4.6 Article

PPH dendrimers grafted on silica nanoparticles: surface chemistry, characterization, silver colloids hosting and antibacterial activity

期刊

RSC ADVANCES
卷 3, 期 41, 页码 19015-19026

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ra43348j

关键词

-

资金

  1. CNRS
  2. French National Agency (ANR
  3. COPPERTREE) [ANR-11-BS07-018]

向作者/读者索取更多资源

Polyphosphorhydrazone (PPH) dendrimers have been grafted on silica nanoparticles, and the surface functions of the dendrimers have been derivatized to phosphonates with lateral poly(ethyleneglycol) (PEG) chains. All materials have been thoroughly characterized by MAS NMR, FT-IR, electron microscopy, TGA and elemental analysis. These materials successfully hosted silver and silver oxide nanoparticles. The resulting composites exhibit antibacterial activity.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Chemistry, Multidisciplinary

Dendriplex-Impregnated Hydrogels With Programmed Release Rate

Evgeny Apartsin, Alya Venyaminova, Jean-Pierre Majoral, Anne-Marie Caminade

Summary: This study presents the method of impregnating neutral hydrogels with siRNA-dendrimer complexes, where the surface chemistry of dendrimers allows adjustment of the release rate. This provides a new material for biomedical applications.

FRONTIERS IN CHEMISTRY (2022)

Article Pharmacology & Pharmacy

Amphiphilic Triazine-Phosphorus Metallodendrons Possessing Anti-Cancer Stem Cell Activity

Evgeny K. Apartsin, Nadezhda Knauer, Ulf Dietrich Kahlert, Anne-Marie Caminade

Summary: Dendritic molecules with metal complexes are potential therapeutic entities, and metallodendrons are particularly of interest as antitumor agents. In this study, we synthesized amphiphilic metallodendrons and tested their antitumor activity against glioblastoma. The results showed that the metallodendrons exhibited higher cytotoxic activity compared to the clinical standard of care for glioblastoma, indicating their potential as antitumor entities.

PHARMACEUTICS (2022)

Meeting Abstract Oncology

Antitumor effects of cationic dendritic molecules and their complexes with microRNA in glioblastoma stem-like cells

N. Knauer, E. Pashkina, V. Kozlov, R. Gomez, A-M. Caminade, U. Kahlert, E. Apartsin

ANNALS OF ONCOLOGY (2022)

Article Materials Science, Biomaterials

Amphiphilic phosphorous dendron micelles co-deliver microRNA inhibitor and doxorubicin for augmented triple negative breast cancer therapy

Liang Chen, Mengsi Zhan, Jin Li, Liu Cao, Huxiao Sun, Regis Laurent, Serge Mignani, Anne-Marie Caminade, Jean-Pierre Majoral, Xiangyang Shi

Summary: This study introduces a nanosystem based on amphiphilic phosphorus dendron micelles for combination therapy of triple negative breast cancer. The micelles exhibit excellent stability and high drug loading efficiency. The co-delivery system of miR-21 inhibitor and doxorubicin can effectively inhibit cancer cells through different anticancer mechanisms, as demonstrated in in vivo experiments.

JOURNAL OF MATERIALS CHEMISTRY B (2023)

Review Materials Science, Composites

Single-Component Physical Hydrogels of Dendritic Molecules

Evgeny Apartsin, Anne-Marie Caminade

Summary: This article reviews different types of amphiphilic dendritic structures, including dendrimers, Janus dendrimers, and dendrons, which can individually generate physical hydrogels. It has been found that these structures can be prospective building blocks for hydrogel networks. The first part introduces positively charged phosphorus dendrimers used to generate hydrogels, which are also suitable for fiber formation, encapsulating substances, and forming complexes for slow delivery of genetic materials. The second part discusses PAMAM dendrimers functionalized with collagen mimetics. The third part focuses on amphiphilic Janus dendrimers, while the fourth part displays different types of amphiphilic dendrons and their use in the fields of materials and drug delivery.

JOURNAL OF COMPOSITES SCIENCE (2023)

Article Chemistry, Multidisciplinary

Phosphorus Dendrimers for Metal-Free Ligation: Design of Multivalent Pharmacological Chaperones against Gaucher Disease

My Lan Tran, Marc Borie-Guichot, Virginie Garcia, Abdelouahd Oukhrib, Yves Genisson, Thierry Levade, Stephanie Ballereau, Cedric-Olivier Turrin, Cecile Dehoux

Summary: The researchers synthesized phosphorus dendrimers with a cyclotriphosphazene core and decorated with monofluorocyclooctyne units. They grafted N-hexyl deoxynojirimycin inhibitors onto the surface of dendrimers. These synthesized iminosugars were tested as multivalent inhibitors of enzymes associated with Gaucher and Pompe lysosomal storage diseases, showing higher potency than the reference inhibitor. These dendrimers were also evaluated as pharmacological chaperones against Gaucher disease, exhibiting increased enzyme activity in Gaucher cells.

CHEMISTRY-A EUROPEAN JOURNAL (2023)

Review Chemistry, Multidisciplinary

Fluorescent Groups at the Core of Phosphorus Dendrons and Their Properties

Anne-Marie Caminade, Aurelien Hameau, Kathleen Moineau-Chane Ching, Cedric-Olivier Turrin

Summary: This review presents the synthesis of dendrons based on cyclotriphosphazene cores, with one function being a fluorescent group, and the five remaining functions used for growing the dendritic branches. The growing of the branches is carried out by a divergent method using a two-step process. Different fluorophores and terminal functions of the dendrons lead to various applications, including catalysis, material elaboration, transfection experiments, anti-cancer property study, and imaging related to the human immune system.

HELVETICA CHIMICA ACTA (2023)

Review Chemistry, Multidisciplinary

The Chemistry of P=N-P=X (X=S, O, NR) Linkages for the Synthesis of Dendritic Structures

Valerie Maraval, Regis Laurent, Anne-Marie Caminade

Summary: The Staudinger reaction is used for the synthesis of phosphorus azides and dendritic structures containing P=N-P=X moieties. The conjugation of P=N bond with P=X bond stabilizes the P=N bond. Various dendritic structures such as dendrons, dendrimers, Janus dendrimers, layered dendrimers, surface-block dendrimers, etc. have been synthesized using this reaction. Alkylation or complexation exclusively occurs on the sulfur atom of P=N-P=S linkages, weakening the strength of P=S bond and allowing the formation of highly sophisticated dendritic structures.

CHEMPLUSCHEM (2023)

Editorial Material Health Care Sciences & Services

Personalized and Precision Medicine 2022

Anne-Marie Caminade

JOURNAL OF PERSONALIZED MEDICINE (2023)

Article Chemistry, Multidisciplinary

Click Chemistry for the Functionalization of Graphene Oxide with Phosphorus Dendrons: Synthesis, Characterization and Preliminary Biological Properties

Omar Alami, Regis Laurent, Marine Tasse, Yannick Coppel, Jerome Bignon, Said El Kazzouli, Jean-Pierre Majoral, Nabil El Brahmi, Anne-Marie Caminade

Summary: In this study, two families of phosphorhydrazone dendrons were synthesized and characterized. These dendrons were then grafted onto graphene oxide (GO) via click reaction. The resulting materials were tested for their biological properties.

CHEMISTRY-A EUROPEAN JOURNAL (2023)

Review Biochemistry & Molecular Biology

Interplay between Nanoparticles and Phosphorus Dendrimers, and Their Properties

Anne-Marie Caminade

Summary: This review provides an overview of the interactions between two different families of nanoobjects: nanoparticles, mainly metal nanoparticles, and dendrimers, mainly phosphorhydrazone dendrimers (or dendrons). The review discusses the encapsulation/protection of existing nanoparticles (organic or metallic) by phosphorus-based dendrimers and dendrons. It also presents various methods for synthesizing metal nanoparticles using dendrimers as templates. The review emphasizes the properties of the associations between dendrimers and nanoparticles, including their application in hybrid materials, chemosensors, biosensors, and catalysis.

MOLECULES (2023)

Review Biochemistry & Molecular Biology

Strategies for the Preparation of Phosphorus Janus Dendrimers and Their Properties

Joel Cejas-Sanchez, Anna Kajetanowicz, Karol Grela, Anne-Marie Caminade, Rosa Maria Sebastian

Summary: Dendrimers are highly branched macromolecules with identical terminal functionalities, but there are cases where having two distinct surface functionalities is advantageous. Janus dendrimers, consisting of two dendrimeric wedges terminated by different functionalities, can be created by synthesizing dendrons with complementary core functionalities. This review discusses various techniques used to fabricate phosphorus-based Janus dendrimers and highlights the advantages of phosphorus dendrimers over classic dendrimers, such as easy monitoring of reactions and purity confirmation through P-31 NMR.

MOLECULES (2023)

Review Pharmacology & Pharmacy

Dendritic Structures Functionalized with Boron Clusters, in Particular Carboranes, and Their Biological Properties

Anne-Marie Caminade, Max Milewski, Evamarie Hey-Hawkins

Summary: The use of boron clusters in nanoparticles for cancer treatment, particularly in dendrimers, is highlighted in this review. The synthesis methods and biological properties of boronated dendritic structures are discussed, along with their efficiency in animal models and potential for boron neutron capture therapy (BNCT) experiments.

PHARMACEUTICS (2023)

Article Chemistry, Physical

Functionalization of graphene oxide surfaces with phosphorus dendrimer and dendron

Omar Alami, Regis Laurent, Marine Tasse, Yannick Coppel, Vincent Colliere, Jerome Bignon, Jean-Pierre Majoral, Said El Kazzouli, Nabil El Brahmi, Anne-Marie Caminade

Summary: In this study, a novel approach for functionalizing graphene oxide (GO) surface with AB5 phosphorus dendron and dendrimer was reported. These functionalized macromolecules were grafted onto the GO surface via covalent bonding. The resulting materials were characterized and evaluated for their biological activity.

FLATCHEM (2023)

暂无数据