Article
Chemistry, Physical
Muhammad Sirajuddin, Saqib Ali, Muhammad Nawaz Tahir
Summary: A series of organotin(IV) carboxylate derivatives were synthesized and characterized, showing interactions with DNA and good antimicrobial activity. Compound 1 exhibited the highest activity against leishmania disease among the studied compounds.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Review
Chemistry, Multidisciplinary
Sharifah Nadhira Syed Annuar, Nurul Farahana Kamaludin, Normah Awang, Kok Meng Chan
Summary: This review discusses the antiproliferative activities of organotin(IV) compounds in various human cancer cell lines, the molecular mechanisms through which they induce cell death via apoptosis through the mitochondrial intrinsic pathway, and the cell cycle arrest induced by these compounds.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Jai Devi, Binesh Kumar, Bharti Taxak
Summary: Cancer is a leading cause of death worldwide. Organotin(IV) complexes have shown potential in cancer treatment, while ligands such as thiosemicarbazones and hydrazones can form stable complexes with tin metal, exhibiting significant biological activities.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Nurul Amalina Abd Aziz, Normah Awang, Kok Meng Chan, Nurul Farahana Kamaludin, Nur Najmi Mohamad Anuar
Summary: Organotin (IV) dithiocarbamate has gained attention as a therapeutic agent due to its unique properties and increased biological activity. The cytotoxicity of organotin (IV) compounds is influenced by the number of Sn-C bonds and the nature of substituents within the structure. Ligands target and react with molecules to prevent unwanted changes in biomolecules. Organotin (IV) dithiocarbamate compounds have various effects at the cellular, biochemical, and molecular levels, and their toxicity depends on their structure. This mini-review focuses on the synthesis, elemental and spectroscopic analyses, and potential cytotoxic effects of these compounds.
Article
Biochemistry & Molecular Biology
Wujiu Jiang, Qiqi Qin, Xiyuan Xiao, Yuxing Tan
Summary: In this study, eight new diorganotin(IV) complexes were synthesized and their structures were characterized. The antiproliferative activity of the complexes was tested, and complex 1c showed stronger antitumor activity, inducing cell apoptosis and DNA damage.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Alexander Kastner, Theresa Mendrina, Florian Bachmann, Walter Berger, Bernhard K. Keppler, Petra Heffeter, Christian R. Kowol
Summary: In this study, oxaliplatin(iv)-based complexes were developed as platinum(iv) prodrugs to release aspirin, which has shown antitumor activity against colon cancer. The newly synthesized complex demonstrated increased reduction stability compared to a cisplatin analog and exhibited desired prodrug properties in cell culture. A derivative with albumin-binding properties showed improved pharmacokinetics and tumor accumulation, leading to enhanced antitumor activity and overall survival in tumor-bearing mice.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Applied
Shagun Sharma, Navneet Agnihotri, Keshav Kumar, Swati Sihag, Vinay Randhawa, Ramandeep Kaur, Raghubir Singh, Varinder Kaur
Summary: A series of glutamine conjugated organotin(IV) Schiff base compounds were synthesized and characterized, with compounds 1, 3, and 4 identified as potential candidates based on their DNA/protein binding properties. Compound 3 was found to be the most promising for further in vivo studies according to QSAR regression models.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Yunzuo Cui, He Wang, Jiajun Wang, Chuanbi Li, Chunling Liu
Summary: The reaction between m-nitrobenzaldehyde oxime acetic acid and di-n-butyltin oxide resulted in the formation of a complex with a complex chain and layered structure. The crystal structure, elemental composition, and physical properties of the complex were analyzed using various experimental techniques.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Pharmacology & Pharmacy
Anife Ahmedova, Rositsa Mihaylova, Silviya Stoykova, Veronika Mihaylova, Nikola Burdzhiev, Viktoria Elincheva, Georgi Momekov, Denitsa Momekova
Summary: Pt(IV) complexes formed by linking pyrene butyric acid with cisplatin exhibit high anticancer potency against leukemia cells and multidrug-resistant derivatives, while showing low toxicity to healthy cells. The larger bis-pyrene complex is found to potentially be trapped in the cytoskeleton, limiting its cytotoxicity to adherent cells.
Article
Chemistry, Multidisciplinary
Shah Hussain, Shaukat Shujah, Abdul Rehman, Syed Tasleem Hussain, Mubbashir Hussain, Iffat Naz, Aiyeshah Alhodaib
Summary: Six new organotin(IV) complexes were synthesized and characterized, and their antimicrobial, antioxidant, and antileishmanial activities were studied.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Physical
Viola, Niaz Muhammad, Ishaq N. Khan, Zafar Ali, Mohammad Ibrahim, Shaukat Shujah, Saqib Ali, Muhammad Ikram, Sadia Rehman, Gul Shahzada Khan, Abdul Wadood, Awal Noor, Carola Schulzke
Summary: This study successfully synthesized two copper(II) carboxylate complexes, which exhibited excellent antioxidant, anti-pathogen, and anti-tumor activities, as well as good DNA binding abilities. These complexes have potential applications.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Multidisciplinary
Qiyuan Zhou, Shu Chen, Zoufeng Xu, Gongyuan Liu, Shuyuan Zhang, Zhigang Wang, Man-Kit Tse, Shek-Man Yiu, Guangyu Zhu
Summary: This study reports the synthesis of Pt-IV complexes bearing axial pyridines through ligand exchange reactions. It was discovered that these axial pyridines can be quickly released after reduction, indicating their potential as axial leaving groups. Two multitargeted Pt-IV prodrugs containing bioactive pyridinyl ligands, a PARP inhibitor and an EGFR tyrosine kinase inhibitor, were successfully obtained using this method. These conjugates show great potential for overcoming drug resistance, with the latter inhibiting the growth of Pt-resistant tumor in vivo. This research expands the synthetic methods for Pt-IV prodrugs and increases the range of bioactive axial ligands that can be conjugated to a Pt-IV center.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Applied
Xiu-Mei Du, Jun-Wei Ma, Qian-Li Li, Shuang Cheng, Yu Cui, Chun-Lin Ma
Summary: Five triorganotin (IV) complexes were prepared and characterized, and their anticancer activities were investigated. Complexes 1 and 3-5 showed superior anticancer activity, and complex 1 also exhibited antimetastatic ability.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Valeria Stefanizzi, Antonella Minutolo, Elena Valletta, Martina Carlini, Franca M. M. Cordero, Anna Ranzenigo, Salvatore Pasquale Prete, Daniel Oscar Cicero, Erica Pitti, Greta Petrella, Claudia Matteucci, Francesca Marino-Merlo, Antonio Mastino, Beatrice Macchi
Summary: Metal-derived platinum complexes are commonly used in the treatment of solid tumors. However, the toxicity and resistance of these drugs necessitate the search for alternative compounds. Organotin compounds have shown potential in inhibiting cell growth and inducing cell death and autophagy. In this study, the biological activities of different organotin compounds were evaluated, and it was found that tributyltin compounds were more cytotoxic than cisplatin. Additionally, the mechanism of action was attributed to the inhibition of glucose uptake. Furthermore, the tumorigenicity of the cells influenced their susceptibility to the compounds, with highly tumorigenic cells being less affected.
Article
Chemistry, Applied
Adrian-Alexandru Somesan, Sabina-Madalina Vieriu, Alexandru Craciun, Cristian Silvestru, Paul Chiroi, Andreea Nutu, Ancuta Jurj, Raduly Lajos, Ioana Berindan-Neagoe, Richard A. Varga
Summary: This study investigates the cytotoxic activity of several organotin(IV) compounds on lung cancer cell lines and normal lung cells, and discusses their synthetic protocols and structural characteristics.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Bibi Hanifa, Muhammad Sirajuddin, Zafran Ullah, Sumera Mahboob, See Mun Lee, Kong Mun Lo, Edward R. T. Tiekink
Summary: The synthesis and spectroscopic characterization of the glutaric acid-amide derivative, 2,4-Cl2C6H3N(H)C(=O)(CH2)(3)C(=O)OH (1), are described. The X-ray crystal structure determination shows the kinked backbone of the molecule and the formation of supramolecular tapes assembled through hydrogen bonding.
Article
Chemistry, Multidisciplinary
Muhammad Salam Khan, Muhammad Sirajuddin, Muhammad Zubair, Hizbullah Khan, Muhammad Tariq, Shaila Mehwish, Nazif Ullah
Summary: This article focuses on the preparation of four new zinc(II) carboxylate complexes based on a specific compound, which showed good antimicrobial and anti-leishmanial activities with no toxicity. The study also evaluated the biological activities of the complexes through molecular docking studies.
BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA
(2021)
Article
Chemistry, Analytical
Hizbullah Khan, Muhammad Najeeb Khan, Muhammad Sirajuddin, Syed Muhammad Salman, Muhammad Bilal
Summary: Water samples were collected and analyzed from 43 sites in Tehsil Isa Khel, revealing that most of the water sources in the area are not suitable for drinking and industrial use, with only a few locations having drinkable water.
PAKISTAN JOURNAL OF ANALYTICAL & ENVIRONMENTAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Muhammad Sirajuddin, Changaiz Ahmad, Hizbuallah Khan, Imdad Ullahkhan, Muhammad Tariq, Nazif Ullah
Summary: This report describes the synthesis, characterization, and evaluation of four novel copper(II) complexes with carboxylate ligand for biological applications. The complexes show good antibacterial, antifungal, and anti-promastigote activities. They interact with DNA through an intercalative mode and have good bioavailability and drug scores.
BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA
(2022)
Article
Pharmacology & Pharmacy
Niaz Muhammad, Mukhtar Ahmad, Muhammad Sirajuddin, Zafar Ali, Nikolay Tumanov, Johan Wouters, Abdelbasset Chafik, Kuebra Solak, Ahmet Mavi, Shabbir Muhammad, Shaukat Shujah, Saqib Ali, Abdullah G. Al-Sehemi
Summary: In this study, four new carboxylates complexes were synthesized and their structures and properties were investigated. The results showed that these complexes exhibited different coordination modes and high activity, and displayed dose-dependent cytotoxic effects on lung cancer cells. Molecular docking analysis also demonstrated significant interactions between these complexes and DNA, tubulin, and coronaviruses proteins.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Muhammad Said, Hizbullah Khan, Ghulam Murtaza, Muhammad Sirajuddin, Amin Badshah, Syed Muhammad Salman, Rukhsana Gul, Najeebullah
Summary: In this study, Cu(II) complexes of substituted guanidines were synthesized and characterized using various analytical techniques. X-ray diffraction analysis revealed the stability of guanidine ligands due to hydrogen bonding. The synthesized compounds exhibited better urease inhibition activity than the parent guanidine ligands and showed good scores in the bioassay compared to the standard drug vincristine.
INORGANIC AND NANO-METAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Bibi Hanifa, Muhammad Sirajuddin, Edward R. T. Tiekink, Ishaq Khan, Maciej Kubicki, Ahmed Bari
Summary: In this study, a series of new tri-organotin(IV) carboxylate complexes were validated using various techniques. The compounds exhibited antimicrobial activity and anticancer potential through interactions with DNA, and they also met the requirements of drug-likeness.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Bibi Hanifa, Muhammad Sirajuddin, Maciej Kubicki, Edward R. T. Tiekink
Summary: In this study, a series of isomeric 4-[(n-bromophenyl)carbamoyl]butanoic acids were synthesized and their structures were confirmed through various analytical techniques. The compounds showed antimicrobial activity against bacterial and fungal strains and exhibited good potential for bioavailability.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Environmental Sciences
Anum Naseer, Saiqa Andleeb, Abdul Basit, Shaukat Ali, Muhammad Siraj ud-Din, Nazish Mazhar Ali, Iram Liaqat, Aisha Nazir
Summary: The research evaluated the impact of organic manure (cow dung and buffalo dung) on vermiremediation and phytoremediation for heavy metal remediation in contaminated soil. Results showed that E. fetida exhibited higher tolerance to lead compared to P. lignicola. The growth and reproduction of E. fetida as well as seed germination and growth of Spinacia oleracea were better in cow dung medium.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Microbiology
Obaid Hayat, Nazif Ullah, Muhammad Sirajuddin, Miriam A. Giardini, Jennifer V. Nguyen, Karol R. Francisco, Lawrence J. Liu, Yujie Uli Sun, Svetlana Maurya, Dominic McGrosso, David J. Gonzalez, Conor R. Caffrey, Anjan Debnath, Jair L. Siqueira-Neto
Summary: The organotin (IV) derivative MS26Et3 shows potential in combating eukaryotic pathogens, with activity against multiple pathogens and low cytotoxicity towards host cells, making it a promising starting point for a broad spectrum antiparasitic alternative. Further studies are needed to investigate its molecular target(s) and mechanism of action for chemical optimization.
Article
Chemistry, Medicinal
Shaker Ullah, Muhammad Sirajuddin, Zafran Ullah, Afifa Mushtaq, Saba Naz, Muhammad Zubair, Ali Haider, Saqib Ali, Maciej Kubicki, Tanveer A. Wani, Seema Zargar, Mehboob Ur Rehman
Summary: In this study, six heteroleptic Cu(II) carboxylates were synthesized and their solid-state behavior was characterized using vibrational spectroscopy. The interaction between the complexes and SS-DNA was found to be intercalative. The complexes exhibited strong inhibitory activity against acetylcholinesterase and butyryl-cholinesterase enzymes, suggesting their potential for the treatment of Alzheimer's disease. Additionally, complexes 2 and 4 showed high free radical scavenging activity.
Article
Chemistry, Medicinal
Hizbullah Khan, Muhammad Sirajuddin, Amin Badshah, Sajjad Ahmad, Muhammad Bilal, Syed Muhammad Salman, Ian S. Butler, Tanveer A. Wani, Seema Zargar
Summary: One homoleptic and three heteroleptic palladium(II) complexes were synthesized and characterized. The antibacterial results showed that compound 1 had the highest activity among the screened compounds. Compound 3 exhibited the best affinity in the molecular docking study. In the anticancer evaluation, compound 2 showed the highest activity against the DU145 human prostate cancer cell line. The physicochemical parameters suggested that the evaluated compounds may be potential candidates for future antibiotics and anticancer agents.
Article
Chemistry, Medicinal
Muhammad Viola, Niaz Muhammad, Awal Noor, Muhammad Sirajuddin, Maciej Kubicki, Shahnaz Rahim, Abdus Samad, Shaukat Shujah, Abdul Wadood, Saqib Ali
Summary: Copper(II) complexes were synthesized and characterized in this study. The complexes exhibited higher activity than the free ligand acid, showing potential as drugs. They also showed strong DNA binding ability and inhibitory activity against alpha-amylase. These compounds exhibited drug-likeness properties and good bioavailability potential.
Article
Chemistry, Multidisciplinary
Muhammad Sirajuddin, Saqib Ali, Hizbullah Khan, Muhammad Tariq
Summary: This study successfully synthesized and characterized a series of ligands and their complexes. The structures and geometries were determined by spectroscopic and X-ray diffraction techniques. The interaction between the compounds and DNA was studied experimentally and computationally, revealing their binding modes.
JOURNAL OF CHEMICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Muhammad Anwar Saeed, Hizbullah Khan, Muhammad Sirajuddin, Syed Muhammad Salman
Summary: The manuscript discusses the synthesis and biological studies of a series of mixed ligand dithiocarbamate Palladium (II) complexes, focusing on their DNA binding, bioactivities like antibacterial and antifungal properties, as well as antioxidant potentials. The complexes showed interaction with DNA solutions, moderate antifungal and antibacterial behavior, and significant anti-mutagenic activities against H2O2-induced oxidative damage at non-genotoxic concentrations. Further structural adjustments may enhance the bioavailability and hydrophilic nature of the complexes.
JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN
(2021)