期刊
ACTA NEUROLOGICA SCANDINAVICA
卷 134, 期 2, 页码 148-153出版社
WILEY-BLACKWELL
DOI: 10.1111/ane.12524
关键词
Parkinson's disease; brain tumor; National Health Insurance (NHI) program
资金
- Taiwan Ministry of Health and the Welfare Clinical Trial and Research Center of Excellence [MOHW104-TDU-B-212-113002]
- China Medical University Hospital
- Academia Sinica Taiwan Biobank
- Stroke Biosignature Project [BM104010092]
- NRPB Stroke Clinical Trial Consortium [MOST 103-2325-B-039 -006]
- Tseng-Lien Lin Foundation in Taichung, Taiwan
- Taiwan Brain Disease Foundation in Taipei, Taiwan
- Katsuzo and Kiyo Aoshima Memorial Funds in Japan
- Health and Welfare Surcharge of Tobacco Products, China Medical University Hospital Cancer Research Center of Excellence in Taiwan [MOHW104-TDU-B-212-124-002]
ObjectivesParkinson's disease (PD) is a neurodegenerative disease. A decreased risk of cancer, except for melanoma, has been observed in patients with PD. The aim of this study was to evaluate the association between brain tumor and PD in a Taiwanese population. Materials and methodsWe used data from the National Health Insurance program of Taiwan. The PD cohort contained 2998 patients, and each patient was frequency-matched, based on age and sex, with 4 people without PD, who were randomly selected from the general population. Cox's proportional hazard regression analysis was conducted to estimate the effects of PD on the risk of brain tumor. ResultsThe risk of developing brain tumor was significantly higher in patients with PD than in those without PD (adjusted hazard ratio = 2.11; 95% confidence interval (CI) = 1.24-3.59), and benign brain tumor exhibited a particularly elevated risk of 2.16-fold (95% CI = 1.26-3.68). The hazard ratio (HR) for developing a benign brain tumor was higher in female patients with PD than in female patients without PD, with the risk being 2.65-fold (95% CI = 1.30-5.43). An analysis of the two age groups, 50-64 years and 65 years, showed that the HR of only the 50-64-year group was significantly higher between the PD and non-PD groups (HR = 2.77, 95% CI = 1.07-7.14). ConclusionThe present study showed that Taiwanese patients with PD are at a higher risk of developing brain tumor than the general population. The exact underlying etiologies require further investigation.
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