Membrane Driven Spatial Organization of GPCRs

The cost of living in the membrane: A case study of hydrophobic mismatch for the multi-segment protein LeuT

(2013) Sayan Mondal et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Asymmetry of the rhodopsin dimer in complex with transducin

(2013) Beata Jastrzebska et al.   FASEB JOURNAL

The rhodopsin-transducin complex houses two distinct rhodopsin molecules

(2013) Beata Jastrzebska et al.   JOURNAL OF STRUCTURAL BIOLOGY

Crystal structure of oligomeric β1-adrenergic G protein–coupled receptors in ligand-free basal state

(2013) Jianyun Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure-Function of the G Protein–Coupled Receptor Superfamily

(2012) Vsevolod Katritch et al.   Annual Review of Pharmacology and Toxicology

Rhodopsin Forms a Dimer with Cytoplasmic Helix 8 Contacts in Native Membranes

(2012) Adam M. Knepp et al.   BIOCHEMISTRY

Improved Parameters for the Martini Coarse-Grained Protein Force Field

(2012) Djurre H. de Jong et al.   Journal of Chemical Theory and Computation

Why GPCRs behave differently in cubic and lamellar lipidic mesophases

(2012) George Khelashvili et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Determinants of the Supramolecular Organization of G Protein-Coupled Receptors in Bilayers

(2012) Xavier Periole et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization

(2012) D. Calebiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessing the Relative Stability of Dimer Interfaces in G Protein-Coupled Receptors

(2012) Jennifer M. Johnston et al.   PLoS Computational Biology

Ligand-Dependent Conformations and Dynamics of the Serotonin 5-HT2A Receptor Determine Its Activation and Membrane-Driven Oligomerization Properties

(2012) Jufang Shan et al.   PLoS Computational Biology

Making Structural Sense of Dimerization Interfaces of Delta Opioid Receptor Homodimers

(2011) Jennifer M. Johnston et al.   BIOCHEMISTRY

Quantitative Modeling of Membrane Deformations by Multihelical Membrane Proteins: Application to G-Protein Coupled Receptors

(2011) Sayan Mondal et al.   BIOPHYSICAL JOURNAL

Full characterization of GPCR monomer–dimer dynamic equilibrium by single molecule imaging

(2011) Rinshi S. Kasai et al.   JOURNAL OF CELL BIOLOGY

Multiple ligand-specific conformations of the β2-adrenergic receptor

(2011) Alem W Kahsai et al.   Nature Chemical Biology

Lessons from Free Energy Simulations of δ-Opioid Receptor Homodimers Involving the Fourth Transmembrane Helix

(2010) Davide Provasi et al.   BIOCHEMISTRY

Contribution of Membrane Elastic Energy to Rhodopsin Function

(2010) Olivier Soubias et al.   BIOPHYSICAL JOURNAL

Cholesterol Modulates the Membrane Effects and Spatial Organization of Membrane-Penetrating Ligands for G-Protein Coupled Receptors

(2010) George Khelashvili et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Formation and dissociation of M1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules

(2010) J. A. Hern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPCR Dimers Fall Apart

(2010) N. A. Lambert   Science Signaling

Constitutive Dimerization of the G-Protein Coupled Receptor, Neurotensin Receptor 1, Reconstituted into Phospholipid Bilayers

(2009) Peter J. Harding et al.   BIOPHYSICAL JOURNAL

Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer

(2009) Juan José Fung et al.   EMBO JOURNAL

Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes

(2009) J. A. Lundbaek et al.   Journal of the Royal Society Interface

Instability of a Class A G Protein-Coupled Receptor Oligomer Interface

(2009) J. M. Fonseca et al.   MOLECULAR PHARMACOLOGY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation

(2009) Yang Han et al.   Nature Chemical Biology

Analysis of receptor oligomerization by FRAP microscopy

(2009) Sandra Dorsch et al.   NATURE METHODS

Energetics of Hydrophobic Matching in Lipid-Protein Interactions

(2008) Derek Marsh   BIOPHYSICAL JOURNAL

The MARTINI Coarse-Grained Force Field: Extension to Proteins

(2008) Luca Monticelli et al.   Journal of Chemical Theory and Computation

Lipid−Rhodopsin Hydrophobic Mismatch Alters Rhodopsin Helical Content

(2008) Olivier Soubias et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of a β1-adrenergic G-protein-coupled receptor

(2008) Tony Warne et al.   NATURE

Identification of a serotonin/glutamate receptor complex implicated in psychosis

(2008) Javier González-Maeso et al.   NATURE

A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

(2008) Michael A. Hanson et al.   STRUCTURE