Review
Chemistry, Multidisciplinary
Yuxi Wei, Honglan Qi, Chengxiao Zhang
Summary: This Feature Article provides a brief overview of the principles and mechanisms of electrochemiluminescence (ECL) biosensors for biomarker detection. It highlights recent advancements in ECL biosensors, including new ECL reagents and materials, novel biological recognition elements, and emerging construction biointerfacial strategies. The article also discusses the challenges and perspectives of ECL biosensors for health analysis.
CHEMICAL COMMUNICATIONS
(2023)
Review
Biochemical Research Methods
Abubakar Abdussalam, Guobao Xu
Summary: ECL has advantages like near-zero background response, and ECL luminophores play an essential role in the light generation process. Despite advancements in synthesizing new luminophores, there is a lack of comprehensive summaries on ECL luminophores. This review discusses recent advances in various types of ECL luminophores and their roles.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Analytical
Zhichen Zhang, Cheng Ma, Qin Xu, Jun-Jie Zhu
Summary: Electrochemiluminescence microscopy (ECLM) is an emerging visualization tool that allows direct study of the morphological structures and functional characteristics of cells. Compared to other imaging methods, ECLM has advantages such as low optical background, high sensitivity, simple instrumentation, and surface-confined mode.
Review
Medicine, Research & Experimental
Shijun Wang, Shu Zhu, Ziqi Kang, Yidan Chen, Xiancheng Liu, Zixin Deng, Kun Hu, Guixue Wang, Yuchan Zhang, Guangchao Zang
Summary: The potential-resolved strategy has great value in ECL biosensing, especially in ratiometric ECL sensors, multiplex ECL sensors, and multicolor ECL sensors. It can provide more accurate analysis results and broader application prospects.
Review
Chemistry, Analytical
Longsheng Jin, Weishuai Liu, Ziying Xiao, Haijian Yang, Huihui Yu, Changxun Dong, Meisheng Wu
Summary: Rapid and efficient detection of mycotoxins is crucial in ensuring food safety. This review discusses various traditional and commercial methods of detection, including HPLC, LC/MS, ELISA, and test strips. ECL biosensors, known for their high sensitivity and specificity, have gained significant attention in mycotoxins detection. This article focuses on the recent advancements in the design of ECL biosensors for mycotoxins assay, particularly with regards to amplification strategies and working mechanisms.
Review
Chemistry, Analytical
Chen Ye-Quan, Quan Shuai, Du Fang-Xin, Lou Bao-Hua, Li Jian-Ping, Xu Guo-Bao
Summary: Chemiluminescence and electrochemiluminescence assays are widely used in various fields for their high sensitivity, rapid analysis, and easy operation. This review focuses on the recent advances in CL and ECL assays for acute myocardial infarction biomarkers, comparing the diagnostic value of different biomarkers and discussing the fabrication and application advantages of biosensors. Future research directions are also discussed.
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2021)
Article
Biophysics
Yan Chen, Yunlei Zhou, Huanshun Yin
Summary: Histone acetylation, a crucial histone modification, is closely related to various diseases. Detection of HAT activity plays a significant role in disease discovery, prevention, and treatment, with recent research focusing on new methods combining different technologies.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Chemistry, Inorganic & Nuclear
Yue Cao, Jia-Lin Zhou, Yanwen Ma, Yang Zhou, Jun-Jie Zhu
Summary: Metal nanoclusters (MeNCs) have attracted extensive interest in electrochemiluminescence (ECL) due to their unique properties and potential applications. This perspective provides a comprehensive overview of the recent advances in MeNCs in the ECL field, including their chemical and optical properties, synthesis strategies, and ECL sensing applications. The future prospects and challenges in this area are also discussed.
DALTON TRANSACTIONS
(2022)
Review
Chemistry, Multidisciplinary
Neeraj Sohal, Banibrata Maity, Soumen Basu
Summary: This review delves into the strategies for preparing heteroatom-doped graphene quantum dots (GQDs), the modification of their optical and electronic properties, and the application of various characterization techniques. It also explores the impact of heteroatom doping on the optical, electrochemical, and electrochemiluminescence properties of GQDs, as well as their potential in sensing various substances.
Article
Chemistry, Analytical
Pinlong Zhao, Wenxin Zhu, Min Zheng, Jiandong Feng
Summary: A deep enhanced ECL microscopy (DEECL) method is proposed, which utilizes artificial neural networks to reconstruct electrochemiluminescence images with millisecond exposure times. DEECL achieves similar quality as high-quality electrochemiluminescence images with second-long exposure time. The DEECL method improves imaging efficiency by 1 to 2 orders than usual and achieves 85% accuracy in cell classification application.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Analytical
Qian Yang, Xiaoyu Huang, Beibei Gao, Lu Gao, Feng Yu, Fu Wang
Summary: In recent years, innovative analytical methods with high sensitivity and spatiotemporal resolution have emerged for qualitative and quantitative analysis at the single-cell and subcellular levels. Among them, single-cell ECL (SCECL) analysis, with excellent spatiotemporal resolution, has become a promising tool for revealing individual cells' heterogeneity and stochastic processes.
Article
Engineering, Environmental
Simon Deepa, Raja Venkatesan, Suseela Jayalakshmi, Monogar Priya, Seong-Cheol Kim
Summary: This article reviews the use of chemiluminescence techniques, specifically focusing on the application of luminol for environmental, chemical, and biological analytes. Significant advances have been made in the past 20 years, improving sensitivity by considering optimal catalyst choices. Bio-based catalysts and metal nanoparticles have shown promise in enhancing sensitivity, selectivity, and stability, as well as expanding the scope of applications and providing unique insights into the reaction mechanism.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Analytical
Tingting Han, Yue Cao, Hong-Yuan Chen, Jun-Jie Zhu
Summary: Porous nanomaterials have high porosity, large specific surface area, and versatile functionality, making them attractive for electrochemiluminescence (ECL) applications. They can effectively load abundant guest ECL luminophores for signal amplification and promote mass and charge transports. This review discusses the synthesis strategies and applications of various porous nanomaterials in ECL biosensing, while also addressing the challenges and future perspectives of these systems.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Analytical
Qing Li, Jing-Tao Wu, Ying Liu, Xiao-Man Qi, Hong-Guang Jin, Chun Yang, Jun Liu, Guang-Li Li, Quan-Guo He
Summary: Black phosphorus has attracted significant attention due to its anisotropic electro-conductivity and tunable direct bandgap, making it suitable for various electrochemical sensing applications. Research efforts have explored synthesis methods, protection strategies, and sensing applications of BP and its derivatives, along with functionalization mechanisms, sensing strategies, and properties.
ANALYTICA CHIMICA ACTA
(2021)
Review
Chemistry, Analytical
Xue-Bo Hu, Yi-Xiao Zhang, Xiao-Hui Chen, Meng-Yuan He, Zi-He Jin
Summary: Graphene, with its single-atom-layer structure, has sparked tremendous interests in various fields due to its extraordinary mechanical, thermal, chemical and electronic properties. This review focuses on the synthesis method and fabrication strategy of graphene-based materials, as well as the construction and performance of graphene-based biosensors, such as field-effect transistors, electrochemical biosensors, and electrochemiluminescence biosensors. The article also highlights the remaining challenges and future development in this field.
Review
Instruments & Instrumentation
Ziyan Li, Rui Liu, Yi Lv
Summary: This review discusses the progress of ICPMS in multiplex bioassay, including various biomarkers and methodological innovations. The limitations are summarized and prospects are proposed for the emergence of more powerful and application-oriented analytical methods.
APPLIED SPECTROSCOPY REVIEWS
(2023)
Review
Instruments & Instrumentation
Sirui Pu, Yi Pan, Lichun Zhang, Yi Lv
Summary: The emission of volatile sulfur compounds (VSCs) poses risks to the environment, product quality, and human health. Establishing sensitive and convenient analytical methods for VSCs detection is of great importance. Chemiluminescence (CL) and cataluminescence (CTL) offer promising techniques for VSCs detection due to their fast response, high sensitivity, and simplicity. CL analysis has been widely applied in various fields using auxiliary CL methods and sulfur chemiluminescence detector (SCD), while CTL detection is prosperous in the construction of gas sensors, including the exploration of sensing materials and detection modes.
APPLIED SPECTROSCOPY REVIEWS
(2023)
Article
Chemistry, Analytical
Kexin Zhang, Hongjie Song, Yingying Su, Qiuyan Li, Mingxia Sun, Yi Lv
Summary: This study presents a strategy for tailoring luminescent molecules through AuNP-catalyzed reaction, resulting in ultrastrong chemical luminescence. By modifying the surface with poly(vinylpyrrolidone) (PVP), a nanoplatform (PVP-Au) is developed for detecting NaClO with a detection limit of 10.68 nM, offering improved sensitivity and selectivity over conventional methods.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Jiaxi Hu, Hongjie Song, Cheng Chen, Lichun Zhang, Mingxia Sun, Yi Lv
Summary: Cataluminescence has gained attention in environmental monitoring and clinical diagnosis. This research constructs an advanced photoinduced thermocatalytic chemiluminescence (PI-TC-CL) gas-sensing system for efficient detection of H2S. The study investigates the gas-sensing mechanism and provides insights into engineering efficient catalysts and innovative sensor systems.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Qiuyan Li, Mingxia Sun, Lichun Zhang, Hongjie Song, Yi Lv
Summary: A novel CTL sensor based on Ce(IV)-MOF was designed for detection of H2S, which showed outstanding selectivity, high sensitivity, and excellent stability. The investigation of the CTL mechanism provided more theoretical support for catalytic reaction. This work broadened the application field of MOF and provided a new clue for the development of catalytic materials in CTL.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Jiaxi Hu, Cheng Chen, Xiaobin Xie, Lichun Zhang, Hongjie Song, Yi Lv
Summary: In response to the increasing threat of explosive-based terrorism and environmental concerns, a reliable and easy-to-use cataluminescence sensor system has been developed for the rapid and accurate detection of six types of military explosive vapors. The sensor device and detection platform constructed in this research provide a new sensing principle for the efficient identification of explosives.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Qiuyan Li, Shuguang Yan, Hongjie Song, Yingying Su, Mingxia Sun, Yi Lv
Summary: In this study, a Ce(IV)-MOF structure with high selectivity and stability in chemiluminescence reaction was fabricated, leading to the successful establishment of a simple, stable, and sensitive fluorescent sensing platform for SO32-.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Suqin Xiong, Shuguang Yan, Mingxia Sun, Hongjie Song, Lichun Zhang, Jiaxi Hu, Yi Lv
Summary: This study modulated the nitrogen vacancy content in g-C3N4 by changing the temperature of secondary calcination. It was found that nitrogen vacancy significantly enhanced the cataluminescence intensity of ammonium sulfide. Furthermore, a CN-600-based sensor with excellent selectivity and stability was developed for the detection of ammonium sulfide.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Mingxia Sun, Hongjie Song, Haiyi Liu, Yingying Su, Xiaobo Xie, Yi Lv
Summary: This study proposes a mild chemiluminescence system for detecting sulfite under neutral conditions. By activating sulfite and enhancing the generation of SO3-, a strong chemiluminescence signal is generated with the aid of APDI NSs. The developed method provides a sensitive and selective platform for sulfite detection.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Zixuan Zhan, Li Chai, Haihui Yang, Yongcheng Dai, Zeliang Wei, Denian Wang, Yi Lv
Summary: In this study, a unique two-photon fluorescent probe (ER-ONOO-) was developed to detect ONOO- in aqueous solution with high sensitivity, high selectivity, and ultrafast response time. The probe successfully evaluated the levels of ONOO- at the endoplasmic reticulum (ER) in a hypoxia-induced endothelial injury model. Furthermore, it was able to monitor the changes in organ fluorescence through ONOO- variation in different stages of a cecum ligation and puncture (CLP) mouse model. The study confirmed the involvement of endoplasmic reticulum stress and oxidative stress in the CLP model, providing a reliable tool for studying ONOO- fluctuation in sepsis and offering new insights into the pathogenic and therapeutic mechanisms involved.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yongcheng Dai, Jing Zhou, Chudong Wei, Li Chai, Xiaobo Xie, Rui Liu, Yi Lv
Summary: This study established a multiplexing LC-MS workflow for simultaneous detection of nitric oxide (NO) and various metabolites in cells. The method, based on a novel iridium signature mass spectrometric probe, showed high accuracy and sensitivity in detecting NO. It also revealed the effects of different NO concentrations on cellular metabolites.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yanyan Zhang, Mingxia Sun, Xiaohan Yuan, Chudong Wei, Yingying Su, Yi Lv
Summary: In recent years, the use of advanced oxidation processes (AOPs) based on peracetic acid (PAA) has gained attention for its high oxidative potential and low byproduct formation. However, there is still a need to study the activation of PAA and the degradation mechanism to develop more efficient and stable PAA-based AOPs. This study investigates a new PAA-based AOP activated by metal-organic framework-derived cobalt phosphide (CoP) and accompanied by chemiluminescence (CL) behavior. The CoP/PAA system showed efficient degradation of RhB, with a degradation rate 23.7 times higher than that of the conventional Co3O4/PAA system, and the degradation process was confirmed to be driven by O-1(2).
Article
Chemistry, Analytical
Xiaohan Yuan, Shuguang Yan, Chudong Wei, Yanyan Zhang, Yingying Su, Yi Lv
Summary: In this study, nitrogen-doped carbon dots (N-CDs) were found to significantly enhance the chemiluminescence (CL) intensity of the Ce (IV)-Na2S system. The mechanism was explored and discussed through experiments with free radical scavengers, CL spectra, and X-ray photoelectron spectroscopy (XPS). The enhancement is mainly attributed to the chemiluminescence resonance energy transfer (CRET) between (1O2)2*/Ce (III)* and N-CDs, where mono-dispersed N-CDs catalyze the production of more 1O2 on their surface. The new CL system was successfully utilized for the detection of H2S with a linear range of 20-200 nM and a limit of detection (LOD) of 0.32 nM. The system also demonstrated good recovery rates in different water samples, making it a promising platform for practical applications.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Ziyan Li, Jing Zhou, Chaoqun Wang, Rui Liu, Jianyu Hu, Yi Lv
Summary: The study presents a triplevalent tetrahedral DNA nanostructure (tTDN) with three overhang isotope probes capable of multiplex simultaneous analysis for accurate and cost-effective detection of different variants of SARS-CoV-2. Using the TDN scaffold and MNAzyme system, the study successfully identified and screened four different variants of concern (VOC) associated with α, β, δ, and Ο, with common mutations in the S gene.
Article
Chemistry, Analytical
Yan Li, Zili Huang, Ziyan Li, Caixia Li, Rui Liu, Yi Lv
Summary: The occurrence of cancers is often accompanied by the abnormal expression of multiple biomarkers. This study proposes a simple and sensitive mass spectrometric method for the simultaneous detection of nucleic acid and protein biomarkers, which may be useful for the early screening of cancers.
ANALYTICAL CHEMISTRY
(2022)
