Article
Cell Biology
Xiaoli Wang, Fei Fang, Yinghao Ni, Hongchi Yu, Jia Ma, Li Deng, Chunli Li, Yang Shen, Xiaoheng Liu
Summary: In this study, it was found that VEC migration and adhesion together contributed to a percentage of endothelial recovery in different models, with migration being more dominant in flat and groove models. As the injury scales increased, the contribution of circulating VEC adhesion to endothelial repair also increased. This suggests the importance of both migration and adhesion in re-endothelialization, providing insights for surface modification of cardiovascular implants.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Lingchuang Bai, Yahui Wang, Jia Xie, Yuan Zhao, Shaokang Guan
Summary: Biodegradable magnesium alloy stents have great potential in treating cardiovascular diseases. However, surface modifications are needed to improve the corrosion resistance and biocompatibility. In this study, a fucoidan-based coating was developed to enhance the performance of magnesium alloy stents, including corrosion resistance, hemocompatibility, and endothelialization.
MATERIALS & DESIGN
(2023)
Article
Engineering, Biomedical
Xuefang Hao, Weiwei Gai, Feng Ji, Jiadi Zhao, Dandan Sun, Fan Yang, Haixia Jiang, Yakai Feng
Summary: The development of platelet membrane cloaked gene complexes based on natural bovine serum albumin and polyethyleneimine has shown promising results in promoting VEGF expression in vascular endothelial cells, enhancing migration and proliferation of VECs, and inhibiting neointimal hyperplasia.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Jiajie Liu, Dian Chen, Xiaoqiang Zhu, Nan Liu, Haibo Zhang, Rui Tang, Zhengni Liu
Summary: This study developed a 1.8-mm-diameter vascular graft composed of a decellularized human amniotic membrane (HAM) and polycaprolactone/silk fibroin composite. In vitro and in vivo experiments demonstrated that the bioengineered graft promoted rapid endothelialization, resisted collagen deposition, and maintained patency with a stable remodeling structure. The findings suggest the potential application of this graft for small-diameter vascular regeneration.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Multidisciplinary
Elisabetta Rosellini, Niccoletta Barbani, Luigi Lazzeri, Maria Grazia Cascone
Summary: The study aimed to produce and characterize small caliber biomimetic and bioactive tubular scaffolds for vascular tissue engineering. The scaffolds, made from a gelatin/gellan/elastin blend using a specially designed mold, showed good porosity and potential for cell infiltration and proliferation.
Article
Materials Science, Multidisciplinary
Dongxu Qiu, Jun Yin, Yanbin Wen, Jiabing Huang, Ting Lei, Changqing Chen, Jian Xia
Summary: This study investigated the effects of diabetes on the degradation of bioresorbable iron stents. The results showed that under hyperglycemic conditions, the degradation of iron stents increased, negatively affecting mechanical support properties and the biocompatibility of endothelial cells. It also promoted inflammatory responses. This is the first study to reveal the biological profile of iron stent degradation under hyperglycemic conditions.
MATERIALS & DESIGN
(2023)
Article
Materials Science, Multidisciplinary
Bob S. L. Lee, Nianji Yang, Miguel Santos, Matthew J. Moore, Angus J. Grant, Jun-Hyeog Jang, Behnam Akhavan, Marcela M. Bilek, Richard P. Tan, Steven G. Wise
Summary: Complete and rapid endothelialization is crucial for the performance of synthetic vascular grafts. In this study, a functionalization approach using a recombinant form of VE-Cad (VEtr) was developed to promote endothelial attachment, spreading, and proliferation. The results showed that VEtr-functionalized scaffolds exhibited enhanced endothelialization and reduced thrombosis and neointimal hyperplasia, indicating the potential of VEtr functionalization in improving the long-term performance of synthetic vascular grafts.
MATERIALS TODAY ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Ling-Yu Li, Zhou Yang, Xiang-Xiang Pan, Bo-Xuan Feng, Rui Yue, Bo Yu, Yu-Feng Zheng, Jin-Yun Tan, Guang-Yin Yuan, Jia Pei
Summary: The use of copper-incorporated coating system improves the biocompatibility and corrosion resistance of biodegradable magnesium-based scaffolds, facilitating vascular cell regeneration and enhancing biological outcomes.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Materials Science, Biomaterials
Dong Yeop Lee, Yongwoo Jang, Eunyoung Kim, Tao Li, Seon Jeong Kim
Summary: The tissue-engineered vascular graft (TEVG) is a promising alternative for small-diameter blood vessel replacement, and a bioresorbable polyglycolic acid (PGA) fiber-knitted tubular scaffold shows potential as a flexible and durable support for vascular cells. The PGA tubular knit serves as a porous three-dimensional matrix for cell attachment and growth, and it can withstand mechanical damage and maintain suturability.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Cell Biology
Yi Si, Fei Liu, Dongqing Wang, Chao Fang, Xiao Tang, Baolei Guo, Zhenyu Shi, Zhihui Dong, Daqiao Guo, Jianing Yue, Weiguo Fu
Summary: In this study, miR-185 was transferred from VSMCs to ECs via exosomes, modulated by hnRNPA2B1, impairing re-endothelialization after vascular injury.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Jing Zhao, Yi Li, Meiyu Wang, Xumin Chen, Deling Kong, Kai Wang, Yakai Feng
Summary: Gene transfection enhances the proliferation and migration of endothelial cells, accelerating the formation of the endothelium layer, offering an effective treatment for small-caliber artificial vascular grafts. The MMP-responsive gene delivery system can smartly release genes to promote vascular graft regeneration.
APPLIED MATERIALS TODAY
(2022)
Article
Biotechnology & Applied Microbiology
Yalin Liu, Haoyong Yuan, Yuhong Liu, Chunyang Chen, Zhenjie Tang, Can Huang, Zuodong Ning, Ting Lu, Zhongshi Wu
Summary: A multifunctional nanoparticle-VEGF system consisting of chitosan, REDV peptide, heparin, and VEGF was developed to enhance anti-thrombosis and promote rapid endothelialization of small-diameter tissue-engineered vascular grafts. The results showed improved patency rates and endothelialization in a rabbit model.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Bita Nasiri, Tai Yi, Yulun Wu, Randall J. Smith, Ashis Kumar Podder, Christopher K. Breuer, Stelios T. Andreadis
Summary: A strategy to recruit monocytes (MCs) from blood to regenerate vascular tissue from unseeded tissue engineered vascular grafts is presented. The fusion protein, H2R5, can capture blood-derived MC under static or flow conditions on the surface of vascular grafts. This bound MC then transforms into macrophages (M phi) expressing specific genes. When these functionalized grafts are implanted, they form a continuous endothelium expressing specific proteins and multiple cell layers expressing specific markers. Lineage tracing analysis provides direct evidence of MC/M phi recruitment to the graft lumen. Circulating MCs may potentially contribute to the endothelialization and vascular wall formation of acellular vascular grafts.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Biomedical
Yuan Gui, Kang Qin, Ye Zhang, Xiangyu Bian, Zhiguang Wang, Dianpeng Han, Yuan Peng, Hongyuan Yan, Zhixian Gao
Summary: The study developed a polycaprolactone vascular graft incorporated with quercetin and found that quercetin reduced pro-inflammatory gene expressions and increased anti-inflammatory gene expressions. In vivo experiments showed that quercetin enhanced the regeneration and remodeling of vascular tissue.
BIOMEDICAL MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Dongwoo Hahn, Donghoon Lee, Woonggyu Hyun, Yunnie Cho, Chang-Hwan Yoon, Ki-Hyun Jeon, Si-Hyuck Kang, Tae-Jin Youn, In-Ho Chae
Summary: This study compared the difference in vascular healing between ultrathin-strut drug-eluting stents (DES) and traditional stents. The results showed that ultrathin-strut DES had faster and denser endothelial cell regeneration at two and twelve weeks. The study also found a close correlation between smooth muscle cell coverage and endothelial cell regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Arghya Paul
Article
Polymer Science
Sayantani Basu, Rea Johl, Settimio Pacelli, Stevin Gehrke, Arghya Paul
Article
Engineering, Biomedical
Settimio Pacelli, Aparna R. Chakravarti, Saman Modaresi, Siddharth Subham, Kyley Burkey, Cecilia Kurlbaum, Madeline Fang, Christopher A. Neal, Adam J. Mellott, Aishik Chakraborty, Arghya Paul
Summary: The study utilized polydopamine (pDA) treatment as a binding platform to create a versatile gelatin-alginate (Gel-Alg) hydrogel, effectively controlling stem cell adhesion and osteogenic differentiation, demonstrating the potential application value in tissue engineering.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Review
Pharmacology & Pharmacy
Yasmeen Shamiya, Shruthi Polla Ravi, Ali Coyle, Subrata Chakrabarti, Arghya Paul
Summary: This article reviews emerging therapeutic nanoparticles for treating diabetic wounds and discusses their discrete delivery mechanisms and sites of action. The current challenges of these nanoengineered materials for successful clinical translation are critically assessed, along with their potential for growth in the clinical marketplace.
DRUG DISCOVERY TODAY
(2022)
Review
Pharmacology & Pharmacy
Shruthi Polla Ravi, Yasmeen Shamiya, Aishik Chakraborty, Cynthia Elias, Arghya Paul
Summary: Vaccines have been essential in training the immune system, but face challenges in manufacturing, large-scale production, and storage, with some showing suboptimal immunogenicity. A new class of biomimetic materials has emerged as an alternative vaccination strategy.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Article
Engineering, Biomedical
Cho-E Choi, Aishik Chakraborty, Ali Coyle, Yasmeen Shamiya, Arghya Paul
Summary: Considerable progress has been made in synthesizing intelligent, biodegradable hydrogels that undergo rapid changes in physicochemical properties once exposed to external stimuli. These advantageous properties of stimulus-triggered materials make them highly appealing to diverse biomedical applications. Of late, research on the incorporation of light-triggered nanoparticles (NPs) into polymeric hydrogel networks has gained momentum due to their ability to remotely tune hydrogel properties using facile, contact-free approaches, such as adjustment of wavelength and intensity of light source.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Harshavardhan Budharaju, Allen Zennifer, Swaminathan Sethuraman, Arghya Paul, Dhakshinamoorthy Sundaramurthi
Summary: DNA, with its outstanding features such as functional molecular recognition motifs and high precision molecular self-assembly, has emerged as a leading biomaterial for 3D bioprinting and other biomedical applications. Researchers are continuously exploring the interesting properties of DNA for various applications, including cell-laden tissue constructs. Advanced design approaches and cost-effective production methods have further enhanced the versatility and potential of DNA in bioprinting.
MATERIALS HORIZONS
(2022)
Article
Medicine, Research & Experimental
Aishik Chakraborty, Settimio Pacelli, Shana Alexander, Sebastian Huayamares, Zachary Rosenkrans, Filippo Elmi Vergel, Yuanyi Wu, Adrija Chakravorty, Arghya Paul
Summary: A mechanically tough nanocomposite hydrogel was prepared by utilizing the electrostatic interaction between nanosilicates and gelatin methacrylate. This hydrogel showed slower degradation rate and sustained release of the encapsulated drug metformin. The nanocomposite material also exhibited cell protective effects in vitro.
MOLECULAR PHARMACEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Shruthi Polla Ravi, Yasmeen Shamiya, Aishik Chakraborty, Ali Coyle, Alap Ali Zahid, Jin Wang, Michael S. H. Boutilier, Emmanuel A. Ho, Arghya Paul
Summary: In this study, a biomimetic cell-derived nanoparticle (CDN) loaded with Dexamethasone was developed, which showed efficient cellular uptake and stem cell differentiation. These CDNs exhibited good cytocompatibility and stability, making them suitable for bone regeneration applications.
ACS APPLIED NANO MATERIALS
(2022)
Article
Materials Science, Biomaterials
Alap Ali Zahid, Aishik Chakraborty, Wei Luo, Ali Coyle, Arghya Paul
Summary: Biobased nanoparticles are promising tools for biomedical research, but their commercial application has not been fully realized. In this perspective, advanced designs of biobased nanoparticles, such as cell membrane nanoparticles, exosomes, and synthetic lipid-derived nanoparticles, are discussed along with their benefits and potential challenges. The future use of artificial intelligence and machine learning in preparing these particles is also critically assessed. This field of research has the potential to greatly impact the rational design of drug transporters and improve therapeutic outcomes.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Chemistry, Multidisciplinary
Alap Ali Zahid, Aishik Chakraborty, Yasmeen Shamiya, Shruthi Polla Ravi, Arghya Paul
Summary: Exploring new avenues for clinical management of chronic wounds is crucial for eliminating socioeconomic burdens and health concerns. Engineered biomaterials with improved functionalities, such as bioadhesiveness, antimicrobial properties, proangiogenic attributes, and anti-inflammatory properties, have been developed to enhance wound healing. Different biomaterial templates, including hydrogels, cryogels, nanomaterials, and biomolecule-functionalized materials, have been utilized to fabricate smart patches, microneedles, electrospun scaffolds, and 3D-bioprinted structures, enabling effective wound healing.
MATERIALS HORIZONS
(2022)
Article
Materials Science, Multidisciplinary
Sayantani Basu, Aishik Chakraborty, Abdul-Rahman Imad Alkiswani, Yasmeen Shamiya, Arghya Paul
Summary: In this study, mechanically tough nanocomposite hydrogels were prepared using natural polymer DNA and two-dimensional nanosheets of WS2. The formation of double network polymeric hydrogels significantly improved the mechanical properties of the hydrogels, while maintaining biocompatibility. These tough DNA-based hydrogels have the potential for various biomedical applications, including drug delivery of proteins and growth factors.
MATERIALS ADVANCES
(2022)
Review
Materials Science, Biomaterials
Aishik Chakraborty, Avinava Roy, Shruthi Polla Ravi, Arghya Paul
Summary: The use of nanoparticles in 3D bioprinting can enhance the mechanical properties, introduce new functionalities, and provide responsiveness to external stimuli in hydrogel-based bioinks. This approach allows for the creation of intricate biostructures, bringing the field of bioprinting closer to printing complex tissue structures and organs.
BIOMATERIALS SCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Aishik Chakraborty, Shruthi Polla Ravi, Yasmeen Shamiya, Caroline Cui, Arghya Paul
Summary: Apart from its role as a genetic material, DNA can also be utilized to construct materials with desired properties, such as hydrogels. Current chemical tools and strategies are being employed to harness the non-genetic functions of DNA.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Aparna R. Chakravarti, Settimio Pacelli, Arghya Paul