Article
Chemistry, Organic
Zhiyuan Yang, Pei-Xue Gong, Junjie Chen, Jie Zhang, Xu Gong, Wei Han
Summary: This ligand-free palladium-catalyzed carbonylation reaction efficiently synthesizes chalcones and α-branched enones at ambient pressure and temperature, even with substoichiometric amounts of base. It is particularly suitable for the late-stage functionalization of complex molecules derived from epiandrosterone.
Article
Chemistry, Organic
Tomohiro Yasukawa, Zhiyuan Zhu, Yasuhiro Yamashita, Shu Kobayashi
Summary: A ligand-free approach using polysilane/alumina-supported palladium nanoparticles has been developed for carbonylative Suzuki-Miyaura coupling reactions to synthesize diaryl ketones. This method shows high yields and selectivities even with low catalyst loading under atmospheric pressure of CO gas. The immobilized palladium nanoparticles can be easily recovered by filtration and maintain catalytic activity for several runs.
Article
Chemistry, Multidisciplinary
Tiefeng Xu, Qi Wang, Zeyi Yang, Lili Yi, Jian-Shu Wang, Wangyang Lu, Jun Ying, Xiao-Feng Wu
Summary: The palladium supported on graphitic carbon nitride (Pd/g-C3N4) catalyzed carbonylative reaction of aryl bromides and arylboronic acids successfully constructed various diaryl ketones using TFBen as the CO source, resulting in moderate to good yields.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Chemistry, Organic
Pallabi Halder, Ashif Iqubal, Krishanu Mondal, Narottam Mukhopadhyay, Parthasarathi Das
Summary: A phosphine-free and efficient protocol for aminocarbonylation and carbonylative Suzuki-Miyaura coupling has been developed using a novel palladium complex as a catalyst, with chloroform-COware chemistry employed for safe and facile insertion of the carbonyl unit. The method enables the synthesis of various pharmaceutically relevant compounds and sequential one-pot synthesis of indenoisoquinolines.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Arvind Singh Chauhan, Ajay Kumar, Ajay Kumar Sharma, Pralay Das
Summary: A decarbonylation free, polystyrene-supported, Pd (Pd@PS)-catalysed carbonylative esterification of 5-hydroxymethyl furfural (5-HMF) has been developed, showing a broad substrate scope, good yield, and recyclability of the catalyst. The study highlights the important role of polystyrene support in avoiding decarbonylation of 5-HMF.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Inci Sogutlu, Evan Abdulkarim Mahmood, Saeid Ahmadizadeh Shendy, Saeideh Ebrahimiasl, Esmail Vessally
Summary: This article discusses the carbonylative Suzuki cross-coupling reaction of aryl halides and arylboronic acids in the presence of carbon monoxide, resulting in the synthesis of biaryl ketones. Nano-sized metal catalysts are proven to be among the most efficient catalysts for this reaction due to their large surface area to volume ratio and reactive morphologies, allowing for faster reaction rates at lower CO pressures and catalyst loadings.
Article
Chemistry, Physical
Alex C. Bissember, Angus Olding, Curtis C. Ho, Nigel T. Lucas, Allan J. Canty
Summary: By covalently tethering a supporting ligand to a boron nucleophile, typically elusive and kinetically unstable Suzuki-Miyaura (SM) pretransmetalation species were able to be controlled. This strategy allowed for the synthesis of an organonickel(II) boronate pretransmetalation intermediate and its characterization through X-ray crystallography. Performing reactions in the presence of carbon monoxide led to pretransmetalation intermediates in carbon-ylative SM reactions-aroylmetal boronates, enabling the determination of the X-ray crystal structures of an aroylnickel(II) boronate (and an aroylpalladium(II) boronate).
Article
Biochemistry & Molecular Biology
Julieta Paez, Adrian de Miguel-Jimenez, Rocio Valbuena-Mendoza, Aditi Rathore, Minye Jin, Alisa Glaser, Samuel Pearson, Aranzazu del Campo
Summary: In this study, the reactivity of the MS partner's heteroaromatic ring was optimized to slow down cross-linking kinetics and degradation of hydrogels. New MS substrates based on Tz and Bt rings were synthesized via simple pathways, extending the working time of precursor mixtures and allowing longer term cell culture. The Tz-based MS substrate was identified as the best candidate, supporting cell cultures for over 2 weeks.
Article
Engineering, Multidisciplinary
R. Prasanna Shankara, N. R. Banapurmath, Abhinandan D'Souza, A. M. Sajjan, N. H. Ayachit, T. M. Yunus Khan, Irfan Anjum Badruddin, Sarfaraz Kamangar
Summary: Recent studies have shown that nanofluids have the potential to enhance the heat transfer properties of coolants in car radiators. By combining ethylene glycol and deionized water with graphene oxide nanoparticles, the heat transfer characteristics of the nanofluids were experimentally investigated. The optimized combination of 60% ethylene glycol, 40% deionized water, and 0.1 wt% graphene oxide exhibited higher heat transfer characteristics and showed potential for reducing frontal area and improving fuel efficiency in industrial design.
ALEXANDRIA ENGINEERING JOURNAL
(2022)
Article
Chemistry, Organic
Mingzhong Cai, Chengkai Luo, Caifeng Xu, Bin Huang
Summary: Pd(2)dba(3)/XPhos in PEG-2000 has been shown to be a highly stable and efficient catalyst for the borylation of aryl chlorides, delivering a wide variety of aryl boronates in good yields with high functional group tolerance at 110 degrees C. The system allows for easy isolation of crude products through simple extraction of the reaction mixture with cyclohexane, and both the catalyst and system can be recycled and reused more than six times without loss of efficiency.
SYNTHESIS-STUTTGART
(2022)
Article
Chemistry, Multidisciplinary
Tengfei Mao, Chongyu Zhu, Lei Tao
Summary: This mini-review summarizes the recent progress in synthesizing multifunctional polymers for protein conjugation through multicomponent reactions (MCRs). These polymers react with therapeutic proteins to form conjugates, showing promise as theranostic agents and antibacterial vaccine candidates. The use of MCRs presents a straightforward and convenient method for preparing these polymers compared to traditional multi-step synthesis, making it a potential new strategy for polymer-protein conjugates in biological and medical applications.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Anushka Koranne, Shrishty Turakhia, Vikesh Kumar Jha, Sangeeta Gupta, Rangnath Ravi, Abhijeet Mishra, Anil K. Aggarwal, Chandan Kumar Jha, Neelu Dheer, Abadh Kishor Jha
Summary: This review discusses the palladium-catalyzed Mizoroki-Heck cross-coupling reactions, which involve the formation of substituted olefins through a typical Heck coupling mechanism, unlike the direct cross-coupling of alkenes with aryl halides in Heck olefination. These reactions address the issue of alkene polymerization at high temperatures and enhance reaction efficiency by reducing reaction time and purification steps.
Article
Multidisciplinary Sciences
Robert M. O'Dea, Paula A. Pranda, Yuqing Luo, Alice Amitrano, Elvis O. Ebikade, Eric R. Gottlieb, Olumoye Ajao, Marzouk Benali, Dionisios G. Vlachos, Marianthi Ierapetritou, Thomas H. Epps
Summary: This study presents an intensified RD-RCD process for deconstructing technical lignins and purifying the aromatic products simultaneously. It demonstrates the economic advantages and develops a facile screening method.
Article
Chemistry, Organic
Lili Tang, Yanqun Gao, Junjie Chen, Linlin Yang, Bing Xiao, Ge Shen, Yuejun Ouyang, Wei Han
Summary: A highly efficient and ligand-free palladium-catalyzed carbonylation of aryl iodides with alkenylboronic acids has been developed, yielding a variety of chalcones and alpha-branched enones in satisfactory to good yields with good substrate compatibilities under room temperature and ambient CO pressure. The transformation also proceeds well with a substoichiometric amount of base. The strategy has been demonstrated to be a promising late-stage functionalization platform by modifying complex substrates derived from estrone and 3-phenyl-L-alanine.
Article
Thermodynamics
Gongxing Yan, Ali Shawabkeh, Rishabh Chaturvedi, R. Nur-Firyal, Mohammad Mehdizadeh Youshanlouei
Summary: In this study, a cavity with cool walls was used to cool a porous medium, and a magnetic field was applied. The findings showed that increasing Hartmann number decreased the heat transfer coefficient, while adding titanium oxide nanoparticles slightly increased the heat transfer coefficient.
CASE STUDIES IN THERMAL ENGINEERING
(2022)
Article
Chemistry, Applied
Dezhong Yu, Fangning Xu, Dan Li, Wei Han
ADVANCED SYNTHESIS & CATALYSIS
(2019)
Article
Multidisciplinary Sciences
Penghui Hu, Mingxi Tan, Lu Cheng, Hongyuan Zhao, Rui Feng, Wei-Jin Gu, Wei Han
NATURE COMMUNICATIONS
(2019)
Article
Chemistry, Organic
Wei Han, Lu Cheng, Hongyuan Zhao
Article
Chemistry, Organic
Zhiyuan Yang, Pei-Xue Gong, Junjie Chen, Jie Zhang, Xu Gong, Wei Han
Summary: This ligand-free palladium-catalyzed carbonylation reaction efficiently synthesizes chalcones and α-branched enones at ambient pressure and temperature, even with substoichiometric amounts of base. It is particularly suitable for the late-stage functionalization of complex molecules derived from epiandrosterone.
Article
Chemistry, Organic
Honglan Zeng, Hongyan Du, Xu Gong, Jie Zhang, Wei Han
Summary: A ligand-free palladium-catalyzed aerobic oxidative carbonylation of amines has been developed for the synthesis of ureas, including unsymmetrically N,N '-disubstituted ureas. This method offers a straightforward and efficient route to symmetrical and unsymmetrical ureas using inexpensive and readily available amines under mild conditions. By using oxygen as the sole oxidant, this novel method provides an attractive alternative to transition-metal-based oxidant systems.
Article
Multidisciplinary Sciences
Lu Cheng, Huihui Wang, Hengrui Cai, Jie Zhang, Xu Gong, Wei Han
Summary: This method utilizes an iron complex as catalyst for the undirected hydroxylation of arene carbon-hydrogen bonds with hydrogen peroxide as oxidant, showing excellent substrate scope, selectivity, and compatibility with sensitive functional groups. It is suitable for polyphenol synthesis and late-stage functionalization of natural products and drug molecules.
Article
Engineering, Electrical & Electronic
Zhichao Luo, Mehanathan Pathmanathan, Wei Han, Shuang Nie, Peter W. Lehn
Summary: This study focuses on the performance of constant current (CC)/constant voltage (CV) charging in the electric vehicle wireless power transfer (WPT) system under misalignment, especially for the multi-coil WPT system. It introduces a resonant tank compensation methodology for the exciter-quadrature-repeaters (EQR) transmitter-based multi-coil WPT system to achieve high power factor CC/CV charging with low leakage flux over a wide misalignment range. Experimental results show that the EQR transmitter-based WPT system achieves high coil-to-coil efficiency and reduces the leakage flux density compared with the existing three-coil system.
IET POWER ELECTRONICS
(2022)
Article
Chemistry, Organic
Lili Tang, Yanqun Gao, Junjie Chen, Linlin Yang, Bing Xiao, Ge Shen, Yuejun Ouyang, Wei Han
Summary: A highly efficient and ligand-free palladium-catalyzed carbonylation of aryl iodides with alkenylboronic acids has been developed, yielding a variety of chalcones and alpha-branched enones in satisfactory to good yields with good substrate compatibilities under room temperature and ambient CO pressure. The transformation also proceeds well with a substoichiometric amount of base. The strategy has been demonstrated to be a promising late-stage functionalization platform by modifying complex substrates derived from estrone and 3-phenyl-L-alanine.
Article
Chemistry, Organic
Yanqun Gao, Lu Cheng, Wei Shi, Yuejun Ouyang, Wei Han
Summary: This account mainly summarizes the latest advances in catalysis inspired by cytochromes P450, including reductive activation strategies for highly efficient oxidations and an Fe/cysteine-based ligand as a biomimetic model for iron-catalyzed undirected arene C-H hydroxylation. These new paradigms highlight some catalytic properties of P450s, such as effective late-stage functionalization of complex targets, good reactive functional group tolerance, and high catalytic efficiency and selectivity.
Article
Chemistry, Multidisciplinary
Pei-Xue Gong, Fangning Xu, Lu Cheng, Xu Gong, Jie Zhang, Wei-Jin Gu, Wei Han
Summary: A practical iron-catalyzed domino decarboxylation-oxidation reaction has been developed for the synthesis of methyl ketones from alpha,beta-unsaturated carboxylic acids. This method is mild, operationally simple, uses ambient air as the sole oxidant, and tolerates sensitive functional groups for late-stage functionalization of complex molecules.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Fangning Xu, Dan Li, Wei Han
Article
Chemistry, Multidisciplinary
Binbin Liu, Lu Cheng, Penghui Hu, Fangning Xu, Dan Li, Wei-Jin Gu, Wei Han
CHEMICAL COMMUNICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Binbin Liu, Penghui Hu, Fangning Xu, Lu Cheng, Mingxi Tan, Wei Han
COMMUNICATIONS CHEMISTRY
(2019)
Review
Chemistry, Organic
Fangning Xu, Wei Han
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2018)
Article
Engineering, Electrical & Electronic
Zhichao Luo, Mehanathan Pathmanathan, Wei Han, Shuang Nie, Peter W. Lehn
Summary: The resonant tank compensation methodology for the EQR transmitter-based multi-coil WPT system was studied to achieve high power factor CC/CV charging with low leakage flux over a 150-mm lateral misalignment range. Experimental results showed that the EQR transmitter-based WPT system achieved 92% coil-to-coil efficiency and reduced leakage flux density by 70% compared to the existing three-coil system in the CV mode at 150-mm lateral misalignment.
IET POWER ELECTRONICS
(2022)
