Article
Cell Biology
Wei Zeng, Jin-Feng Zhu, Jian Guo, Gen-Jie Huang, Li-Sha Ai, Yu Zeng, Wang-Jun Liao
Summary: This study found that circFNDC3B plays a tumor-suppressing role in CRC by inhibiting stemness and metastasis through ASB6 degradation. Regulation of ASB6 and RNF41 has crucial impact on survival and metastasis in CRC.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Santosh Phuyal, Elena Djaerff, Anabel-Lise Le Roux, Martin J. Baker, Daniela Fankhauser, Sayyed Jalil Mahdizadeh, Veronika Reiterer, Amirabbas Parizadeh, Edward Felder, Jennifer C. Kahlhofer, David Teis, Marcelo G. Kazanietz, Stephan Geley, Leif Eriksson, Pere Roca-Cusachs, Hesso Farhan
Summary: Mechanical strain induces the formation of ER exit sites and accelerates ER-to-Golgi trafficking. Impaired ER exit sites function results in reduced ability of cells to expand their surface area under mechanical stress and increases susceptibility to plasma membrane defects. Rac1 plays a crucial role in linking mechanical strain to ER export.
Article
Oncology
Fangyuan Zhou, Haiyang Gao, Luorui Shang, Jinxiao Li, Mengqi Zhang, Shuhan Wang, Runze Li, Lin Ye, Shenglan Yang
Summary: Traditional Chinese medicine therapy has a unique effect in prolonging survival time and improving the prognosis of patients with colorectal cancer. Oridonin has anti-cancer effects, possibly through inducing ER stress, upregulating TP53, and inhibiting TCF4 transactivation in colorectal cancer cells.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Kaisa Cui, Liang Gong, Han Zhang, Ying Chen, Bingxin Liu, Zhicheng Gong, Jiuming Li, Yuanben Wang, Shengbai Sun, Yajun Li, Qiang Zhang, Yulin Cao, Qilin Li, Bojian Fei, Zhaohui Huang
Summary: This study reveals that the RNA exosome gene (EXOSC8) promotes colorectal cancer (CRC) tumorigenesis by regulating cancer-related ribosome biogenesis in CRC. Silencing of EXOSC8 decreases levels of nucleolar proteins and proliferation markers, as well as rRNA/DNA and global protein syntheses. EXOSC8 knockdown triggers ribosomal stress, releasing nucleolar protein RPL5/11 into the nucleoplasm and hijacking Mdm2 to block its E3 ubiquitin ligase function, thereby releasing and activating p53. EXOSC8 may serve as a potential therapeutic target in CRC.
Article
Cell Biology
Yuan Dong, Wenhong Xu, Da Qi, Huinan Qu, Qiu Jin, Minghao Sun, Xudong Wang, Chengshi Quan
Summary: This study found that low expression of CLDN6 in colorectal cancer (CRC) patients was associated with pathological grade and prognosis, and CLDN6 inhibited CRC proliferation through the PTEN/AKT/MDM2 pathway by regulating ubiquitination to enhance p53 stability and nuclear import. These findings enrich the theoretical basis for CLDN6 as a potential biomarker for diagnosis, therapy, and prognosis of CRC.
CELLULAR SIGNALLING
(2023)
Article
Pharmacology & Pharmacy
Xiaojing Fu, Wenwen Zhao, Kangkang Li, Jingyi Zhou, Xuehong Chen
Summary: The study reveals the anticancer effects of cryptotanshinone (CPT) in colorectal cancer (CRC) by activating autophagy signaling mediated by ER stress. CPT selectively inhibits the growth and proliferation of HCT116 and SW620 cells while having little effect on SW480 cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Youngsic Jeon, Taejung Kim, Hyukjoon Kwon, Jeong-Kook Kim, Young-Tae Park, Jungyeob Ham, Young-Joo Kim
Summary: This study provides evidence that the combination treatment of cabozantinib and CBD leads to increased apoptosis in HCC cells. This enhanced apoptosis is mediated, at least in part, through the induction of ER stress and subsequent activation of the p53 pathway. However, there is no association found between the combination treatment and CNR.
Article
Cell & Tissue Engineering
Panida Sittipo, Hyun Kyu Kim, Jaeseok Han, Man Ryul Lee, Yun Kyung Lee
Summary: Vitamin D-3 enhances differentiation of intestinal epithelial cells into specialized lineages while suppressing intestinal cell stemness and promoting apoptotic cell death. Additionally, it inhibits the formation of crypt-villus structure and upregulates unfolded protein response genes, ultimately leading to ER stress activation.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, Research & Experimental
Iwao Shimomura, Naoaki Watanabe, Tomofumi Yamamoto, Minami Kumazaki, Yuji Tada, Koichiro Tatsumi, Takahiro Ochiya, Yusuke Yamamoto
Summary: The study found that verteporfin can effectively inhibit the viability of KRAS-mutant lung cancer cells and suppress KRAS-driven lung tumors. The mechanism of verteporfin action is partially independent of YAP1 inhibition and leads to apoptotic cell death in KRAS-mutant lung cancer cells by inducing endoplasmic reticulum stress pathway.
Article
Biochemistry & Molecular Biology
Ling Ding, Yuning Yang, Qin Lu, Dongfeng Qu, Parthasarathy Chandrakesan, Hailan Feng, Hong Chen, Xuzheng Chen, Zhuhui Liao, Jian Du, Zhiyun Cao, Nathaniel Weygant
Summary: This study investigates the function and mechanism of bufalin against colorectal cancer stemness. The results demonstrate that bufalin inhibits CRC stemness by targeting the C-Kit/Slug signaling axis, leading to inhibited CRC growth and progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yuhan Chang, Juan Zhang, Xinying Huo, Xinliang Qu, Chunlei Xia, Kaizong Huang, Fuyang Xie, Nuofan Wang, Xiaowei Wei, Qiong Jia
Summary: In this study, it is found that the F-actin regulator CRAD plays a negative role in the progression, stemness, and metastasis of colorectal cancer. Mechanistically, decreased CRAD in soft substrates enhances the stemness and metastasis potential of colorectal cancer by affecting the localization of YAP and the expression of stemness markers. Furthermore, CRAD deficiency also promotes colorectal tumor cell softening and epithelial-mesenchymal transition, contributing to its metastasis potential.
Article
Oncology
Changhong Li, Kui Zhang, Guangzhao Pan, Haoyan Ji, Chongyang Li, Xiaowen Wang, Xin Hu, Ruochen Liu, Longfei Deng, Yi Wang, Liqun Yang, Hongjuan Cui
Summary: DEH inhibits cell growth in colorectal cancer by arresting the cell cycle and inducing cellular autophagy. Additionally, it activates endoplasmic reticulum stress pathways, suggesting its potential as an anticancer agent by inhibiting autophagy.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Correction
Medicine, General & Internal
Zhijie Gao, Helei Wang, Bo Zhang, Xuemei Wu, Yanfeng Zhang, Pengfei Ge, Guangfan Chi, Jianmin Liang
Summary: The authors regret dividing the blots from the same group of samples into multiple images and using the same beta-actin. They acknowledge the improper use and plan to merge the relevant images into one.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Hematology
Elena Tonc, Yoshiko Takeuchi, Chun Chou, Yu Xia, Melanie Holmgren, Chika Fujii, Saravanan Raju, Gue Su Chang, Masahiro Iwamoto, Takeshi Egawa
Summary: The study reveals the essential role of c-MYC in B cell proliferation and its involvement in tumor suppression through TFAP4, providing protection against the transformation of developing B cells.
Article
Biochemistry & Molecular Biology
Rochelle Fletcher, Jingshan Tong, Denise Risnik, Brian J. Leibowitz, Yi-Jun Wang, Fernando Concha-Benavente, Jonathan M. DeLiberty, Donna B. Stolz, Reet K. Pai, Robert L. Ferris, Robert E. Schoen, Jian Yu, Lin Zhang
Summary: The study reveals that NSAIDs induce endoplasmic reticulum stress and activate BID protein to suppress tumor formation, and the immunogenic cell death effect induced by NSAIDs plays a crucial role in tumor suppression.
Article
Gastroenterology & Hepatology
Tsung-Hsien Chiang, Yen-Nien Chen, Yi-Ru Chen, Yu-Hua Tseng, Chun-Fu Shieh, Cheng-Ying Liu, Han-Mo Chiu, Hung Chiang, Chia-Tung Shun, Ming-Shiang Wu, Jaw-Town Lin, Yi-Chia Lee
Summary: This study demonstrates the effectiveness of PG testing for mass screening after eradication of H. pylori. Tests from different manufacturers, even using different analytical methods and cutoff criteria, can perform equivalently.
BMC GASTROENTEROLOGY
(2022)
Article
Clinical Neurology
Chin-Hsien Lin, Han-Yi Lin, En-Pong Ho, Yi-Ci Ke, Mei-Fang Cheng, Chyng-Yann Shiue, Chi-Han Wu, Peng-Hsiang Liao, Angela Yu-Huey Hsu, Li-An Chu, Ya-Ding Liu, Ya-Hui Lin, Yi-Cheng Tai, Chia-Tung Shun, Han-Mo Chiu, Ming-Shiang Wu
Summary: The study found that LRRK2 G2019S mice are more susceptible to DSS-induced colitis, with increased inflammation and neuronal loss. TNF-alpha plays a detrimental role in the gut-brain axis of PD.
MOVEMENT DISORDERS
(2022)
Letter
Clinical Neurology
Chin-Hsien Lin, Han-Yi Lin, En-Pong Ho, Yi-Ci Ke, Mei-Fang Cheng, Chyng-Yann Shiue, Chi-Han Wu, Peng-Hsiang Liao, Angela Yu-Huey Hsu, Li-An Chu, Ya-Ding Liu, Ya-Hui Lin, Yi-Cheng Tai, Chia-Tung Shun, Han-Mo Chiu, Ming-Shiang Wu
MOVEMENT DISORDERS
(2022)
Article
Geriatrics & Gerontology
Peng-Hsiang Liao, Han-Lin Chiang, Chia-Tung Shun, Jen-Fan Hang, Han-Mo Chiu, Ming-Shiang Wu, Chin-Hsien Lin
Summary: This study investigated the expression of LRRK2 in colonic biopsies obtained from PD patients and healthy controls. The results showed that the fraction of LRRK2-positive cells was significantly higher in PD patients compared to controls, and individuals with LRRK2 genetic variants had higher colonic LRRK2 immunoreactivity. LRRK2 expression correlated with disease severity, and PD patients in the prodromal phase had a faster increase in colonic LRRK2 expression.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Oncology
Li-Hsin Cheng, Chung-Chi Hsu, Hung-Wen Tsai, Wen-Ying Liao, Pei-Ming Yang, Tai-Yan Liao, Hsiao-Yen Hsieh, Tze-Sian Chan, Kelvin K. Tsai
Summary: Small cell lung cancer (SCLC) is a highly aggressive and deadly tumor. The upregulation of neurogenesis-associated protein ASPM-I1 is found in SCLC cells and is associated with poor patient prognosis. ASPM-I1 plays a crucial role in maintaining SCLC stemness and tumorigenesis through the regulation of multiple pathways and the Wnt signaling pathway.
Article
Gastroenterology & Hepatology
Yu-Ting Kuo, Yu-Long Chu, Weng-Fai Wong, Ming-Lun Han, Chieh-Chang Chen, I-Shiow Jan, Wern-Cherng Cheng, Chia-Tung Shun, Ming-Chang Tsai, Tsu-Yao Cheng, Hsiu-Po Wang
Summary: This study compared two different sampling strategies for EUS-FNB and found that there was no significant difference in diagnostic accuracy between the fanning technique and contrast guidance. Therefore, the fanning technique may be a preferable option.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Jyh-Ming Liou, Xiao-Tao Jiang, Chieh-Chang Chen, Jiing-Chyuan Luo, Ming-Jong Bair, Po-Yueh Chen, Chu-Kuang Chou, Yu-Jen Fang, Mei-Jyh Chen, Chien-Chuan Chen, Ji-Yuh Lee, Tsung-Hua Yang, Chien-Chun Yu, Chia-Chi Kuo, Min-Chin Chiu, Chi-Yi Chen, Chia-Tung Shun, Wen-Hao Hu, Min-Horn Tsai, Yao-Chun Hsu, Cheng-Hao Tseng, Chi-Yang Chang, Jaw-Town Lin, Emad M. El-Omar, Ming-Shiang Wu
Summary: This study compared the effectiveness, tolerability, and short-term and long-term effects of levofloxacin-based sequential quadruple therapy and bismuth-based quadruple therapy as second-line regimens for Helicobacter pylori eradication. The results showed no significant difference between the two therapies in terms of eradication rate, antibiotic resistome, fecal microbiota composition, and metabolic parameters.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Li-Chun Chang, Chi-Yang Chang, Chi-Yi Chen, Cheng-Hao Tseng, Peng-Jen Chen, Chia-Tung Shun, Wen-Feng Hsu, Yen-Nien Chen, Chieh-Chang Chen, Tien-Yu Huang, Chia-Hung Tu, Mei-Jyh Chen, Chu-Kuang Chou, Ching-Tai Lee, Po-Yueh Chen, Ming-Shiang Wu, Han-Mo Chiu
Summary: In this multicenter randomized controlled study, it was found that cold snare polypectomy significantly reduces the risk of delayed postpolypectomy bleeding, including severe events, compared to hot snare polypectomy in the general population.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Sze-Kwan Lin, Han-Wei Wang, Chia-Tung Shun, Cheng-Ning Yang, Chi-Yuan Hong, Eddie Hsiang-Hua Lai, Shih-Jung Cheng, Mu-Hsiung Chen, Hsiang Yang, Hung-Ying Lin, Fang-Yu Wu, Sang-Heng Kok
Summary: The study indicated that the benefits of SIRT6 to inflammatory arthritis and bone resorption are at least partially derived from its modulation of the CREB/CCN1/COX2 pathway in osteoblasts.
JOURNAL OF BONE AND MINERAL METABOLISM
(2023)
Article
Dentistry, Oral Surgery & Medicine
Chi-Yuan Hong, Sze-Kwan Lin, Han-Wei Wang, Chia-Tung Shun, Cheng-Ning Yang, Eddie Hsiang-Hua Lai, Shih-Jung Cheng, Mu-Hsiung Chen, Hsiang Yang, Hung-Ying Lin, Fang-Yu Wu, Sang-Heng Kok
Summary: The study demonstrates that metformin promotes osteoblast differentiation and reduces osteoclast formation, thereby alleviating bone resorption in apical periodontitis. These findings support the role of metformin as an effective medication for treating inflammatory bone diseases.
JOURNAL OF ENDODONTICS
(2023)
Article
Medicine, Research & Experimental
Hsiang-Po Huang, Chung-Hsin Chen, Kai-Hsiung Chang, Ming-Shyue Lee, Cheng-Fan Lee, Yen-Hsiang Chao, Shih-Yu Lu, Tzu-Fan Wu, Sung-Tzu Liang, Chih-Yu Lin, Yuan Chi Lin, Shih-Ping Liu, Yu-Chuan Lu, Chia-Tung Shun, William J. Huang, Tzu-Ping Lin, Ming-Hsuan Ku, Hsiao-Jen Chung, Yen-Hwa Chang, Chun-Hou Liao, Chih-Chin Yu, Shiu-Dong Chung, Yao-Chou Tsai, Chia-Chang Wu, Kuan-Chou Chen, Chen-Hsun Ho, Pei-Wen Hsiao, Yeong-Shiau Pu
Summary: This study aimed to develop urine tests to predict potentially lethal prostate cancer, and successfully constructed four predictive models using metabolomic profiling. By combining urine metabolic markers with clinical factors, these models showed high accuracy in predicting clinically significant PC and could potentially reduce unnecessary biopsies by up to 50%.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Yao-Yu Hsieh, Jia-Ling Du, Pei-Ming Yang
Summary: By employing a gene expression-based drug repositioning strategy, this study identifies VU-0365114 as a novel type of tubulin inhibitor with broad-spectrum anticancer activity, especially in colorectal cancer cells. It is not limited by multidrug resistance proteins and does not exhibit significant off-target effects.
MOLECULAR ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Mei-Jyh Chen, Po-Yueh Chen, Yu-Jen Fang, Ming-Jong Bair, Chieh-Chang Chen, Chien-Chuan Chen, Tsung-Hua Yang, Ji-Yuh Lee, Chien-Chun Yu, Chia-Chi Kuo, Min-Chin Chiu, Chu-Kuang Chou, Chi-Yi Chen, Wen-Hao Hu, Min-Horn Tsai, Yao-Chun Hsu, Chia-Tung Shun, Jiing-Chyuan Luo, Jaw-Town Lin, Emad M. El-Omar, Ming-Shiang Wu, Jyh-Ming Liou
Summary: This study compared the efficacy and safety of molecular testing-guided therapy and traditional culture-based susceptibility testing-guided therapy for H pylori infection in first-line and third-line treatment. The results showed that molecular testing-guided therapy was similar to susceptibility testing-guided therapy in both first-line and third-line treatment, indicating its potential use for H pylori eradication.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Cheng-Hsuan Tsai, An -Li Yu, Yuan-Kun (Aden) Wu, Mao -Yuan Su, Mei -Fang Cheng, Chia -Hung Chou, Chia -Tung Shun, Hsueh-Wen Hsueh, Jimmy Jyh-Ming Juang, Ming -Jen Lee, Ping-Huei Tseng, Sung -Tsang Hsieh, Chi-Chao Chao, Yen-Hung Lin
Summary: This study aimed to investigate the efficacy of tafamidis in patients with hereditary A97S ATTR-CM after 6 months of treatment. The results showed that the patients had decreased levels of NT-proBNP after 6 months of tafamidis treatment, especially in those with more severe cardiac involvement.
ACTA CARDIOLOGICA SINICA
(2023)
Letter
Cardiac & Cardiovascular Systems
An-Li Yu, Cheng-Hsuan Tsai, Chi-Chao Chao, Chia-Tung Shun, Yen-Hung Lin
ACTA CARDIOLOGICA SINICA
(2022)
