Article
Chemistry, Analytical
Valfredo Azevedo Lemos, Jeferson Alves Barreto, Luana Bastos Santos, Rosivan dos Santos de Assis, Cleber Galvao Novaes, Ricardo J. Cassella
Summary: Dispersive liquid-liquid microextraction (DLLME) is widely used for the separation and preconcentration of various chemical species, with some systems using a syringe as an extraction environment. This review discusses methods utilizing this approach, critical aspects like dispersion promotion, analytical characteristics, and the pros and cons of the methods, as well as future trends in in-syringe microextraction systems.
Article
Chemistry, Analytical
F. Vela-Soria, J. Garcia-Villanova, V Mustieles, T. de Haro, J. P. Antignac, M. F. Fernandez
Summary: The study developed a method to determine 10 PFAS in placental tissue, demonstrating its suitability in evaluating fetal exposure to PFAS and providing key data on the subject.
Article
Biochemical Research Methods
Karen Sze Jie Tay, Michael C. Breadmore, Ee Shan Soh, Hong Heng See
Summary: A new DICM approach coupled with UPLC-MS/MS was demonstrated for the determination of n-nitrosamine impurities in medicinal products, showing good linearity, acceptable reproducibility, low limits of detection, and satisfactory relative recoveries. The method was found to be at least 10 times more sensitive compared to validated direct sample dissolutions coupled with UPLC-MS/MS approach.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Food Science & Technology
Xiaolin Luo, Xiaoyuan Wang, Ming Du, Xianbing Xu
Summary: The determination of flavor compounds in food systems, especially solid samples, can be interfered with by complex food matrices. In this study, dispersive liquid-liquid microextraction (DLLME) was applied prior to headspace solid-phase microextraction (HS-SPME) to reduce the matrix effect in solid seafood samples. The developed method showed high sensitivity, excellent linear relationship, and good recovery rate, and was able to detect maltol and ethyl maltol in selected seafood samples. DLLME coupled with HS-SPME effectively removed the influence of sample matrix and improved the sensitivity of the method.
Article
Biochemistry & Molecular Biology
Chiara Dal Bosco, Francesca Mariani, Alessandra Gentili
Summary: A green solvent-based DLLME/HPLC-MS method has been developed for the determination of 19 pesticides in wine samples. The method shows high recovery, good precision, and low detection limits, making it a quick and cost-effective analysis.
Article
Chemistry, Applied
J. A. Custodio-Mendoza, C. Caamano-Fernandez, M. A. Lage, P. J. Almeida, R. A. Lorenzo, A. M. Carro
Summary: A new, fast, simple, and effective UA-DLLME method was successfully developed and validated for the determination of malondialdehyde, acrolein, and 4-hydroxy-2-nonenal in beverages. The method demonstrated good linearities, recoveries, and reproducibility, and was applied to analyze 60 different beverage samples, showing the presence of secondary lipid oxidation products.
Article
Engineering, Environmental
Qiyue Zhao, Han Li, Hui Chen, Chao Wu, Hesham EI-Seedi, Xianbing Xu, Ming Du
Summary: The study successfully demonstrated rapid detection of a batch of samples using plasmonic nanoshell enhanced MALDI-TOF MS technology, providing a new method for high-throughput metabolomics and clinical diagnosis.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemical Research Methods
Jufang Li, Congyan Chen, Xingchao Sun, Zhineng Hu, Chaochao Wu, Qiang Gao, Guoqing Ying
Summary: A green and inexpensive pretreatment, dispersive liquid-liquid microextraction (DLLME), was developed in this assay coupled with the LC-MS/MS method for routine analysis of fat soluble vitamins (FSVs). The developed DLLME method was validated and found suitable for determining FSVs in serum. The method was more cost-effective compared to the traditional LC-MS/MS method and can be applied in the future.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Article
Chemistry, Analytical
Elnaz Marzi Khosrowshahi, Mir Ali Farajzadeh, Mustafa Tuzen, Mohammad Reza Afshar Mogaddam, Mahboob Nemati
Summary: A dispersive solid-phase microextraction method using magnetic carbon nano-onions was developed for the extraction of pesticides from water and vegetable samples, followed by a dispersive liquid-liquid microextraction step. The method showed wide linear ranges, low limits of detection and quantification, good precision, and satisfactory accuracy, making it an efficient and environmentally friendly approach for analyte extraction from vegetable and fruit juices and water samples.
ANALYTICAL METHODS
(2021)
Article
Biochemical Research Methods
Mohamed A. Abdelaziz, Fotouh R. Mansour, Neil D. Danielson
Summary: A hydrophobic gadolinium-based magnetic ionic liquid was studied as an extraction solvent in DLLME for the first time, showing higher extraction efficiency than iron or manganese analogues, leading to improved sensitivity and reproducibility of the method, along with a reduced analysis time.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Olga Maliszewska, Anna Roszkowska, Marcin Lipinski, Natalia Treder, Ilona Oledzka, Piotr Kowalski, Tomasz Baczek, Ewa Bien, Malgorzata Anna Krawczyk, Alina Plenis
Summary: Therapeutic drug monitoring (TDM) is essential for precise control of pharmacokinetic parameters in docetaxel (DOC)-based anticancer therapy. This study presents a new method for isolating DOC from plasma and urine samples using ultrasound-assisted dispersive liquid-liquid microextraction (UA-DLLME) and liquid chromatography with tandem mass spectrometry (LC-MS/MS). The method was validated and successfully applied to monitor DOC levels in a pediatric patient with cardiac angiosarcoma (AS). The study provides valuable pharmacokinetic information and demonstrates the usefulness of the method for routine DOC monitoring.
Article
Spectroscopy
Monireh Shahvalinia, Arash Larki, Kamal Ghanemi
Summary: In this study, a simple and cost-effective method based on UA-DLLME and smartphone colorimetric measurement was introduced for the separation and determination of TCS in contaminated waters. By optimizing various experimental parameters and considering their effects, this method can accurately measure TCS in a wide concentration range and provides satisfactory results in multiple water and wastewater samples.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Reyla A. S. Dias, Eliane R. Sousa, Gilmar S. Silva, Lanna K. Silva, Arlan S. Freitas, Diana L. D. Lima, Erika M. L. Sousa
Summary: This study developed an HPLC-FLD methodology for the separation of fluoroquinolones and optimized the DLLME process for clean-up and preconcentration of enrofloxacin in water samples. The method showed successful results in samples with low salinity content.
MICROCHEMICAL JOURNAL
(2021)
Article
Biochemical Research Methods
Zikun Liu, Wenhui Li, Xianbin Zhu, Rimao Hua, Xiangwei Wu, Jiaying Xue
Summary: An economical and effective thin film microextraction method was developed for simultaneous analysis of ten neonicotinoid insecticides and metabolites in fruit juice and tea. The PU/PMMA composite demonstrated rapid adsorption and strong accumulation towards neonicotinoids, with the ability to be reused without significant loss in performance. Parameters such as agitation mode, film size, ionic strength, desorption solvent, and sample pH were found to dominate the microextraction process, showing great potential as an alternative to exhaustive extraction techniques.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Chemistry, Applied
Malek Hassan, Furkan Uzcan, Usama Alshana, Mustafa Soylak
Summary: A novel method combining switchable-hydrophilicity liquid-liquid microextraction and magnetic nanoparticle-based dispersive solid-phase microextraction was proposed for the determination of erythrosine using UV/Vis spectrophotometry. The method showed excellent analytical performance with high sensitivity, low detection limits, and good reproducibility, making it suitable for the extraction and determination of erythrosine in food and consumer products.
Article
Biochemistry & Molecular Biology
Bader Saud Alotaibi, Jatin Joshi, Mohammad Raghibul Hasan, Mohd Shahnawaz Khan, Salem Hussain Alharethi, Taj Mohammad, Fahad A. Alhumaydhi, Abdelbaset Mohamed Elasbali, Md Imtaiyaz Hassan
Summary: In this study, potential inhibitors of ROCK1 were identified through structure-based virtual screening of natural compounds. Isoononin and Candidissiol showed appreciable binding affinity and selectivity towards ROCK1, and molecular dynamics simulations confirmed their stability.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Computer Science, Information Systems
Mohamed Hassaoui, Mohamed Hanini, Said El Kafhali
Summary: The use of C2 servers in cyberattacks has increased significantly, with attackers using DGA technique to hide their servers. Existing techniques for binary classification of domain names have issues with real-time detection and sensitivity to data. This paper proposes the DTFS-DGA model, which combines neural networks and traditional machine learning models to detect DGA in real-time without relying on reverse engineering and being insensitive to data size.
JOURNAL OF COMPUTER SECURITY
(2023)
Article
Chemistry, Applied
Hani Nasser Abdelhamid, Ghada Abd-Elmonsef Mahmoud
Summary: In this study, copper-based metal-organic frameworks (MOFs) were used to synthesize copper oxide (CuO) embedded into carbon (CuO@C), which displayed high antifungal activity against four economic postharvest plant pathogens. The CuO@C nanoparticles inhibited the growth of the fungal species and decreased their enzyme activity, reducing the potentiality of fruit disease. The successful formation of CuO@C nanoparticles was confirmed using various characterization techniques.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Hani Nasser Abdelhamid
Summary: One-pot co-precipitation method for synthesizing microporous-mesoporous zeolitic imidazolate frameworks-8 (ZIF-8) crystals, using organic dyes as target molecules, was reported. The crystal growth involves an intermediate phase of zinc hydroxyl nitrate nanosheets, allowing the adsorption of the dyes. The materials showed potential for CO2 adsorption and ATP biosensing.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Walid Sharmoukh, Hani Nasser Abdelhamid
Summary: A metal-organic framework (MOF) of cerium (Ce) ions and 4,4 ',4 ''-nitrilotribenzoic acid linker was synthesized via a hydro thermal method. The Ce-MOF showed Fenton-like properties and displayed excellent catalytic oxidation activity for various organic compounds and water pollutants. It exhibited high efficiency in the oxidative degradation of dyes and could be recycled multiple times without significant loss of catalytic performance.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Nojood Altwaijry, Ghaliah S. Almutairi, Mohd Shahnawaz Khan, Gouse M. Shaik, Majed S. Alokail
Summary: Amyloid fibrils accumulation can cause lethal conditions, but the use of Chlorothiazide (CTZ) can prevent or treat this disease. In this study, the effects of CTZ on hen egg white lysozyme (HEWL) aggregation were examined using various methods. The results showed that CTZ can reduce the formation of amyloid fibrils and prevent aggregation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mohd Shahnawaz Khan, Nojood Altwaijry, Moneera Saud Al-Bagmi, Nouf Omar Alafaleq, Majed S. Alokail, Moyad Shahwan, Anas Shamsi
Summary: Proto-oncogene tyrosine-protein kinase ROS (ROS1) is a member of a receptor family that affects epithelial cell differentiation and is highly expressed in various tumors. This study identified two potential inhibitors of ROS1 through virtual screening of phytochemicals. The findings highlight the role of ROS1 in multiple physiological processes and suggest the potential use of phytochemicals for therapeutic development targeting ROS1-associated non-small cell lung cancer.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Ajamaluddin Malik, Javed Masood Khan, Abdullah S. S. Alhomida, Mohammad Shamsul Ola, Majed S. S. Alokail, Mohd Shahnawaz Khan, Amal M. M. Alenad, Nojood Altwaijry, Nouf Omar Alafaleq, Hamza Odeibat
Summary: Several proteins and peptides have the ability to form amyloid fibrils, which can lead to a variety of diseases. The process by which these proteins transition from a folded and soluble state to an amyloid fibril is not well understood.
JOURNAL OF MOLECULAR RECOGNITION
(2023)
Review
Chemistry, Medicinal
Nazia Nazam, Nasimudeen R. Jabir, Iftikhar Ahmad, Saif A. Alharthy, Mohd Shahnawaz Khan, Rashid Ayub, Shams Tabrez
Summary: Cancer is a global health problem that is on the rise, and ovarian cancer is one of the leading causes of mortality worldwide. Current treatments for ovarian cancer have limited effectiveness and come with side effects, recurrence risk, and drug resistance. Therefore, there is a need for alternative, cost-effective, and safer therapeutic strategies.
Article
Multidisciplinary Sciences
Nojood Altwaijry, Ghaliah S. Almutairi, Mohd Shahhnawaz Khan, Majed S. Alokail, Nouf Alafaleq, Rizwan Ali
Summary: Protein misfolding can lead to amyloid fiber aggregation, which is associated with various diseases. This study examines the anti-aggregating effect of Valsartan on HEWL amyloid fibrils through spectroscopy, docking, and microscopic analysis.
Article
Chemistry, Physical
Hani Nasser Abdelhamid, Islam M. A. Mekhemer, Abdel-Aal M. Gaber
Summary: In this study, benzimidazole derivatives were successfully synthesized through photocatalytic synthesis using a solid-state acid catalyst ZrOSO4@C. The reaction, which allowed for condensation and cyclization in a single vessel, resulted in high yield (77-98%) and high purity of the benzimidazoles. The catalyst showed improvement in the synthesis of various benzimidazole derivatives using a wide range of aromatic aldehydes and heterocycles.
MOLECULAR CATALYSIS
(2023)
Article
Energy & Fuels
Moushira Saleh, Hani Nasser Abdelhamid, Dina M. Fouad, Haitham M. El-Bery
Summary: The use of light radiation to split water into hydrogen gas has great potential for green hydrogen production. A comparative study was conducted on the photocatalytic activity of TiO2 nanocomposites with two co-catalysts, Pt or Cu nanocrystals, using different synthesis methods. The study found that the deposition technique of the co-catalyst has a significant influence on the efficiency of photocatalysis for hydrogen production.
Article
Pharmacology & Pharmacy
Mohammad Rashid Khan, Sheikh Fayaz Ahmad, Ahmed Nadeem, Faisal Imam, Naif O. Al-Harbi, Mohd Shahnawaz Khan, Meshal Alsahli, Khaled Alhosaini
Summary: This study explored the therapeutic outcome of Cathepsin B inhibitor (CA-074) against retinopathy and optic neuritis caused by experimental autoimmune encephalomyelitis (EAE). The findings showed that CA-074 could ameliorate optic neuritis and retinopathy by reducing inflammation, as well as reducing demyelination and axonal injuries in EAE mice.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Chemistry, Inorganic & Nuclear
Hani Nasser Abdelhamid, Sahar Sultan, Aji P. Mathew
Summary: 3D printing of cellulose/leaf-like zeolitic imidazolate frameworks (CelloZIF-L) allows for the creation of structures with high adsorption efficiency, capable of adsorbing carbon dioxide and heavy metals.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Dimitrios Georgouvelas, Hani Nasser Abdelhamid, Ulrica Edlund, Aji P. Mathew
Summary: In this study, nanocellulose/alginate composite hydrogel beads were successfully prepared and modified with in situ TEMPO-mediated oxidation. The modified beads exhibited improved adsorption efficiency and water flux, making them promising candidates for large-volume, high flux water treatment.
NANOSCALE ADVANCES
(2023)