4.6 Article

A novel assembling complex of hydrobobic phthalocyanine-cyclodextrin: preparation, characterization, molecular modeling, and in vitro activity

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RSC ADVANCES
卷 4, 期 104, 页码 59759-59763

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra12654h

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资金

  1. National Natural Science Foundation of China [21201102]
  2. Natural Science Foundation of Jiangsu Higher Education Institutions of China [13KJA150003, 12KJB150015]
  3. Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
  4. Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials

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The stable 4 : 1 host-guest complex of phthalocyanine (Pc) and hydroxypropyl-beta-cyclodextrin was designed, computer modeled and prepared. The complex formation can greatly increase water solubility, reactive oxygen generation ability, biocompatibility and, thereby, the in vitro phototoxicity of Pc to cancer cells.

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