Article
Genetics & Heredity
Yulin Dai, Hui Yu, Qiheng Yan, Bingrui Li, Andi Liu, Wendao Liu, Xiaoqian Jiang, Yejin Kim, Yan Guo, Zhongming Zhao
Summary: This study conducted literature mining and protein-protein interaction analysis to identify a core gene network associated with COVID-19. The network was found to be enriched with genes related to immune cell function, cellular signaling cascade, and severe symptoms of COVID-19. These findings have implications for drug discovery and repurposing to combat SARS-CoV-2 and other severe infectious diseases.
Review
Pharmacology & Pharmacy
Wolfgang Loescher
Summary: Rationally designed multi-target drugs have emerged as an attractive drug discovery paradigm for diseases with complex etiology and drug-resistance problems. While some drugs targeting multiple mechanisms have shown promising effects, others discovered purely by phenotype-based screening have exhibited better efficacy in recent studies. It remains key to identify and validate new target combinations to improve treatment outcomes for drug-resistant epilepsy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Michael Rode, Kolja Nenoff, Kerstin Wirkner, Katrin Horn, Andrej Teren, Ralf Regenthal, Markus Loeffler, Joachim Thiery, Achim Aigner, Janne Pott, Holger Kirsten, Markus Scholz
Summary: By investigating the impact of drugs on blood transcriptome, researchers have developed a catalogue of 14 substances affecting differential gene expression in a total of 534 genes. In an observational study of stable coronary artery disease or myocardial infarction patients, they successfully replicated differential gene expression for three active substances affecting 80 genes in peripheral blood mononuclear cells.
Article
Cardiac & Cardiovascular Systems
Yeon-Jik Choi, Seung-Jun Lee, Byeong-Keuk Kim, Sung-Jin Hong, Chul-Min Ahn, Jung-Sun Kim, Hyeon-Cheol Gwon, Hyo-Soo Kim, Woo Jung Chun, Seung-Ho Hur, Chang-Wook Nam, Seung Hwan Han, Seung-Woon Rha, In-Ho Chae, Jin-Ok Jeong, Jung Ho Heo, Junghan Yoon, Do-Sun Lim, Jong-Seon Park, Kwang Soo Cha, Doo-Il Kim, Sang Yeub Lee, Kiyuk Chang, Byung-Hee Hwang, So-Yeon Choi, Myung Ho Jeong, Ki-Hong Choi, Young-Bin Song, Soon-Jun Hong, Joon-Hyung Doh, Bon-Kwon Koo, Myeong-Ki Hong, Yangsoo Jang
Summary: This study found that side branch wire jailing before main vessel stenting can prevent occlusion of the side branch after the 1-stent strategy for bifurcation percutaneous coronary intervention. However, it is not associated with overall bifurcation lesions. The long-term clinical outcomes were comparable between the two groups.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Biochemical Research Methods
Yijie Ding, Jijun Tang, Fei Guo, Quan Zou
Summary: Targeted drugs have shown therapeutic effects in cancer treatment, but detecting drug-target interactions through biochemical experiments is time-consuming. Machine learning has been widely used in large-scale drug screening, but there is a lack of methods for multiple information fusion. Researchers propose a multiple kernel-based triple collaborative matrix factorization method to predict drug-target interactions.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Cardiac & Cardiovascular Systems
Bernard R. Chaitman, Karen P. Alexander, Derek D. Cyr, Jeffrey S. Berger, Harmony R. Reynolds, Sripal Bangalore, William E. Boden, Renato D. Lopes, Marcin Demkow, Gian Piero Perna, Robert K. Riezebos, Edward O. McFalls, Subhash Banerjee, Akshay Bagai, Gilbert Gosselin, Sean M. O'Brien, Frank W. Rockhold, David D. Waters, Kristian A. Thygesen, Gregg W. Stone, Harvey D. White, David J. Maron, Judith S. Hochman
Summary: The ISCHEMIA trial showed that an initial invasive strategy did not reduce cardiovascular events or all-cause mortality in patients with stable ischemic heart disease. Procedural MI rates were higher with the invasive strategy compared to conservative strategy, with the use of the secondary MI definition.
Editorial Material
Hematology
Alberto Vera, Fernando Rivero, Jorge Salamanca, Teresa Alvarado-Casas, Fernando Alfonso
Summary: The article describes a case of thrombotic coronary side effect in a 72-year-old woman with advanced breast cancer following treatment with abemaciclib, highlighting the need to be cautious of potential cardiotoxic effects of new cancer treatment drugs.
THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Medicine, General & Internal
Mina Ghobrial, Bilal Bawamia, Timothy Cartlidge, Ioakim Spyridopoulos, Vijay Kunadian, Azfar Zaman, Mohaned Egred, Adam Mcdiarmid, Matthew Williams, Mohamed Farag, Mohammad Alkhalil
Summary: This review focuses on the phenomenon of microvascular obstruction (MVO) following mechanical reperfusion in patients with ST-segment elevation myocardial infarction (STEMI). The accuracy of invasive and non-invasive methods to detect and measure MVO varies, and the presence of MVO increases the risk and leads to adverse cardiac remodeling and worse prognosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemical Research Methods
Bin Liu, Dimitrios Papadopoulos, Fragkiskos D. Malliaros, Grigorios Tsoumakas, Apostolos N. Papadopoulos
Summary: The study proposes a novel optimization framework called Multiple similarity DeepWalk-based Matrix Factorization (MDMF) to predict drug-target interactions, achieving unified embedding generation and interaction prediction, as well as improved accuracy and novelty in prediction.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Biochemistry & Molecular Biology
Daniel Cesarini, Iacopo Muraca, Martina Berteotti, Anna Maria Gori, Andrea Sorrentino, Alessia Bertelli, Rossella Marcucci, Renato Valenti
Summary: Ticagrelor is a recommended medication for DAPT in ACS patients, but it is associated with increased risk of dyspnea and bradyarrhythmias. The molecular mechanisms of these side effects and their management strategies are not well-defined. This article presents a case report and reviews the available evidence to propose decision-making algorithms for managing these side effects in clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Bridget Simonson, Mark Chaffin, Matthew C. Hill, Ondine Atwa, Yasmine Guedira, Harshit Bhasin, Amelia W. Hall, Sikander Hayat, Simon Baumgart, Kenneth C. Bedi, Kenneth B. Margulies, Carla A. Klattenhoff, Patrick T. Ellinor
Summary: Using single-nucleus RNA sequencing and computational analysis, the cellular and molecular signature of ischemic cardiomyopathy (ICM) was investigated. The study revealed alterations in the cellular composition of the ischemic heart, with decreased cardiomyocytes and increased proportions of lymphatic, angiogenic, and arterial endothelial cells in ICM patients. Furthermore, increased LAMININ signaling from endothelial cells and similarities in transcriptional changes were observed between ICM, hypertrophic, and dilated cardiomyopathies, which may help identify potential drug targets for end-stage heart failure.
Article
Biochemistry & Molecular Biology
Biswajit Naik, Nidhi Gupta, Priya Godara, Varshita Srivastava, Prateek Kumar, Rajanish Giri, Vijay Kumar Prajapati, Kailash C. Pandey, Dhaneswar Prusty
Summary: Compared to last year, there has been a significant increase in malaria cases in 2021. The emergence of drug-resistant strains of the malaria parasite Plasmodium falciparum has reduced the effectiveness of current antimalarial drugs. To address this issue, researchers aimed to identify natural compounds that can inhibit multiple validated drug targets of Plasmodium falciparum. Screening of natural compounds from the NPASS database led to the identification of 20 compounds with promising potential. Molecular simulations confirmed the stable binding affinity of six of these compounds, indicating their potential as future antimalarial drugs.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Susanna Fiorelli, Andrea Anesi, Benedetta Porro, Nicola Cosentino, Jose P. Werba, Alessandro Di Minno, Chiara Maria Manega, Simone Barbieri, Gualtiero Colombo, Giancarlo Marenzi, Viviana Cavalca, Elena Tremoli, Sonia Eligini
Summary: The study focused on investigating the migration capacity of monocytes isolated from patients with acute myocardial infarction (AMI) at hospital presentation and its correlation with cellular lipid profile. It was found that AMI patients' monocytes exhibited increased migration and a distinct lipidomic profile compared to controls, with lactosylceramide levels positively correlating with migration and lactosylceramide synthase inhibition significantly reducing monocyte migration induced by fetal bovine serum. These results suggest a potential mechanism involving lactosylceramide in the development of atherothrombosis and AMI.
Article
Biophysics
Divya Soundararajan, Lakshmi Narashimhan Ramana, Prakash Shankaran, Uma Maheswari Krishnan
Summary: Nanotechnology-based interventions have the potential to improve the therapeutic efficacy of antiretroviral drugs for HIV infections. The use of nanocarriers for drug delivery is gaining momentum, offering the possibility to overcome some of the disadvantages associated with conventional drugs.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Riccardo Concu, Maria Natalia Dias Soeiro Cordeiro, Martin Perez-Perez, Florentino Fdez-Riverola
Summary: This study developed a novel multi-target machine learning (MTML) quantitative structure-activity relationship (QSAR) model for predicting interactions between different drugs and enzyme targets. The model was based on a large dataset of drug-enzyme pairs and used topological drug features and artificial neural network (ANN) multi-layer perceptron (MLP). The validated model showed an overall accuracy of over 96%. To maximize its diffusion, a public and accessible web-based tool was developed for users to make their own predictions.
Article
Cardiac & Cardiovascular Systems
Andrew I. Lumley, Lu Zhang, Isabelle Ernens, Przemyslaw Leszek, Yvan Devaux
Summary: The study identified differentially expressed lncRNAs during cardiac regeneration in adult zebrafish after HF, indicating their potential as therapeutic targets. A subset of these lncRNAs had human homologs, suggesting a novel avenue for future research on cardiac regeneration.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cell Biology
Melanie Vausort, Magdalena Niedolistek, Andrew I. Lumley, Marta Okninska, Aleksandra Paterek, Michal Maczewski, Xiangyi Dong, Christian Jager, Carole L. Linster, Przemyslaw Leszek, Yvan Devaux
Summary: Development of heart failure (HF) after myocardial infarction (MI) is responsible for premature death. This study investigated the association between the epitranscriptomic RNA modification N6-methyladenosine (m6A) and HF after MI. The results showed that m6A content increased in the infarcted area of rat hearts and decreased in blood. Furthermore, patients with lower m6A content in blood were more likely to develop HF after MI.
Editorial Material
Cardiac & Cardiovascular Systems
Yvan Devaux
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2022)
Review
Medical Laboratory Technology
Paivi Lakkisto, Louise Torp Dalgaard, Thalia Belmonte, Sara-Joan Pinto-Sietsma, Yvan Devaux, David De Gonzalo-Calvo
Summary: The implementation of cell-free microRNAs as biomarkers is limited due to lack of reproducibility. Technical variability and analytical caveats make the interpretation of miRNA data challenging. Standardization efforts and consideration of specific aspects in sample handling and data analysis are important for reproducibility. Providing a checklist can facilitate the control of miRNA quantification and analysis.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Reza Parvan, Milad Hosseinpour, Yousef Moradi, Yvan Devaux, Alessandro Cataliotti, Gustavo J. J. da Silva
Summary: Circulating miRNAs have diagnostic potential for different types of chronic heart failure (CHF), according to a systematic review and meta-analysis. Specific miRNA panels showed high accuracy and sensitivity in detecting heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF).
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Environmental Sciences
Aurelie Fischer, Nolwenn Badier, Lu Zhang, Abir Elbeji, Paul Wilmes, Pauline Oustric, Charles Benoy, Markus Ollert, Guy Fagherazzi
Summary: This study classified patients with Long COVID into three subcategories based on the severity of symptoms, which are Mild, Moderate, and Severe. Patients in different subcategories have distinct characteristics and symptom presentations. This classification method can help clinicians provide better care for patients with Long COVID.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Daniel Benak, Frantisek Kolar, Lu Zhang, Yvan Devaux, Marketa Hlavackova
Summary: Epitranscriptomic modifications, specifically N-6,2'-O-dimethyladenosine (m(6)Am), have gained attention from researchers due to their significant regulatory effects on gene expression and cellular physiology. This review focuses on the current knowledge and gaps regarding m(6)Am modification and its regulators in cardiac biology. It also highlights the technical challenges and available techniques for measuring m(6)Am. A better understanding of these modifications is crucial for uncovering molecular regulations in the heart and developing novel cardioprotective strategies.
Editorial Material
Cardiac & Cardiovascular Systems
Shubhra Acharya, Andrew Lumley, Yvan Devaux
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Miron Sopic, Georgios Kararigas, Yvan Devaux, Paolo Magni
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Shubhra I. Acharya, Andrew I. Lumley, Lu Zhang, Melanie Vausort, Yvan Devaux
Summary: This study investigated the levels of GATA3 mRNA in whole blood samples of idiopathic Parkinson's disease (iPD) patients with different disease severities as a biomarker for iPD. The results showed that blood GATA3 mRNA expression was significantly lower in iPD patients compared to controls. Logistic regression models demonstrated a significant association between GATA3 expression and the diagnosis of iPD, and the addition of GATA3 expression improved the diagnostic capacity. This study suggests that blood GATA3 expression may serve as a novel biomarker for the diagnosis and assessment of disease severity in iPD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lu Zhang, Sabrina Fritah, Petr V. Nazarov, Tony Kaoma, Eric Van Dyck
Summary: By generating protein diversity, alternative splicing plays an important role in oncogenesis. The IDH1 and IDH2 mutations, as well as the 1p/19q co-deletion, have become crucial for the molecular classification of diffuse gliomas, which also considers DNA methylation profiling. This study demonstrates the impact of IDH mutation, 1p/19q co-deletion, and glioma CpG island methylator phenotype (G-CIMP) on alternative splicing in diffuse gliomas from The Cancer Genome Atlas (TCGA). The findings suggest that alternative splicing contributes to epigenetic regulation in diffuse gliomas and targeting the genes and pathways affected by alternative splicing may offer potential therapeutic opportunities against gliomas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Sabine Steffens, Katrin Schroeder, Martina Krueger, Christoph Maack, Katrin Streckfuss-Boemeke, Johannes Backs, Rolf Backofen, Bettina Baessler, Yvan Devaux, Ralf Gilsbach, Jordi Heijman, Jochen Knaus, Rafael Kramann, Dominik Linz, Allyson L. Lister, Henrike Maatz, Lars Maegdefessel, Manuel Mayr, Benjamin Meder, Sara Y. Nussbeck, Eva A. Rog-Zielinska, Marcel H. Schulz, Albert Sickmann, Goekhan Yigit, Peter Kohl
Summary: Sharing and documentation of cardiovascular research data are essential but challenges like lack of time, incentives, funding, standardization, and legal understanding exist. More tools, education, and training are needed for effective data sharing and an open science culture. Long-term effort is required for FAIR RDM.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Miron Sopic, Baiba Vilne, Eva Gerdts, Fabio Trindade, Shizuka Uchida, Soliman Khatib, Stephanie Bezzina Wettinger, Yvan Devaux, Paolo Magni
Summary: Multiomics studies offer accurate strategies for ASCVD, and AI and ML can integrate multiple datasets for personalized approaches. Challenges in data quality and privacy need to be addressed.
TRENDS IN MOLECULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Miron Sopic, Emma L. Robinson, Costanza Emanueli, Prashant Srivastava, Claudio Angione, Carlo Gaetano, Gianluigi Condorelli, Fabio Martelli, Thierry Pedrazzini, Yvan Devaux
Summary: The field of epigenetics has gained attention in cardiovascular research due to its association with disease development. Multi-omics approaches that integrate different levels of disease regulation, such as DNA, histone, and RNA modifications, are essential for understanding complex diseases like cardiovascular diseases. This review focuses on discussing the role of epigenetic mechanisms in regulating gene expression and their interlinkage in the development of cardiac disease, particularly heart failure. The review also presents current methods and tools used for data integration and analysis, which can contribute to the discovery of novel therapeutic approaches and biomarkers for precision healthcare and improved clinical outcomes.
BASIC RESEARCH IN CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Louis Chauviere, Lucien Hoffbeck, Muhammad Shoaib, Florent Tessier, Huseyin Firat, Venkata Satagopam, Yvan Devaux
Summary: Firalink is a bioinformatics pipeline developed for analyzing lncRNA data generated by targeted sequencing. It can be applied to different lncRNA panels and transcriptomics data for investigations in various diseases, such as cardiovascular disease and brain disease.
NON-CODING RNA RESEARCH
(2023)