期刊
SCIENTIFIC REPORTS
卷 4, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/srep04273
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资金
- European Research Council (ERC) Starting Independent Researcher Grant [278212]
- National Science Foundation (NSF) Cyber-Enabled Discovery and Innovation (CDI) [OIA-1028394]
- Serbian Ministry of Education and Science [III44006]
- Israel Science Foundation [241/11]
- Office Of The Director
- Office of Integrative Activities [1028394] Funding Source: National Science Foundation
The topology behind biological interaction networks has been studied for over a decade. Yet, there is no definite agreement on the theoretical models which best describe protein-protein interaction (PPI) networks. Such models are critical to quantifying the significance of any empirical observation regarding those networks. Here, we perform a comprehensive analysis of yeast PPI networks in order to gain insights into their topology and its dependency on interaction-screening technology. We find that: (1) interaction-detection technology has little effect on the topology of PPI networks; (2) topology of these interaction networks differs in organisms with different cellular complexity (human and yeast); (3) clear topological difference is present between PPI networks, their functional sub-modules, and their inter-functional linkers;(4) high confidence PPI networks have more geometrical topology compared to predicted, incomplete, or noisy PPI networks; and (5) inter-functional linker proteins serve as mediators in signal transduction, transport, regulation and organisational cellular processes.
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