Article
Chemistry, Analytical
Tianyi Qin, Bin Liu, Zhongyong Xu, Guangkai Yao, Hanhong Xu, Chen Zhao
Summary: Flavonols, as important natural botanical functional pigments, exhibit unique environmental-sensitive dual emissions as fluorophore skeleton for probe design. This review summarizes recent progress of flavonol-based fluorescent probes for diverse sensing applications, including detection of anions, cations, proteins, DNA, etc.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Inorganic & Nuclear
Ya-Lin Qi, Yun-Zhan Li, Ming-Jun Tan, Fang-Fang Yuan, Niren Murthy, Yong-Tao Duan, Hai-Liang Zhu, Sheng-Yu Yang
Summary: In recent years, there has been great interest in the development of organic near-infrared (NIR) ratiometric fluorescent probes. Traditional intensity-based probes lack an internal standard method, resulting in unreliable and inaccurate detection signals as well as an inability to achieve quantitative determination of analytes. Smart dual emission probes with built-in correction ability have overcome the limitations of single channel fluorescent probes and enable reliable quantitative image analysis. Moreover, fluorescent chemosensors in the NIR window offer advantages such as high signal-to-noise ratio, low tissue damage, and deep tissue penetration. The combination of the advantages of ratiometric fluorescent probes and single-intensity-based NIR probes in NIR ratiometric fluorescent probes has led to their widespread application in biomedical research and clinical practice. This review provides a systematic summary of the recent advances (2020-2022) in this field, discussing the design strategies, sensing mechanisms, and bioapplications of these intelligent fluorescent probes. The challenges and prospects in this promising field are also addressed, with the anticipation that this work will inspire the development of organic NIR ratiometric fluorescent probes.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Chemistry, Analytical
Yongfei Huang, Junping Liang, Zhefeng Fan
Summary: In recent years, there has been great interest in the development of dual/multi-organelle-targeted fluorescent probes based on small organic molecules, which exhibit good biocompatibility and allow visualization of interactions between different organelles. These probes also have the ability to detect small molecules within organelle environments, such as active sulfur species, reactive oxygen species, pH, and viscosity. However, there is a lack of systematic reviews on dual/multi-organelle-targeted fluorescent probes for small organic molecules, which may hinder the progress of this field. This review focuses on the design strategies and bioimaging applications of these probes, and categorizes them based on the targeted organelles.
Article
Chemistry, Multidisciplinary
Xue Tian, Lloyd C. Murfin, Luling Wu, Simon E. Lewis, Tony D. James
Summary: Small-molecule based fluorescent probes play an increasingly important role in detecting and imaging biological signaling molecules due to their simplicity, high selectivity, and real-time analysis capabilities. Various sensing mechanisms, including FRET, ICT, PeT, ESIPT, AIE, as well as dual/triple sensing mechanisms, are highlighted, but challenges remain. Future development should focus on improving small-molecule fluorescent probes for biosensing applications.
Review
Chemistry, Medicinal
Ting Li, Xuyang Chen, Kai Wang, Zhigang Hu
Summary: Sulfite is commonly used in food and beverages as an antioxidant and preservative, with abnormal levels in the body linked to various diseases. There is a need for a rapid, accurate, sensitive, and non-invasive method to monitor sulfite levels. Fluorescent probes offer advantages such as real-time imaging, ease of operation, cost-effectiveness, rapid response, and non-invasiveness for sulfite detection.
Review
Chemistry, Inorganic & Nuclear
Zi-Xuan Chu, Qi Song, Yong-Qiang Zhang, Jie Jiang
Summary: Formaldehyde (FA) is a reactive carbonyl species that is generated in the environment and produced in organisms. It plays important roles in physiological processes at low concentrations and is associated with diseases at elevated levels. Fluorescent probes have emerged as useful tools for detecting and visualizing FA in various contexts, enabling the exploration of its diverse functions. This review summarizes recent advancements in the development of FA probes, including organic and material-based probes, and discusses future prospects for design and research.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Chemistry, Analytical
Zeng-Hui Yuan, Yu-Shun Yang, Peng-Cheng Lv, Hai-Liang Zhu
Summary: This article introduces small-molecule fluorescent probes developed in recent years for detecting mercury ions. Compared to traditional quantitative methods, these fluorescent probes have advantages such as convenient detection, high sensitivity, and good selectivity. By comparing the performances and explaining the mechanisms of these probes, it is hoped to provide certain reference value for the design and application of metal ion fluorescent probes.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Inorganic & Nuclear
Qingtao Meng, Miaomiao Wu, Zhuye Shang, Zhiqiang Zhang, Run Zhang
Summary: Magnetic resonance imaging (MRI) is a widely used molecular imaging technology in biomedical and clinical diagnostics. Responsive MRI probes based on gadolinium(III) (Gd(III)) complexes, which can detect and visualize target analytes, have been systematically summarized in this work. The development of strategies, the progresses in developing Gd(III) complex-based responsive MRI probes for different target analytes, and the limitations and future research directions are discussed.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Inorganic & Nuclear
Yuyu Fang, Wim Dehaen
Summary: F-block elements, including lanthanides and actinides, play important roles in various fields but can be harmful to human health upon long-term exposure. Selective detection and determination of f-block cations is necessary, with fluorescent chemosensors offering advantages such as high selectivity and sensitivity for real-time visualization and in vivo bioimaging analysis.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Chemistry, Inorganic & Nuclear
Xinyu Liu, Bing Yu, Youqing Shen, Hailin Cong
Summary: Near-infrared fluorescence imaging has gained attention in biomedical research due to its high sensitivity and specificity. Near-infrared II (NIR-II) fluorescence imaging further enhances the imaging effect by reducing tissue absorption, scattering, and autofluorescence. Organic small molecule fluorophores have shown promising potential as fluorescent probes. This review summarizes the latest progress in organic small molecule fluorescent probes for NIR-II imaging, including molecular structure, performance improvement methods, probe delivery in organisms, and their applications in biological imaging and tumor therapy.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Analytical
Hyo Won Lee, Vinayak Juvekar, Dong Joon Lee, Hwan Myung Kim
Summary: Biological events occur in specific cellular organelles to perform specialized roles in cells and collaborate with other organelles. Various methods have been used to study organelle dynamics, including two photon microscopy. This review focuses on the design strategies, photo-physical properties, and bioimaging applications of recent two-photon probes specifically localized in the endoplasmic reticulum, Golgi, lipid droplets, lysosomes, plasma membrane, and mitochondria. The summary is limited to research from 2017 onwards. © 2023 Elsevier B.V. All rights reserved.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Inorganic & Nuclear
Binghuan Huang, Bing Liang, Renshuai Zhang, Dongming Xing
Summary: This review summarizes the applications of fluorescent ATP probes in cancer cells based on small molecules and water-soluble conjugated polymers, highlighting their organelle-targeting abilities. The sensing mechanisms of these probes are also emphasized.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Analytical
Zixuan Zhan, Yongcheng Dai, Qiuyan Li, Yi Lv
Summary: Small molecules-based bioluminescence and chemiluminescence probes have emerged as powerful tools for biomarkers imaging without requiring excitation light source, showing intriguing properties and fast development. However, probes for reactive species have not been reviewed comprehensively in the past decade. Recent research indicates the significant potential of these probes in the field of biomedical imaging.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Mikhail Panfilov, Darya Chernova, Irina Khalfina, Alexander Moskalensky, Aleksey Vorob'ev
Summary: Nitric oxide (NO) is an important signaling molecule involved in various physiological and pathological processes. Fluorescent imaging is a useful tool for monitoring NO concentration, which could be essential in different biological and biochemical studies. A novel small-molecule fluorescent probe based on 9(10H)acridone moiety has been designed for nitric oxide sensing, showing capability in living Jurkat cells.
Review
Chemistry, Multidisciplinary
Pei Huang, Yongkang Yue, Caixia Yin, Fangjun Huo
Summary: Intracellular redox homeostasis plays a significant role in pathophysiology. Fluorescent probes that can detect both reactive oxygen species (ROS) and reactive sulfur species (RSS) simultaneously or sequentially are crucial for understanding the correlation and pathophysiological effects of these two signaling molecules in oxidative stress. These dual detection probes provide strong support for the study of redox homeostasis in complex cellular environments.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
