期刊
RSC ADVANCES
卷 4, 期 86, 页码 45687-45695出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra06628f
关键词
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资金
- Korean Health Technology RAMP
- D Project, Korean Ministry of Health Welfare [A111014]
- Research Center Program of the Institute for Basic Science (IBS) in Korea [IBS-R006-D1]
- Engineering Research Center of Excellence Program of Korea [NRF-2014R1A5A1009799]
- Basic Science Research Program through the National Research Foundation of Korea - Ministry of Science, ICT AMP
- Future Planning [NRF-2014R1A1A1003555]
We describe a simple method for synthesizing mesoporous silica-coated luminescent europium-doped gadolinium vanadate (GdVO4:Eu3+@mSiO(2)) nanoparticles. Their biomedical applications as a potential imaging nanoprobe for both fluorescence imaging and magnetic resonance imaging (MRI) and as a simultaneous anti-cancer drug delivery vehicle are also discussed. Eu3+ doped GdVO4 nanoparticles exhibit strong red photoluminescence and the Gd3+ in GdVO4 can be used as a T-1 contrast agent for MRI. T-1-weighted MR contrast enhancement as well as sustained intracellular drug delivery can be achieved by the mesoporous silica layer coating onto a single nanoparticle. Enhanced T-1 MR contrast was proven by relaxometric studies on water access to the paramagnetic core. GdVO4:Eu3+@mSiO(2) nanoparticles as a new type of theragnostic (imaging and treatment) agent can provide new opportunities in a cancer treatment.
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