期刊
WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY
卷 4, 期 4, 页码 335-356出版社
WILEY
DOI: 10.1002/wdev.181
关键词
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资金
- NSF [IOS-0919855, IOS-1256565]
- Lake Forest College
- Michigan State University
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1406547, 0845847] Funding Source: National Science Foundation
The developmental regulation of final body and organ size is fundamental to generating a functional and correctly proportioned adult. Research over the last two decades has identified a long list of genes and signaling pathways that, when perturbed, influence final body size. However, body and organ size are ultimately a characteristic of the whole organism, and how these myriad genes and pathways function within a physiological context to control size remains largely unknown. In this review, we first describe the major size-regulatory signaling pathways: the Insulin/IGF-, RAS/RAF/MAPK-, TOR-, Hippo-, and JNK-signaling pathways. We then explore what is known of how these pathways regulate five major aspects of size regulation: growth rate, growth duration, target size, negative growth and growth coordination. While this review is by no means exhaustive, our goal is to provide a conceptual framework for integrating the mechanisms of size control at a molecular-genetic level with the mechanisms of size control at a physiological level. (C) 2015Wiley Periodicals, Inc.
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