Article
Materials Science, Multidisciplinary
Qi Li, Mingju Xian, Anhe Wang, Yi Jia, Shuo Bai, Xuehai Yen, Junbai Li
Summary: Dipeptides are biocompatible building blocks that can be assembled into various sensing materials. These sensors interact with force, electricity, light, and chemical stimulus to generate electrical, optical, and mechanical signals, making them applicable in microelectronics and healthcare fields. Dipeptide-based sensing materials have the advantages of biological molecules and also possess excellent mechanical and electrical properties. This perspective article summarizes the molecular assembly of dipeptides, focusing on their application as biogenic sensors, and discusses the challenges and prospects for the future development of dipeptide-based sensing materials.
Article
Cell Biology
Elma Sakinatus Sajidah, Keesiang Lim, Tomoyoshi Yamano, Goro Nishide, Yujia Qiu, Takeshi Yoshida, Hanbo Wang, Akiko Kobayashi, Masaharu Hazawa, Firli R. P. Dewi, Rikinari Hanayama, Toshio Ando, Richard W. Wong
Summary: Small extracellular vesicles (sEVs) play a crucial role in cell communication and can be used for drug delivery and structural characterization of nanoparticles. The high-speed atomic force microscopy (HS-AFM) can evaluate the structural changes of sEVs under different physicochemical stresses.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Chemistry, Multidisciplinary
Hai Lei, Quan Ma, Zhangxia Wang, Di Zhang, Xiaoyu Huang, Meng Qin, Haibo Ma, Wei Wang, Yi Cao
Summary: This study developed a single-molecule assay to investigate the force-dependent ester hydrolysis. The results showed that the ester hydrolysis rate is surprisingly insensitive to forces. The study revealed that the rate-limiting step for the formation of intermediate states is not affected by applied forces.
Article
Chemistry, Physical
Laure Bar, Martin Eduardo Villanueva, Claudio Martin, Andrea Valencia Ramirez, Jonathan Goole, Frank Uwe Renner, Patricia Losada-Perez
Summary: Hybrid lipid bilayers composed of different types of molecules are suitable for studying biomembrane-related phenomena and can be produced in a controlled array fashion. The formation and stability of hybrid supported membranes are influenced by lipid phase, substrate surface energy, and topography. The lateral organization of hybrid membranes is weaker compared to standard supported lipid bilayers due to suboptimal organization of the underlying self-assembled monolayer. The self-assembled monolayer can undergo non-trivial reorganization in an aqueous environment.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Physical
A. Rodriguez, M. S. Jaman, O. Acikgoz, B. Wang, J. Yu, P. G. Grutzmacher, A. Rosenkranz, M. Z. Baykara
Summary: Ti3C2Tx nano-sheets exhibit solid lubrication properties on the nanoscale, reducing friction on silicon dioxide substrates, although not as effectively as few-layer graphene. This paves the way for further investigations into nanoscale solid lubrication achieved by Ti3C2Tx (MXene) nano-sheets.
APPLIED SURFACE SCIENCE
(2021)
Article
Multidisciplinary Sciences
Devin T. Edwards, Marc-Andre Leblanc, Thomas T. Perkins
Summary: Single-molecule force spectroscopy was used to study protein folding dynamics, revealing intrinsic changes in protein folding dynamics and transition state height under different pH conditions. Despite differences in destabilization mechanisms, constant-force landscapes showed minimal differences in transition state height, while force-dependent rates increased as pH decreased. This study provides insights for future AFM-based studies of mechanoresponsive proteins.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Polymer Science
Xiaobin Liang, Makiko Ito, Ken Nakajima
Summary: In this study, atomic force microscopy nanomechanics were used to visualize the nanoscale stress distribution in carbon black-reinforced isoprene rubber vulcanizates at different elongations, revealing the stress concentrations in the protofibrous structure formed around the CB filler. The relationship between local nanoscale stress distribution and macroscopic tensile properties was established based on microscopic stress distribution and spatial structure, providing insights into the microscopic reinforcement mechanism of carbon black-containing rubber composites.
Article
Nanoscience & Nanotechnology
Keivan Asadi, Junghoon Yeom, Hanna Cho
Summary: Investigating internal resonance (IR) mechanisms in micro/nanoresonators reveals that intermodal coupling between second and third flexural modes in asymmetric structures provides an optimal condition for strong IR, with high energy transfer to the resonated mode. This study introduces design strategies that can be easily integrated into typical micro/nanoelectromechanical systems, offering potential for paradigm-shifting applications in micro/nanosystems.
MICROSYSTEMS & NANOENGINEERING
(2021)
Review
Biochemistry & Molecular Biology
Aritz B. Garcia-Arribas, Felix M. Goni, Alicia Alonso
Summary: Model lipid membranes serve as important tools in studying biophysical processes such as lipid self-assembly and lipid-lipid interactions. These membranes offer advantages like greater stability, controllable lipid composition, and can aid in understanding various events occurring in cellular membranes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Siying Li, Ruixia Wang, Junfeng Li, Yulin Liu, Yanfeng Fu, Jing Zhou, Guocheng Yang, Yuping Shan
Summary: The peptide HAIYPRH (T7) is commonly used as a ligand in tumor-targeted nanodrug delivery systems. This study used atomic force microscopy to track the dynamic process of a T7-conjugated gold nanoparticle (AuNP-T7) entering cells, revealing that transferrin can both decrease endocytosis force and increase endocytosis speed depending on the cell type. This research provides important insights for the redesign and development of T7-conjugated nanodrug carriers in targeted nanodrug delivery systems.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Physical
Siddhartha Banerjee, Ayanjeet Ghosh
Summary: The aggregation of tau protein plays a central role in neurodegenerative diseases, with the study revealing structural heterogeneities in tau aggregates associated with different diseases, as well as multiple fibrillar polymorphs within the same tau aggregate. Additionally, mature fibrils were found to contain significant amounts of antiparallel beta sheets. The research demonstrates the promise of using nanoscale infrared spectroscopy for spatially resolved investigation of protein aggregation.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Editorial Material
Multidisciplinary Sciences
Telmo O. Paiva, Albertus Viljoen, Yves F. Dufrene
Summary: Advancements in atomic force microscopy (AFM) techniques and methodologies in microbiology have enhanced our understanding of microbial cell surfaces. Recent studies have shown that AFM imaging of cells and membranes at or near molecular resolution enables detailed visualization of membrane-drug interactions.
NATURE COMMUNICATIONS
(2022)
Article
Electrochemistry
Inhee Park, Florian Hausen, Helmut Baltruschat
Summary: In this study, in situ electrochemical lateral force microscopy was used to investigate the ordered structure of Li+ containing tetraglyme on I-modified Au(111) and its impact on friction. The results showed that the adsorbed iodine formed a (root 3 x root 3) R30 degrees structure, and the structure changed with increasing normal load. Multiple ordered layers were observed in G4 solvent and Li+ containing electrolyte.
Article
Nanoscience & Nanotechnology
Ogulcan Acikgoz, Enrique Guerrero, Alper Yanilmaz, Omur E. Dagdeviren, Cem Celebi, David A. Strubbe, Mehmet Z. Baykara
Summary: In this study, atomic force microscopy was used to measure the friction on Re-doped MoS2. Unlike the common observation of decreasing friction with increasing number of layers in two-dimensional materials, Re-doped MoS2 exhibits friction that is inversely proportional to the number of layers. Raman spectroscopy measurements and ab initio calculations reveal that this phenomenon is related to Re intercalation, with an increase in out-of-plane stiffness inversely correlating with the number of layers as the physical mechanism behind this remarkable observation, revealing a distinctive regime of puckering for 2D materials.
Article
Chemistry, Physical
Tianmao Lai, Yuguo Chen, Jianchao Sun, Mingli Guo
Summary: The adhesion force between silicon, glass, and sapphire samples increases logarithmically with dwell time and then saturates, while it does not depend on dwell time for other samples due to the low viscosity of the film. Abnormal behaviors were observed on some samples, possibly related to the evolution of a liquid bridge in the contact zone.
APPLIED SURFACE SCIENCE
(2021)
Article
Engineering, Mechanical
Deliang Zhang, Yuge Zhang, Qiang Li, Mingdong Dong
Summary: The study found that environmental adsorbates play an important role in load-dependent friction hysteresis in graphene, leading to a positive friction hysteresis. After the removal of environmental adsorbates, a negative friction hysteresis was observed.
Article
Chemistry, Analytical
Jingjing Zhao, Ying Zhang, Xiangxiang Zhang, Chao Li, Hang Du, Steffan Moller Sonderskov, Wei Mu, Mingdong Dong, Xiaojun Han
Summary: Mass transport across cell membranes is essential for cellular metabolism. Electrostatically mediated membrane fusion is used to transport small molecules and macromolecules between oppositely charged vesicles, triggering important biological processes such as enzyme reactions and gene expression. These findings provide a crucial step for investigating complex cellular metabolism.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Zibo Li, Qian Liu, Qiang Li, Mingdong Dong
Summary: This study investigates the lubrication effect of hydrated halogen anions on positively charged surfaces using atomic force microscopy and friction force microscopy. The results show that the mechanical properties of the hydration layers depend on the concentration of electrolyte solutions, and the friction coefficient and friction dissipation are significantly lower at low concentrations. Superlubricity can be achieved in low concentration electrolyte solution. These findings provide insights into the origins of hydration lubrication.
Article
Chemistry, Multidisciplinary
Ziwei Su, Xiangxiang Zhang, Weichen Wang, Mingdong Dong, Xiaojun Han
Summary: This study demonstrates an efficient way to build self-powered artificial cells containing thylakoids that convert light energy into chemical energy to supply ATP. The generated ATP and NADPH can be used in promoting biological enzyme cascade reactions and provide a pathway for building more complex artificial cells.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Rongrong Wu, Xinwen Ou, Liwei Zhang, Xiaolu Song, Zengkai Wang, Mingdong Dong, Lei Liu
Summary: The study demonstrates that electric field can inhibit the co-fibrillation of multiple amyloid peptides, preventing the formation of fibril aggregates and promoting the formation of amorphous particles. The inhibitory effect is attributed to the disruption of the secondary structure of amyloid peptides under small static EF, while maintaining the strong interaction between different peptides. This finding suggests the potential of noninvasive treatment for amyloid-related diseases.
Article
Nuclear Science & Technology
Shichang Dong, Shengjie Gong, Botao Zhang, Yidan Yuan, Weimin Ma
Summary: This study establishes a new prediction model for critical heat flux (CHF) in subcooled flow boiling at low pressure. The model accurately predicts the effects of thermal-hydraulic and geometric factors on CHF and demonstrates good adaptability to non-water systems.
PROGRESS IN NUCLEAR ENERGY
(2022)
Article
Materials Science, Multidisciplinary
Deliang Zhang, Zibo Li, Lasse Hyldgaard Klausen, Qiang Li, Mingdong Dong
Summary: This article summarizes the friction behaviors and underlying physical mechanisms of 2D materials, with an increased understanding of their friction properties thanks to the development of atomic and friction force microscopy. The effects of atomic structures and external factors on friction, as well as strategies for friction modulation, are discussed. The challenges in practical applications of 2D materials as atomically thin lubricants and the prospects for future progression are also provided.
MATERIALS TODAY PHYSICS
(2022)
Article
Thermodynamics
Botao Zhang, Shengjie Gong, Shichang Dong, Zhenqin Xiong, Qiang Guo
Summary: Boiling-induced vibration characteristics and mechanisms were investigated in pool boiling experiments. Turbulence and bubble collapse were identified as the two main mechanisms causing vibration. The peak amplitude of the first natural frequency increased with increasing heat flux and decreasing subcooling degree for turbulence-induced vibration. The peak amplitude of the second natural frequency increased with increasing heat flux for a certain subcooled temperature above 10 degrees C, and remained stable for lower subcooled temperatures. The dominant mechanism transitioned from bubble collapse to turbulence with decreasing subcooled temperature for a certain heat flux. The highest root-mean-square (RMS) value of vibration velocity corresponded to an increasing subcooled temperature with increasing heat flux.
APPLIED THERMAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Jordi Amagat, Yingchun Su, Frederik Hobjerg Svejso, Alice Le Friec, Steffan Moller Sonderskov, Mingdong Dong, Ying Fang, Menglin Chen
Summary: In this study, porous and conductive hydrogel-based nerve guidance conduits (NGCs) with anisotropic, self-snapping properties were successfully fabricated for peripheral nerve regeneration. The electroactive g-C3N4 H/rGO3 hydrogel supported normal viability and proliferation of neural cells, with significantly longer neurites observed compared to pristine g-C3N4 H hydrogel. Furthermore, the NGC with aligned microchannels showed optimal neurite guidance, indicating great potential for repairing peripheral nerve injuries.
MATERIALS TODAY BIO
(2022)
Article
Nanoscience & Nanotechnology
Shengjie Liang, Mengyuan Hu, Baoe Li, Dan Xia, Chunyong Liang, Feng Peng, Donghui Wang
Summary: This study reports on the development of an intelligent implant capable of detecting and disinfecting early bacterial adhesion. The implant integrates a biosensor electrode based on AC impedance technology to monitor the growth and elimination of E.coli. The biosensor electrode showed high correlation with classical OD monitoring and was able to eradicate bacteria on the electrode surface. In vitro cellular experiments also demonstrated the biocompatibility and bone differentiation-promoting effect of the PPy coating.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Jiatian Chen, Zihang Huang, Xiaotong Wu, Dan Xia, Ziyu Chen, Donghui Wang, Chunyong Liang, Jinhua Li
Summary: In this paper, a three-dimensional (3D) nanofiber sponge with dimethyloxaloglycine (DMOG) loaded mesoporous spheres of derivatives of Prussian blue analogues (PBAs) was prepared. The nanostructure, composition, and mechanical properties of the nanofiber sponge were characterized, showing regular nanostructure and good mechanical property. The study demonstrated that the 3D-PBA(FeCo)-DMOG nanofiber sponge could provide a new strategy for promoting angiogenesis and wound healing for clinical applications.
BIOMEDICAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Rongrong Wu, Zengkai Wang, Zili Jia, Chenglong Li, Jie Wang, Lei Liu, Mingdong Dong
Summary: This study investigates the cross-fibrillation of A beta peptides and different hIAPP structures. The experimental results show that hIAPP aggregates enhance the fibrillation of A beta, especially hIAPP fibrils. Using quantitative nanomechanical mapping and molecular dynamic simulations, different hybrid amyloid strains can be distinguished based on their mechanical properties and structural transformations.
Article
Multidisciplinary Sciences
Steven J. Roeters, Kris Strunge, Kasper B. Pedersen, Thaddeus W. Golbek, Mikkel Bregnhoj, Yuge Zhang, Yin Wang, Mingdong Dong, Janni Nielsen, Daniel E. Otzen, Birgit Schiott, Tobias Weidner
Summary: This study reports a mechanism explaining why lipid membranes catalyze the formation of harmful aggregates at elevated concentrations.
NATURE COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Mingrui Zhang, Ying Zhang, Wei Mu, Mingdong Dong, Xiaojun Han
Summary: The bottom-up construction of artificial cells using chemically synthesized lipid analogues allows for better understanding of cellular mechanisms. This article describes four methods of synthesizing lipid analogues and their use in constructing and division of artificial cells. Challenges and future directions in this field are also discussed.
Review
Chemistry, Multidisciplinary
Dan Xia, Jiatian Chen, Zhongyang Zhang, Mingdong Dong
Summary: The demand for patients' organ and tissue repair and regeneration is increasing. However, autologous or allograft treatments are often hindered by issues such as donor shortage and possible rejection. Artificial constructs that mimic the extracellular matrix have been developed as substitutes to promote cell attachment and differentiation, ultimately forming functional tissues or organs. Polymeric materials have been widely used in regenerative medicine due to their manufacturing ease, flexibility, biocompatibility, and good mechanical, chemical, and thermal properties. This review provides a comprehensive overview of various polymeric materials and their applications, as well as discussing the challenges and perspectives in the development and clinical transformation of these biomaterials.
