Article
Neurosciences
David A. Cinalli, Sarah J. Cohen, Mariah Calubag, Goksu Oz, Lylybell Zhou, Robert W. Stackman
Summary: This study used the DREADDs method to investigate the effects of CA1 pyramidal neurons in the hippocampus on the retrieval of long-term memory for nonspatial and spatial information in mice. The results showed that the inhibition of CA1 neuronal activity significantly impaired the memory retrieval in mice. These findings support the use of mice as a model system to study the neurobiological mechanisms of human episodic memory.
Review
Behavioral Sciences
Tingting Lv, Mengfei Ye, Fangyi Luo, Baiqi Hu, Anzhe Wang, Jiaqi Chen, Junwei Yan, Ziyi He, Feng Chen, Chao Qian, Jian Zhang, Zheng Liu, Zhinan Ding
Summary: The gut-brain axis and the concept of psychobiotics have drawn attention for their potential positive effects on cognitive function. Probiotics supplementation enhanced cognitive function, with a greater effect observed in cognitively impaired individuals. Single strains of probiotics were more effective in human studies, suggesting a customized approach may be beneficial for improving cognitive disorders.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Endocrinology & Metabolism
Lian Jingxuan, Ma Litian, Tu Yanyang, Fu Jianfang
Summary: This study investigates the changes and roles of CLC-3 in diabetic encephalopathy, suggesting that CLC-3 may regulate insulin receptor signaling and downstream PI3K/AKT/GSK3 ss signaling pathways, ultimately affecting the pathogenesis of the disease.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Behavioral Sciences
Amanda Dyer, Maxine De Butte
Summary: This study aimed to examine the effects of chronic low-dose vanadium administration on the behavior of young male rats. The findings suggest that vanadium does not significantly affect exploration, locomotion, or anxiety-like behavior in rats, but does affect novel object recognition performance. Additionally, vanadium administration led to lower latency times in the Morris Water maze task.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Yuxi Chen, Audrey Branch, Cecelia Shuai, Michela Gallagher, James J. Knierim
Summary: The hippocampal formation is vulnerable to normal aging, and Long-Evans rats serve as a valuable model to study aging. This study found individual differences in spatial navigation and episodic-like memory abilities in aged rats, similar to age-related cognitive decline observed in humans. These findings suggest that aged Long-Evans rats can be used to explore the changes in cognitive function during aging.
Article
Pharmacology & Pharmacy
Zahra Gholami Mahmoudian, Ali Ghanbari, Iraj Rashidi, Iraj Amiri, Alireza Komaki
Summary: This study investigated the effects of minocycline on cognitive abilities, antioxidant enzyme activities, neuronal loss, and plaque number in rats with Alzheimer's disease induced by Aβ. The results showed that minocycline improved anxiety behavior, restored learning and memory deficits, and had antioxidant and anti-apoptotic effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Behavioral Sciences
Jhana O. Hendrickx, Sofie De Moudt, Elke Calus, Peter Paul De Deyn, Debby Van Dam, Guido R. Y. De Meyer
Summary: This study evaluated the neurobehavioral phenotyping of hippocampus-dependent spatial learning and memory in aging C57BL/6J mice using the Morris Water Maze and Novel Object Recognition tests. The results indicated age-related memory loss in the animals starting at 6 months, as shown by decreased discrimination indexes and recognition indexes. These findings contribute to understanding the spontaneous cognitive behaviors of the widely used C57BL/6J mouse strain and can serve as a benchmark for distinguishing spontaneous from pathological neurodegenerative behavior in dementia mouse models.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Lisa Wintzell, Samuel Klemetz, Stefan Lange, Eric Hanse, Caroline Wass, Joakim Strandberg
Summary: The endogenous peptide antisecretory factor (AF) enhances long-term potentiation (LTP) and spatial learning and memory by disinhibiting GABAergic transmission in the rat hippocampus.
Review
Behavioral Sciences
Lilian Juliana Lissner, Krista Mineia Wartchow, Ana Paula Toniazzo, Carlos-Alberto Goncalves, Leticia Rodrigues
Summary: Object recognition (OR) and the Morris water maze (MWM) are classical tasks used to assess memory parameters in rodents, involving hippocampus and prefrontal cortex connections. Despite controversy, these tests offer practical tools for evaluating hippocampal-related memory deficits in rats, with minimal manageable stressful conditions.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Luis Angel Lima-Castaneda, Maria Elena Bringas, Leonardo Aguilar-Hernandez, Linda Garces-Ramirez, Julio Cesar Morales-Medina, Gonzalo Flores
Summary: The prevalence of autism spectrum disorder (ASD) is increasing, and exposure to valproic acid (VPA) during pregnancy can cause ASD-like traits in offspring. Olanzapine (OLZ), an atypical antipsychotic, is found to improve cognitive and neuroplastic abnormalities caused by VPA.
JOURNAL OF CHEMICAL NEUROANATOMY
(2023)
Article
Neurosciences
Sachin P. Borikar, Shruti I. Dongare, Kishor R. Danao
Summary: The study aimed to investigate the therapeutic and preventive effects of agmatine on LPS-induced learning and memory impairment in mice. Results showed that agmatine treatment increased exploration to novel objects and reduced escape latency and time spent in the target quadrant in mice with LPS-induced memory deficits. Co-administration of agmatine with LPS also improved discrimination index in NOR test and decreased escape latency and time spent in the target quadrant in MWM test.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Cheryl A. Frye, Vincent F. Lembo, Alicia A. Walf
Summary: The study found that progesterone can enhance cognitive performance in male mice by increasing allopregnanolone concentrations, BDNF levels, and GABA(A) activity. These effects may be independent of traditional progestin receptors' trophic actions.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Physiology
Caitlin S. Mitchell, Elisabeth K. Goodman, Caitlin R. Tedesco, Kathy Nguyen, Lei Zhang, Herbert Herzog, Denovan P. Begg
Summary: This study investigated the effect of disrupted insulin signaling in NPY neurons on diet-induced deficits in hippocampal-dependent memory. The results showed that obesogenic diets can lead to hippocampal insulin resistance and impairments to hippocampal-dependent cognition. However, chronic sucrose intake did not have adverse effects on metabolic outcomes or hippocampal-dependent memory. These findings suggest that the effects of high-fat diet on hippocampal-dependent memory may depend on insulin signaling in hippocampal NPY cells.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Plant Sciences
Imane Es-safi, Hamza Mechchate, Amal Amaghnouje, Amine Elbouzidi, Mohamed Bouhrim, Noureddine Bencheikh, Christophe Hano, Dalila Bousta
Summary: The study aimed to investigate the effects of different doses of Pimpinella anisum total extract on anxiety, depression, and memory in mice. The results showed that PATE has anxiolytic and antidepressant effects, but no impact on memory.
Article
Neurosciences
Jemi Feiona Vergil Andrews, Divya Bharathi Selvaraj, Akshay Kumar, Syed Aasish Roshan, Muthuswamy Anusuyadevi, Mahesh Kandasamy
Summary: This study investigated the effect of aspirin on spatial memory in ageing experimental mice. Aspirin was found to enhance working memory, increase the number of new neurons in the hippocampus, reduce the number of microglial cells, and decrease the activity of AChE in the blood.
Article
Neurosciences
Duyilemi C. Ajonijebu, Oualid Abboussi, Musa Mabandla, William M. U. Daniels
Article
Psychiatry
Nirvana Morgan, William Daniels, Ugasvaree Subramaney
COMPREHENSIVE PSYCHIATRY
(2019)
Review
Cell Biology
Ernest Dalle, Musa Mabandla, William M. U. Daniels
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Neurosciences
S. S. Zulu, O. Abboussi, N. Simola, M. V. Mabandla, W. M. U. Daniels
ACTA NEUROPSYCHIATRICA
(2020)
Article
Cell Biology
Ernest Dalle, William M. U. Daniels, Musa Vuyisile Mabandla
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Neurosciences
Simo Siyanda Zulu, Oualid Abboussi, Nicola Simola, Musa Vuyisile Mabandla, William Mark Uren Daniels
Summary: Long-term exposure to cART resulted in increased escape latency in the Morris water maze test, elevated levels of oxidative damage marker 4-hydroxynonenal, and expression of autophagic marker LC3B, while decreasing synaptophysin and brain-derived neurotrophic factor (BDNF) expression in the hippocampus of mice.
JOURNAL OF NEUROVIROLOGY
(2021)
Article
Substance Abuse
Nhanisi A. Ndlovu, Nirvana Morgan, Stella Malapile, Ugasvaree Subramaney, William Daniels, Jaishree Naidoo, Martijn P. van den Heuvel, Tanya Calvey
Summary: Sub-Saharan Africa is one of the top regions with high rates of opioid-related premature mortality, where the street drug "Nyaope" is believed to be a cocktail of drugs, predominantly heroin with cannabis. The study found extensive grey matter atrophy in specific brain regions of Nyaope users, impacting impulse control, decision making, social- and self-perception, and working memory. These affected brain regions overlap with cortical abnormalities observed in heroin use disorder.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Oncology
Monica N. Gomes, Pascaline Fru, Tanya N. Augustine, Davison Moyo, Eliton Chivandi, William M. U. Daniels
Summary: Cancer patients, including breast cancer patients, are prone to blood clotting. The use of chemotherapy and hormone therapy in breast cancer treatment further increases the risk of thrombosis. Ethnomedicines, such as the seed oils of Kigelia africana, Ximenia caffra, and Mimusops zeyheri, are being explored as potential alternatives for breast cancer treatment in developing countries with low survival rates. These seed oils have shown anti-proliferative and cytotoxic effects on hormone-dependent and hormone-independent breast cancer cells, and can reduce the thrombogenic ability of MDA-MB-231 cells.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Psychiatry
Nirvana Morgan, Ellen-ge Denton, Ugasvaree Subramaney, William Daniels, Tilman Steinert
Summary: Among heroin users, comorbid mental illness, poorer physical health, and poorer social functioning are important factors associated with suicidal ideation and behavior. Although there was a decrease in overall suicidal ideation and behavior scores 3 months after detoxification, this trend was not sustained at the 9-month follow-up. The findings suggest that treatment exposure did not adequately mitigate suicide risk. Reviewing the treatment approach and implementing targeted screening and management of suicidal ideation and behavior in heroin users receiving treatment services are necessary.
FRONTIERS IN PSYCHIATRY
(2022)
Editorial Material
Biology
Kirsten A. Donald, Mahmoud Maina, Nilesh Patel, Carine Nguemeni, Wael Mohammed, Amina Abubakar, Matthew Brown, Raliza Stoyanova, Andrew Welchman, Natasha Walker, Alexis Willett, Symon M. Kariuki, Anthony Figaji, Dan J. Stein, Amadi O. Ihunwo, William Daniels, Charles R. Newton
Summary: Working in Africa offers neuroscientists unique opportunities due to the genetic diversity, diverse ecosystems, and unique stresses to brain health in the region. However, the African neuroscience community has not reached its full potential. Meetings were held to identify barriers and opportunities, resulting in the recognition of six distinct domains of African neuroscience and plans to advance the field.
Article
Medicine, General & Internal
N. Morgan, W. Daniels, U. Subramaney
SAMJ SOUTH AFRICAN MEDICAL JOURNAL
(2020)
Article
Biotechnology & Applied Microbiology
Stefanie Malan-Mueller, Vladimir B. C. de Souza, Willie M. U. Daniels, Soraya Seedat, Mark D. Robinson, Sian M. J. Hemmings
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2020)
Article
Substance Abuse
Nirvana Morgan, William Daniels, Ugasvaree Subramaney
SUBSTANCE ABUSE AND REHABILITATION
(2020)
Article
Substance Abuse
Nirvana Morgan, William Daniels, Ugasvaree Subramaney
HARM REDUCTION JOURNAL
(2019)
Article
Neurosciences
Ziphozethu Ndlazi, Oualid Abboussi, Musa Mabandla, Willie Daniels