期刊
WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY
卷 5, 期 1, 页码 67-84出版社
WILEY-BLACKWELL
DOI: 10.1002/wdev.200
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资金
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- Centre National de la Recherche Scientifique (CNRS)
- Universite de Strasbourg (UDS)
- Hopital de Strasbourg
- Association pour la Recherche sur le Cancer (ARC)
- Ligue contre le Cancer (LIGUE)
- Agence Nationale de la Recherche (ANR)
- Institut d'Etudes Avances de l'Universite de Strasbourg (USIAS)
- Fondation pour la Recherche Medicale (FRM)
- Neurex Network (TriNeuron Programme Interreg IV Upper Rhine)
- Region Alsace
Throughout evolution, glia have key regulatory roles in neural development and function. Typically, they control the response to developmental and/or pathological signals, thereby affecting neural proliferation, remodeling, survival, and regeneration. Such complex biology depends on the plastic features of glial cells, but also on the presence of different classes of glial cells, hence the importance of understanding the cellular and the molecular mechanisms underlying their development. The fly community has made major breakthroughs by characterizing the bases of gliogenesis and here we describe the glial lineages as well as the glial promoting factor active in the embryo of Drosophila melanogaster.
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