Article
Infectious Diseases
Chuanmin Liu, Zhisheng Wang, Qiannan Zhang, Bo Zhang, Tao Xue, Jinping Fu
Summary: Exogenous nitric oxide (NO) inhibits PCV2 replication in vitro in a dose-dependent and time-dependent manner, possibly through the regulation of NF-kappa B activity. These findings offer a new potential antiviral therapy against PCV2 infection.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Microbiology
Yingshan Zhou, Xiaojie Zhou, Wanyu Dong, Yuxin Zhang, Jing Du, Xingdong Zhou, Weihuan Fang, Xiaodu Wang, Houhui Song
Summary: This study found that PCV2 infection increased the expression of proapoptotic proteins CHOP and ERO1 alpha, and induced cell apoptosis through the CHOP-ERO1 alpha-ROS signaling.
VETERINARY MICROBIOLOGY
(2022)
Article
Microbiology
Tong Xu, Li-Shuang Deng, Zhi-Jie Jian, Lei Xu, Feng-Qin Li, Si-Yuan Lai, Yan-Ru Ai, Ling Zhu, Zhi-Wen Xu
Summary: This study reports the molecular detection of PCV4 in cats from Sichuan Province, China, confirming the presence of PCV4 in this species. The PCV4 strain from cats showed high nucleotide homology with strains from other species and clustered closely with a strain from a pig in Fujian Province, China.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Guyu Niu, Xinwei Zhang, Weilong Ji, Si Chen, Xue Li, Lin Yang, Liying Zhang, Hongsheng Ouyang, Chang Li, Linzhu Ren
Summary: In this study, PCV4 was successfully rescued and shown to be pathogenic in pigs. Visible pathological changes were observed in the inoculated piglets, and effective humoral and cellular immune responses were stimulated.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Microbiology
Liu-Hui Zhang, Tong-Xuan Wang, Peng-Fei Fu, You-Yi Zhao, Hong-Xuan Li, Dong-Mei Wang, Shi-Jie Ma, Hong-Ying Chen, Lan-Lan Zheng
Summary: This study is the first to report the presence of PCV4 in dogs worldwide, and the first complete genome sequence was obtained from a dog affected with diarrhea. Three genotypes of PCV4 strains (PCV4a, PCV4b, and PCV4c) were determined, as supported by specific amino acid markers (V239L for open reading frame 1 [ORF1] and N27S R28G and M212L for ORF2).
MICROBIOLOGY SPECTRUM
(2023)
Article
Spectroscopy
Izabel C. V. P. Gogone, Glaucia H. Ferreira, Danielle Gava, Rejane Schaefer, Fabiola F. de Paula-Lopes, Raquel de A. Rocha, Flavia R. O. de Barros
Summary: The study evaluated Raman spectroscopy as a diagnostic tool for porcine parvovirus and porcine circovirus type 2, demonstrating its ability to effectively discriminate virus-infected cells and providing promising bases for future diagnostic applications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biochemistry & Molecular Biology
S. Parthiban, A. Ramesh, Anbu Kumar Karuppannan, G. Dhinakar Raj, S. Hemalatha, M. Parthiban, K. Senthilkumar, D. Balasubramaniyam, R. Sumanth Kumar, S. Ranganatha, Chintu Ravishankar
Summary: This study reveals a high prevalence of PCV2d genotype in the field conditions of southern states of India, indicating the widespread circulation of PCV2 in the region.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Virology
Rongdi Luo, Changchao Huan, Qingqing Gao, Haochun Pan, Pengxiang Chen, Xiufan Liu, Song Gao
Summary: In this study, the proteomic analysis of PCV2-infected cells revealed significant alterations in protein expression, affecting various biological processes including cellular processes, environmental information processing, genetic information processing, disease, metabolism, and body systems. Enrichment analysis highlighted the significant involvement of innate immune responses in PCV2 infection. This study also demonstrated the impact of the protein CRYAB on PCV2 replication, shedding light on the mechanism of PCV2 pathogenesis and host response to infection.
Article
Infectious Diseases
Giulia Faustini, Michele Drigo, Maria Luisa Menandro, Daniela Pasotto, Franzo Giovanni
Summary: Four porcine circoviruses, including PCV-2, -3, and the recently identified PCV-4, have a common history of circulating and coexisting with domestic pigs undetected for decades. The phylodynamic analysis of PCV-4 sequences suggests an ancient origin at least a few decades ago, followed by a gradual increase in circulation and a moderate rise in viral population size since the second half of the 20th century. PCV-4 shows limited spreading capacity and a geographically clustered distribution, which requires further investigation.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Veterinary Sciences
Joaquim Segales, Marina Sibila
Summary: Current knowledge on Porcine circovirus diseases (PCVD) caused by Porcine circovirus 2 (PCV-2) includes subclinical infection, systemic disease, reproductive disease, and other related conditions. The diagnosis of PCVD is based on clinical signs, lesions, and viral detection. Molecular biology methods have been used for monitoring PCVD, but should be considered as monitoring tools rather than diagnostic ones. The epidemiological picture of PCV-2 has changed due to vaccination, leading to a decrease in infectious pressure and overall herd immunity. The need for diagnosing PCVD has increased in cases with PCV-2-like conditions after vaccination.
VETERINARY SCIENCES
(2022)
Article
Infectious Diseases
Viviane Sisdelli Assao, Marcus Reboucas Santos, Carlos Eduardo Real Pereira, Fabio Vannucci, Abelardo Silva-Junior
Summary: PCV3 is a newly discovered virus detected in swine populations worldwide, with uncertain pathogenicity. There are at least six different lineages of PCV3 circulating in North and South American countries. Further studies are needed to determine the role of PCV3 in different clinical syndromes and its epidemiology in swine herds in the Americas.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Xue Li, Si Chen, Guyu Niu, Xinwei Zhang, Weilong Ji, Ying Ren, Liying Zhang, Linzhu Ren
Summary: This study analyzed the genetic relationship between PCV4 and other circoviruses, and found that PCV4 is more similar to MiCV, suggesting a potential common origin or derivation from MiCV. This raises concerns about the potential threat of PCV4 to animals and even humans. Therefore, continuous monitoring of PCV4 infection and variation, as well as the establishment of prevention and treatment methods, is necessary.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Veterinary Sciences
Libin Wen, Kongwang He
Summary: PCV2, associated with PCVAD in pigs, has caused economic losses in the pig industry worldwide. Since its discovery in the late 1990s, PCV2 has evolved with new genotypes and recombination between different genotypes.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Virology
Yaima Burgher Pulgaron, Chantale Provost, Marie-Jeanne Pesant, Carl A. Gagnon
Summary: This study investigates the pathogenesis of porcine circovirus type 2b (PCV2b) and swine influenza A virus (SwIV) co-infection in swine respiratory cells. The results show that the co-infection has different outcomes in different cell types, affecting viral replication and cytokine expression. RNA-sequencing reveals the modulation of gene expression and cellular pathways during PCV2b and SwIV H1N1 co-infection, providing new insights on the pathogenesis of porcine viral co-infections.
Article
Microbiology
Huansheng Wu, Chengyao Hou, Zhiru Wang, Puyan Meng, Hongying Chen, Huabin Cao
Summary: This study investigated the epidemiology and genetic diversity of Porcine circovirus type 4 (PCV4) in wild boars in Jiangxi province, China. The study found that some wild boars were positive for PCV4, and the PCV4 strains derived from wild boars were similar to those found in domestic pigs but distinct from other circoviruses. These findings expand our understanding of PCVs in wild boars and provide insights into the molecular epidemiology of PCV4.
VETERINARY MICROBIOLOGY
(2022)
