Article
Polymer Science
Yong-Fu Li, Wen-Li Guan, Chun-Yu Wang, Yan Wang, Qi Lin, Ying-Wei Yang
Summary: A metallosupramolecular polymer network (DSPy subset of SHP5@Zn) was constructed by hierarchical self-assembly of a double-armed pillar[5]arene host (SHP5), a ditopic guest (DSPy), and Zn2+ ions, with host-guest recognition and metal-ligand coordination interactions playing a crucial role. The DSPy subset of SHP5@Zn assembly exhibits reversible sol-gel transition properties in response to various external stimuli, making it an excellent candidate for constructing smart gels. In addition, it can be used as a highly selective dual-channel sensor for OH anions, facilitating the development of a convenient test kit for OH sensing.
Review
Chemistry, Multidisciplinary
Yan Zhou, Min Ye, Chengzhi Hu, Huihuan Qian, Bradley J. Nelson, Xiaopu Wang
Summary: Stimuli-responsive functional micro-/nanorobots (srFM/Ns) are intelligent, efficient, and promising microrobots that react to external stimuli and perform designated tasks. They have significant roles in targeted therapy, biological detection, tissue engineering, and other fields. However, there are few reviews focusing on them, hence the necessity of providing an overview of their current development to inspire further advancements in this field.
Review
Biochemistry & Molecular Biology
Niranjana Jaya Prakash, Supriya Sanatkumar Sarkar, Balasubramanian Kandasubramanian
Summary: The development of implantable devices using biocompatible shape memory polymers offers a less invasive alternative to the insertion of large, impliable devices. Silk materials exhibit heterogeneity in their genetic structure and physical properties due to folding and unfolding processes, and possess stimuli-responsive properties. This article explores the stimuli-responsive nature of silk and its potential applications in biomedical devices.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Dengshuai Wei, Yong Sun, Hu Zhu, Qinrui Fu
Summary: Stimuli-responsive polymers have been widely used in biomedical applications due to their ability to respond to internal and external stimuli. In the context of the tumor microenvironment, these polymers are used to prepare smart nanovehicles for targeted drug delivery. TME-responsive nanosystems offer many advantages over conventional drug delivery systems, leading to significant advances in cancer diagnosis and therapy.
Article
Materials Science, Multidisciplinary
Pooyan Makvandi, Rezvan Jamaledin, Guojun Chen, Zahra Baghbantaraghdari, Ehsan Nazarzadeh Zare, Concetta Di Natale, Valentina Onesto, Raffaele Vecchione, Jesse Lee, Franklin R. Tay, Paolo Netti, Virgilio Mattoli, Ana Jaklenec, Zhen Gu, Robert Langer
Summary: Microneedle (MN) patches, made up of miniature needles, have emerged as a promising tool for minimally invasive translocation of biomolecules into the dermis. Stimuli-responsive MN patches are a new drug delivery system that can release cargos in response to internal or external triggers, with various mechanisms of action for different indications. Future opportunities and challenges in clinical translation are also discussed.
Article
Chemistry, Multidisciplinary
Yisheng He, Haoyu Li, Anja Maria Steiner, Andreas Fery, Yuan Zhang, Chunhong Ye
Summary: This study presents a synthetic approach to fabricate 3D plasmonic chiral structures by rolling gold nanospheres-decorated polymer micro-sheets into micro-tubules. The resulting structures exhibit distinctive circularly polarized light-dependent optical responses over a broad range of frequencies, offering great potential for photonic and biomedical applications.
ADVANCED MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Dalei Wang, Xiaoxia Han, Bin Dong, Feng Shi
Summary: In the past decade, there have been significant advances in the field of micromotors, especially in the development of stimuli-responsive polymer based micromotors. These micromotors show unprecedented properties and have potential applications in various fields.
APPLIED MATERIALS TODAY
(2021)
Article
Medicine, Research & Experimental
Mohammad Arad Zandieh, Melika Heydari Farahani, Mahshid Daryab, Alireza Motahari, Sarah Gholami, Farshid Salmani, Fatemeh Karimi, Seyedeh Setareh Samaei, Aryan Rezaee, Parham Rahmanian, Ramin Khorrami, Shokooh Salimimoghadam, Noushin Nabavi, Rongjun Zou, Gautam Sethi, Mohsen Rashidi, Kiavash Hushmandi
Summary: The use of phytochemicals in cancer therapy has been accelerated due to tumor cell resistance to conventional chemotherapy drugs. However, the poor bioavailability and lack of specific accumulation at tumor sites pose challenges. The use of nanocarriers for targeted delivery of phytochemicals shows promise in improving pharmacokinetics and therapeutic indices. Stimuli-responsive nanostructures and surface functionalization with ligands further enhance the internalization and cytotoxicity of natural compounds in cancer cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Chemistry, Multidisciplinary
Liuzhou Mao, Panqin Ma, Xi Luo, Hongwei Cheng, Zhanxiang Wang, Enyi Ye, Xian Jun Loh, Yun-Long Wu, Zibiao Li
Summary: The development of nanovaccines that use polymeric delivery carriers has gained significant attention for therapeutic treatment of cancer and infectious diseases. Stimuli-responsive polymeric nanocarriers have shown promise for targeted delivery of antigens and adjuvants, improving immune responses and immunotherapy. This review presents the recent advancements in stimulus-responsive polymer-based nanovaccines for immunotherapeutic applications and discusses strategies for future designs of multifunctional polymeric nanovaccines.
Review
Chemistry, Multidisciplinary
Shan Mohanan, Xinwei Guan, Mingtao Liang, Ajay Karakoti, Ajayan Vinu
Summary: The design of novel drug delivery systems is crucial in disease treatments, and mesoporous silica nanoparticles (MSNs) have shown great promise due to their stability, tunable morphologies/sizes, and loading capability. Functionalization of MSNs with drugs, imaging, and targeting agents is enabled by the presence of surface silanol groups, making them versatile and popular among researchers. Stimuli-responsive silanol conjugates have emerged as an effective way to deliver therapeutic drugs precisely and on-demand, and it is important to understand the role of surface silanols in MSN as a drug delivery platform. This review provides an analytical understanding of surface silanols, their chemistry, identification methods, and their correlation with properties and performance.
Review
Chemistry, Multidisciplinary
Santanu Panja, Dave J. Adams
Summary: Supramolecular gels are formed by small molecules through non-covalent interactions, allowing for fine tuning of properties through external stimuli. Dynamic modifications enable gel-to-gel transitions, altering physical and chemical properties over time.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Polymer Science
Siyang Wang, Qianhui Liu, Lei Li, Marek W. Urban
Summary: Responsive polymers, known for their adaptability and capability of transport control of molecules, play a significant role in advancing scientific discoveries. Recent developments in commodity polymers with stimuli-responsiveness to various factors have diverse applications, ranging from drug delivery to color-changing coatings. Current technological advances and future opportunities and applications in stimuli-responsive chemistries are also discussed in this review.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Dong Yan, Zhifang Wang, Zhenjie Zhang
Summary: Stimuli-responsive smart materials that can undergo reversible chemical/physical changes are attracting attention in various fields. Crystalline materials, with their well-defined structures and regular molecular arrays, offer the opportunity to create smart materials with improved responsiveness. However, challenges such as decreased processability and mechanical properties need to be addressed for practical applications.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Chemistry, Physical
Tomasz Kruk, Karolina Chojnacka-Gorka, Marta Kolasinska-Sojka, Szczepan Zapotoczny
Summary: This paper reviews the formation, structure determination, and properties of polyelectrolyte multilayer (PEM) films and capsules that respond to physical, chemical, and biological stimuli. It discusses their applications as microcarriers for controlled release, substrates for controlled cell growth, coatings for enhanced surface adhesion, and self-healing anticorrosive systems. The impacts of various stimuli on the integrity and permeability of the films or capsules shell are presented, along with their applications in controlled drug release, biotechnology, and industrial protective coatings.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Thashini Moodley, Moganavelli Singh
Summary: Cancer remains a devastating non-communicable disease with increasing incidence and mortality rates. The development of novel therapeutic strategies using multimodal nanotechnology is critical in enhancing therapeutic outcomes and overcoming resistance. Mesoporous silica nanoparticles have shown promising potential in cancer therapy with their stimuli-responsive controlled release functions and increased bioavailability.
Article
Chemistry, Physical
Hiroaki Mamiya, Hironori Sudo, Jhon L. Cuya Huaman, Kazumasa Suzuki, Hiroshi Miyamura, Jeyadevan Balachandran
Summary: Hierarchal structures of magnetic fluids were studied by dispersing monodispersed magnetite particles in kerosene. Results showed that under magnetic fields, nanoparticles formed different microscopic arrangements based on their sizes, which are crucial for various applications.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Chemistry, Physical
Masanori Takemoto, Yasuaki Tokudome, Hidenobu Murata, Kenji Okada, Masahide Takahashi, Atsushi Nakahira
Summary: In this study, nano Li-Al LDH was synthesized and transformed into Li-Al MMO, showing high specific surface area and abundant strong basic sites. Compared to samples prepared by co-precipitation method, LiAl MMO exhibited higher catalytic activity due to the larger amount of active sites.
APPLIED CLAY SCIENCE
(2021)
Article
Chemistry, Inorganic & Nuclear
Hisashi Kaneko, Takatoshi Matsumoto, Jhon L. Cuya Huaman, Masanao Ishijima, Kazumasa Suzuki, Hiroshi Miyamura, Jeyadevan Balachandran
Summary: The development of a technology for the synthesis of monometallic or multimetallic nanoparticles is crucial for preparing novel magnetic, optical, and catalytic functional materials. The polyol process is a safe and scalable method for preparing metal nanoparticles with controlled sizes and shapes. However, the criteria for selecting metal salt and solvent types that determine the kinetics of reduction reaction affecting particle morphology need further investigation.
INORGANIC CHEMISTRY
(2021)
Article
Materials Science, Ceramics
Daisuke Kino, Kenji Okada, Yasuaki Tokudome, Masahide Takahashi, Luca Malfatti, Plinio Innocenzi
Summary: Controlling the steric effects around silanol groups in the intermediate oligomers allows modulation of the crosslink density of siloxane skeletons, thereby tuning the structure and chemical properties of the resultant siloxane materials.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2021)
Article
Physics, Applied
Ken-ichi Matsuoka, Shoto Banya, Ippei Hosoi, Natsuki Koyama, Kazumasa Suzuki, Balachandran Jeyadevan, Takeo Oku, Katsuhiko Fujita, Sunao Yamada, Tsuyoshi Akiyama
Summary: This study introduces new suprastructure products composed of C-60-ethylenediamine microparticles and silver nanoparticles, loaded onto surfaces of microparticles through electrostatic adsorption. These products can be deposited onto indium tin oxide electrodes by electrostatic deposition, generating cathodic photocurrents in the presence of ascorbic acid and oxygen. The photocurrent generation suggests a combination of silver-nanoparticle-mediated electron transfer in the cathodic direction and plasmon-induced charge separation in the anodic direction.
APPLIED PHYSICS EXPRESS
(2021)
Article
Chemistry, Inorganic & Nuclear
Masanao Ishijima, Takatoshi Matsumoto, Jhon L. Cuya Huaman, Kozo Shinoda, Masahito Uchikoshi, Kohei Matsuo, Kazumasa Suzuki, Hiroshi Miyamura, Jeyadevan Balachandran
Summary: This study successfully demonstrated the controlled synthesis of bimetallic nanoparticles using alcohol reduction technique, showcasing the relationship between alcohol chain length and reduction potential. The experimental evaluation matched the theoretical predictions, and the formation mechanism of metallic particles was studied in detail, leading to the synthesis of Cu-Ni bimetallic nanostructures.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yukako Naito, Ryo Moriguchi, Chitoshi Kitamura, Taisuke Matsumoto, Toshitada Yoshihara, Tsutomu Ishi-I, Yuka Nagata, Hiroki Takeshita, Kazunari Yoshizawa, Yoshihito Shiota, Kazumasa Suzuki, Shin-ichiro Kato
Summary: This study reports the self-assembly behavior of TPT fluorescent dyes with different linker structures, and shows that ester linkers enhance the self-association process. Theoretical calculations suggest that ester linkers induce attractive electrostatic forces and augment self-association, leading to the formation of well-defined 1D clusters with high aspect ratios. TPTs with ester linkers exhibit a columnar liquid crystalline mesophase in the condensed phase.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Materials Science, Ceramics
Yasuaki Tokudome, Akihiro Koyama, Hidenobu Murata, Kenji Okada, Atsushi Nakahira, Shigenori Nishimura, Masahide Takahashi
Summary: Chiral inorganic materials have gained increasing attention in fields such as catalysis, electronics, photonics, and sensing. This study focuses on the synthesis of nanometric nickel layered hydroxide salt (Ni-LHS) modified with chiral amino acids and demonstrates its potential as an advanced adsorbent for molecule detection.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Ceramics
Kazumasa Suzuki, Haruka Nabata, Saya Ueno, Shu Morita, Hiroshi Miyamura, Jeyadevan Balachandran
Summary: Carbon dots (C-dots) are nanocarbon materials with fluorescence and chemical/physical properties that depend on the precursors and synthesis conditions. This study explores the impact of surface modification and organosilica matrix on the fluorescence properties of C-dots.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Masanao Ishijima, Tsukasa Takada, Jhon L. Cuya Huaman, Takuya Mizutomi, Osamu Sakai, Kozo Shinoda, Masahito Uchikoshi, Hiroaki Mamiya, Kazumasa Suzuki, Hiroshi Miyamura, Jeyadevan Balachandran
Summary: Co-Ni alloy nanoparticles were successfully synthesized by tuning the reduction timing of Co and Ni ions. The formation mechanism was elucidated and the microwave absorption properties of the alloy nanoparticles were found to be superior to core-shell particles.
INORGANIC CHEMISTRY
(2022)
Review
Materials Science, Ceramics
Kazumasa Suzuki
Summary: The development of nanocarbon-integrated ceramic composites is essential for enhancing the functionalities of oxide-based materials. Carbon dots (C-dots), which are fluorescent nanocarbon materials with distinct properties, have gained significant attention. This review provides an overview of the synthesis of nanocomposite materials with C-dots in semiconductor oxides and glass matrices using solution processes, focusing on the microstructure of the matrix, bonding-induced immobilization and dispersion of C-dots, and the physicochemical approaches to understand the fluorescence factors of C-dots.
JOURNAL OF THE CERAMIC SOCIETY OF JAPAN
(2023)
Article
Materials Science, Multidisciplinary
Naoki Tarutani, Sota Kimura, Takuya Sakata, Kazumasa Suzuki, Kiyofumi Katagiri, Kei Inumaru
Summary: Two-dimensional materials modified with low molecular weight species exhibit unique electronic properties. In this study, metal hydroxide salt monolayer nanoparticles were synthesized and modified with different molecules to enhance their electrochemical functions. The synthesized nickel hydroxide carbonate monolayer nanoparticles modified with short alkylcarboxylate showed improved redox processes and electrochemical functions due to higher proton diffusion coefficient, lower electron transfer resistance, and improved intrinsic catalytic activity.
ACS MATERIALS LETTERS
(2022)
Article
Engineering, Biomedical
Yasuaki Tokudome, Gowsihan Poologasundarampillai, Koki Tachibana, Hidenobu Murata, Amy J. Naylor, Akio Yoneyama, Atsushi Nakahira
Summary: High resolution imaging of vascular structures can be achieved by using a concentrated colloidal dispersion system of NiAl layered double hydroxide (LDH) nanoparticles.
ADVANCED NANOBIOMED RESEARCH
(2022)
Article
Polymer Science
Shohei Ida, Takahiro Okuno, Miki Morimura, Kazumasa Suzuki, Hiroki Takeshita, Masatoshi Oyama, Keiji Nakajima, Shokyoku Kanaoka
Summary: This study investigates the structure-property correlation of a hydrogel with a thermoresponsive crosslinked domain structure prepared by polymerization-induced self-assembly. The molecular weight of the macro-chain transfer agent used in the polymerization process affects the swelling behavior and mechanical properties of the hydrogel. Furthermore, the composition of the hydrogel has a significant impact on its mechanical properties and transparency at high temperatures. Additionally, the hybridization of the hydrogel with carbon dots enhances its photoluminescence performance.
