Article
Chemistry, Multidisciplinary
Chaemin Lim, Duhyeong Hwang, Mostafa Yazdimamaghani, Hannah Marie Atkins, Hyesun Hyun, Yuseon Shin, Jacob D. Ramsey, Patrick D. Raedler, Kevin R. Mott, Charles M. Perou, Marina Sokolsky-Papkov, Alexander V. Kabanov
Summary: The presence of immunosuppressive immune cells in tumors is a barrier to therapeutic immune responses. This study used polymeric micelles to enhance the adaptive T cell immunity against triple-negative breast cancers (TNBCs) by delivering the small molecule drugs paclitaxel (PTX) and CSF1R inhibitor PLX3397. The combination therapy repolarized the immunosuppressive tumor microenvironment, resulting in inhibited primary tumor growth and metastasis.
Article
Pharmacology & Pharmacy
Jinyu Liu, Yanhao Zhang, Chao Liu, Yuhao Jiang, Zihao Wang, Xinsong Li
Summary: Polypeptides are a promising carrier for delivering hydrophobic drugs. In this study, a redox and pH responsive micelle encapsulated with a disulfide bridged paclitaxel-pentadecanoic acid prodrug was developed for cancer chemotherapy. The micelles exhibited a high drug-loading rate, excellent stability, pH and redox dual responsiveness, increased bioavailability, extended circulation time, and showed high antitumor efficacy and low systemic toxicity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Chae Eun Jin, Moon Sup Yoon, Min Jeong Jo, Seo Yeon Kim, Jae Min Lee, Su Jeong Kang, Chun-Woong Park, Jin-Seok Kim, Dae Hwan Shin
Summary: Ovarian cancer has a high mortality rate due to difficult early detection, necessitating the development of a novel anti-cancer treatment with improved efficacy and reduced toxicity. Micelles encapsulating paclitaxel and sorafenib were prepared using the freeze-drying method, and the optimal polymer was selected based on various factors. The PTX/SRF micelles demonstrated slower release, improved bioavailability, and enhanced anticancer effects compared to single-drug therapy in ovarian cancer.
Article
Biotechnology & Applied Microbiology
Cong Hua, Yi Zhang, Yuanhao Liu
Summary: The research explores the potential of polymer micelles as carriers for chemotherapeutic agents, demonstrating their effectiveness in suppressing tumor growth and reducing systemic toxicity. By manipulating the chemical and physical properties of amphiphilic Y-shaped polypeptides, the self-assembly performance of micelles and the controlled release of drugs can be significantly regulated.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Paulina Kobylka, Malgorzata Kucinska, Jacek Kujawski, Dawid Lazewski, Marcin Wierzchowski, Marek Murias
Summary: Resveratrol, a plant-derived phytoalexin, has pleiotropic biological activities, particularly anticancer and chemopreventive properties. It interacts with estrogen receptors and functions as a mixed agonist/antagonist. The hydroxyl groups are crucial for its cytotoxic and antioxidative activities. Through experiments and computational simulations, specific analogues of resveratrol were found to act as selective estrogen receptor modulators.
Article
Nanoscience & Nanotechnology
Md Korban Ali, Rahman Md Moshikur, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto
Summary: The new MF showed enhanced transdermal absorption of PTX, lower toxicity profile compared to conventional carriers, demonstrating potential as a biocompatible nanocarrier for effective delivery of poorly soluble chemotherapeutics.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Antonella Grigoletto, Gabriele Martinez, Daniela Gabbia, Tommaso Tedeschini, Michela Scaffidi, Sara De Martin, Gianfranco Pasut
Summary: This study demonstrates that the use of polymer-drug conjugates with the correct folate/PEG ratio can significantly enhance the activity and selectivity of drugs in cancer cells. Cytotoxicity studies on leukemia cell lines show that the 3-FA conjugate is more active than the 1-FA conjugate, while folate targeting significantly affects cell migration and invasiveness.
Article
Materials Science, Multidisciplinary
Hanlei Xing, Yanhao Zhang, Ji Wang, Chao Liu, Wenhui Zha, Yang Wang, Shuo Dong, Xinsong Li
Summary: In this report, redox and pH dual-responsive poly(glutamic acid) micelle-encapsulated doxorubicin (DOX) was developed. The micelles were formed through the electrostatic interaction between poly(ethylene glycol)-block-poly(glutamic acid) (PEG-SS-PG) and DOX. The micelles exhibited efficient drug release under the conditions of high glutathione concentration and low pH, and demonstrated effective inhibition of tumor growth.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Linxi Zhu, Qingxin Mu, Jesse Yu, James I. Griffin, Xiaolin Xu, Rodney J. Y. Ho
Summary: By incorporating an ICAM-1-binding peptide on a novel drug-combination nanoparticle, researchers successfully improved the binding and localization of gemcitabine and paclitaxel in breast cancer cells. This strategy may provide a potential solution to overcome drug resistance in advanced metastatic breast cancer, and further clinical development is warranted.
Article
Nanoscience & Nanotechnology
Yuzhu Wang, Lu Jia, Tingting Hu, Zhuoran Yang, Chunyu Yang, Huiming Lin, Feng Zhang, Kai Yu, Fengyu Qu, Wei Guo
Summary: Although phototherapy has been extensively studied in recent years, its efficacy in treating tumors is often unsatisfactory due to the complex and variable tumor microenvironment. In this study, we report the discovery of novel hollow carriers named CoSn(OH)6@CoOOH with oxidase properties, which can enhance the effectiveness of phototherapy. These carriers react with oxygen to generate singlet oxygen and consume glutathione, and their hollow structure allows for the delivery of drug molecules. Loading indocyanine green and AIPH onto the carriers resulted in enhanced phototherapy effects through oxidase-catalyzed reactions, generation of alkyl radicals, and glutathione consumption. Cell and mouse experiments demonstrated that these carriers, combined with near-infrared laser irradiation, significantly inhibited tumor growth. Enrichment analysis revealed the involvement of the PI3K-Akt and MAPK signaling pathways in this therapeutic system. Hollow carriers with oxidase activity like these have great potential for the design of multifunctional drug delivery vehicles for tumor therapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Oncology
AmirAhmad Arabzadeh, Tohid Mortezazadeh, Tayebeh Aryafar, Esmaeil Gharepapagh, Mehrsa Majdaeen, Bagher Farhood
Summary: Glioblastoma is an aggressive type of brain tumor with resistance to conventional therapies. Resveratrol, a natural polyphenolic compound, has shown to have anti-tumoral effects by regulating various cellular pathways such as cell cycle progression, autophagy, and apoptosis. Studies have also explored the potential of using resveratrol in combination with radiation therapy and chemotherapy for glioblastoma treatment.
CANCER CELL INTERNATIONAL
(2021)
Review
Pharmacology & Pharmacy
Nisar Ul Khaliq, Juyeon Lee, Sangwoo Kim, Daekyung Sung, Hyungjun Kim
Summary: Pluronics are amphiphilic triblock copolymers consisting of hydrophilic poly (ethylene oxide) (PEO) chains connected by a hydrophobic polypropylene oxide (PPO) segment. Pluronics can induce micelle formation and gelation at critical micelle concentrations and temperatures due to their low molecular weight and more PEO segments. Pluronics F-68 and F-127, the only FDA-approved Pluronic classes in the United States, have been extensively used in biomedical applications such as drug delivery systems and tissue regeneration scaffolds.
Review
Pharmacology & Pharmacy
Ying Wang, Yixuan Xu, Xianghuan Guo, Lei Wang, Jing Zeng, Haixia Qiu, Yizhou Tan, Defu Chen, Hongyou Zhao, Ying Gu
Summary: This article reviews the recent progress in the combination therapy using ultrasound and antimicrobial photodynamic therapy (aPDT) and discusses the potential mechanisms underlying the enhanced antimicrobial effect. The future research directions are also highlighted.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Physical
Makoto Obata, Shiho Hirohara
Summary: Polymer micelles are potential drug delivery systems for hydrophobic photosensitizers in photodynamic therapy (PDT). A new pH-responsive polymer micelle, P(BA-co-DMAEA)-b-PPEGA, was synthesized to investigate the role of neutral hydrophobic units in photosensitizer delivery. The micelles showed pH-responsive ability and exhibited higher photocytotoxicity for photosensitizer delivery compared to free photosensitizers.
Article
Biotechnology & Applied Microbiology
Zhuomin Xu, Shanshan Zheng, Xin Gao, Yulu Hong, Yue Cai, Qiuqin Zhang, Jiani Xiang, Dehui Xie, Fuxing Song, Huawei Zhang, Hong Wang, Xuanrong Sun
Summary: Nanoparticles of Na(2)GA/CA-BM (131.6 nm, -11.7 mV) prepared by simple and low-cost mechanochemical technology can improve the oral bioavailability and antitumor efficacy of CA in vivo, suggesting a potential formulation for efficient anticancer treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yanzuo Chen, Wantong Song, Limei Shen, Nasha Qiu, Mengying Hu, Yun Liu, Qi Liu, Leaf Huang
Review
Chemistry, Multidisciplinary
Mengying Hu, Leaf Huang
ADVANCED FUNCTIONAL MATERIALS
(2019)
Article
Chemistry, Multidisciplinary
Sai An, Karthik Tiruthani, Ying Wang, Ligeng Xu, Mengying Hu, Jingjing Li, Wantong Song, Hongnan Jiang, Jirui Sun, Rihe Liu, Leaf Huang
Article
Multidisciplinary Sciences
Mengying Hu, Ying Wang, Ligeng Xu, Sai An, Yu Tang, Xuefei Zhou, Jingjing Li, Rihe Liu, Leaf Huang
NATURE COMMUNICATIONS
(2019)
Article
Engineering, Biomedical
Huan Xu, Mengying Hu, Mengrui Liu, Sai An, Kaiyun Guan, Menglin Wang, Lei Li, Jing Zhang, Jun Li, Leaf Huang
Article
Chemistry, Multidisciplinary
Mengying Hu, Xuefei Zhou, Ying Wang, Kaiyun Guan, Leaf Huang
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Chemistry, Multidisciplinary
Zhuo Yu, Jianfeng Guo, Mengying Hu, Yueqiu Gao, Leaf Huang
Article
Nanoscience & Nanotechnology
Mengying Hu, Ying Wang, Zhengsheng Liu, Zhuo Yu, Kaiyun Guan, Mengrui Liu, Menglin Wang, Jun Tan, Leaf Huang
Summary: The study reveals the key role of hepatic macrophages in mediating relaxation-induced alleviation of liver fibrosis. By developing lipid nanoparticles that target activated hepatic stellate cells and encapsulate relaxin gene and miR-30a-5p mimic, a synergistic antifibrosis effect is achieved in mouse liver fibrosis models. This approach demonstrates a proof-of-concept for devising antifibrotic strategies through the complementary application of nanotechnology and basic science.
NATURE NANOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Nasha Qiu, Yun Liu, Qi Liu, Yanzuo Chen, Limei Shen, Mengying Hu, Xuefei Zhou, Youqing Shen, Jianqing Gao, Leaf Huang
Summary: CEL not only induces strong immunogenic cell death (ICD), but also downregulates the expression of PD-L1 in tumor cells. This allows CEL to activate dendritic cells (DCs) and T-cells simultaneously, while interrupting the PD-1/PD-L1 signaling pathway between T-cells and tumor cells. This approach shows promise as a more cost-effective immunotherapy strategy against melanoma compared to traditional immune checkpoint inhibitors.
Article
Multidisciplinary Sciences
Xuefei Zhou, Yun Liu, Mengying Hu, Menglin Wang, Xiangrui Liu, Leaf Huang
Summary: The study demonstrates that targeting gene delivery-induced RLN can modulate macrophages to reduce tumor-associated fibrosis and promote infiltration of anti-tumor T cells. In addition, RLN gene delivery synergizes with PD-L1 blockade to enhance the effectiveness of immunotherapy against tumors.
Article
Chemistry, Multidisciplinary
Ying Wang, Karthik Tiruthani, Sirui Li, Mengying Hu, Guojie Zhong, Yu Tang, Sourav Roy, Lillian Zhang, Jun Tan, Chengheng Liao, Rihe Liu
Summary: Liver malignancies are resistant to immune checkpoint inhibition therapy due to the presence of tumor-associated macrophages (TAMs) that induce immunosuppression. The study identified CCL2 and CCL5 as major chemokines responsible for TAM infiltration in liver malignancies and developed a bispecific antibody BisCCL2/5i to reverse this immunosuppressive process.
ADVANCED MATERIALS
(2021)
Correction
Engineering, Biomedical
Nasha Qiu, Yun Liu, Qi Liu, Yanzuo Chen, Limei Shen, Mengying Hu, Xuefei Zhou, Youqing Shen, Jianqing Gao, Leaf Huang
Article
Oncology
Hossein Sendi, Mostafa Yazdimamaghani, Mengying Hu, Nikhila Sultanpuram, Jie Wang, Amber S. Moody, Ellie McCabe, Jiajie Zhang, Amanda Graboski, Liantao Li, Juan D. Rojas, Paul A. Dayton, Leaf Huang, Andrew Z. Wang
Summary: Efficient delivery of miR-122 to hepatocytes using a nanomedicine-based formulation has the potential to prevent and treat colorectal cancer liver metastasis. Mechanistically, it downregulates key genes involved in metastatic and cancer inflammation pathways, increases CD8(+)/CD4(+) T-cell ratio, and decreases immunosuppressive cell infiltration, making the liver more conducive to antitumor immune response.
Meeting Abstract
Gastroenterology & Hepatology
Xiaoyu Liu, Jingying Zhou, Man Liu, Ying Wang, Mengying Hu, Rihe Liu, Leaf Huang, Hanzhuang Liu, Alfred Sze-Lok Cheng
Article
Pharmacology & Pharmacy
Yang Xiong, Wantong Song, Limei Shen, Ying Wang, Jing Zhang, Mengying Hu, Yun Liu, Jingjing Li, Sara Musetti, Rihe Liu, Leaf Huang
ADVANCED THERAPEUTICS
(2020)