Article
Biophysics
Tomoya Inose, Narufumi Kitamura, Mayumi Takano-Kasuya, Masayuki Tokunaga, Norikazu Une, Chihiro Kato, Mayu Tayama, Yukina Kobayashi, Noriko Yamauchi, Daisuke Nagao, Takuji Aimiya, Naoko Furusawa, Yasushi Nakano, Yoshio Kobayashi, Kohsuke Gonda
Summary: The development of novel contrast agents using gold nanoparticles has demonstrated promising results in capturing changes in tumor vessel morphology over time using X-ray computed tomography (CT). The use of high atomic number elements for angiography has shown potential benefits in improving blood retention time and imaging quality.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Yang Liu, Christian Kornig, Bing Qi, Oliver Schmutzler, Theresa Staufer, Carlos Sanchez-Cano, Elisabeth Magel, Jason C. White, Neus Feliu, Florian Gruner, Wolfgang J. Parak
Summary: This study incubated Matricaria chamomilla flowers with gold nanoparticles of different sizes and measured the gold distribution. The results show that the transport of nanoparticles is size-dependent and the surface chemistry also plays a role. The nanoparticles coated with acetylcysteine could be efficiently transported into the petals.
Article
Chemistry, Inorganic & Nuclear
R. Figueroa, J. Guarda, J. Leiva, F. Malano, M. Valente
Summary: Nuclear medicine procedures have been efficient for diseases diagnosis and treatment, but they pose risks to patient and public health due to radiation exposure and storage/elimination of radiopharmaceuticals. Alternative methods have been proposed to reduce/eliminate radionuclides in these procedures.
APPLIED RADIATION AND ISOTOPES
(2021)
Article
Nanoscience & Nanotechnology
Abdullah Khamis Ali Al Saidi, Ahrum Baek, Shuwen Liu, Tirusew Tegafaw Mengesha, Mohammad Yaseen Ahmad, Dejun Zhao, Ying Liu, Ji-ung Yang, Ji Ae Park, Dong Wook Hwang, Kwon Seok Chae, Sung-Wook Nam, Yongmin Chang, Gang Ho Lee
Summary: This study successfully synthesized polymer-grafted ultrasmall PbO nanoparticles, which possess good hydrophilicity and biocompatibility. In vitro and in vivo experiments demonstrated their potential as X-ray contrast agents.
ACS APPLIED NANO MATERIALS
(2023)
Article
Computer Science, Information Systems
Sandun Jayarathna, Md Foiez Ahmed, Liam O'ryan, Hem Moktan, Yonggang Cui, Sang Hyun Cho
Summary: Pixelated semi-conductor detector HEXITEC was characterized for its performance in benchtop XFCT system, demonstrating the necessity for application-specific detector characterization and highlighting the characteristics of HEXITEC under different working conditions. The investigation also showed the potential of high energy resolution in parallel acquisition of XRF signals using HEXITEC.
Article
Chemistry, Multidisciplinary
Marc Pretze, Valeska von Kiedrowski, Roswitha Runge, Robert Freudenberg, Rene Hubner, Gullu Davarci, Ralf Schirrmacher, Carmen Wangler, Bjorn Waengler
Summary: This study developed tumor-specific gold nanoparticles for targeted accumulation and detection of tumor angiogenesis, as well as potential therapeutic applications. The nanoparticles showed favorable diagnostic properties both in vitro and in vivo, and could potentially be used as radiosensitizers in future therapeutic concepts.
Article
Biochemistry & Molecular Biology
Chien-Chou Lin, Li-Hsuan Chiu, Walter H. H. Chang, Cheng-An J. Lin, Ruei-Ming Chen, Yuan-Soon Ho, Chun S. S. Zuo, Austin Changou, Yue-Fa Cheng, Wen-Fu T. Lai
Summary: Computed tomography and conventional X-ray radiography often create micro-artifacts around metal implants, leading to false diagnoses of bone maturation or pathological peri-implantitis. A novel NIRF molecular imaging system was developed to repair these artifacts and monitor bone maturation. The system accurately identified image loss caused by metal artifacts and can be used to evaluate new types of implant fixtures or surface treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Liu-Chun Wang, Li-Chan Chang, Guan-Lin Su, Po-Ya Chang, Hsiao-Fen Hsu, Chin-Lai Lee, Jie-Ren Li, Min-Chiao Liao, Suresh Thangudu, Jongjit Treekoon, Chun-Chieh Yu, Hwo-Shuenn Sheu, Ting-Yuan Tu, Wen-Pin Su, Chia-Hao Su, Chen-Sheng Yeh
Summary: This article introduces the evaluation of the efficacy of delivering drugs to disease sites using nanoparticle-based drugs. The authors prepared different shapes of nanoparticles and found that shape and structure have an impact on therapeutic efficacy. Flat-shaped nanoparticles showed superior performance in lung cancer treatment, and structural differences in nanoparticles also affect treatment efficacy. In addition, surface area is an important factor affecting treatment efficacy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Nicolas Debons, Dounia Dems, Christophe Methivier, Christophe Calers, Antoine Miche, Thibaud Coradin, Carole Aime
Summary: Functionalization of nanomaterial surfaces is crucial for improving stability, tuning reactivity, and introducing specific properties. Mapping functional groups at nanometer scale is challenging, especially for organic groups and non-planar objects like nanoparticles. A strategy using chemically-modified gold colloids to map amine groups on silica particle surfaces is presented, showing correlation between spatial distribution of gold colloids and chemical state of silica particles as revealed by X-ray photoelectron spectroscopy. The strategy's potential for mapping organic groups at nanomaterial interfaces and its implications for biofunctional nano-objects are discussed.
APPLIED SURFACE SCIENCE
(2021)
Review
Chemistry, Inorganic & Nuclear
Quan-Bing Chen, Ling-Yue Zhou, Ling-Xin Shi, Yang Cheng, Kui Wu, Qiong Yuan, Zhi-Jun Dong, Hua-Zhi Gu, Xian-Zheng Zhang, Tao Zou
Summary: Many cisplatin analogs have been synthesized and used clinically, but they can cause adverse reactions and drug resistance. To address these issues, researchers are focusing on Pt(IV) complexes with unique chemical structures. Loading Pt(IV) complexes into nanoparticles can enhance targeted therapy and achieve multimodal theranostics through photosensitive activity.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Biotechnology & Applied Microbiology
Shan-Shan Wang, Zi-Kai Liu, Jing-Jing Liu, Qing Cheng, Yan-Xia Wang, Yan Liu, Wen-Wen Ni, Hong-Zhuan Chen, Mingke Song
Summary: Researchers successfully demonstrated that in vivo imaging assay assessing brain AEP activity using modified gold nanoparticles can serve as a potential biomarker for early diagnosis of AD. They found that AEP increases in the early stages of AD, and AEP inhibitors can reduce beta-amyloid production and improve memory loss.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Taeyun Kim, Woo Seung Lee, Miyeon Jeon, Hyejin Kim, Mingi Eom, Seongmoon Jung, Hyung-Jun Im, Sung-Joon Ye
Summary: A dual imaging modality of pinhole XRF and CT imaging system and L-shell XRF detection system were successfully developed. The developed systems are a promising modality for in vivo imaging and ex vivo quantification for preclinical studies using MNPs. In addition, we discussed further improvements for the routine preclinical applications of the systems.
Article
Chemistry, Analytical
Zhen Yuan, Qiuni Zhao, Chunyan Xie, Junge Liang, Xiaohui Duan, Zaihua Duan, Shaorong Li, Yadong Jiang, Huiling Tai
Summary: In this study, gold-loaded tellurium nanobelts were synthesized through a hydrothermal process, and the resulting Au@Te sensor demonstrated rapid response, high sensitivity, good repeatability, and selectivity for the detection of NO2. The long-term stability of the sensor was also evaluated, with stable response observed over a period of 28 days.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Ailing Kan, Shuai Wang, Liyan Zhang, Xiaowen Xu, Nan Zhang, Wei Jiang
Summary: This study developed a novel probe for simultaneous imaging of the acidic tumor microenvironment and tumor-associated membrane proteins. The probe sensitively responded to acidic changes and enabled in-situ imaging of related proteins. This provides a useful tool for multifactor research on tumor progression.
Article
Medicine, Research & Experimental
Ben Ouyang, Benjamin R. Kingston, Wilson Poon, Yi-Nan Zhang, Zachary P. Lin, Abdullah M. Syed, Julien Couture-Senecal, Warren C. W. Chan
Summary: This study quantified the impact of biological barriers on the delivery of therapeutic nanoparticles to macrophages. The delivery of gold nanoparticles to macrophages in liver was compared to those in tumors. Results showed that the delivery of nanoparticles to tumor-associated macrophages was 75% less than to liver macrophages due to structural barriers. Tumor-associated macrophages took up more nanoparticles in the absence of barriers.
MOLECULAR PHARMACEUTICS
(2022)
Article
Biochemical Research Methods
Satarupa Banerjee, Mousumi Pal, Jitamanyu Chakrabarty, Cyril Petibois, Ranjan Rashmi Paul, Amita Giri, Jyotirmoy Chatterjee
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2015)
Article
Biochemical Research Methods
Vladimir Bobroff, Cyril Rubio, Valerie Vigier, Cyril Petibois
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2016)
Article
Biotechnology & Applied Microbiology
Sheng-Feng Lai, Bai-Hung Ko, Chia-Chi Chien, Chia-Ju Chang, Shun-Ming Yang, Hsiang-Hsin Chen, Cyril Petibois, Dueng-Yuan Hueng, Shuk-Man Ka, Ann Chen, G. Margaritondo, Y. Hwu
JOURNAL OF NANOBIOTECHNOLOGY
(2015)
Article
Physics, Multidisciplinary
Hsiang-Hsin Chen, V. Bobroff, M. Delugin, R. Pineau, Razia Noreen, Yao Seydou, S. Banerjee, J. Chatterjee, S. Javerzat, C. Petibois
ACTA PHYSICA POLONICA A
(2016)
Article
Physics, Multidisciplinary
Seydou Yao, M. Cestelli Guidi, M. Delugin, G. Della-Ventura, A. Marcelli, C. Petibois
ACTA PHYSICA POLONICA A
(2016)
Article
Biochemical Research Methods
Vladimir Bobroff, Hsiang-Hsin Chen, Maylis Delugin, Sophie Javerzat, Cyril Petibois
JOURNAL OF BIOPHOTONICS
(2017)
Review
Chemistry, Analytical
Vladimir Bobroff, Hsiang-Hsin Chen, Sophie Javerzat, Cyril Petibois
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2016)
Article
Engineering, Environmental
Seydou Yao, Gianluca Iezzi, Giancarlo Della Ventura, Fabio Bellatreccia, Cyril Petibois, Augusto Marcelli, Manuela Nazzari, Francesco Lazzarin, Mario Di Gioacchino, Claudia Petrarca
JOURNAL OF HAZARDOUS MATERIALS
(2017)
Review
Chemistry, Analytical
Abiodun Ogunleke, Vladimir Bobroff, Hsiang-Hsin Chen, Jeremy Rowlette, Maylis Delugin, Benoit Recur, Yeukuang Hwu, Cyril Petibois
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2017)
Review
Biotechnology & Applied Microbiology
Cyril Petibois
TRENDS IN BIOTECHNOLOGY
(2017)
Article
Chemistry, Analytical
Hsiang-Hsin Chen, Tsung-Tse Lee, Ann Chen, Yeukuang Hwu, Cyril Petibois
ANALYTICAL CHEMISTRY
(2018)
Article
Chemistry, Multidisciplinary
Abiodun Ogunleke, Benoit Recur, Hugo Balacey, Hsiang-Hsin Chen, Maylis Delugin, Yeukuang Hwu, Sophie Javerzat, Cyril Petibois
Article
Materials Science, Multidisciplinary
Zhaobin Guo, Chih-Tsung Yang, Michelle F. Maritz, Huanjin Wu, Puthenparampil Wilson, Majid Ebrahimi Warkiani, Chia-Chi Chien, Ivan Kempson, Amir R. Aref, Benjamin Thierry
ADVANCED MATERIALS TECHNOLOGIES
(2019)
Article
Engineering, Biomedical
Ludivine C. Delon, Zhaobin Guo, Anna Oszmiana, Chia-Chi Chien, Rachel Gibson, Clive Prestidge, Benjamin Thierry
Article
Chemistry, Physical
Zhaobin Guo, Chih-Tsung Yang, Chia-Chi Chien, Luke A. Selth, Pierre O. Bagnaninchi, Benjamin Thierry
Summary: Measuring the optical cellular micromotion can accurately determine the invasive behavior of single tumor cells within tissues, providing a new tool for studying tumor invasion mechanisms and identifying therapeutic targets.
