-assembly of dipeptide-protected gold nano-clusters (Ac-CG-Au NCs) into 1-D assemblies. The resulting assemblies exhibit enhanced stability and higher charge transfer efficiency, leading to a 2-fold larger photoluminescence quantum yield compared to Ac-CG-Au NCs. The pH-sensitive emission of the 1-D assemblies makes them suitable for selective labeling of lysosomes in HeLa cells, providing a potential tool for subcellular trafficking observation.
ACS MATERIALS LETTERS
(2022)
Review
Engineering, Biomedical
Tanziela Tanziela, Xiawei Dong, Jing Ye, Zengchao Guo, Hui Jiang, Zuhong Lu, Xiaohui Liu, Xuemei Wang
Summary: Exosomes, as natural nanocarriers, have shown great potential in the field of nanomedicine. They can be engineered or modified with different therapeutic substances to improve their specificity, efficiency, and safety in cancer therapy.
PROGRESS IN BIOMEDICAL ENGINEERING
(2022)
Article
Chemistry, Analytical
Fangfang Yu, Yihan Wang, Tengfei Liu, Xiaohui Liu, Hui Jiang, Xuemei Wang
Summary: Hypochlorite plays an important role in biological systems and daily life. A new method for the detection of hypochlorite in living cells was developed using EY/UiO-66-NH2 as a self-calibrating sensing nanoprobe. The EY/UiO-66-NH2 probe exhibited a wide linear range, low detection limit, turn-on fluorescence, and ratiometric response, making it advantageous over previously reported probes.