期刊
RSC ADVANCES
卷 4, 期 87, 页码 46545-46554出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra09832c
关键词
-
资金
- National Basic Research Program of China [2009CB623505]
A facile and environmentally friendly method is presented for the asymmetric oxidation of sulfides with H2O2, utilizing a pre-formed manganese complex. Just in the presence of a low catalytic amount of carboxylic acid (CA), a variety of sulfide substrates, including aryl alkyl, aryl benzyl and cyclic sulfides, reacted to form chiral sulfoxides in high yields (up to 95%) and excellent enantioselectivities (>99% ee) under mild conditions. Moreover, the practical utility of the method has been demonstrated by the synthesis of esomeprazole and albendazole sulfoxide (ABZO).
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