期刊
SCIENTIFIC REPORTS
卷 2, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/srep00910
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资金
- Agence Nationale de la Recherche [ANR-08-MNP-018 MCHPRIMAPARK]
- Biotheque Primate - Centre National de la Recherche Scientifique Life Sciences Department
- Fondation pour la Recherche Medicale
- FP7-PEOPLE-2009-RG
Since age-dependent deposition of A beta-amyloid has been reported in the Microcebus murinus, we posited that this animal could as well be a model of age-related synucleinopathy. We characterized the distribution of A beta-amyloid, alpha-synuclein and two of its modified forms in the brain of Microcebus murinus aged from 1.5 to 10 years. Intracytoplasmic alpha-synuclein aggregates were observed only in aged animals in different brain regions, which were also phospho-Ser129 and nitrated alpha-synuclein immunoreactive. Age-dependent alpha-synuclein aggregation occurs spontaneously in mouse lemur primates. Microcebus murinus may provide a model to study age-associated alpha-synucleinopathy and for testing putative therapeutic interventions for both Alzheimer's and Parkinson's diseases.
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