期刊
WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY
卷 4, 期 6, 页码 591-608出版社
WILEY
DOI: 10.1002/wdev.195
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资金
- Departement de l'Instruction Publique of the Canton of Geneva, SNSF
- SystemsX epiPhysX grant, ERC
- NCCR
- Polish-Swiss research program
How a developing organ grows and patterns to its final shape is an important question in developmental biology. Studies of growth and patterning in the Drosophila wing imaginal disc have identified a key player, the morphogen Decapentaplegic (Dpp). These studies provided insights into our understanding of growth control and scaling: expansion of the Dpp gradient correlated with the growth of the tissue. A recent report on growth of a Drosophila organ other than the wing, the eye imaginal disc, prompts a reconsideration of our models of growth control. Despite striking differences between the two, the Dpp gradient scales with the target tissues of both organs and the growth of both the wing and the eye is controlled by Dpp. The goal of this review is to discuss whether a parsimonious model of scaling and growth control can explain the relationship between the Dpp gradient and growth in these two different developmental systems. (C) 2015 Wiley Periodicals, Inc.
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