Article
Oncology
Alexander Heinzel, Daniela Dedic, Norbert Galldiks, Philipp Lohmann, Gabriele Stoffels, Christian P. Filss, Martin Kocher, Filippo Migliorini, Kim N. H. Dillen, Stefanie Geisler, Carina Stegmayr, Antje Willuweit, Michael Sabel, Marion Rapp, Michael J. Eble, Marc Piroth, Hans Clusmann, Daniel Delev, Elena K. Bauer, Garry Ceccon, Veronika Dunkl, Jurij Rosen, Caroline Tscherpel, Jan-Michael Werner, Maximilian I. Ruge, Roland Goldbrunner, Jurgen Hampl, Carolin Weiss Lucas, Ulrich Herrlinger, Gabriele D. Maurer, Joachim P. Steinbach, Joerg Mauler, Wieland A. Worthoff, Bernd N. Neumaier, Christoph Lerche, Gereon R. Fink, Nadim Jon Shah, Felix M. Mottaghy, Karl-Josef Langen
Summary: PET imaging using O-(2-[F-18]fluoroethyl)-L-tyrosine (FET) as a tracer has become essential for diagnosing brain tumors, with increasing demand seen for differentiating tumor progress and treatment-related changes. Referring physicians rate FET PET highly for diagnosing recurrent gliomas and brain metastases.
Article
Chemistry, Medicinal
Nils Walter, Jan Bertram, Birte Drewes, Victor Bahutski, Marco Timmer, Markus B. Schuetz, Felicia Kraemer, Felix Neumaier, Heike Endepols, Bernd Neumaier, Boris D. Zlatopolskiy
Summary: A protocol for radiolabeling of aryl fluorosulfates using ultrafast isotopic exchange has been developed and optimized. This method allows for efficient labeling of low nanomolar amounts of aryl fluorosulfates without the need for azeotropic drying, base addition, and HPLC purification. The labeled compounds demonstrated sufficient stability in vivo and showed promise as tracers for visualizing specific molecular expressions.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Olivia Kertels, Juergen Krauss, Camelia Maria Monoranu, Samuel Samnick, Alexander Dierks, Malte Kircher, Milena I. Mihovilovic, Mirko Pham, Andreas K. Buck, Matthias Eyrich, Paul-Gerhardt Schlegel, Michael C. Fruehwald, Brigitte Bison, Constantin Lapa
Summary: This retrospective study analyzed the diagnostic utility and impact on clinical management of [F-18]FET-PET in 21 pediatric and adolescent patients with CNS tumors. The results showed that [F-18]FET-PET had an impact on the treatment decisions of 14 patients, including avoidance of invasive surgery or biopsy, biopsy guidance, change of treatment, and confirmation of diagnosis.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Medicine, General & Internal
Cecile Tissot, Joseph Therriault, Peter Kunach, Andrea L. Benedet, Tharick A. Pascoal, Nicholas J. Ashton, Thomas K. Karikari, Stijn Servaes, Firoza Z. Lussier, Mira Chamoun, Dana L. Tudorascu, Jenna Stevenson, Nesrine Rahmouni, Nina Margherita Poltronetti, Vanessa Pallen, Gleb Bezgin, Min Su Kang, Sulantha S. Mathotaarachchi, Yi-Ting Wang, Jaime Fernandez Arias, Pamela Cristina Lukasewicz Ferreira, Joao Pedro Ferrari-Souza, Eugeen Vanmechelen, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Neto
Summary: This study investigated the agreement between [F-18]MK6240 tau-PET, plasma pTau181, and pTau231 in Alzheimer's disease. The findings suggest that these biomarkers reflect different stages of tau progression and can be useful in diagnosing and evaluating the disease stage.
Article
Neurosciences
Mengfei Xiong, Sahar Roshanbin, Dag Sehlin, Hanne D. Hansen, Gitte M. Knudsen, Johanna Rokka, Jonas Eriksson, Stina Syvanen
Summary: This study explores the use of SV2A PET to investigate synaptic density at different ages in healthy mice. The results show a decrease in synaptic density in the oldest age group, consistent with previous findings in humans.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yong Du, Jennifer M. Coughlin, Alireza Amindarolzarbi, Shannon Eileen Sweeney, Courtney K. Harrington, Mary Katherine Brosnan, Adeline Zandi, Laura K. Shinehouse, Alejandra N. Reyes Sanchez, Rehab Abdallah, Daniel P. Holt, Hong Fan, Wojciech G. Lesniak, Ayon Nandi, Steven P. Rowe, Lilja B. Solnes, Robert F. Dannals, Andrew G. Horti, Martin A. Lodge, Martin G. Pomper
Summary: This study reported the test-retest repeatability of [F-18]FNDP brain PET binding and [F-18]FNDP whole-body dosimetry in healthy individuals. The results showed that [F-18]FNDP brain PET imaging and whole-body dosimetry had favorable repeatability in healthy individuals.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Medicine, Research & Experimental
Marius E. Mayerhoefer, Markus Raderer, Wolfgang Lamm, Verena Pichler, Sarah Pfaff, Michael Weber, Barbara Kiesewetter, Markus Hacker, Lukas Kazianka, Philipp B. Staber, Hans-Juergen Wester, Johannes Rohrbeck, Ingrid Simonitsch-Klupp, Alexander Haug
Summary: In this prospective study, [Ga-68]Pentixafor-PET showed higher sensitivity and detection rates compared to [F-18]FDG-PET in patients with mantle cell lymphoma (MCL), indicating that it may be a potential alternative for imaging in these patients. The study also found that SUVs and TBRs were significantly higher for [Ga-68]Pentixafor-PET, with the most notable difference observed in mean TBRblood values.
Review
Biochemistry & Molecular Biology
Felix Francis, Frank Wuest
Summary: Positron emission tomography (PET) is a vital imaging technique used for studying biological and physiological processes, with fluorine-18 (F-18) being a commonly used positron emitter in PET imaging. The presence of fluorine atoms in many drugs opens up possibilities for developing radioligands labeled with fluorine-18.
Article
Biochemistry & Molecular Biology
Guolong Huang, Xiaolei Lu, Yifan Qiu, Lei Bi, Peizhen Ye, Min Yang, Yanfang Shen, Hongjun Jin, Junbin Han
Summary: A novel P2X7R targeting radiotracer was synthesized and proved to stably retain and target P2X7R in vivo without defluorination in major organs. It shows potential as a promising PET radioligand for clinical translation.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Amanda Nguyen, Felipe Martinez, Ba D. Nguyen
Summary: This case report presents chest wall keloids detected on F-18-piflufolastat PET/CT during the evaluation of prostate cancer recurrence.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lijuan Feng, Xu Yang, Xia Lu, Ying Kan, Chao Wang, Dehui Sun, Hui Zhang, Wei Wang, Jigang Yang
Summary: This study developed and validated a radiomics nomogram based on F-18-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for non-invasive prediction of bone marrow involvement (BMI) in pediatric neuroblastoma. The radiomics nomogram incorporated radiomics signature and independent clinical risk factors, and showed good predictive performance in predicting BMI.
INSIGHTS INTO IMAGING
(2022)
Article
Cell Biology
Robert K. Doot, Anthony J. Young, Ilya M. Nasrallah, Reagan R. Wetherill, Andrew Siderowf, Robert H. Mach, Jacob G. Dubroff
Summary: Neuroinflammation is an important factor in neurodegenerative diseases and is mediated by microglia. This study used [F-18]NOS PET imaging to measure neuroinflammation in idiopathic Parkinson's disease patients and found increased oxidative stress as a marker of inflammation in early-stage disease.
Article
Clinical Neurology
Antonio Canosa, Alessio Martino, Alessandro Giuliani, Cristina Moglia, Rosario Vasta, Maurizio Grassano, Francesca Palumbo, Sara Cabras, Francesca Di Pede, Filippo De Mattei, Enrico Matteoni, Giulia Polverari, Umberto Manera, Andrea Calvo, Marco Pagani, Adriano Chio
Summary: This study aimed to evaluate the ability of brain 2-[F-18]FDG-PET to reveal the metabolic features characterizing patients with pure bulbar or spinal motor impairment. The results showed that ALS patients with bulbar onset exhibited relative hypometabolism in the bilateral precentral gyrus, and the SVM classifier performed the best.
JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, Research & Experimental
Daniel Kwon, Jerome Lozada, Zhengxing Zhang, Jutta Zeisler, Richel Poon, Chengcheng Zhang, Aron Roxin, Kuo-Shyan Lin, David Perrin, Francois Benard
Summary: C-X-C chemokine receptor 4 (CXCR4) is highly expressed in cancer and plays a role in metastasis and poor prognosis. Two new radiotracers, BL08 and BL09, demonstrate high tumor uptake and visualization, showing potential for CXCR4-targeted PET imaging with improved contrast ratios compared to existing radioligands.
MOLECULAR PHARMACEUTICS
(2021)
Article
Multidisciplinary Sciences
Ou Yamaguchi, Kyoichi Kaira, Ichiro Naruse, Yukihiro Umeda, Takeshi Honda, Satoshi Watanabe, Kosuke Ichikawa, Kazunari Tateishi, Norimitsu Kasahara, Tetsuya Higuchi, Kosuke Hashimoto, Shun Shinomiya, Yu Miura, Ayako Shiono, Atsuto Mouri, Hisao Imai, Kunihiko Iizuka, Tamotsu Ishizuka, Koichi Minato, Satoshi Suda, Hiroshi Kagamu, Keita Mori, Ichiei Kuji, Nobuhiko Seki
Summary: This study aimed to investigate the clinical relevance of F-18-FDG PET/CT compared to CT in predicting the response to PD-1 blockade in the early phase. The results showed that metabolic assessment by MTV or TLG was superior to morphological changes on CT for predicting the therapeutic response and survival.
SCIENTIFIC REPORTS
(2022)
