Article
Biochemistry & Molecular Biology
Alexander J. Knights, Shanshan Liu, Yingxu Ma, Victoria S. Nudell, Eric Perkey, Matthew J. Sorensen, Robert T. Kennedy, Ivan Maillard, Li Ye, Heejin Jun, Jun Wu
Summary: This study demonstrates that macrophages play a crucial role in regulating thermogenesis by secreting acetylcholine in adipose tissue. The abundance of ChAMs increases in response to acute cold exposure, and their regulation is mediated through adrenergic signaling. Deletion of the enzyme ChAT impairs cold-induced thermogenesis in mice.
Article
Immunology
Philipp Kruppa, Sabrina Gohlke, Kamila Lapinski, Francisco Garcia-Carrizo, George A. Soultoukis, Manfred Infanger, Tim J. Schulz, Mojtaba Ghods
Summary: This study found that subcutaneous adipose tissue (SAT) in lipedema patients exhibits features such as adipocyte hypertrophy, immune cell recruitment, and fibrosis, which are associated with the disease stage. These findings contribute to a better understanding of the development of lipedema.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Alisha Kang, Gluke Ye, Ramandeep Singh, Sam Afkhami, Jegarubee Bavananthasivam, Xiangqian Luo, Maryam Vaseghi-Shanjani, Fatemah Aleithan, Anna Zganiacz, Mangalakumari Jeyanathan, Zhou Xing
Summary: BCG vaccine can provide non-specific protection against unrelated pathogens by modulating the innate immune system, known as trained innate immunity. A study shows that subcutaneous BCG vaccination can enhance innate protection against heterologous respiratory bacterial infections, and this enhanced protection is mediated by increased neutrophilia in the lung, independent of centrally trained circulating monocytes. This study provides new insights for designing novel effective vaccination strategies against unrelated respiratory bacterial pathogens.
EMBO MOLECULAR MEDICINE
(2023)
Article
Cell Biology
Nuria Alegret, Antonio Dominguez-Alfaro, David Mecerreyes, Maurizio Prato, Luisa Mestroni, Brisa Pena
Summary: The study shows that combining CNT with different conductive polymers has a positive impact on the growth, survival, and beating behavior of cardiac cells. NRVMs cultured on CNT-based substrates exhibit improved cellular function, especially on PEDOT/CNT substrates, which show higher beating amplitudes and a more mature cardiac phenotype.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Nutrition & Dietetics
Marianthi Kalafati, Michael Lenz, Gokhan Ertaylan, Ilja C. W. Arts, Chris T. Evelo, Marleen M. J. van Greevenbroek, Ellen E. Blaak, Michiel Adriaens, Martina Kutmon
Summary: This study utilized publicly available datasets to analyze the impact of macrophage frequencies on gene expression in subcutaneous adipose tissue. It was found that individuals with high macrophage frequencies showed increased inflammation gene expression accompanied by decreased gene expression in pathways related to lipid metabolism and mitochondrial respiration in the adipose tissue.
FRONTIERS IN NUTRITION
(2021)
Article
Peripheral Vascular Disease
Vlatka Pandzic Jaksic, Danijela Grizelj, Ana Livun, Marko Ajduk, Drago Boscic, Ana Vlasic, Maruska Marusic, Branimir Gizdic, Rajko Kusec, Ozren Jaksic
Summary: The study found that neck adipose tissue, especially the pericarotid compartment, exhibits enhanced inflammatory properties in patients with carotid stenosis, but the proportion of anti-inflammatory macrophages in advanced atherosclerosis seems to be maintained.
Article
Energy & Fuels
Junsheng Lin, Yangcheng Mo, Zhenwei Li, Kaochun Yang, Jie Yu
Summary: A highly efficient sulfur carrier for Li-S batteries, N-doped carbon nanotubes (CNTs) with Co/Co2P nanoparticles encapsulated inside and vertical graphene (VG) nanosheets grown outside (CCP@NCNT@VGs), has been successfully prepared, which significantly improves the electrochemical performance of the batteries.
Article
Environmental Sciences
Robert Mujkic, Darija Snajder Mujkic, Ivana Ilic, Edi Rodak, Antun Sumanovac, Andela Grgic, Dalibor Divkovic, Kristina Selthofer-Relatic
Summary: The study examined adipose tissue remodeling in healthy male children based on weight status. Results showed that obese children had higher triglyceride levels, larger adipocyte size, more collagen in subcutaneous adipose tissue, crown-like structures in fat tissues, and more CD163(+) cells in visceral adipose tissue. Obesity in male children leads to hypertrophy of adipocytes, increased collagen deposition in subcutaneous adipose tissues, and changes in macrophage polarization and accumulation.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Bojana Micic, Ana Teofilovic, Ana Djordjevic, Natasa Velickovic, Djuro Macut, Danijela Vojnovic Milutinovic
Summary: Overfeeding during the postnatal period may predispose individuals to metabolic disturbances associated with PCOS, with visceral adipose tissue (VAT) maintaining its insulin sensitivity through increased AMPK activity, while subcutaneous adipose tissue (SAT) demonstrates worsened metabolic function, leading to systemic insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Ninad Varkhede, Peters Bjorn-Hendrik, K. Ryan Moulder, Philip Gao, Christian Schoneich, M. Laird Forrest
Summary: This study used ultra-pressure chromatography-mass spectrometry to investigate the oxidation of TPs in biological matrices. The researchers did not observe oxidation of rGH in ex-vivo and in vitro biological matrices, possibly due to factors such as minor yields of oxidation products or lack of sensitivity of the mass spectrometry method.
ANALYTICAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Thenmozhi Rajarathinam, Dinakaran Thirumalai, Minho Kwon, Seulah Lee, Sivaguru Jayaraman, Hyun-jong Paik, Jaewon Lee, Seung-Cheol Chang
Summary: A voltammetric sensor for detecting norepinephrine (NE) was developed by modifying a disposable screenprinted carbon electrode (SPCE) with de-bundled single-walled carbon nanotubes (D-SWCNTs). The sensor showed improved sensitivity towards NE compared to other types of modifications, and was optimized for detection under specific conditions. Interferents were investigated, and the sensor demonstrated practical potential by quantifying NE in ex vivo rat tissue samples.
BIOELECTROCHEMISTRY
(2022)
Article
Engineering, Biomedical
Madeline Cramer, Jordan Chang, Hongshuai Li, Aurelie Serrero, Mohammed El-Kurdi, Martijn Cox, Frederick J. Schoen, Stephen F. Badylak
Summary: The study demonstrates that different biomaterials elicit distinct types of macrophage infiltration and host remodeling responses, suggesting that the rat subcutaneous implantation model can be used to predict in vivo biocompatibility and regenerative potential for cardiovascular biomaterials.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Chemistry, Physical
Qing-Yun Wang, Gang Nan, Yao-Yu Chen, Yong-Chun Tong, Xin-Jian Xu, Qing-Ling Bai
Summary: In this study, the adsorption properties of Fe, Co, and Ni atoms on the surface of single-walled carbon nanotubes (SWCNTs) and defective carbon nanotubes were investigated using density functional theory (DFT). The results showed that Ni had the strongest adsorption ability, and the adsorption of atoms on single vacancy defect (SV) carbon nanotubes was more stable. Furthermore, external adsorption structures were found to be more stable than internal adsorption structures.
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A
(2022)
Article
Engineering, Biomedical
Marcela Borsatto Queiroz, Rafaela Nanami Handa Inada, Camila Soares Lopes, Juliane Maria Guerreiro-Tanomaru, Estela Sasso-Cerri, Mario Tanomaru-Filho, Paulo Sergio Cerri
Summary: This study compared the tissue response of Bio-C Pulpo, Biodentine, and White MTA in dentistry. The results demonstrated that Bio-C Pulpo has similar biocompatibility and bioactive potential as Biodentine and White MTA.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Review
Materials Science, Multidisciplinary
Steve W. F. R. Waqanivavalagia, Marcus B. Ground, Consuelo Alarcon, Paget Milsom, Jillian Cornish
Summary: This study systematically assessed the characteristics of subcutaneous surgical rat models used for evaluating the immunogenicity of decellularised heart valves. The results showed homogeneity in donor scaffold characteristics, while animal and surgical characteristics were heterogeneous and poorly reported. It suggests the need for a standardized subcutaneous rat model for studying the immunogenicity of decellularised heart valves.
Article
Chemistry, Physical
Minfang Zhang, Mei Yang, Takahiro Morimoto, Naoko Tajima, Kayo Ichiraku, Katsuhide Fujita, Sumio Iijima, Masako Yudasaka, Toshiya Okazaki
Article
Nanoscience & Nanotechnology
Katsutoshi Kokubun, Sachiko Matsumura, Masako Yudasaka, Sumio Iijima, Kiyotaka Shiba
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2018)
Article
Multidisciplinary Sciences
Yoko Iizumi, Masako Yudasaka, Jaeho Kim, Hajime Sakakita, Tsukasa Takeuchi, Toshiya Okazaki
SCIENTIFIC REPORTS
(2018)
Article
Chemistry, Physical
Ryota Yuge, Fumiyuki Nihey, Kiyohiko Toyama, Masako Yudasaka
Article
Multidisciplinary Sciences
Masako Yudasaka, Yohei Yomogida, Minfang Zhang, Masako Nakahara, Norihiko Kobayashi, Takeshi Tanaka, Yuko Okamatsu-Ogura, Kumiko Saeki, Hiromichi Kataura
SCIENTIFIC REPORTS
(2018)
Article
Biochemical Research Methods
Tsukasa Takeuchi, Yoko Iizumi, Masako Yudasaka, Shinae Kizaka-Kondoh, Toshiya Okazaki
BIOCONJUGATE CHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Minfang Zhang, Yinmei Deng, Mei Yang, Hideaki Nakajima, Masako Yudasaka, Sumio Iijima, Toshiya Okazaki
SCIENTIFIC REPORTS
(2019)
Article
Nanoscience & Nanotechnology
Mei Yang, Minfang Zhang, Hideaki Nakajima, Masako Yudasaka, Sumio Iijima, Toshiya Okazaki
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2019)
Article
Chemistry, Physical
Yukari Maeda, Eri Hirata, Yuta Takano, Norihito Sakaguchi, Natsumi Ushijima, Ayumi Saeki, Sadahito Kimura, Ken-ichiro Shibata, Masako Yudasaka, Atsuro Yokoyama
Article
Nanoscience & Nanotechnology
Maki Nakamura, Katsuya Ueda, Yumiko Yamamoto, Kaoru Aoki, Minfang Zhang, Naoto Saito, Masako Yudasaka
Summary: Carbon nanohorns (CNHs) have been explored for drug delivery systems due to their unique properties, with OxCNH-CaP-IBN composite nanoparticles showing stronger cell-suppressive effects by releasing IBN through CaP dissociation.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biotechnology & Applied Microbiology
Sari Takada, Eri Hirata, Masatoshi Sakairi, Eijiro Miyako, Yuta Takano, Natsumi Ushijima, Masako Yudasaka, Sumio Iijima, Atsuro Yokoyama
Summary: The study found that modifying the surface of anodised titanium (AnTi) with carbon nanohorns (CNH) can more effectively promote bone tissue formation, accelerating contact osteogenesis. This is especially beneficial for the early stages of bone regeneration after surgery.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Yukiko Nagai, Kenta Nakamura, Masako Yudasaka, Tomohiro Shiraki, Tsuyohiko Fujigaya
ACS APPLIED NANO MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Yukiko Nagai, Masako Yudasaka, Hiromichi Kataura, Tsuyohiko Fujigaya
CHEMICAL COMMUNICATIONS
(2019)
Article
Nanoscience & Nanotechnology
Minfang Zhang, Mei Yang, Toshiya Okazaki, Masako Yudasaka
E-JOURNAL OF SURFACE SCIENCE AND NANOTECHNOLOGY
(2018)
Article
Chemistry, Physical
Ryota Yuge, Fumiyuki Nihey, Kiyohiko Toyama, Masako Yudasaka