Article
Polymer Science
Mina Ahsani, Reza Sabouri, Mathias Ulbricht, Hossein Hazrati, Abbas Jafarizad, Reza Yegani
Summary: The hydrophilic and antibacterial Ag-SiO2-PVP nanoparticles were successfully synthesized through multiple steps. The vinyl groups and PVP brushes were successfully generated onto the silica nanoparticles using silanization and grafting-through polymerization methods. The Ag-SiO2-PVP nanoparticles showed outstanding bactericidal properties when assessed using the plate colony counting method.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Chemistry, Physical
Anna Gorczyca, Ewa Pociecha, Julia Maciejewska-Pro, Monika Kula-Maximenko, Magdalena Ocwieja
Summary: This study investigated the phytotoxic effects of silver nanoparticles (AgNPs) with different surface properties on wheat plants. The results showed that AgNPs stabilized with sodium hexametaphosphate exhibited the highest toxicity, while citrate-stabilized AgNPs showed the least toxicity to the seedlings.
SURFACE INNOVATIONS
(2022)
Article
Chemistry, Physical
Tiago Fernandes, Sara Fateixa, Marta Ferro, Helena I. S. Nogueira, Ana L. Daniel-da-Silva, Tito Trindade
Summary: The use of dendrimers in the controlled synthesis of Ag:Au hybrid nanostructures enhances SERS sensitivity to organic pollutants. Dendrimers play a crucial role as multipurpose ligands in the formation of hybrid nanostructures, improving stability and sensitivity. Interparticle plasmonic coupling templated by dendrimer macromolecules contributes to the high SERS sensitivity of the hybrid nanostructures.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Infectious Diseases
Chengang Ni, Yuening Zhong, Weixi Wu, Yaping Song, Pooyan Makvandi, Chengzhong Yu, Hao Song
Summary: This study successfully combined vancomycin and nano-Ag onto pollen-like silica nanoparticles to enhance bacterial killing. The silver nanoparticles were observed to be well-distributed on the surface of silica nanoparticles, with a unique spiky morphology promoting adhesion to bacterial surfaces for localized drug release to kill bacteria.
Article
Engineering, Environmental
Ammar Tarar, Ching-An Peng
Summary: In this study, silver nanoparticles with enhanced antibacterial activity were synthesized using sinigrin as both reducing and capping agent. The sinigrin-capped silver nanoparticles exhibited increased zone of inhibition against E. coli and prolonged inhibitory effect on bacterial growth.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Chemistry, Applied
A. Wasilewska, U. Klekotka, M. Zambrzycka, G. Zambrowski, I. Swiecicka, B. Kalska-Szostko
Summary: Understanding the properties of silver nanoparticles is crucial for developing new antimicrobial agents. In this study, silver nanoparticles were synthesized using natural reducing agents from plant extracts, and their antimicrobial properties were evaluated against various microorganisms. The results showed that the nanoparticles obtained from different extracts exhibited specific characteristics and varied antimicrobial activities.
Article
Chemistry, Multidisciplinary
Alcina Johnson Sudagar, Neha Venkatesh Rangam, Artur Ruszczak, Pawel Borowicz, Jozsef Toth, Laszlo Koever, Dorota Michalowska, Marek L. Roszko, Krzysztof R. Noworyta, Beata Lesiak
Summary: In this study, silver phosphate nanocomposites were synthesized using brewery wastes at different temperatures and times to obtain varying component ratios. It was found that BW7 nanocomposites exhibited higher antibacterial activity due to a larger silver phosphate content and a thinner organic overlayer compared to BW5 nanocomposites. The presence of Ag-met in the structure adversely affected the antimicrobial property of the nanocomposites.
Article
Polymer Science
Hazem Idriss, Roman Elashnikov, Silvie Rimpelova, Barbora Vokata, Petr Hausild, Zdenka Kolska, Oleksiy Lyukatov, Vaclav Svorcik
Summary: A chemical approach is presented for grafting silver nanoparticles into a resin matrix for 3D printing, showing excellent antibacterial effect. The homogenous distribution of nanoparticles is achieved in samples prepared this way, while preserving physical properties.
Article
Materials Science, Ceramics
Shaosheng Rao, Qinqin Liu, Bing Li, Yangyang Sun, Yinmao Wang, Guozhong Gao, Zhongti Sun, Juan Yang
Summary: A novel antibacterial material, silver/polyethyleneimine/reduced gra-phene oxide (Ag/PEI/rGO), was designed with good dispersibility and permeability for the capture of bacteria and controlled release of biocidal agents. Compared to Ag/rGO, Ag/PEI/rGO showed excellent stability and higher sterilization efficacy against Escherichia coli and Staphylococcus aureus. The outstanding biocompatibility of this antibacterial material makes it highly promising for sterilization applications in solving infection problems caused by bacterial biofilm formation.
CERAMICS INTERNATIONAL
(2023)
Article
Chemistry, Multidisciplinary
Neha Venkatesh Rangam, Alcina Johnson Sudagar, Artur Ruszczak, Pawel Borowicz, Jozsef Toth, Laszlo Kover, Dorota Michalowska, Marek Lukasz Roszko, Krzysztof Robert Noworyta, Beata Lesiak
Summary: This study reports the valorization of brewery waste to synthesize silver nanocomposites, which has been largely unexplored. By using brewery waste and silver as precursors, silver nanocomposites were synthesized at different temperatures and time periods. The nanocomposites showed high antibacterial activity.
Article
Chemistry, Physical
Yufeng Li, Yangyang Yan, Jie Wang, Lidong Li, Fu Tang
Summary: In this study, rod-like silver nanoparticles were successfully prepared in mesoporous silica nanoparticles by a simple method, with tunable optical properties. The resulting gelatin-mixed hydrogel exhibited efficient antibacterial properties due to excellent photothermal performance.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Physical
Kanchan Mehta, Virendra Kumar, Bhuvaneshwar Rai, Meenu Talwar, Gulshan Kumar
Summary: This study developed an antibacterial and hydrophilic non-woven polypropylene fabric with excellent breathability through a two-step process. Acrylic acid was introduced onto the fabric using simultaneous irradiation graft polymerization and pre-irradiation graft polymerization methods. The fabric was then immobilized with silver nanoparticles. The resulting fabric samples exhibited desired properties and demonstrated excellent antibacterial efficacy.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Tiago Fernandes, Helena I. S. Nogueira, Carlos O. Amorim, Joao S. Amaral, Ana L. Daniel-da-Silva, Tito Trindade
Summary: This study focuses on the use of surface-enhanced Raman scattering (SERS) for detecting trace water contaminants in water quality monitoring, with the design of novel nanostructures through different chemical strategies and functionalities integration.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Editorial Material
Chemistry, Multidisciplinary
T. Fernandes, H. I. S. Nogueira, C. O. Amorim, J. S Amaral, A. L. Daniel-da-Silva, T. Trindade
Summary: This study investigates chemical strategies for preparing magneto-plasmonic nanostructures for SERS detection in water quality monitoring. Three chemical routes were explored, leading to different ways of evaluating SERS detection using distinct interfaces.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Viktoryia Kulikouskaya, Viktoryia Nikalaichuk, Kseniya Hileuskaya, Alena Ladutska, Karine Grigoryan, Irina Kozerozhets, Varduhi Hovsepyan, Mariam Sargsyan, Anastasiya Sidarenka
Summary: This study provides a simple, green, sustainable, and rapid technique to synthesize biogenic alginate-capped silver nanoparticles (Alg-Ag NPs) suitable for the treatment of Pseudomonas infections. In vitro studies showed that Alg-Ag NPs exhibited prominent antimicrobial activity against Pseudomonas strains, indicating their potential for combating Pseudomonas infections in rainbow trout.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Evgeny Apartsin, Alya Venyaminova, Jean-Pierre Majoral, Anne-Marie Caminade
Summary: This study presents the method of impregnating neutral hydrogels with siRNA-dendrimer complexes, where the surface chemistry of dendrimers allows adjustment of the release rate. This provides a new material for biomedical applications.
FRONTIERS IN CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Evgeny K. Apartsin, Nadezhda Knauer, Ulf Dietrich Kahlert, Anne-Marie Caminade
Summary: Dendritic molecules with metal complexes are potential therapeutic entities, and metallodendrons are particularly of interest as antitumor agents. In this study, we synthesized amphiphilic metallodendrons and tested their antitumor activity against glioblastoma. The results showed that the metallodendrons exhibited higher cytotoxic activity compared to the clinical standard of care for glioblastoma, indicating their potential as antitumor entities.
Meeting Abstract
Oncology
N. Knauer, E. Pashkina, V. Kozlov, R. Gomez, A-M. Caminade, U. Kahlert, E. Apartsin
ANNALS OF ONCOLOGY
(2022)
Article
Materials Science, Biomaterials
Liang Chen, Mengsi Zhan, Jin Li, Liu Cao, Huxiao Sun, Regis Laurent, Serge Mignani, Anne-Marie Caminade, Jean-Pierre Majoral, Xiangyang Shi
Summary: This study introduces a nanosystem based on amphiphilic phosphorus dendron micelles for combination therapy of triple negative breast cancer. The micelles exhibit excellent stability and high drug loading efficiency. The co-delivery system of miR-21 inhibitor and doxorubicin can effectively inhibit cancer cells through different anticancer mechanisms, as demonstrated in in vivo experiments.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Materials Science, Composites
Evgeny Apartsin, Anne-Marie Caminade
Summary: This article reviews different types of amphiphilic dendritic structures, including dendrimers, Janus dendrimers, and dendrons, which can individually generate physical hydrogels. It has been found that these structures can be prospective building blocks for hydrogel networks. The first part introduces positively charged phosphorus dendrimers used to generate hydrogels, which are also suitable for fiber formation, encapsulating substances, and forming complexes for slow delivery of genetic materials. The second part discusses PAMAM dendrimers functionalized with collagen mimetics. The third part focuses on amphiphilic Janus dendrimers, while the fourth part displays different types of amphiphilic dendrons and their use in the fields of materials and drug delivery.
JOURNAL OF COMPOSITES SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
My Lan Tran, Marc Borie-Guichot, Virginie Garcia, Abdelouahd Oukhrib, Yves Genisson, Thierry Levade, Stephanie Ballereau, Cedric-Olivier Turrin, Cecile Dehoux
Summary: The researchers synthesized phosphorus dendrimers with a cyclotriphosphazene core and decorated with monofluorocyclooctyne units. They grafted N-hexyl deoxynojirimycin inhibitors onto the surface of dendrimers. These synthesized iminosugars were tested as multivalent inhibitors of enzymes associated with Gaucher and Pompe lysosomal storage diseases, showing higher potency than the reference inhibitor. These dendrimers were also evaluated as pharmacological chaperones against Gaucher disease, exhibiting increased enzyme activity in Gaucher cells.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Anne-Marie Caminade, Aurelien Hameau, Kathleen Moineau-Chane Ching, Cedric-Olivier Turrin
Summary: This review presents the synthesis of dendrons based on cyclotriphosphazene cores, with one function being a fluorescent group, and the five remaining functions used for growing the dendritic branches. The growing of the branches is carried out by a divergent method using a two-step process. Different fluorophores and terminal functions of the dendrons lead to various applications, including catalysis, material elaboration, transfection experiments, anti-cancer property study, and imaging related to the human immune system.
HELVETICA CHIMICA ACTA
(2023)
Review
Chemistry, Multidisciplinary
Valerie Maraval, Regis Laurent, Anne-Marie Caminade
Summary: The Staudinger reaction is used for the synthesis of phosphorus azides and dendritic structures containing P=N-P=X moieties. The conjugation of P=N bond with P=X bond stabilizes the P=N bond. Various dendritic structures such as dendrons, dendrimers, Janus dendrimers, layered dendrimers, surface-block dendrimers, etc. have been synthesized using this reaction. Alkylation or complexation exclusively occurs on the sulfur atom of P=N-P=S linkages, weakening the strength of P=S bond and allowing the formation of highly sophisticated dendritic structures.
Editorial Material
Health Care Sciences & Services
Anne-Marie Caminade
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Omar Alami, Regis Laurent, Marine Tasse, Yannick Coppel, Jerome Bignon, Said El Kazzouli, Jean-Pierre Majoral, Nabil El Brahmi, Anne-Marie Caminade
Summary: In this study, two families of phosphorhydrazone dendrons were synthesized and characterized. These dendrons were then grafted onto graphene oxide (GO) via click reaction. The resulting materials were tested for their biological properties.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Anne-Marie Caminade
Summary: This review provides an overview of the interactions between two different families of nanoobjects: nanoparticles, mainly metal nanoparticles, and dendrimers, mainly phosphorhydrazone dendrimers (or dendrons). The review discusses the encapsulation/protection of existing nanoparticles (organic or metallic) by phosphorus-based dendrimers and dendrons. It also presents various methods for synthesizing metal nanoparticles using dendrimers as templates. The review emphasizes the properties of the associations between dendrimers and nanoparticles, including their application in hybrid materials, chemosensors, biosensors, and catalysis.
Review
Biochemistry & Molecular Biology
Joel Cejas-Sanchez, Anna Kajetanowicz, Karol Grela, Anne-Marie Caminade, Rosa Maria Sebastian
Summary: Dendrimers are highly branched macromolecules with identical terminal functionalities, but there are cases where having two distinct surface functionalities is advantageous. Janus dendrimers, consisting of two dendrimeric wedges terminated by different functionalities, can be created by synthesizing dendrons with complementary core functionalities. This review discusses various techniques used to fabricate phosphorus-based Janus dendrimers and highlights the advantages of phosphorus dendrimers over classic dendrimers, such as easy monitoring of reactions and purity confirmation through P-31 NMR.
Review
Pharmacology & Pharmacy
Anne-Marie Caminade, Max Milewski, Evamarie Hey-Hawkins
Summary: The use of boron clusters in nanoparticles for cancer treatment, particularly in dendrimers, is highlighted in this review. The synthesis methods and biological properties of boronated dendritic structures are discussed, along with their efficiency in animal models and potential for boron neutron capture therapy (BNCT) experiments.
Article
Chemistry, Physical
Omar Alami, Regis Laurent, Marine Tasse, Yannick Coppel, Vincent Colliere, Jerome Bignon, Jean-Pierre Majoral, Said El Kazzouli, Nabil El Brahmi, Anne-Marie Caminade
Summary: In this study, a novel approach for functionalizing graphene oxide (GO) surface with AB5 phosphorus dendron and dendrimer was reported. These functionalized macromolecules were grafted onto the GO surface via covalent bonding. The resulting materials were characterized and evaluated for their biological activity.