Article
Chemistry, Applied
Imtiyaz Yousuf, Masrat Bashir
Summary: A new organoruthenium(II) complex was designed, synthesized, and evaluated for cytotoxicity. The complex exhibited significant intermolecular interactions in the crystal structure, and showed preferential affinity toward minor groove in DNA photocleavage activity. Cytotoxic studies revealed moderate but selective activity against pancreatic and cervical cancer cell lines.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Lukas Masaryk, Darina Muthna, Petr Halas, Pavel Zoufaly, Eva Peterova, Radim Havelek, Bohuslav Drahos, David Milde, Alena Mrkvicova, Pavel Starha
Summary: In the presence of carboxypeptidase, the hydrolytically stable complex partially released the bioactive substituent indomethacin, which was bound through the amide bond to the chelating moiety. The stability in the presence of other relevant biomolecules and cancer cell viability were also investigated in this study.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Russell J. Needham, Ivan Prokes, Abraha Habtemariam, Isolda Romero-Canelon, Guy J. Clarkson, Peter J. Sadler
Summary: In this study, the synthesis and characterization of an organo-osmium anticancer complex, along with its potent activity against human ovarian cancer cells, were reported. The X-ray crystal structure confirmed the unique configuration of the complex, and analysis of the isotopically-enriched compound provided insights into its chemical shifts and bonding interactions.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Julijan Sarcevic, Tobias Heitkemper, Christian P. Sindlinger
Summary: This study presents the synthesis and initial observations of the reactivity between borole-based half-sandwich complexes with apical divalent group 14 elements germanium and tin. The 2,5-disilylborole substitution pattern allows their access through salt metathesis of the respective borole dianions.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Carsten Mueller, Justin Schu, Bernd Morgenstern, Michael Zimmer, Marc Schmidtmann, Andre Schaefer
Summary: Phosphanyl-substituted tin(ii) half sandwich complexes, which form head-to-tail dimers due to the Lewis acidic tin center and Lewis basic phosphorous atom, were reported. Their properties and reactivities were investigated both experimentally and theoretically. Furthermore, related transition metal complexes of these species are presented.
Article
Chemistry, Inorganic & Nuclear
Artem A. Mikhailov, Taisiya S. Sukhikh, Natalia Kuratieva, Denis P. Pishchur, Gennadiy A. Kostin
Summary: Two new complexes are synthesized and characterized, showing high thermal stability of Ru-ON and Ru-(η2-(NO)) isomers. These findings are important for the design of photochromic materials and the investigation of states.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Dmitri Gelman, Ilya Kisets, Sofiya Zabelinskaya
Summary: The synthesis and catalytic studies of a prototypical coordinatively rigid carbometalated half-sandwich Ru(II) complex with a rigid polyaromatic tether were described. Despite its coordinatively and electronically saturated nature, the complex demonstrated the ability to activate and transfer hydrogen to polar and nonpolar double bonds. The catalytic activity was benchmarked in the Ru-catalyzed chemoselective hydrogenation of alpha,beta-unsaturated ketones, with initial mechanistic studies suggesting an inner-sphere mechanism via dihydride intermediates.
Review
Biochemistry & Molecular Biology
Oscar A. Lenis Rojas, Sandra Cordeiro, Pedro V. Baptista, Alexandra R. Fernandes
Summary: The ruthenium arene fragment is a valuable source for designing anticancer drugs, and the co-ligand plays a crucial role in obtaining effective anticancer complexes. N-heterocyclic carbenes (NHCs), despite their versatility and ability to stabilize metal ions, have not been extensively explored. However, recent advancements have been made in the development of NHC ruthenium arene complexes as potent anticancer agents.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Lukas Masaryk, Ivan Nemec, Jana Kasparkova, Viktor Brabec, Pavel Starha
Summary: In this study, model compounds such as Ru-dca and Ir-dca were used to investigate the behavior of complexes containing bioactive substituents like dichloroacetate (dca) in solution, with characterization done using techniques such as single-crystal X-ray analysis. However, these complexes did not demonstrate antiproliferative activity in four human cancer cell lines.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Wei-Guo Jia, Xue-Ting Zhi, Xiao-Dong Li, Jun-Peng Zhou, Rui Zhong, Haibo Yu, Richmond Lee
Summary: A mild and environmentally friendly method was reported for synthesizing half-sandwich ruthenium complexes through the Wittig reaction using phosphorus ylide mechanochemically. The synthesized complexes exhibited high catalytic activity in the transfer hydrogenation of ketones without the need for harsh reaction conditions and organic solvents. Density functional theory was used to propose a mechanism for the transfer hydrogenation process, highlighting the importance of the labile p-cymene ligand in modulating catalyst reactivity.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Ondrej Mozdiak, Pooja Dubey, Libor Dostal, Zdena Ruzickova, Jiri Tydlitat, Roman Jambor
Summary: In this study, we compared the application of different ligands in divalent ruthenium complexes and investigated the effect of stannylene ligand on catalytic oxidation reaction.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Ramya Prabaharan, Ramesh Rengan, Devan Umapathy, Antony Joseph Velanganni Arockiam, Jan Grzegorz Malecki
Summary: The study synthesized six new arene ruthenium (II) complexes and evaluated their anticancer activity through MTT assay and staining techniques, demonstrating good cytotoxicity against cancer cell lines, particularly with complex 6 showing potential anticancer activity.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Yuliang Yang, Xiaofeng Zou, Yanyan Sun, Feihong Chen, Jian Zhao, Shaohua Gou
Summary: This article presents a rational design of half-sandwich Ru(II) complexes for mitochondria-targeted anticancer and antimetastatic agents by introducing the NDI unit into the N,N-chelating ligand of these complexes, which exhibit excellent emission performance. These complexes have potential applications in the design of multifunctional theranostic agents and fluorescent biomarkers.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Tianyu Han, Yuying Wu, Weinan Han, Kaiwen Yan, Jian Zhao, Yanyan Sun
Summary: The facile modification of ligands in organometallic Ru(II)-arene complexes provides more opportunities for optimizing their pharmacological profiles. This study designed and synthesized three Ru(II)-arene complexes containing a GST inhibitor (NBDHEX), with in vitro results showing increased activities against tumor cells, especially in complex 3 which demonstrated the highest activity. Complex 3, with more alkyl groups in the arene ligand, exhibited increased electron density at the Ru(II) center leading to improved hydrolysis rate and higher anticancer activity.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Aditi Vatsa, Sumanta Kumar Padhi
Summary: Water splitting is an emerging field within sustainable energy systems. A new complex [Ru-hdm] has been synthesized and characterized, showing efficient O-2 generation through both chemical and electrochemical water oxidation. The kinetics of chemical water oxidation demonstrate a first-order dependency on CAN and catalyst concentration.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Raja Mitra, Richard Goddard, Klaus-Richard Poerschke
INORGANIC CHEMISTRY
(2017)
Review
Chemistry, Physical
Raja Mitra, Jochen Niemeyer
Article
Chemistry, Inorganic & Nuclear
Noor U. Din Reshi, Dineshchakravarthy Senthurpandi, Ashoka G. Samuelson
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2018)
Article
Chemistry, Applied
Noor U. Din Reshi, Dineshchakravarthy Senthurpandi, Ashoka G. Samuelson
APPLIED ORGANOMETALLIC CHEMISTRY
(2019)
Article
Chemistry, Inorganic & Nuclear
Noor U. Din Reshi, Lakshay Kathuria, Ashoka G. Samuelson
INORGANICA CHIMICA ACTA
(2019)
Article
Chemistry, Inorganic & Nuclear
Noor U. Din Reshi, Lakshay Kathuria, Ashoka G. Samuelson
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Lakshay Kathuria, Noor U. Din Reshi, Ashoka G. Samuelson
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Physical
Noor U. Din Reshi, Ashoka G. Samuelson
APPLIED CATALYSIS A-GENERAL
(2020)
Article
Chemistry, Inorganic & Nuclear
Lakshay Kathuria, Ashoka G. Samuelson
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Roberta Properzi, Philip S. J. Kaib, Markus Leutzsch, Gabriele Pupo, Raja Mitra, Chandra Kanta De, Lijuan Song, Peter R. Schreiner, Benjamin List
Article
Nanoscience & Nanotechnology
Naresh Mandal, Raja Mitra, Bidhan Pramanick
Summary: According to a report from WHO, there have been a staggering number of cases and deaths from COVID-19 worldwide. The spread of the virus is attributed to various factors, including the lack of detection kits and techniques, the presence of asymptomatic cases, and failures in mass screening. In this study, a simple and cost-effective method using a surface functionalized glassy carbon electrode was developed to rapidly detect the SARS-CoV-2 spike protein.
MICROSYSTEMS & NANOENGINEERING
(2023)
Article
Chemistry, Inorganic & Nuclear
Shriya Saha, Thomas Doughty, Dibyendu Banerjee, Sunil K. Patel, Dibyendu Mallick, E. Siva Subramaniam Iyer, Souvik Roy, Raja Mitra
Summary: A series of organometallic Re(I)(L)(CO)(3)Br complexes with 4'-substituted terpyridine ligands (L) were synthesised and used as electrocatalysts for CO2 reduction. The effect of substitution on the 4'-position of terpyridine on CO2 electroreduction was investigated. All complexes catalyse CO evolution in homogeneous organic media at moderate overpotentials with high faradaic yields. The influence of the pK(a) of the proton sources on the electrochemical catalytic activity was also demonstrated.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Physical
C. Karthika, S. R. Sarath Kumar, L. Kathuria, P. K. Das, A. G. Samuelson
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2019)
Article
Chemistry, Multidisciplinary
Raja Mitra, Hui Zhu, Stefan Grimme, Jochen Niemeyer
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)
Article
Chemistry, Multidisciplinary
Frescilia Octa-Smolin, Raja Mitra, Maike Thiele, Constantin G. Daniliuc, Linda Stegemann, Cristian Strassert, Jochen Niemeyer
CHEMISTRY-A EUROPEAN JOURNAL
(2017)
